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All Journal Universa Medicina Eksakta : Berkala Ilmiah Bidang MIPA Jurnal Ilmu Faal Olahraga Indonesia Current Research on Biosciences and Biotechnology eJournal Kedokteran Indonesia Makara Journal of Health Research Jurnal Kedokteran Meditek
Imelda Rosalyn Sianipar
Department Of Medical Physiology And Biophysics, Faculty Of Medicine Universitas Indonesia, Jakarta, Indonesia
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Public Health

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Journal : Eksakta : Berkala Ilmiah Bidang MIPA

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Molecular Pathway of Phytochemicals in Preventing Sarcopenia Sari, Desy Nofita; Goenarjo, Roman Ardian; Sianipar, Imelda Rosalyn
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 26 No. 03 (2025): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol26-iss03/621

Abstract

Sarcopenia, the age-related decline in muscle mass and function, poses a significant global health challenge. This systematic review synthesizes evidence from preclinical studies published between 2020 and 2025 to elucidate the molecular pathways through which phytochemicals prevent sarcopenia. Following PRISMA guidelines, a systematic search of databases identified 16 eligible studies. The analysis reveals that phytochemicals, including flavonoids, polyphenols, and botanical extracts, mitigate muscle atrophy by concurrently enhancing anabolic signaling via the IGF-1/PI3K/Akt/mTOR axis, suppressing proteolysis, improving mitochondrial biogenesis, and reducing oxidative stress and inflammation. Notably, combinatorial formulations and multi-target extracts demonstrate superior efficacy. The review concludes that phytochemicals represent a promising multi-targeted strategy against sarcopenia; however, this promising potential necessitates future validation through standardized clinical trials to establish efficacy and safety in human populations.
Co-Authors Ahmad Aulia Amirah Yusnidar Antarianto, Radiana Dhewayani Antoni, Marcel Desy Nofita Sari Fasha, Iqbal Gita Pratama Goenarjo, Roman Ardian Inna Rahmawati Iqbal Fasha Irena Ujianti Jalma, Monica Dwi Murti, Krishna Aditya Naibaho, Fitri Boru Neng Tine Kartinah Almuktabar Nisa Kartika Komara Nuraditya, Robby Nuraini Diah Noviati Nurhadi Ibrahim Nurul Paramita Patwa Amani, Patwa Putu Indah Paramita Adi Putri Radiana Dhewayani Antarianto Rahmawati, Inna Retno Lestari Retno Lestari Robby Nuraditya Samuel Febrian Wijaya Santoso, Dewi Irawati Soeria Sophie Yolanda Trinovita Andraini Trinovita Andraini Wijaya, Samuel Febrian