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All Journal Jurnal Sain Veteriner Jurnal Biologi Tropis JOURNAL LA MEDIHEALTICO JUKESHUM: Jurnal Pengabdian Masyarakat Journal of Pharmaceutical and Sciences.
Fitri, Khairani
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Antifungal Activity Test of Jamaican Cherry Leaf (Muntingia calabura l.) Ethanol Extract in Inhibiting Growth of Fungi Malassezia furfur and Pityrosporum ovale Khairani, Tetty Noverita; Neswita, Elfia; Nurasni, Nurasni; Fitri, Khairani; Amanda, Asri
Jurnal Biologi Tropis Vol. 25 No. 3 (2025): Juli-September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i3.9510

Abstract

The plant species known as Jamaican Cherry Leaf (Muntingia calabura L.) belongs to the Muntingiaceae family. Flavonoid compounds, tannins, saponins, and steroids are all found in Jamaican cherry leaves. One of them has antifungals that can stop Pityrosporum ovale and Malassezia furfur from growing, and it is utilized as a traditional medication. This study aimed to determine the antifungal activity and the most effective concentration of Jamaican cherry leaves in inhibiting the growth of Malassezia furfur and Pityrosporum ovale fungi. Methods research is an experimental research. The research phase includes sampling, making simplicia, extract making, testing the characteristics of simplicia and extract, testing the inhibitory power of ethanol extract of Jamaican cherry leaf against fungi (Malassezia furfur and Pityrosporum ovale) by comparing the 2% ketoconazole antibiotic. The results showed the inhibition of ethanol extract of Jamaican cherry leaf (Muntingia calabura L.) against the growth of Malassezia furfur at F1 (7.2 mm), F2 (9.8 mm), F3 (11 mm) with and F4 (6.8 mm). mm) while against the growth of the fungus Pityrosporum ovale at F1 (7.0 mm), F2 (9.11 mm), F3 (10.2 mm) and F4 (6.3 mm). The best inhibition zone was formed at 30% concentration treatment with strong category. The conclusion shows that the ethanol extract of Jamaican cherry leaf (Muntingia calabura L.) can inhibit the growth of Malassezia furfur and Pityrosporum ovale fungi.
Aktivitas Ekstrak Etanol Daun Bandotan Terhadap Pertumbuhan Bakteri Vibrio sp. Isolat Ikan Lele Dumbo (Clarias gariepinus) Admi, Masda; Fitri, Khairani; Hennivanda, Hennivanda; Jamin, Faisal; Rosmaidar, Rosmaidar; Syafruddin, Syafruddin; Winaruddin, Winaruddin; Azhari, Azhari
Jurnal Sain Veteriner Vol 43, No 2 (2025): Agustus
Publisher : Faculty of Veterinary Medicine, Universitas Gadjah Mada bekerjasama dengan PB PDHI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jsv.96568

Abstract

     Daun bandotan merupakan salah satu tanaman obat yang banyak dimanfaatkan  dalam mengobati berbagai jenis penyakit karena mengandung senyawa fitokimia yang dapat menghambat pertumbuhan bakteri seperti alkaloid, flavonoid, tanin, saponin dan steroid. Penelitian ini bertujuan untuk mengetahui aktivitas ekstrak etanol daun bandotan terhadap pertumbuhan bakteri Vibrio sp. isolat ikan lele dumbo. Pelaksanaan penelitian ini menggunakan metode Kirby Bauer disk diffusion yang diawali dengan peremajaan stok isolat bakteri pada media Nutrient Broth, reidentifikasi dengan media Thiosulfate Citrate Bile Salt Sucrose Agar dan pewarnaan Gram. Selanjutnya dilakukan uji daya hambat menggunakan media Mueller Hinton Agar. Studi ini terdiri dari 5 perlakuan yaitu ekstrak etanol daun bandotan konsentrasi 25% (P1), 50% (P2), dan 75% (P3), siprofloksasin sebagai kontrol positif dan CMC 1% sebagai kontrol negatif. Hasil penelitian menunjukkan diameter zona hambat yang terbentuk pada kontrol positif (45,13 ± 0,04mm) dua kali lebih besar dibandingkan daya hambat yang terbentuk pada ekstrak daun bandotan konsentrasi 25% (23,30 ± 0,15mm), konsentrasi 50% (24,29 ± 0,17 mm), dan konsentrasi 75% (25,29 ± 0,16mm), kontrol negatif tidak menunjukkan terbentuknya zona hambat. Kesimpulan penelitian adalah ekstrak etanol daun bandotan berpotensi dapat menghambat pertumbuhan bakteri Vibrio sp. hasil isolat lele dumbo.      
Comparative Preclinical Evaluation of Nelumbo Nucifera and Related Herbal Extracts in Breast Cancer Models: Molecular Pathways and Effectiveness Fitri, Khairani; Azzubaidi, Marwan Saad; Hassan, Nurul Huda Mat
Journal La Medihealtico Vol. 6 No. 4 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i4.2560

