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All Journal MNJ (Malang Neurology Journal) Majalah Kesehatan FKUB SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan JIMR - Journal of Islamic Medicine Research Jurnal Kesehatan Islam : Islamic Health Journal Jurnal Teknik Sipil Cendekia (JTSC) Narra J Prosiding Seminar Nasional Pengabdian Kepada Masyarakat Geoplanart Jurnal Kedokteran Komunitas (Journal of Community Medicine) JAPI: Jurnal Akses Pengabdian Indonesia Jurnal Sosial dan Sains PAPUMA: Journal of Comunnity Services
Kusumawati, Shinta
Fakultas Kedokteran, Universitas Islam Malang
Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Transportation Other

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PREDICTION OF MADECASSOSIDE (CENTELLA ASIATIACA) AFFINITY AS ANTIPARKINSON DRUG ON DOPAMINE RECEPTOR D1: MOLECULAR DOCKING ANALYSIS Shinta Kusumawati; Khotimah, Husnul; Endharti, Agustina Tri; Balafif, Farhad; Zakiyah, Rima
MNJ (Malang Neurology Journal) Vol. 11 No. 2 (2025): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.02.03

Abstract

Background: Parkinson's disease results from the gradual degeneration of dopamine neurons in the brain's substantia nigra pars compacta. The Dopamin receptor D1 (DRD1), which controls nerve growth and behavior, is the most prevalent dopamine receptor in the human nervous system. Objective: To determine the affinity of madecassoside on dopamine D1 receptors as a potential for anti-Parkinson's medications. Methods: The RSCB PDB database provided the chosen target protein's three-dimensional structure. namely DRD1. The PubChem database provided the 3D structure of the Madecassoside sample (CID: 45356919) and the PDB ligand control Rotigotine (CID: 59227). Autodock Vina, which was integrated with Pyrx v.1, was used for docking. Results: The madecassoside has a lower binding energy than the PDB control in the form of Rotigotine. The docking results showed that  madecassoside compounds formed more hydrogen bonds than Rotigotine. It was predicted that madecassoside and the dopamin receptor 1 receptor would create a stability complex. Conclusion: Madecassoside was predicted create a stability complex with DRD1.
IDENTIFIKASI TIPOLOGI JALUR PEJALAN KAKI DI KORIDOR JALAN BANDUNG – CIREBON DESA TANJUNGSARI Kusumawati, Shinta; Nurdiana, Deden; Anisarida, An An
JURNAL TEKNIK SIPIL CENDEKIA (JTSC) Vol 5 No 1 (2024): February
Publisher : Departement of Civil Engineering, Universitas Winaya Mukti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51988/jtsc.v5i1.188

Abstract

Pedestrian paths or pedestrian paths are facilities that must exist in a city. Pedestrian paths generally function to facilitate pedestrian movement from one place to another easily, smoothly, safely, comfortably and independently. Pedestrian paths are created so that road users, especially pedestrians, can avoid accidents and can enjoy walking activities safely, relaxed and comfortably without having to worry about vehicles crossing them. The unavailability of pedestrian paths on the Jalan Bandung - Cirebon corridor in Tanjungsari Village, Tanjungsari District, Sumedang Regency has caused various problems related to pedestrian safety with many traffic accidents occurring on this route. As a first step in creating a concept plan for pedestrian routes in the Jalan Bandung - Cirebon corridor, it is necessary to identify the typology of pedestrian routes using an overlay analysis method between the land cover map and the spatial pattern map. The study findings in the form of segments will become a land plan for planning pedestrian paths that comply with safety and comfort standards. The results of the analysis state that there are 3 (three) segments that can be used as pedestrian path plans, namely road segment 1 (one) in the trade and services zone in the south with a segment length of 450 meters, road segment 2 (two) in the mixed zone with segment length of 476 meters and segment 3 (three) in the trade and services zone in the north with a segment length of 374 meters, which will be the basis for determining further analysis.
Peningkatan Usaha Kecil Industri Rumah Tangga Keripik Usus Di Kelurahan Kedungkandang Fuady, Anies; Saefuddin, Ruli; Kusumawati, Shinta; Mustaufir, Mustaufir
JAPI (Jurnal Akses Pengabdian Indonesia) Vol 8, No 3 (2023)
Publisher : Universitas Tribhuwana Tunggadewi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33366/japi.v8i3.4854

