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All Journal Journal of Health Sciences Medical and Health Science Journal Jurnal Pemberdayaan Masyarakat Universitas Al Azhar Indonesia PREPOTIF : Jurnal Kesehatan Masyarakat BERNAS: Jurnal Pengabdian Kepada Masyarakat International Islamic Medical Journal Prosiding Seminar Nasional Pengabdian Kepada Masyarakat
Putri, Winawati Eka
Universitas Nahdlatul Ulama Surabaya
Religion Agriculture, Biological Sciences & Forestry Humanities Computer Science & IT Dentistry Education Environmental Science Health Professions Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : International Islamic Medical Journal

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The Effect of Sunscreen Use on The Incidence of Melasma in Police Officers: Meta-Analysis and Systemic Review Putri, Intan Nurmawati; Putra, Aldo Primananda; Juniano, Nandika; Budi, Eko; Putri, Winawati Eka; Mayangsari, Renata; Prabawaningrum, Kinanti; Andriansyah, Julian
Jurnal Medis Islam Internasional Vol 6 No 2 (2024): December
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v6i2.6257

Abstract

Introduction: Melasma is a matter of concern for certain individuals due to its ability to cause changes in the visual appearance of the skin, ultimately impacting one's self-esteem and overall quality of life. Exposure to direct sunlight significantly influences the development of melasma. Indonesia's location below the equator results in a tropical environment with high temperatures throughout the year. Police officers are exposed to solar radiation for more than 6 hours every day while on duty. For certain police officers, particularly female officers, this is an issue as it can result in melasma, which affects appearances Objective: This study aims to estimate the effect of sunscreen usage in the police environment on melasma incidence in police officers. Methods: Electronic databases such as MEDLINE/PubMed, Cochrane Library, ClinicalTrials.gov, EBSCO, Scopus, ProQuest, Cambridge Core, reference lists, conference proceedings, and researchers in relevant fields of study were searched. The impact of sunscreen application on the prevalence of melasma in police personnel was evaluated using many parameters Results: Based on the systematic review, police officers continue to have a very high prevalence of melasma because they have a low awareness of the importance of using sunscreen. Conclusions: Awareness of sunscreen application on the skin is required to prevent the development of melasma in police personnel. Education on the prognosis, propensity, and chronicity of melasma is extremely important. In a police institution, Dermatovenereologists (DVE) play an important role.
The Pro-Apoptotic Effect of Diallyl Trisulfide (DATS) on MDA-MB-231 Breast Cancer Cells Ailany, Erla Syah Dilla; Veterini, Lysa; Putri, Winawati Eka; Kurniasari, Diyan Wahyu
Jurnal Medis Islam Internasional Vol 7 No 1 (2025): June
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v7i1.7314

Abstract

Introduction: Breast cancer is the most prevalent cancer globally, impacting almost 2.1 million people each year. The MDA-MB-231 exemplifies the aggressive nature of the triple-negative breast cancer (TNBC) subtype. Diallyl Trisulfide (DATS) in Allium sativum (garlic) demonstrates potential anticancer characteristics primarily by causing the generation of ROS that may trigger apoptosis. Objective: The study evaluates the effect of DATS on apoptosis in MDA-MB-231 cells via the ROS pathway. Methods: An in vitro study utilizing MDA-MB-231 cells, categorized into four groups: (1) Medium control, (2) Negative control, (3) 20 µM DATS after 24 hours, and (4) 40 µM DATS after 24 hours. The study used Annexin V-FITC/PI flow cytometry to measure apoptotic cell death, the MTT assay to measure cell viability, and DCFH-DA fluorescence to measure ROS production. Results: Cell viability was decreased after DATS treatment and a substantial increase in intracellular ROS production was observed that varies with time and dose (p < 0.001). In comparison to the other groups, the group that received 40 µM DATS for 24 hours had the highest rate of apoptosis and the largest accumulation of reactive oxygen species (ROS). Conclusions: DATS significantly elevates intracellular ROS levels to promote apoptosis in MDA-MB-231 cells as a pro-oxidant therapy for aggressive breast cancer.
Co-Authors Ailany, Erla Syah Dilla Andriansyah, Julian Ariefianto, Satrio Eko Budi, Eko Dinana, Arina Faizin, Maimunah Faizin Irmawan Farindra Juniano, Nandika Khamida Khamida khamidah, khamidah Kinanti Prabawaningrum, Kinanti Krismawati, Amelia Kurniasari, Diyan Wahyu Lysa Veterini Maimunah Faizin Faizin Maria Ulfa Mayangsari, Renata Meidyta Sinantryana W Meidyta Sinantryana Widyaswari, Meidyta Sinantryana Muhammad, David Sajid Nailuvar, Revani Yuni Nisa, Fauziyatun Nur Ainiyah Nur Ainiyah Putra, Aldo Primananda Putri, Intan Nurmawati Putri, Salsabil Nabila Wigayana Rahayu Anggraini Ramadhany, Rahmat Rizal Rizki Amalia Saffanah, Vena Saksia Prima Syafiuddin, Achmad Tantawi Djauhari Ulliyatul Laili Warda Elmaida Rusdi Wibowo, Bakti Yuli Kurniawati Yunik Windarti Yuriske Agnovianto