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All Journal Syntax Literate: Jurnal Ilmiah Indonesia Proceedings of the International Conference on Applied Science and Health Tunas Medika Jurnal Kedokteran & Kesehatan InaBHS (Indonesian Journal of Biomedicine and Health Science)
Mulyaningsih, Ruri Eka Maryam
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Humanities Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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THE CORRELATION OF EDUCATION AND SOCIAL ECONOMIC LEVELS WITH ANTIBIOTIC SELF-MEDICATION IN THE COMMUNITY OF CIREBON Handayani, Tridaya Putri; Satrianugraha, Muhammad Duddy; Pratiwi, Witri; Mulyaningsih, Ruri Eka Maryam
Proceedings of the International Conference on Applied Science and Health No 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Abstract

Background: People in developing countries, like Indonesia, often conduct self-medication. One of the most common drugs used in self-medication is antibiotics. Antibiotics should be used with caution since it can cause antibiotic resistance and possible unwanted side effects of the drug. There are several factors that influence self-medication behavior such as education and socio-economic levels. This research aims to find the correlation between education and social economic levels with antibiotic self-medication in the community of Cirebon.Method: This study was an analytical survey with cross-sectional method. This study was conducted from December 2018 to February 2019. A total of 300 respondents were recruited as samples using consecutive sampling technique. The respondents were recruited from 5 different pharmacies from each sub-district in Cirebon City and a validated questionnaire were used to obtain data. The collected data are analyzed using the Spearman correlation test.Results: The results of this study show that there was a significant but weak positive correlation of education level (r=0.224, p=0.001) and socio-economic (r=0.210, p=0.001) with self-medication using antibiotics. Conclusion: There is a significant positive correlation between education and socio-economic levels with antibiotic self-medication.
CORRELATION BETWEEN ANXIETY LEVEL AND SELF DIRECTED LEARNING READINESS (SDLR) WITH STUDENT PEFORMANCE IN PROBLEM BASED LEARNING (PBL) Safitri, Nita; Khasanah, Uswatun; Mulyaningsih, Ruri Eka Maryam
Proceedings of the International Conference on Applied Science and Health No 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: The pattern of medical education in Indonesia has changed from teacher-centered learning to student-centered learning. This change has an impact on methods, learning activities, and learning achievements of medical students. Problem Based Learning (PBL) is one of the main learning methods used in the faculty of medicine. PBL is a learning method that requires students to play an active role and facilitate collaborative learning. Due to the change of learning method, new medical students experience a lot of stress from in doing Problem Based Learning such as anxiety and may affect their PBL results as can be evaluated using Self-Directed Learning Readiness (SDLR). There are very few studies found to date investigating this phenomenon.Aims: This research aims to see the correlation between anxiety level and SDLR with student?s performance participating in first-year PBL in the Musculoskeletal and Locomotory System block in the faculty of medicine Universitas Swadaya Gunung Jati Cirebon.Methods: This is a cross-sectional observational study with total sampling. The samples were recruited from 167 first-year 2018 intake students of the faculty of medicine Universitas Swadaya Gunung Jati. Zung Self Rating Anxiety Scale questionnaire is used to measure anxiety levels and the SDLR questionnaire is used to measure Self Directed Learning Readiness (SDLR).Results: The Spearman test showed a medium negative correlation value of -0.49 (p>0.05) for the level of anxiety. It means that there is no significant effect of anxiety on the PBL performance. In addition, it shows a weak positive correlation value of 0.196 (p <0.05) for SDLR (self-directed learning readiness) showing a significant influence on PBL performance.Conclusions: The level of anxiety does not significantly influence PBL performance while SDLR has a significant effect on PBL performance.
THE EFFECT OF LEMON JUICE (Citrus limon) IN LIVER HISTOPATHOLOGIC APPEARANCE OF MALE MICE (Mus musculus L.) EXPOSED BY MONOSODIUM GLUTAMATE (MSG) Aji, Dela Destiani; Mulyaningsih, Ruri Eka Maryam; MZZ, Ahmad Fariz
Proceedings of the International Conference on Applied Science and Health No 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Abstract

