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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Biomedika Indonesian Journal of Medicine Journal Orthopaedi and Traumatology Surabaya (JOINTS) The Hip and Knee Journal Indonesian Journal of Biomedicine and Clinical Sciences
Utomo, Pamudji
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Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Clinical Characteristic of Patients Underwent Bone Mineral Density Examination in Prof. Dr. R. Soeharso Orthopaedic Hospital in 2022-2023: A Cross-Sectional Study Prijosedjati, R. Andhi; Utomo, Pamudji; Sabariyah, Leli; Fauzi, Ahmad
(JOINTS) Journal Orthopaedi and Traumatology Surabaya Vol. 13 No. 1 (2024): April 2024
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/joints.v13i1.2024.1-11

Abstract

Background: In Indonesia, osteoporosis affects roughly 23% of men and women aged 50-70 and a staggering 53% of those over 70. Understanding the characteristics of patients undergoing bone mineral density (BMD) examinations is crucial for developing better strategies for prevention, diagnosis, and treatment. This study investigates the characteristics of patients who had BMD examinations at the Prof. Dr. R. Soeharso Orthopaedic Hospital. Methods: A cross-sectional study was conducted at Prof. Dr. R. Soeharso Orthopaedic Hospital from April 2022 to April 2023, using a total sampling approach and data extracted from digital medical records. The variables included age, gender, body mass index (BMI), BMD T-score from the lumbar spine, hip, and forearm, frequency and location of fragility fracture (FF), osteoporosis frequency, and fracture risk assessment (FRAX) score for major osteoporotic fracture (MOF) and hip fracture. Patients with incomplete data were excluded. Results: This study involved 168 patients, mainly women (83%) and men (17%). Most (81.5%) were aged 50-74, with osteoporosis affecting 29.2% and severe osteoporosis affecting 60.7%. The spine was the most common site of FF (88.2%). Osteoporosis severity correlated with higher BMI (p<0.05). FRAX scores for MOF and hip fractures were mostly in the low-risk category. Conclusions: A high prevalence of osteoporosis and severe osteoporosis among women, particularly those in the age of 50 to 74 years, and higher BMI was correlated with greater severity of osteoporosis. FF was found more common among women with the spine as the most frequently affected site.
Umbilical cord mesenchymal stem cells and their secretome in peripheral nerve regeneration: a narrative review promising therapeutic strategy Sumarwoto, Tito; Hadinoto, Seti Aji; Romaniyanto; Rhatomy, Sholahudin; Utomo, Pamudji; Idulhaq, Mujaddid; Santoso, Asep; Suroto, Heri
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 4 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i4.24055

Abstract

The injuries of peripheral nerves remain a substantial clinical challenge because of their limited regenerative capacity, the complexity of nerve repair, and limitations of current treatment strategies. Umbilical cord mesenchymal stem cells (UC-MSCs) and their secretome have shown promise as regenerative treatments due to their distinct biological characteristics. This review explores the possibility of UC-MSCs and their secretome in promoting peripheral nerve regeneration, by their action mechanisms, therapeutic applications, and current preclinical - clinical evidence. UC-MSCs have proven to be capable of support Wallerian degeneration, improving axonal growth, reducing inflammation, and improving functional recovery in both animal models and early clinical studies. Their secretome has been shown to promote neuroprotection and functional repair, avoiding the risks of receiving a direct stem cell transplant. Challenges remain in standardizing UC-MSC-based therapies, ensuring long-term safety, and enhancing delivery strategies. Further clinical trials are needed to determine the efficacy, safety, and scalability of UC-MSC therapies for widespread clinical use. UC-MSCs and their secretome provide a unique, cell-free and cell-based strategy to peripheral nerve regeneration. Future advancements in biomaterial integration, gene editing, and personalized medicine will be essential to implementing these treatments in clinical settings.
Co-Authors Adriansyah, Denny Agus Wahyudi Akbar, Hillan Arimuqti, Zarkasyi Bayudono, Sigit Brilianto, Bagus Iman Dharma, Adi Surya Effendi, Fajar Ivan Ermawan, Rieva Ernawan, Rieva Fauzi Ahmad Muda Hadinoto, Seti Aji Handojo, Handry Tri Heri Suroto Idulhaq, Mujaddid Islami, Umar Kharisma Iwan Budiwan Anwar Jiwandono, Bayu Sakti jiwandono, bayu sakti jiwandono Kumara, Hendra Cahya Mariyanto, Ismail Pradhana, Adhitya Indra Prijosedjati, Andhi Prijosedjati, R. Andhi Rhatomy, Sholahudin Rian, Rahmad Riyadli, Muhammad Romaniyanto Sabariyah, Leli Santoso, Asep Saputra, Rhyan Darma Sentana, Okkie Mharga Sibarani, Tangkas SMHS Sumarwoto, Tito Surya, Wan Adi Totok Siswanto Tulandi, M qathar RF Tulandi Widhiarso, Bagas Yurisworo, Anggita Tri