Abstract

Usaha kecil rumah tangga saat ini banyak digeluti oleh masyarakat dengan tujuan untuk meningkatkan produktivitas ekonomi dan kesejahteraan, serta membantu mendukung ketahanan ekonomi nasional. Salah satu contohnya adalah industri kripik usus yang dimiliki oleh Ibu Siti Lailatul Muclifah, yang berlokasi di Jalan Mayjend Sungkono RT: 08 RW: 06, Kota Malang. Namun, ada beberapa permasalahan yang masih dihadapi oleh pelaku usaha tersebut. Salah satunya adalah kesulitan dalam meningkatkan jumlah dan kualitas produksi kripik usus, yang disebabkan oleh beberapa faktor seperti kurangnya penggunaan alat berbasis teknologi dan kurangnya pemahaman dalam mengelola sistem keuangan serta permasalahan dalam pemasaran produk. Dalam rangka membantu mitra usaha industri keripik usus tersebut maka metode pengabdian yang digunakan yaitu melalui kegiatan pengabdian kepada masyarakat seperti melakukan sosialisasi dan pelatihan, yaitu memberikan pemahaman materi terkait pengelolaan keuangan dan administrasi usaha, serta pendampingan terhadap alat inovatif berbasis teknologi untuk mengembangkan dan meningkatkan industri kripik usus yang berkualitas. Hasil dari kegiatan pengabdian kepada masyarakat ini mencakup pelatihan dan pendampingan dalam pengembangan alat berbasis IPTEK, serta manajemen keuangan dan pemasaran yang optimal. 
Upaya pencegahan kanker serviks melalui deteksi dini dengan USG ginekologi dan pap smear Zakiyah, Rima; Kusumawati, Shinta; Rosidah, Aris; Anisa, Rizki; Aulia, Nihara
SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Vol 10, No 1 (2026): February
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v10i1.37744

Abstract

Abstrak Kanker serviks masih menjadi penyebab utama morbiditas pada perempuan, terutama akibat rendahnya pengetahuan dan minimnya keterlibatan dalam deteksi dini. Kegiatan pengabdian ini bertujuan meningkatkan pemahaman dan mendorong perilaku preventif melalui edukasi dan skrining. Sasaran kegiatan adalah  dosen dan karyawan perempuan di lingkungan Universitas Islam Malang usia 20-74 tahun. Metode pelaksanaan meliputi skrining resiko kanker serviks, pre dan post test penyuluhan mengenai pencegahan kanker serviks, serta pemeriksaan Pap smear dan USG. Dari 17 peserta didapatkan skrining resiko tinggi sebanyak 76,5%, resiko sedang 11,8%, dan resiko rendah 11,8%. Pre dan post test penyuluhan tidak menunjukkan perubahan. Sementara hasil Pemeriksaan USG mengidentifikasi hasil normal 88,2% dan abnormal 11,8%, sedangkan hasil pap smear menunjukkan hasil abnormal (76,2%) yang meliputi adanya inflamasi, atropic smera dan ASCUS. Hasil abnormal pada peserta disarankan dirujuk untuk evaluasi lanjutan. Secara keseluruhan, kegiatan ini membuktikan bahwa edukasi terstruktur dan skrining terintegrasi efektif dalam meningkatkan kesadaran serta partisipasi perempuan produktif  terhadap pencegahan kanker serviks. Kata kunci: deteksi dini; edukasi kesehatan; kanker serviks; pap smear; pengabdian masyarakat. Abstract Cervical cancer remains a leading cause of morbidity in women, primarily due to low knowledge and minimal involvement in early detection. This community service activity aims to increase understanding and encourage preventive behavior through education and screening. The target group is female lecturers and staff at the Islamic University of Malang aged 20-74 years. The implementation method included cervical cancer risk screening, pre- and post-test counseling on cervical cancer prevention, as well as Pap smear and ultrasound examinations. Of the 17 participants, 76.5% were high-risk, 11.8% were moderate-risk, and 11.8% were low-risk. The pre- and post-test counseling showed no change. Meanwhile, the ultrasound examination results identified normal results in 88.2% and abnormal results in 11.8%. Meanwhile, Pap smear results showed abnormal results (76.2%), including inflammation, atrophic smears, and ASCUS. Participants with abnormal results were referred for further evaluation. Overall, this activity demonstrates the effectiveness of structured education and integrated screening in increasing awareness and participation of productive women in cervical cancer prevention. Keywords: early detection; health education; cervical cancer; pap smear; community service.
SOSIALISASI PENTINGNYA SANITASI LINGKUNGAN DAN GIZI BAGI SISWA-SISWI SDN 1 BUGEMAN KABUPATEN SITUBONDO Kartika Sari, Vega; Abraham, Natanael Firstly; Aszhuraini, Aszhuraini; Rofi’ah, Rizka Febby; Mahendra, Aldi; Ferdiansyah, Mohammad Feri; Christanty, Natasya Rahel; Basuki, Basuki; Kusumawati, Shinta
PAPUMA: Journal of Community Services Vol. 4 No. 01 (2026): April 2026
Publisher : Department of Agronomy, Faculty of Agriculture, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/papuma.v4i01.60000