Background: Excessive consumption of MSG can cause the formation of free radicals in the body. Continuous use of MSG will cause free radical accumulation and oxidative stress in the liver. An antioxidant is one of the substances that has an ability to eliminate free radicals and protect the liver from oxidative stress. Lemon is a fruit that has benefits as a natural antioxidant. This study aims to determine the effect of administering lemon juice on the histopathological appearance of the liver exposed by MSG.Methodology: This post-test only control group design experimental study used 30 male white mice which were randomly divided into five groups: NC group, C(-) group, D1 group, D2 group, and D3 group. After 7 days of adaptation and randomized grouping, the mice were treated differently based on their group. All groups, except the NC group, were exposed to 4mg/gBW dose of MSG orally for 14 days. On the 15th day, MSG exposure was stopped and after that D1 group, D2 group, and D3 group were given lemon juice with a dose of each group 3.33ml/kgBW, 6.67 ml/kgBW, 13.33 ml/kgBW. The lemon juice was given once a day for 14 days using the gastric sonde. Histopathology examination was analyzed by pathologist in Gunung Jati Hospital, Cirebon, IndonesiaResults: Significant differences of liver histopathology were obtained between the normal control group with the dose 3 group (p = 0.005), the normal control group with the dose 2 group (p = 0.019), the normal control group with the dose group (p = 0.019) and between the negative control groups with dose 3 group (p = 0.027). Dose 3 group has higher liver damage compared to a normal control group and negative control group characterized by the form of parenchymatous degeneration. Conclusion: Lemon juice has a negative effect on the histopathology appearance of male white mice?s (Mus musculus L.) liver exposed by monosodium glutamate (MSG). Further studies are needed to validate the effect of the active compound and toxicity of lemon juice and to reveal the precise mechanisms on how lemon juice affects the hepatocytes.
INHIBITORY OF SOURSOP LEAVES (Annona muricata L.) EXTRACT AGAINST Malassezia furfur GROWTH Rizqilah, Rike; Apriyanto, Dadan Ramadhan; Mulyaningsih, Ruri Eka Maryam
Proceedings of the International Conference on Applied Science and Health No 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Abstract

Background: Malassezia furfur in certain conditions can turn into a pathological phase, from the yeast phase to the mycelia phase that attacks the stratum corneum. Malassezia furfur is one of the causes of Pityriasis versicolor. The prevalence of pityriasis versicolor in Indonesia is quite high at around 40-50%.  Several studies suggested that soursop leaves (Annona muricata L.)  contains active substances with anti-fungal properties.  This study aims to determine the inhibition of soursop leaves (Annona muricata L.) extract against the growth of Malassezia furfur.Methods: This study was an experimental study with Post-test Only Control Group Design.  Malassezia furfur fungi is used as subject in this study and ethanol extract of soursop leaves as a natural antifungal against Malassezia furfur. The concentrations of extract tested were 100%, 80%, 60%, 30%. Miconazole 2% was used as a positive control while DMSO 10% was used a negative one. The result of the study was analyzed by descriptive analysis which showed by increasing average diameter of antifungal.Results: The results showed that soursop leaves (Annona muricata L.)  extract had inhibitory effect on the growth of Malassezia furfur fungi  at 100% concentration of 2.50 mm, 80% at 1.50 mm, 60% at 0.47 mm, 30%  concentration at 0.25 mm and positive control of 14.50 mm. While as negative control, no inhibition zones were formed on SDA media.Conclusion: Soursop leaves (Annona muricata L.)  extract can inhibit the growth of Malassezia furfur, but the formed inhibition zone is weak. Further research is needed to found the best type of antifungal metabolites to maximize antifungal effects.
Pengaruh Pemberian Zinc, Fe dan Vitamin A Terhadap Kejadian Infeksi dan Pertumbuhan Wirandoko, Ignatius Hapsoro; Mulyaningsih, Ruri Eka Maryam
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : CV. Ridwan Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (152.926 KB) | DOI: 10.36418/syntax-literate.v5i1.858

