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All Journal Indonesian Journal of Chemical Science Jurnal Abdi Insani Humanism : Jurnal Pengabdian Masyarakat International Journal of Community Service Journal of Experimental and Clinical Pharmacy (JECP) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Prosiding Seminar Nasional Biologi Jurnal Komunitas Farmasi Nasional
Umarudin, Umarudin
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Porcine Detection on Anti-Covid 19 Immunity Gelatin Capsules Sold at Market X in North Surabaya Using Quartz Crystal Microbalance (QCM) Sensors Syukrianto, Syukrianto; Umarudin, Umarudin; Madurani, Kartika Anoraga; Kurniawan, Fredy
Indonesian Journal of Chemical Science Vol 10 No 3 (2021)
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/ijcs.v10i3.50456

Abstract

Immune gelatin capsules, which have not been fully indicated on the packaging, need to be investigated porcine or bovine using a Quartz crystal microbalance (QCM) tool. The advantages of the QCM tool are sensitivity to the crystal oscillation frequency at a specific temperature, humidity, pressure, speed, and vibration, which will make this piezoelectric oscillator used as a sensor with a high accuracy level. The purpose of this study was to determine the content of porcine (pork) or bovine (beef) in anticovi19 immunity gelatin capsules sold at market X, North Surabaya. The method used to distinguish pork gelatin and beef gelatin is a Quartz crystal microbalance (QCM) tool. In this study, the detection of anti-covid19 immunity gelatin capsules was carried out using a QCM tool. This research method was carried out in a factual experimental manner, and sampling with the quota technique was 3 grams for each sample with a different brand. The results of research conducted on four samples with other brands originating from the market X area of North Surabaya showed the detection results of 2 samples with adverse effects (-), and two samples with positive results (-), meaning that the negative samples contained beef gelatin (bovine) and the positive sample contains pork (porcine). A decrease in frequency characterized the sample of immunity gelatin capsules containing bovine gelatin. In contrast, the sample of immunity gelatin capsules containing porcine gelatin was characterized by increased frequency.
Human Resource Management Training In The Digital Era For Dawuhan Tourism Village Managers Frans Assa, Adrie; Johanis Rumambi, Freddy; Adinirekso, Gidion; Widjaja, Daniel; Umarudin, Umarudin
International Journal Of Community Service Vol. 4 No. 3 (2024): August 2024 (Indonesia - Malaysia)
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijcs.v4i3.285

Abstract

Awareness of becoming a Disaster Resilient Society encourages people to increase their preparedness for the threat of disasters and increase income from this awareness by creating the Dawuhan tourist village. Dawuhan Village, Wanayasa District, Banjarnegara Regency, Central Java has extraordinary potential for the natural environment, community and village government working together to develop the village's potential. This ongoing community service has produced a significant impact on managers and employees as well as the community around the tourist village area. This training aims to provide practical skills and knowledge needed by managers and employees to manage tourist villages well. As a result of implementing these community service activities, managers and employees are very enthusiastic about being involved in increasing the capacity and competence of managers and employees for the development and progress of tourist villages.
SENYAWA FITOKIMIA DAN AKTIVITAS ANTI COVID STUDI IN SILICO EKSTRAK CABE JAWA (Piper retrofractum Vahl) Umarudin, Umarudin; Syafitri, Meyke Herina; Aristyawan, Andhika Dwi
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 1 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i1.1591

Abstract

Javanese chili has the potential to develop, one of which is that it contains phytochemical compounds and essential oils, which can act as antioxidants in preventing COVID-19, so it is necessary to utilize the natural potential in Indonesia, namely Javanese chili. This research aims to determine the phytochemical screening and anti-covid activity of an in silico study of Javanese chili extract. This research method carried out phytochemical screening of ethanol extracts, tested for alkaloids, flavonoids, tannins, saponins, and terpenoids, tests for determining levels of piperine, essential oils, and cavitsin, as well as in silico studies with piperine ligands with RdRP and ACE2 receptors docked with Hex.8.0.0 and visualized with discovery studio. This research shows that the phytochemical screening results of Javanese chili fruit extract are positive for containing alkaloids, flavonoids, tannins, saponins, terpenoids, piperine 3.36%. This research concludes that in silico, the Javanese chili piperine compound can bind to the active site of ACE Sarcov 2 through RdRP inhibition.
Pengaruh Variasi Jenis dan Konsentrasi Gelling Agent Terhadap Karakteristik Fisik Emulgel Koenzim Q10 Wulansari, Silvi Ayu; Umarudin, Umarudin; Sa’diyah, Lailatus
Journal of Experimental and Clinical Pharmacy (JECP) Vol 2, No 2 (2022): August 2022
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v2i2.464