Abstract

This study provides a comparative preclinical evaluation of Nelumbo nucifera (lotus) and related herbal extracts in breast cancer models, focusing on their targeted molecular pathways and effectiveness. The analysis includes both in vitro and in vivo studies involving lotus leaf, seedpod, and related plant extracts from Nymphaea, Moringa, and Taraxacum. The findings demonstrate that N. nucifera leaf alcoholic extract exhibits the most comprehensive anticancer profile, with effects validated in multiple models, including those of ER-negative and radioresistant cells. The lotus seedpod extracts also demonstrated promising activity against resistant tumors by inhibiting DNA repair. Other herbal candidates demonstrated apoptotic or cytotoxic effects but were limited in scope or lacked in vivo confirmation. These results support the further development of lotus-derived compounds as promising multi-pathway therapeutic agents for breast cancer.
Anti-Fungal Activity Testing of Purple Cabbage (Brassica oleracea Linn.) Ethanol Extract in Inhibiting The Fungi Growth Candida albicans and Malassezia furfur Khairani, Tetty Noverita; Fitri, Khairani; Andry, Muhammad; Sarumaha, Paska Eli
Jurnal Biologi Tropis Vol. 24 No. 4 (2024): Oktober - Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i4.8009

Abstract

One of the plants that has the potential to be utilized as medicine is purple cabbage (Brassica oleracea Linn.). Commensal fungi like Candida albicans and Malassezia furfur can be found in the genitourinary tract, vagina, urethra, skin, fingers, and toes, among other places on the body. The purpose of: The study aimed to learn more about the antifungal properties of the ethanol extract of purple cabbage in preventing the growth of Malassezia furfur and Candida albicans. This study used an experimental design to examine the independent variables of the purple cabbage extract with various doses of the growth activity test of Candida albicans and Malassezia furfur, as well as their inhibition zones. Purple cabbage contains steroids, saponins, tannins, and flavonoid compounds. With concentrations of 10%, 20%, 30%, and positive control, the average diameter of the inhibitory zone for Candida albicans was 4.83 mm, 7.2mm, 8.75mm, and 6.21mm. The concentrations of Malassezia furfur at 10%, 20%, 30%, and the positive control were 4.61mm, 6.36mm, 8.83mm, and 6.15mm, respectively. As a negative control, DMSO failed to exhibit an inhibitory zone. Statistics revealed a substantial difference, indicating that the concentration had an impact on how the inhibition zone developed. The ethanol extract of purple cabbage has antifungal action, and the treatment with the 30% extract concentration forms the optimal concentration. It is advised that more research be done on the antifungal activity of purple cabbage extract against various kinds of fungus and that dosage forms be created for it.
Empowerment and Welfare of Bakaran Batu Village Families in Making Empon Menieer Mixture as Body Immunity to Improve the Community's Economy: Pemberdayaan dan Kesejahteraan Keluarga Desa Bakaran Batu Dalam Pembuatan Racikan Empon Menieer Sebagai Imunitas Tubuh Untuk Meningkatkan Perekonomian Masyarakat Shufyani, Fahma; Fitri, Khairani; Manaharawan Siregar, Syati
Jukeshum: Jurnal Pengabdian Masyarakat Vol. 5 No. 1 (2025): Edisi Januari 2025
Publisher : Universitas Haji Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51771/jukeshum.v5i1.1186

