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UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN PIRDOT (SAURAUIA VULCANI KORTH.) TERHADAP BAKTERI SALMONELLA THYPI Octora, Debi Dinha; Teresia Marbun, Romauli Anna; Koto, Rahmadona
Jurnal FARMASIMED (JFM) Vol 2 No 1 (2019): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Indonesia is known for the many plants that are used as traditional medicine for disease prevention, including the leaves of the pirdot (Saurauia vulcani Korth) family Actinidiaceae. This study aims to determine the antibacterial activity of ethanol extract of pirdot leaves (Saurauia vulcani Korth). The results of the characterization of pirdot leaf simplicia powder were obtained 3.99% water content, water soluble extract 12.15%, ethanol soluble extract 8.89%, total ash content 9.97%, insoluble ash content in acids 3.17%. The results of phytochemical screening tests contained the chemical compounds of steroids / triterpenoids, flavonoids, glycosides, tannins and saponins. Ethanol extract of pirdot leaf has antibacterial activity against Salmonella typhi bacteria. The treatment consisted of 4 concentrations, pirdot leaf extract with 3 repetitions, each blank (DMSO), 50 mg / ml, 100 mg / ml, 150mg / ml, 200 mg / ml. After that, it was incubated for 24 hours at 37oC. Inhibition zone diameter observations were made using calipers. The results obtained showed that administration of pirdot leaf extract at concentrations of 50 mg / ml, 100 mg / ml, 150 mg / ml and 200 mg / ml can inhibit the growth of Salmonella typhi bacteria. The results of the antibacterial activity test of pirdot leaf ethanol extract against Salmonella typhi bacteria obtained the highest inhibitory concentration of 200 mg / ml with a diameter of 20.48 mm.

FORMULASI SEDIAAN SABUN MANDI PADAT EKSTRAK ETANOL BONGGOL NANAS (Ananas cosmosus L.) UNTUK KELEMBAPAN KULIT Octora, Debi Dinha; Situmorang, Yuliana; Marbun, Romauli Anna Teresia
Jurnal FARMASIMED (JFM) Vol 2 No 2 (2020): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v2i2.369

Tanaman nanas dapat diformulasikan menjadi sediaan sabun mandi padat karna berdasarkan penelitian sebelumnya bonggol nanas menggandung antioksidan tinggi karena memiliki senyawa flavonoid dan saponin. Senyawa yang mampu menangkal radikal bebas adalah antioksidan. Penelitian ini menggunakan metode quasi eksperimental. Pengumpulan sampel, pembuatan simplisia, pembuatan ekstraksi secara maserasi menggunakan pelarut etanol dan pembuatan sediaan sabun padat dengan ekstrak etanol bonggol nanas masing-masing dengan konsentrasi 3%, 4% dan 5%. Kemudian dilakukan uji sabun meliputi: pengukuran pH, ketingian busa sabun, dan uji kemampuan sediaan untuk melembabkan kulit pada responden sebanyak 10 orang selama Â± 1 jam dengan menggunakan alat skin analyzer. Ekstrak etanol bonggol nanas dapat diformulasikan menjadi sediaan sabun mandi padat dengan hasil uji pH menunjukan konsentrasi 5% lebih tinggi, hasil uji ketinggian busa menunjukan konsentrasi 5% lebih tinggi dan hasil pemeriksaan kelembaban kulit menunjukan konsentrasi 5% lebih lembab. Hasil penelitian menunjukan sediaan sabun mandi padat dari ekstrak etanol bonggol nanas (AnanasCosmosusL) untuk melembabkan kulit dengan variasi konsentrasi yang berbeda dapat diformulasikan menjadi sediaan sabun mandi padatdengan hasil uji pH menunjukan stabil pada kulit dan hasil pemeriksaan kelembaban kulit menunjukan konsentrasi 5% lebih lembab. Diharapkan untuk penelitian selanjutnya agar dapat membuat sediaan lain dari ekstrak etanol bonggol nanas (Ananas cosmosus L.) dalam bentuk sediaan lain seperti sabun cair, lotion, sabun transparan, krim dan sebagainya.