Abstract

Kekurangan zat zinc dapat mengganggu pertumbuhan dan meningkatkan resiko mendapat diare dan infeksi saluran nafas. Suplementasi zinc dan besi mungkin meningkatkan pertumbuhan anak. Defisiensi vitamin A dapat menyebabkan kebutaan pada anak usia dini, sehingga menghambat tumbuh kembang anak.Membuktikan efek pemberian zinc, fe, dan vitamin A dalam menurunkan kejadian infeksi dan memperbaiki pertumbuhan pada anak gizi kurang usia 2-5 tahun. Pre n post test. Satu bulan sebelum diintervensi pengambilan sampel darah kadar Zink,Fe dan Vitamin A, ditanyakan kejadian infeksi (berapa kali dalam 1 bulan terakhir) dan pertumbuhan TB di lihat di KMS. Satu bulan setelah diintervensi diambil sampel darah lagi kadar Zink,Fe, dan Vitamin A, ditanyakan lagi pertumbuhan dan kejadian infeksi. Sebelum Penelitian dilakukan sidang Komisi Etik oleh Tim Komisi Etik Fakultas Kedokteran Unswagati Cirebon (Full Board). Intake vitamin A (µg) rata-rata 303±11 dan untuk intake zat besi rata-rata 5,74±0,3 mg, sedangkan intake zink rata-rata 3,8±0. Bila dibandingkan dengan Angka Kecukupan Gizi (AKG) maka intake vitamin A, zat besi dan zink secara rata-rata tidak ada yang memenuhi Angka AKG yaitu 75,7±2,9 persen, 75,0±4,3 persen dan 47,4±1,8 persen. Indikator Tinggi Badan/ Umur (TB/U) banyak anak dengan stunting sebesar 15,9 persen, sedangkan anak dengan obese indikator berat badan/tinggi badan (BB/TB) sebesar 1 persen. Keadaan kesehatan sampel penelitian ditemukan lebih dari separuh sampel menderita Infeksi Saluran Pernafasan Akut (ISPA) 60,4 persen dan diare 21,3 persen diare. Intake makanan zat besi, zink dan vitamin A anak 24-60 bulan di Indonesia masih tidak dapat memenuhi kebutuhan dan jauh di bawah Angka Kecukupan Gizi (AKG). Faktor yang secara konsisten berpengaruh terhadap pemenuhan kebutuhan mikronutrien tersebut (zat besi, zink, vitamin A) dan status sosial ekonomi rendah. Kata kunci: Zinc, Fe, Vitamin A, Infeksi dan Pertumbuhan
PERBANDINGAN EFEKTIVITAS EKSTRAK DAUN BANDOTAN (Ageratum conyzoides Linnaeus) DAN EKSTRAK DAUN SINTRONG (Crassocephalum crepidioides) TERHADAP PERTUMBUHAN BAKTERI Staphylococcus aureus ATCC 6538 Andiri, Mochammad; Mulyaningsih, Ruri Eka Maryam; Naldi, Yandri; Wahdini, Maya; Risman, Muhammad; Afifah, Helga Marwa
Tunas Medika Jurnal Kedokteran & Kesehatan Vol 11 No 1 (2025): TUNAS MEDIKA JURNAL KEDOKTERAN & KESEHATAN
Publisher : Fakultas Kedokteran UGJ Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33603/tumed.v11i1.10048