Abstract

Community service aims to increase economic income from Empon Menieer concoctions as health products, acquire new skills with high economic value in the market, and improve family welfare by developing additional businesses that can enhance body immunity. The benefits of Empon Menieer and its processing methods, along with skills in entrepreneurship and small business management, can be enhanced through training and mentoring. Herbal and traditional medicine practices, passed down through generations, are part of the parents' responsibility to preserve customs and traditions. The method involves preparing activities through coordination in the initial meeting, obtaining permission and support from the Head of the PKK (Family Welfare Movement), forming a team consisting of students, lecturers, and village community representatives, collecting materials for making Empon Menieer concoctions, and preparing visual aids for socialization. The community participants are divided into 3 groups, each consisting of 10 people, totaling 30 people for direct practice in making Empon Menieer with guidance from lecturers and students. The results of making the Empon Menieer concoctions can improve economic income as health products, provide new skills with high market value, and enhance family welfare by developing additional businesses that can boost immunity, thus maintaining the health of the village community. Participants also gain new knowledge about the benefits of Empon Menieer and its processing methods, and skills in entrepreneurship and small business management are improved through training and mentoring. The conclusions of the progress of the Community Service Program (PKM) include: the village PKK actively participates in forming the village PKK groups during the mentoring process of making Empon Menieer concoctions, enhancing the knowledge of the Bakaran Batu village community and students after attending the training.
Pengaruh Ekstrak Daun Nanas Terhadap Pertumbuhann Candida albicans Dan Malassezia furfur Dalam Bentuk Sediaan Shampo Herbal Abadi , Hafizhatul; Khairani , Tetty Noverita; Fitri, Khairani; Diana, Vivi Eulis; Leny, Leny; Hasibuan, Amalia Juliani
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1181

Abstract

Background: Dandruff is a common scalp problem often caused by the overgrowth of fungi such as Candida albicans and Malassezia furfur. Pineapple leaves (Ananas comosus (L.) Merr.) are known to contain active antifungal compounds, such as alkaloids, flavonoids, saponins, and tannins, making them a potential active ingredient for anti-dandruff preparations. Objective: This study aimed to formulate an herbal anti-dandruff shampoo using pineapple leaf ethanol extract and to evaluate its effectiveness in inhibiting the growth of Candida albicans and Malassezia furfur. Methods: This experimental research used the disc diffusion method with PDA and SDA media to test antifungal inhibition. The shampoo preparations were formulated with varying extract concentrations (10%, 20%, 30%). The evaluation of the preparations included organoleptic tests, homogeneity, pH, foam height, viscosity, stability (cycling test), skin irritation, and hedonic tests. Results: The resulting shampoo preparation had a blackish-brown color, liquid form, and a menthol odor. Evaluation results showed the preparation was homogeneous, with pH values (5.0-5.8), foam height, and viscosity meeting the requirements. The preparation was also stable during the cycling test and did not cause irritation. The antifungal activity test showed that increasing the extract concentration increased the inhibitory power. The formula with a 30% concentration (F3) provided the greatest inhibition against Candida albicans (average 15.76 mm) and Malassezia furfur (average 15.9 mm), which is categorized as strong. Conclusion: Pineapple leaf ethanol extract was successfully formulated into an effective herbal anti-dandruff shampoo preparation, with the 30% concentration being the most optimal. It is recommended that further research investigate the antifungal activity of this extract against other types of fungi and in different dosage forms.
Co-Authors Abadi , Hafizhatul Amanda, Asri Azhari Azhari Azzubaidi, Marwan Saad Diana, Vivi Eulis Faisal Jamin Hasibuan, Amalia Juliani Hassan, Nurul Huda Mat Hennivanda, Hennivanda Khairani , Tetty Noverita Khairani, Tetty Noverita Leny Leny, Leny Manaharawan Siregar, Syati Masda Admi Muhammad Andry Neswita, Elfia nurasni, nurasni Rosmaidar Rosmaidar, Rosmaidar Sarumaha, Paska Eli Shufyani, Fahma Syafruddin Syafruddin Winaruddin Winaruddin