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All Journal Althea Medical Journal Mutiara Medika: Jurnal Kedokteran dan Kesehatan Oto Rhino Laryngologica Indonesiana Majalah Patologi Indonesia Medica Hospitalia Medica Arteriana (Med-Art) Diponegoro International Medical Journal (DIMJ)
Karlowee, Vega
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Dentistry Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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Effect of Topical Dayak Onion (Eleutherine palmifolia) Cream on Epidermal Thickness in UVB-Exposed Male Wistar Rats: An Experimental Study Setyanegari, Aditya Putri; Damayanti, Galih Sari; Afriliana, Liza; Karlowee, Vega
Diponegoro International Medical Journal Vol 6, No 2 (2025): December 2025
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v6i2.29621

Abstract

Background: Exposure to ultraviolet B (UVB) radiation, particularly in tropical regions like Indonesia, can cause skin damage characterized by increased epidermal thickness due to keratinocyte hyperproliferation, contributing to photoaging. Natural photoprotective agents rich in antioxidants such as Dayak onion (Eleutherine palmifolia) extract are expected to mitigate these effects. Objective: This study aims to evaluate the effect of applying Dayak onion extract cream at varying concentrations on epidermal thickness of UVB-induced male Wistar rat skin. Methods: This study was a true experimental study with a post-test only control group design. A total of 36 male Wistar rats were randomly divided into four groups: a control group (given placebo cream) and three treatment groups given Dayak onion extract cream at concentrations of 10%, 15%, and 20%. UVB exposure was carried out every two days for 30 days, along with application of the cream before and after UVB radiation. Epidermal thickness was analyzed through histopathological examination using Hematoxylin-Eosin staining and observed under 400x magnification. Results: Statistical analysis showed significant differences (p < 0,05) in epidermal thickness between the control group and the treatment groups. The mean epidermal thickness in the treatment groups was lower than that of the control group, with the greatest reduction observed in the 20% concentration group, followed by the 15% and 10% groups. There was no significant difference between the 15% and 20% concentrations. Conclusion: Application of Dayak onion extract cream is effective in reducing epidermal thickness, with a concentration of 20% providing optimal protective effects. These findings support the potential of Dayak onion as a natural photoprotective agent.Keywords: Dayak onion, Eleutherine palmifolia, epidermal thickness, photoaging, antioxidant
Co-Authors AA Sudharmawan, AA Afriliana, Liza Apriana, Ledisda Astuti, Meira Dewi Kusuma Awal Prasetyo Damayanti, Galih Sari Devia Eka Listiana, Devia Eka Dewi Kusuma Astuti, Meira Dewi, Anna Mailasari Kusuma Dik Puspasari, Dik Halim, Fenny Hamidiyah, Silpi Hariyati, Riece Hermawan Istiadi Ika Pawitra Miranti Kesumayadi, Irfan Melvern, Bryan Muniroh, Muflihatul Nur, Rizki Widya RR. Ella Evrita Hestiandari Sabig, Lidya Septarina, Faiza Rizky Aryani Setyanegari, Aditya Putri Udadi Sadhana, Udadi Utami, Asih Ratna Yora Nindita Yusuf, Franky