Abstract

Latar Belakang Staphylococcus aureus merupakan penyebab infeksi dan kematian bayi di Indonesia, terutama pneumonia. Menurut data Kementerian Kesehatan Republik Indonesia Tahun 2022, kematian akibat pneumonia ditemukan 14,4% kasus pada bayi dan 9,4% kasus pada balita dengan 1.475 kasus berada di Kota Cirebon. Reaksi alergi akibat antibiotik menjadi masalah serius dalam pengobatan, sehingga diperlukan alternatif bahan alami seperti daun bandotan (Ageratum conyzoides Linnaeus) dan daun sintrong (Crassocephalum crepidioides). Kandungan senyawa alkaloid, flavonoid, saponin, dan tanin pada daun bandotan (Ageratum conyzoides Linnaeus) dan daun sintrong (Crassocephalum crepidioides) diduga efektif menghambat pertumbuhan bakteri. Tujuan Mengetahui perbandingan efektivitas ekstrak daun bandotan (Ageratum conyzoides Linnaeus) dan ekstrak daun sintrong (Crassocephalum crepidioides) terhadap pertumbuhan bakteri Staphylococcus aureus. Metode Penelitian eksperimen dengan rancangan posttest only control group design dan dilakukan dari bulan April-Juli 2023. Penelitian ini menggunakan 8 kelompok perlakuan berupa ekstrak daun bandotan (Ageratum conyzoides Linnaeus) dan ekstrak daun sintrong (Crassocephalum crepidioides) dengan konsentrasi uji 50%, 75%, dan 100% serta kloramfenikol (kontrol positif) dan DMSO 10% (kontrol negatif). Data dianalisis menggunakan uji One-way Anova, Post-hoc Tukey HSD, dan uji T Independent. Hasil Terdapat perbandingan efektivitas ekstrak daun bandotan (Ageratum conyzoides Linnaeus) dan ekstrak daun sintrong (Crassocephalum crepidioides) terhadap pertumbuhan bakteri Staphylococcus aureus. Ekstrak daun sintrong (Crassocephalum crepidioides) memiliki efektifvitas rata-rata daya hambat ± 10,44083 mm (P value 0,000). Kesimpulan Kelompok ekstrak daun sintrong (Crassocephalum crepidioides) adalah kelompok yang paling efektif menghambat pertumbuhan bakteri Staphylococcus aureus. Background Staphylococcus aureus is a leading cause of infections and infant mortality in Indonesia, especially pneumonia. According to data from the Indonesian Ministry of Health in 2022, pneumonia accounted for 14.4% of cases in infants and 9.4% in toddlers, with 1,475 cases reported in Cirebon city. Allergic reactions from antibiotics have become a serious issue in treatment, prompting the need for natural alternatives such as bandotan leaf (Ageratum conyzoides Linnaeus) and sintrong leaf (Crassocephalum crepidioides). The compounds alkaloids, flavonoids, saponins, and tannins present in these leaves are believed to effectively inhibit bacterial growth. Aim To compare the effectiveness of bandotan leaf extract (Ageratum conyzoides Linnaeus) and sintrong leaf extract (Crassocephalum crepidioides) on the growth of Staphylococcus aureus bacteria. Method Experimental research with posttest-only control group design from April to July 2023. The study used 8 groups consisting of bandotan leaf extract (Ageratum conyzoides Linnaeus) and sintrong leaf extract (Crassocephalum crepidioides) at concentrations 50%, 75%, and 100%, as well as chloramphenicol (positive control) and DMSO 10% (negative control). Data were analyzed using One-way ANOVA, Post-hoc Tukey HSD, and Independent T-test. Results There is a comparison of the effectiveness of bandotan leaf extract (Ageratum conyzoides Linnaeus) and sintrong leaf extract (Crassocephalum crepidioides) against the growth of Staphylococcus aureus bacteria. Sintrong leaf extract (Crassocephalum crepidioides) exhibits an average inhibitory zone effectiveness of ± 10.44083 mm (P-value 0.000). Conclusion The Crassocephalum crepidioides extract group was the most effective in inhibiting the growth of Staphylococcus aureus bacteria.
EFEKTIVITAS EKSTRAK KULIT , DAGING DAN BONGGOL BUAH NANAS ( Ananas comosus L.Merr) DALAM MENGHAMBAT Propionibacterium acnes Novitasari, Devi; Mulyaningsih, Ruri Eka Maryam; Meidianawaty, R. Vivi
InaBHS (Indonesian Journal of Biomedicine and Health Science) Vol 1 No 1 (2022)
Publisher : Fakultas Kedokteran UGJ Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33603/inabhs.v1i1.7309