Abstract

Koenzim Q10 berperan sebagai antioksidan untuk mencegah penuaan akibat radikal bebas. Koenzim Q10 untuk memenuhi kebutuhan sel jumlahnya terbatas, sehingga untuk mencegah timbulnya penuaan dengan menggunakan skin care secara topical, salah satu bentuk sediaan topikal yaitu emulgel. Penggunaan bahan pembentuk gel merupakan komponen penting dalam sediaan gel, karena jenis dan konsentrasi bahan pembentuk gel dapat mempengaruhi karakteristik fisik gel. Penelitian ini bertujuan untuk mengetahui pengaruh variasi jenis dan konsentrasi gelling agent terhadap sifat fisik emugel koenzim Q10. Pada penelitian ini dibuat 6 formula dengan variasi jenis dan konsentrasi gelling agent. F1, F2, F3 mengandung carbopol 940 (0,5; 0,75 dan 1%) F4, F5, F6 mengandung CMC-Na (3; 3,5 dan 4%) dan semua formula emugel mengandung koenzim Q10 0,5%. Parameter yang diamati adalah karakteristik fisik emulgel koenzim Q10 (pengamatan organoleptis dan homogenitas, pengujian pH, daya sebar, pengujian viskositas, dan pengujian daya lekat). Analisa data penelitian ini dengan One Way Anova. Hasil penelitian karakteristik fisik sediaan pada formula 1-6 emulgel koenzim Q10 dari segi organoleptis memiliki karateristik sesuai dengan spesifikasi dari bentuk sediaan, warna, aroma dan homogenitas. Temuan penelitian ini sediaan emulgel yang mengandung carbopol 940 pada F1, F2, F3 memiliki nilai pH (5,91c; 5,77b; 5,32a) daya sebar (6,4c; 6,1b; 5,8a) viskositas (2.445a; 2.976b; 3.083c) dan daya lekat (18a; 21b; 29c) dan sediaan emulgel yang mengandung CMC-Na pada F4, F5, F6  memiliki nilai pH (6,25a ; 6,28a; 6,27a) daya sebar (6,6c; 6,3b; 5,1a) viskositas (2.379a; 2.926b; 3.157c) dan daya lekat (13a; 19b; 37c). Simpulan penelitian ini gelling agent yang digunakan pada emulgel koenzim Q10 dapat berpengaruh terhadap karakteristis fisik sediaan, dari keenam formula (F1-F6) formula F2 yang menggunakan gelling agent carbopol 940 merupakan formula yang paling optimum.Coenzyme Q10 acts as an antioxidant to prevent aging caused by free radicals. Coenzyme Q10 to meet the needs of cells is limited in number, so to prevent aging by using skin care topically, one of the topical dosage forms is emulgel. The use of gelling agents is an important component in gel preparations, because the type and concentration of gelling agents can affect the physical characteristics of the gel. This study aims to determine the effect of variations in the type and concentration of gelling agent on the physical properties of emugel coenzyme Q10. In this study, 6 formulas were made with variations in the type and concentration of gelling agent . F1, F2, F3 contained carbopol 940 (0.5 ; 0.75 and 1%) F4, F5, F6 contained CMC-Na (3; 3.5 and 4%) and all emugel formulas contained coenzyme Q10 0.5% . Parameters observed were physical characteristics of coenzyme Q10 emulgel (organoleptic and homogeneity observations, pH testing, dispersion, viscosity testing, and adhesion testing). Analysis of this research data with One Way Anova . The results of the research on the physical characteristics of the dosage form 1-6 emulgel coenzyme Q10 in terms of organoleptic have characteristics in accordance with the specifications of the dosage form, color, aroma and homogeneity. The findings of this study were that the emulgel preparation containing carbopol 940 at F1, F2, F3 had a pH value (5.91 c ; 5.77 b ; 5.32 a ) dispersion (6.4 c ; 6.1 b ; 5.8 ). a ) viscosity (2,445 a ; 2,976 b ; 3,083 c ) and adhesion (18 a ; 21 b ; 29 c ) and emulgel preparations containing CMC-Na at F4, F5, F6 had a pH value (6.25 a ; 6 ,28 a ; 6.27 a ) dispersibility ( 6.6 c ; 6.3 b ; 5.1 a ) viscosity ( 2,379 a ; 2,926 b ; 3,157 c ) and adhesion (13 a ; 19 b ; 37 c ). The conclusion of this research is that the gelling agent used in emulgel coenzyme Q10 can affect the physical characteristics of the preparation, of the six formulas (F1-F6) formula F2 using the gelling agent carbopol 940 is the most optimum formula.
DS DETEKSI SENYAWA PIPERINE DARI CABE JAWA (Piper retrofractum Vahl) UNTUK TERAPI ANTI HIPERKOLESTEROLEMIA STUDI In Silico: DETEKSI SENYAWA PIPERINE DARI CABE JAWA (Piper retrofractum Vahl) UNTUK TERAPI ANTI HIPERKOLESTEROLEMIA STUDI In Silico Umarudin, Umarudin
Jurnal Komunitas Farmasi Nasional Vol. 4 No. 02 (2024): Jurnal Komunitas Farmasi Nasional
Publisher : Akademi Farmasi Yarsi Pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Increased cholesterol levels in the blood characterize Hypercholesterolemia due to excessive fat consumption, leading to an imbalance between fat intake and metabolism. The plant Piper retrofractum Vahl, commonly known as Javanese long pepper, is recognized for its various benefits and properties, including its use in traditional medicine formulations and as a functional food ingredient. The secondary metabolite present in Javanese long pepper is piperine, which imparts a characteristic intense flavor and has been shown to have the potential to lower Hypercholesterolemia, necessitating an in silico study. This research aims to detect the piperine compound from Piper retrofractum Vahl as an anti-hypercholesterolemia therapy through an in silico study. The methodology involves the preparation of compounds using the Pyrx 0.8 application in PDB format, followed by preparing the HMG-CoA Reductase protein using Discovery Studio to remove ligands and water molecules. Molecular docking was conducted using an in silico approach with HEX Cuda 8.0.0 software. The results of the in silico study indicate that piperine from Javanese long pepper interacts with HMG-CoA Reductase, demonstrating a binding affinity value of -317.90 and interacting with three amino acid residues. These findings suggest that Javanese long pepper can be used as an anti-hypercholesterolemia therapy.
Penyuluhan Pemanfaatan Ekstrak Daun Mimba sebagai Sabun Kertas Antiseptik Wulansari, Silvi Ayu; Sa’diyah, Lailatus; Umarudin, Umarudin
Humanism : Jurnal Pengabdian Masyarakat Vol 3 No 3 (2022): Desember
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/hm.v3i3.14595