EVALUASI PENGGUNAAN OBAT GASTRITIS PADA PASIEN RAWAT INAP DI RS GRANDMED LUBUK PAKAM TAHUN 2020 Mayasari, Dini; Hutahean, Delfi Mutiara; Octora, Debi Dinha
Jurnal FARMASIMED (JFM) Vol 4 No 1 (2021): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v4i1.577

Gastritis is a disease caused by the bacterium Helicobacter phylory, this first gastritis drug, namely Antacids, Omeprazole, and Ranitidine. The increasing number of Gastritis patients from 2019 to 2020 at Grandmed Lubuk Pakam Hospital is encouraging researchers to conduct this study. The purpose of this study was to determine the description of the use of Gastritis drugs and the rationality of the use of Gastritis medications in Gastritis patients at Grandmed Lubuk Pakam Hospital in 2019. This study was a descriptive (non-experimental) study with retrospective data collection taken from patient medical records. Gastritis at Grandmed Lubuk Pakam Hospital. Data were collected using a purposive sampling technique in accordance with the inclusion criteria and exclusion criteria using the Data Collection Sheet. The number of samples used in this study were 64 medical records of patients diagnosed with gastritis. Data analysis was performed using Univariat with the help of SPSS. Results of distribution of duration of treatment data for which most patients undergo treatment. And the number of Chronic Diseases suffered by Diarrhea patients is 20 patients (31.2%). All three have a significant relationship with patient care outcomes. While in the age range 31-60 years, 45 people (70.3%) affected by gastritis. and The results of evaluating the rationality of treatment for gastritis are the right indications (96.9%), (62 patients), 100% correct patients (64 patients), the right medication by (96.9%) (62 patients), and the correct dosage 100% correct (64).

ANTIBACTERIAL ACTIVITY OF ETHANOL EXTRACT PACAR AIR LEAVES (IMPATIENS BALSAMINA L.) AGAINST PROPIONIBACTERIUM ACNE Octora, Debi Dinha; Waruwu, Krismawati
Jurnal FARMASIMED (JFM) Vol 4 No 2 (2022): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v4i2.1067

ABSTRAK Aktivitas antibakteri Impatiens balsamina L. telah dipelajari selama bertahun-tahun. Daun inai air mengandung flavonoid, saponin dan tanin yang memiliki kemampuan untuk menghambat pertumbuhan bakteri. P. acnes merupakan salah satu jenis bakteri yang dapat menyebabkan infeksi pada jerawat. Salah satu tujuan penelitian ini adalah untuk mengetahui aktivitas antibakteri ekstrak etanol daun inai air dan konsentrasi yang paling efektif dalam menghambat bakteri P. acnes. Penelitian ini merupakan penelitian eksperimen murni. Daun inai air dimaserasi dengan pelarut etanol 96%. Uji aktivitas antibakteri dilakukan dengan metode difusi cakram. Penelitian dilakukan dengan 3 variasi konsentrasi yang berbeda. Hasil penelitian menunjukkan adanya aktivitas antibakteri pada setiap konsentrasi. Kesimpulannya ekstrak etanol daun inai dengan konsentrasi 25%, 50% dan 75% memberikan penghambatan pertumbuhan bakteri paling efektif dengan konsentrasi 25%, 50% dan 75% yang termasuk dalam kategori kuat. Saran diharapkan bagi peneliti selanjutnya untuk dapat menguji bakteri lain dan membuat formulasi dari ekstrak daun inai air. ABSTRACT The antibacterial activity of Impatiens balsamina L. has been studied for many years. Water henna leaves contain flavonoids, saponins and tannins which have the ability to inhibit bacterial growth. P. acnes is one type of bacteria that can cause infection in acne. One of the objectives of this study was to determine the antibacterial activity of the ethanol extract of henna water leaves and the most effective concentration in inhibiting P. acnes bacteria. This research is a pure experimental research. Water henna leaves were macerated with 96% ethanol as solvent. Antibacterial activity test was carried out by disc diffusion method. The research was conducted with 3 different concentration variations. The results showed that there was antibacterial activity at each concentration. The conclusion is that the ethanol extract of henna leaves with concentrations of 25%, 50% and 75% gave the most effective bacterial growth inhibition with concentrations of 25%, 50% and 75% which were included in the strong category. Suggestions are expected for further researchers to be able to test other bacteria and make formulations from water henna leaf extract.