Abstract

 ABSTRAKLatar Belakang : Propionibacterium acnes merupakan bakteri Gram positif yang menyebabkan akne vulgaris. Untuk mengurangi resistensi antibiotik, dikembangkan pengobatan alternatif untuk menghambat pertumbuhan bakteri menggunakan bahan alami dengan sifat antibakteri, salah satunya adalah nanas (Ananas comosus L. Merr).  Tujuan  : Penelitian ini bertujuan untuk membuktikan efektivitas ekstrak kulit, daging buah dan bonggol nanas (Ananas comosus L.Merr) dalam menghambat pertumbuhan Propionibacterium acnes. Metode: Penelitian Experimental Laboratory dengan Post-test Only Control Group Design. Sampel penelitian adalah bakteri Propionibacterium acnes pada pembenihan nutrien agar darah. Kulit, daging buah dan bonggol nanas diencerkan dengan 3 konsentrasi, yaitu 50%,75%, 100% dengan 2 kontrol yaitu kontrol positif Doksisiklin dan kontrol negatif DMSO. Hasil Penelitan    : Hasil yang diperoleh dari penelitian ini menunjukan bahwa rerata daya hambat ekstrak kulit 50% (1,5 mm) 75% (3,3 mm), 100% ( 12,7 mm), ekstrak daging buah 50% (0,7 mm), 75% (2,5 mm), 100% (4,6 mm), ekstrak bonggol 50% (2,1 mm), 75% (5 mm), 100% (12,9 mm), kontrol DMSO (0,2 mm), serta kontrol Doksisiklin (20,4 mm). Hasil analisis data menunjukkan bahwa ekstrak bonggol nanas lebih efektif dibandingkkan dengan ekstrak kulit nanas dan ekstrak daging buah nanas. Simpulan  : Ekstrak bonggol nanas lebih efektif menghambat pertumbuhan Propionibacterium acnes dibandingkan dengan ekstrak kulit nanas dan ekstrak daging buah nanas dengan konsentrasi yang sama. Daya hambat yang paling tinggi adalah 12,9 mm yang didapat dari daya hambat ekstrak bonggol nanas dengan konsentrasi 100%. Kata kunci   : Ekstrak nanas,  Propionibacterium acnes , Ananas comosus L.Merr, Antibakteri. 
AKTIVITAS ANTIJAMUR EKSTRAK ETANOL DAUN ALPUKAT (Persea americana Mill.) TERHADAP Malassezia furfur Nurdianti, Helma; Brajawikalpa, Rama Samara; Mulyaningsih, Ruri Eka Maryam
InaBHS (Indonesian Journal of Biomedicine and Health Science) Vol 3 No 2 (2024): Indonesian Journal of Biomedicine and Health Science
Publisher : Fakultas Kedokteran UGJ Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33603/inabhs.v3i2.10525

