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SYNTHESIS OF TETRACYCLINE IMPRINTED POLYMERS WITH METHACRYLIC ACID AS FUNCTIONAL MONOMER IN METHANOL-CHLOROFORM MIXTURE USING BULK AND PRECIPITATION POLYMERIZATION METHOD Suryana, Shendi; Shabrina, Kharisma Devy; Soni, Dang
Jurnal Ilmiah Farmako Bahari Vol 15, No 1 (2024): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v15i1.2790

The content of tetracycline residues in poultry meat products can cause antibiotic resistance in humans who consume these products, so it is necessary to develop sensitive analytical techniques to determine the levels of tetracycline residues to assess the safety of these products for consumption. The molecular imprinting technique is a method to produce sorbents with molecular recognition capability of target compounds that can be used to increase the selectivity of solid phase extraction to extract tetracycline residues for further analysis. This study aimed to obtain a sorbent synthesized by molecular imprinting technique to analyze tetracycline in poultry meat products. The stages of the research began with the study of the interaction of functional monomers with template molecules, determining the association constants of functional monomers with template molecules, synthesis of imprinted polymer molecules using bulk and precipitation methods, evaluating the ability and adsorption capacity of the synthesized polymers, assess the selectivity of polymers for analog structures and physical characteristics with FTIR. The research showed that methacrylic acid was the best functional monomer with a binding energy value of -27.3776 kcal/mol. The higher adsorption capacity was achieved by Molecularly Imprinted Polymer (MIP) that was synthesized by precipitation method (MIP2) than the other MIP synthesized by bulk polymerization (MIP1) with a value of 0.8748 mg/g and 0.4077 mg/g, respectively. The analogous compounds' imprinting factor values for each MIP were 1.197 and 1.1272. The polymer synthesized by molecular imprinting technique is selective for extracting and analyzing tetracycline from poultry meat matrix.

Selective Determination of Tetracycline in Broiler Chicken Meat by Molecularly Imprinted Polymer Suryana, Shendi; Najihudin, Aji; Elivania, Salma; Suherman, Meillia
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i0.58889

Tetracycline (TC) residues in poultry meat products can create antibiotic resistance in humans who consume them. Hence, sensitive analytical procedures to evaluate the quantities of tetracycline residues are required to assess the safety of these products for consumption. The study aimed to develop a sorbent using molecular imprinting technology to analyze tetracycline in chicken broiler meat products. The study used several tests and computational techniques to increase the effectiveness of screening for the best MIP systems. According to the bond energybased computational analysis, methacrylate acid (MAA) was the best functional monomer at a TC-to-MAA molar ratio of 1:6. The mixture of methanol and chloroform yielded the greatest Ka. The Job plot showed that a TC-to-MAA-molar ratio of 1:6 was best for synthesizing imprinted polymer in the mixture of methanol and chloroform. We generated MIPs using two alternative production methods: bulk (MIP1) and precipitation (MIP2). Adsorption capacity results revealed that MIP1 matches well with the Langmuir model, whereas MIP2 fits better with the Freundlich. MIP1 application produced recovery rates of 82,74±4.1% and MIP2 results of 92.14±3.2% for TC in spike-chicken meat. The outcomes of the selectivity test also demonstrated that MIP2 is superior to MIP1 and can recover TC from spiked chicken meat while coexisting with another antibiotic drug. The study’s findings indicate that MIP2 helps determine TC in spike chicken meat.

Improving Elderly Knowledge on Hypertension through Health Education in Parakan Village, Garut Sadino, Asman; Lubis, Novriyanti; Suryana, Shendi; Prasetiawati, Riska; Hermawan, Belya Anindia; Cahyati, Effan; Apriani, Riza; Karina, Karina; Rena, Rena
Indonesian Journal of Community Empowerment (IJCE) Vol 6 No 2 (2025): Indonesian Journal of Community Empowerment (May)
Publisher : Fakultas Kewirausahaan Universitas Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35899/ijce.v6i2.1034

Hypertension is a non-communicable disease often referred to as a "silent killer" because it may develop without noticeable symptoms and can lead to serious complications if left untreated. Elderly individuals are among the high-risk groups who require special attention in efforts to prevent and control hypertension. This community service activity aimed to improve the knowledge of elderly residents regarding hypertension through health education as a preventive measure against further complications. The program was conducted in Parakan Village, Garut Regency, involving 30 elderly participants. The method used was health education combined with pre-test and post-test assessments to evaluate knowledge improvement. The results showed a significant increase in understanding after the session, particularly regarding the symptoms and prevention of hypertension. Another notable finding was that most participants had only elementary-level education, which influenced their receptiveness to health information. In conclusion, health education proved effective in enhancing the elderly's knowledge of hypertension and its potential complications. Periodic follow-up education and collaboration with local health services are recommended to sustain the impact.