Abstract

The nutritional status of children in Indonesia needs serious attention because of the significant prevalence of malnutrition, stunting, and wasting in several regions, including Situbondo Regency. Bugeman Village, Kendit District, has a score of 37.21 for clean water and sanitation, and 33.33 for hunger-free. This service aimed to educate school children about the importance of sanitation in an effort to improve nutritional status. The target of this activity was elementary school students in grades 5 and 6 of SDN 1 Bugeman, Situbondo Regency. The pre-test and post-test results of 43 elementary school students who had participated in the socialization showed an increase of 40.466 points. This significant change was expected to have a positive impact on students understanding of the importance of sanitation and balanced nutrition. The knowledge provided would be more meaningful if it is supported by concrete steps in improving sanitation, nutrition education, and developing health facilities.
STUDI MOLECULAR DOCKING POTENSI ANTI-PARKINSON SENYAWA AKTIF BIJI Nigella sativa PADA RESEPTOR DOPAMIN D1/D2 Barqillah, Izzunnazel Achmad; Denis Mery Mirza; Kusumawati, Shinta
Majalah Kesehatan Vol. 0 No. 00 (2026): Article in Press
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Abstract

Penyakit Parkinson adalah gangguan neurodegeneratif progresif akibat defisiensi dopamin. Parkinson menjadi penyakit terbanyak setelah Alzheimer. Terapi menggunakan rotigotin yang bekerja pada reseptor dopamin D1 dan D2 memberikan efek samping halusinasi, depresi, gangguan hati dan ginjal. Biji jinten hitam (Nigella sativa) memiliki senyawa antioksidan dan antiinflamasi dengan potensi anti-Parkinson, namun interaksinya dengan reseptor dopamin belum banyak dikaji. Selain itu, obat herbal diketahui memiliki efek samping yang minimal. Penelitian ini bertujuan untuk mengetahui afinitas senyawa aktif biji jinten hitam sebagai anti-Parkinson dengan mekanisme peningkatan potensi reseptor dopamin D1/D2. Sebanyak 22 senyawa aktif Nigella sativa dipilih dari literatur dan Dr. Duke’s Database. Struktur reseptor D1 (PDB ID: 8IRR) dan D2 (PDB ID: 8IRS) diperoleh dari Protein Data Bank. Molecular docking dilakukan dengan PyRx, sementara evaluasi fisikokimia dan blood-brain barrier (BBB) dianalisis menggunakan SwissADME. Tryptophan (ΔG -7.6 kkal/mol) dan linoleic acid (ΔG -7 kkal/mol) memiliki afinitas tertinggi pada D1, linoleic acid (ΔG -7.4 kkal/mol) dan tryptophan (ΔG -7.3 kkal/mol) juga memiliki afinitas tertinggi pada D2. Namun, tryptophan tidak memiliki kemampuan yang baik dalam menembus BBB. Carvacrol (ΔG -6.7 kkal/mol) dan palmitic acid (ΔG -6.9 kkal/mol & -6.7 kkal/mol) menunjukkan afinitas moderat dengan interaksi residu mirip ligan kontrol (rotigotin) serta kemampuan penetrasi BBB yang baik. Linoleic acid, carvacrol, dan palmitic acid berpotensi sebagai kandidat anti-Parkinson melalui potensi peningkatan reseptor dopamin D1 dan D2.
Co-Authors Abraham, Natanael Firstly Agustina Tri Endharti Amelia Aziz Daeng Matadjo Anaqah, Rabjhany Anies Fuady Anies Fuady anisa, rizki Anisarida, An An Aris Rosidah Aszhuraini, Aszhuraini Aulia, Nihara Balafif, Farhad Barqillah, Izzunazel A. Barqillah, Izzunnazel Achmad Basuki , Christanty, Natasya Rahel Daniel Happy Putra Denis Mery Mirza Endharti, Agustina T. Faisal Fahad Alfuraydi Ferdiansyah, Mohammad Feri Fuady, Anies Ina Revayanti Kartika Sari, Vega Kurniawan, Shahdevi N. Mahendra, Aldi Mahfudhoh, Millah Millah Mahfudhoh mustaufir Mustaufir Mustaufir Mustaufir, Mustaufir Nurdiana, Deden Rahma Triliana Rima Zakiyah Rofi’ah, Rizka Febby Ruli Saefuddin Saefuddin, Ruli Verry Setiawan Primadhiputra