Abstract

Latar Belakang: Pertumbuhan Malassezia furfur secara berlebihan dapat menyebabkan penyakit ketombe dan jika dibiarkan akan menjadi dermatitis seboroik di kulit kepala. Prevalensi ketombe di dunia mencapai 15-20% dan di Indonesia >70% populasi. Daun alpukat (Persea americana Mill.) memiliki senyawa bioaktif sebagai antijamur yang dapat digunakan sebagai alternatif pengobatan. Tujuan: Mengetahui efektivitas antijamur ekstrak etanol daun alpukat (Persea americana Mill.) terhadap pertumbuhan Malassezia furfur. Metode: Desain penelitian menggunakan post-test only with control group design dengan 8 kelompok terdiri dari 6 kelompok perlakuan yang diberikan ekstrak etanol daun alpukat (Persea americana Mill.) konsentrasi 6,25%, 12,5%, 25%, 50%, 75%, dan 100%, serta 2 kelompok kontrol, yaitu kelompok kontrol (+) yang diberi ketokonazol dan kontrol (-) yang diberi DMSO 10%. Pengujian menggunakan metode dilusi padat dengan media Sabouraud Dextrose Agar (SDA). Hasil: Ekstrak etanol daun alpukat (Persea americana Mill.) dengan konsentrasi 6,25%, 12,5%, 25%, 50%, 75%, dan 100% secara signifikan dapat menghambat pertumbuhan Malassezia furfur (p value < 0,05) dengan rerata TPC secara berturut-turut sebanyak 7,8 x 108 CFU/mL, 6,5 x 108 CFU/mL, 6,3 x 108 CFU/mL, 6 x 108 CFU/mL, 5,6 x 108 CFU/mL, dan 6,2 x 108 CFU/mL. Simpulan: Ekstrak etanol daun alpukat (Persea americana Mill.) memiliki aktivitas antijamur dengan Konsentrasi Hambat Minimum (KHM) pada konsentrasi 6,25% dengan jumlah TPC 7,8 x 108 CFU/mL dan konsentrasi paling efektif pada konsentrasi 75% dengan jumlah rerata TPC 5,6 x 108 CFU/mL. Kata Kunci: Antijamur, Daun alpukat, Malassezia furfur, Persea americana Mill. ABSTRACT Background: Overgrowth of Malassezia furfur can cause dandruff disease and if left untreated will become seborrheic dermatitis on the scalp. The prevalence of dandruff in the world reaches 15-20% and in Indonesia >70% of the population. Avocado leaves (Persea americana Mill.) have bioactive compounds as antifungals that can be used as alternative treatments. Aim: To determine the antifungal effectiveness of ethanol extract of avocado leaves (Persea americana Mill.) against the growth of Malassezia furfur. Methods: Laboratory experimental true research with post-test only with control group design. Using 8 groups, consisting of 6 treatment groups given ethanol extract of avocado leaves (Persea americana Mill.) concentrations of 6.25%, 12.5%, 25%, 50%, 75%, and 100%, and 2 control groups, namely the control group (+) which was given ketoconazole and control (-) which was given 10% DMSO. The test used the solid dilution method with Sabouraud Dextrose Agar (SDA) media. Results: Ethanol extract of avocado leaves (Persea americana Mill.) with concentrations of 6.25%, 12.5%, 25%, 50%, 75%, and 100% can significantly inhibit the growth of Malassezia furfur (p value <0.05) with a mean TPC of 7.8 x 108 CFU/mL, 6.5 x 108 CFU/mL, 6.3 x 108 CFU/mL, 6 x 108 CFU/mL, 5.6 x 108 CFU/mL, and 6.2 x 108 CFU/mL, respectively. Conclusion: Ethanol extract of avocado leaves (Persea americana Mill.) has antifungal activity with a Minimum Inhibitory Concentration (KHM) at a concentration of 6.25% with a TPC count of 7.8 x 108 CFU/mL and the most effective concentration at a concentration of 75% with a mean TPC count of 5.6 x 108 CFU/mL. Keywords: Antifungal, Avocado leaf, Malassezia furfur, Persea americana Mill.
Co-Authors Aji, Dela Destiani Andiri, Mochammad Apriyanto, Dadan Ramadhan Devi Novitasari, Devi Handayani, Tridaya Putri Helga Marwa Afifah, Helga Marwa Ignatius Hapsoro Wirandoko Maya Wahdini, Maya Meidianawaty, R. Vivi MZZ, Ahmad Fariz Naldi, Yandri Nurdianti, Helma Raden Mohamad Herdian Bhakti Rama Samara Brajawikalpa Risman, Muhammad Rizqilah, Rike Safitri, Nita Satrianugraha, Muhammad Duddy Witri Pratiwi