SYNTHESIS OF TETRACYCLINE IMPRINTED POLYMERS WITH METHACRYLIC ACID AS FUNCTIONAL MONOMER IN METHANOL-CHLOROFORM MIXTURE USING BULK AND PRECIPITATION POLYMERIZATION METHOD Suryana, Shendi; Shabrina, Kharisma Devy; Soni, Dang
Jurnal Ilmiah Farmako Bahari Vol 15 No 1 (2024): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v15i1.2790

The content of tetracycline residues in poultry meat products can cause antibiotic resistance in humans who consume these products, so it is necessary to develop sensitive analytical techniques to determine the levels of tetracycline residues to assess the safety of these products for consumption. The molecular imprinting technique is a method to produce sorbents with molecular recognition capability of target compounds that can be used to increase the selectivity of solid phase extraction to extract tetracycline residues for further analysis. This study aimed to obtain a sorbent synthesized by molecular imprinting technique to analyze tetracycline in poultry meat products. The stages of the research began with the study of the interaction of functional monomers with template molecules, determining the association constants of functional monomers with template molecules, synthesis of imprinted polymer molecules using bulk and precipitation methods, evaluating the ability and adsorption capacity of the synthesized polymers, assess the selectivity of polymers for analog structures and physical characteristics with FTIR. The research showed that methacrylic acid was the best functional monomer with a binding energy value of -27.3776 kcal/mol. The higher adsorption capacity was achieved by Molecularly Imprinted Polymer (MIP) that was synthesized by precipitation method (MIP2) than the other MIP synthesized by bulk polymerization (MIP1) with a value of 0.8748 mg/g and 0.4077 mg/g, respectively. The analogous compounds' imprinting factor values for each MIP were 1.197 and 1.1272. The polymer synthesized by molecular imprinting technique is selective for extracting and analyzing tetracycline from poultry meat matrix.

PENINGKATAN KESADARAN MASYARAKAT DENGAN ATUR NUTRISI KENDALIKAN HIPERTENSI MELALUI PELATIHAN PEMBUATAN MINUMAN KESEHATAN GARJUS Hermawan, Belya Anindia; Junaedi, Effan Cahyati; Prasetiawati, Riska; Suryana, Shendi; Pitriani, Karina; Lubis, Novriyanti
JMM (Jurnal Masyarakat Mandiri) Vol 10, No 1 (2026): Februari
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jmm.v10i1.37122

Abstrak: Hipertensi merupakan salah satu penyakit tidak menular dengan prevalensi tinggi yang dipengaruhi oleh pola makan dan gaya hidup masyarakat. Permasalahan yang dihadapi mitra adalah rendahnya pemahaman mengenai pencegahan hipertensi melalui pengaturan nutrisi serta belum optimalnya pemanfaatan bahan herbal lokal sebagai minuman kesehatan. Kegiatan pengabdian ini bertujuan untuk meningkatkan pengetahuan dan keterampilan masyarakat dalam mengendalikan hipertensi melalui edukasi nutrisi dan pelatihan pembuatan minuman kesehatan GARJUS metode yang digunakan meliputi penyuluhan kesehatan, workshop, kuis interaktif, dan praktik langsung pembuatan GARJUS dengan melibatkan 35 peserta dari masyarakat Desa Parakan. Evaluasi dilakukan menggunakan angket pre-test dan post-test serta observasi selama kegiatan berlangsung. Hasil kegiatan menunjukkan adanya peningkatan tingkat pemahaman peserta pada seluruh indikator pengetahuan hipertensi, dengan rentang peningkatan sekitar ±10% hingga ±44% setelah penyuluhan. Selain itu, seluruh peserta (100%) mampu dan bersedia membuat minuman kesehatan GARJUS secara mandiri. Kegiatan ini efektif dalam meningkatkan kesadaran dan keterampilan masyarakat sebagai upaya pencegahan hipertensi berbasis pemanfaatan bahan herbal local.Abstract: Hypertension is a non-communicable disease with high prevalence influenced by dietary patterns and lifestyle. The main problems faced by the community include limited knowledge of nutritional management for hypertension prevention and the underutilization of local herbal ingredients as health beverages. This community service activity aimed to improve public knowledge and skills in hypertension control through nutritional education and training in preparing GARJUS health drinks. The methods included health education sessions, workshops, interactive quizzes, and hands-on practice involving 35 participants from Desa Parakan. Evaluation was conducted using pre- and post-test questionnaires and direct observation during the activity. The results showed an improvement in participants’ knowledge across all hypertension-related indicators, with an increase ranging from approximately ±10% to ±44% after the intervention. In addition, all participants (100%) were able and willing to independently prepare GARJUS health drinks. This program proved effective in enhancing community awareness and skills for hypertension prevention through the utilization of local herbal resources.

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