Abstract

COVID-19 (Corona Virus Diseases-19) yang ditetapkan oleh World Health Organization (WHO) sebagai pandemi di level dunia mulai tahun 2020.  Provinsi Jawa Timur memiliki jumlah kasus positif Covid-19 nomor urut dua setelah DKI Jakarta. Berbagai  upaya telah dilakukan pemerintah untuk menekan angka kasus Covid-19 dengan cara menjaga prokes seperti mencuci tangan dengan sabun. Sabun perperan penting dalam pencegahan dan penurunan angka penyebaran Covid-19, upaya penyebaran tersebut perlu adanya solusi pemanfaatan daun nimba sebagai zat aktif pada sabun. Daun mimba terdapat senyawa yang bersifat antibakteri dan antivirus, sehingga daun mimba dapat dijadikan sebagai senyawa bioaktif pada sabun kertas dengan dilakukan penyuluhan program pengabdian mengenai pemanfaatan herbal untuk pencegah penyebaran Covid-19. Program pengabdian masyarakat ini mendukung Sustainable Development Goals (SDGs). Sasaran kegiatan pengabdian ini pada siswa SMK Farmasi Kapasari Surabaya. Kegiatan ini dilakukan secara luring dengan metode penyuluhan. Target dari kegiatan pengabdian kepada siswa untuk meningkatkan kepedulian terhadap kesadaran mengenai bahan alam yang diolah untuk dapat menghasilkan suatu produk yang bermanfaat dalam ikut serta mencegah penyebaran Covid-19. Berdasarkan hasil yang didapatkan dari sepuluh aspek penilaian pada pre-test, terdapat kenaikan pada setiap aspek setelah di lakukan penyuluhan. Hal ini menunjukkan siswa dari Sekolah Menegah Farmasi lebih memahami pemanfaatan bahan alam sebagai sabun kertas untuk mencegah penyebaran Covid-19.
EDUKASI ECO ENZYME DARI LIMBAH BUAH DAN SAYUR MENJADI SABUN CAIR CUCI TANGAN SEBAGAI UPAYA MENCIPTAKAN EKONOMI MASYARAKAT PRODUKTIF DALAM MENDUKUNG SUSTAINABLE DEVELOPMENT GOALS (SDGs) DI KELURAHAN KETINTANG 4 SURABAYA Umarudin, Umarudin; Syukrianto, Syukrianto; Anidnya, Widya Dara; Wulansari, Silvi Ayu; Aryanti, Evy
Jurnal Abdi Insani Vol 11 No 2 (2024): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v11i2.1593

Abstract

The abundance of fruit and vegetable waste in the Ketintang 4 area has a detrimental impact on the surrounding environment. Therefore, it is necessary to implement educational initiatives on utilizing this waste to produce eco-enzyme, which can be used as an active ingredient in liquid hand soap. This activity aims to educate on eco enzymes from fruit and vegetable waste into liquid hand soap as an effort for Clean and Healthy Living Behavior (PHBS) and the "Let's Wash Hands" movement to change community behavior from unhealthy to healthy. The activity method consists of 4 stages: preparation stage, material preparation stage, education and workshop stage, and evaluation stage. This activity showed that the youth organization members were enthusiastic and experienced increased knowledge from the pre-test results, with "yes" answers at 9.33% and "no" answers at 90.67%. The post-test results showed "yes" answers at 82% and "no" answers at 18%. The increase in knowledge in utilizing eco enzymes for their needs and benefits as active ingredients in liquid hand soap has become a valuable product to encourage the surrounding community to wash hands with soap, an effort to prevent the spread of microorganisms. The satisfaction questionnaire results of the community service activity showed a satisfaction rate of with 87.43% very satisfied, 2.57% satisfied, and 0% unsatisfied. This activity strongly supports the SDGs and the KEMENDIKBUD in 2021 in implementing Clean and Healthy Living Behavior (PHBS) for the Ketintang 4 Subdistrict. It can create a productive economy for the community.
EDUKASI TENTANG TANAMAN OBAT ASLI INDONESIA YANG BERPOTENSI SEBAGAI AFRODISIAK BAGI PRIA DI SMK FARMASI Umarudin, Umarudin; Ulfa, Ninik Mas; Kusumo, Galuh Gondo; Syukrianto, Syukrianto
Prosiding Seminar Nasional Biologi Vol. 13 (2025)
Publisher : Prosiding Seminar Nasional Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Tujuan dari kegiatan ini adalah memberikan edukasi kepada siswa SMK Farmasi tentang tanaman obat asli Indonesia yang berpotensi sebagai afrodisiak. Metode pelaksanaannya meliputi sesi edukasi, sesi tanya jawab, dan diskusi. Media yang digunakan berupa slide PowerPoint, foto tanaman, dan simplisia (bahan tanaman kering) dari tanaman obat asli Indonesia yang dikenal memiliki sifat afrodisiak. Sebelum penyampaian materi, dilakukan pre-test dan dilanjutkan dengan post-test di akhir kegiatan. Hasil kedua tes dianalisis menggunakan tabulasi grafik. Hasil pre-test menunjukkan skor rata-rata 40 dari 100, yang mencerminkan pemahaman awal siswa tentang tanaman asli Indonesia yang berpotensi afrodisiak. Selanjutnya, diberikan edukasi tentang tiga tanaman herbal yang diperkenalkan kepada siswa SMK Farmasi: lada Jawa (Piper retrofractum) yang berasal dari Madura dan Jember; purwaceng (Pimpinella alpina atau Pimpinella pruatjan) yang bersumber dari Dataran Tinggi Dieng, Jawa Tengah; Gunung Semeru dan Pegunungan Tengger, Jawa Timur; Gunung Pangrango, Jawa Barat; serta Gunung Lawu dan Gunung Galunggung; dan pasak bumi (Eurycoma longifolia) yang ditemukan di Sumatra dan Kalimantan. Edukasi awal ini bertujuan mengurangi ketergantungan pada obat sintetis yang sering menimbulkan efek samping. Hasil post-test menunjukkan peningkatan dengan skor rata-rata 98. Kegiatan ini memberi kontribusi positif dengan memperluas pengetahuan siswa tentang morfologi tanaman, habitus, dan efek farmakologis sebagai afrodisiak pada pria, yang didukung oleh studi ilmiah. Selain memberi manfaat bagi siswa, inisiatif ini juga memberikan wawasan berharga bagi masyarakat luas sebagai langkah penting untuk meningkatkan kesehatan reproduksi secara menyeluruh melalui pendekatan alami dan berbasis pengetahuan.
Co-Authors Adinirekso, Gidion Anidnya, Widya Dara Aristyawan, Andhika Dwi Evy Aryanti Frans Assa, Adrie Fredy Kurniawan Johanis Rumambi, Freddy Kusumo, Galuh Gondo Madurani, Kartika Anoraga Sa’diyah, Lailatus Sa’diyah, Lailatus Surahmaida, Surahmaida Syafitri, Meyke Herina Syukrianto, Syukrianto Ulfa, Ninik Mas Widjaja, Daniel Wulansari, Silvi ayu