ACTIVITY TESTS OF ANTIBACTERIAL CREAM OF BAY LEAF (Syzygium polyanthum) ETHANOL EXTRACT AGAINST BACTERIA Propionibacterium acnes Octora, Debi Dinha; Sari, Delima
Jurnal FARMASIMED (JFM) Vol 5 No 2 (2023): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v5i2.1659

Bay leaf (Syzygium polyanthum) is a plant that is widely used as a flavor enhancer. Based on research that has been done, bay leaves contain flavonoids, alkaloids, tannins, and saponins that have the ability to act as natural antibacterial agents. Improper use of antibiotics in the treatment of infections can cause resistance, so it is necessary to use antibiotics from natural ingredients that have an optimal working power and are relatively safe. P. acnes is one type of bacteria that can cause acne. The purpose of this research is to find out the effective antibacterial activity of bay leaf ethanol extract cream preparation against P. acnes bacteria. This research is an experimental research with 3 different concentration variations. The research results show that there is antibacterial activity at each concentration with an average diameter of the clear zone of 10.06 mm, 14.4 mm and 20.16 mm, the higher the concentration of EEDS, the higher the inhibitory power against P. acnes bacteria growth. The conclusion of the activity of salam leaves with a concentration of 5%, 10%, and 15% provides the most effective inhibition of bacterial growth with a concentration of 10%, 15% which is included in the strong category. Suggestions are expected to the next researcher to be able to test other bacteria and make a greater concentration than the previous research from EEDS.

TEST OF THE INHIBITOR EFFECTIVENESS OF THE COMBINATION OF ETHANOL EXTRACT OF LEMON LEAVES (Cymbopogon citratus) AND GREEN BETEL LEAF (Piper betle L.) AGAINST Staphylococcus aureus BACTERIA Octora, Debi Dinha; Samuel Marpaung; Jhoti Sumitra
Jurnal FARMASIMED (JFM) Vol 6 No 1 (2023): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v6i1.1860

The discovery of natural substances has the potential for applications in the development of pharmaceuticals or natural alternatives to combat bacterial infections. Green betel leaves (Piper betle L.) and lemongrass stems (Cymbopogon citratus) may aid in treating infections due to their specific strength in bacteria eradication. Staphylococcus aureus is one of the pathogenic bacteria types that can cause serious infections and skin disorders under conducive conditions, such as acne and boils. The aim of this study is to determine the antibacterial activity using the maceration and disk diffusion methods on lemongrass stem and green betel leaf extracts against Staphylococcus aureus bacteria. The research conducted is qualitative in nature and aims to assess the inhibitory effect of the combination of ethanol extracts from lemongrass and green betel leaves at various concentrations on the growth of Staphylococcus aureus bacteria. Different concentrations of green betel leaf and lemongrass stem extracts were also tested to determine the most effective concentration in inhibiting bacterial growth. The results demonstrate that specific concentrations of green betel leaf and lemongrass stem extracts have a stronger antibacterial effect compared to other concentrations. The combination of ethanol extracts from lemongrass stems and green betel leaves can inhibit the growth of Staphylococcus aureus bacteria using the paper disk method, with inhibition zone diameters observed for each extract concentration and the positive control Ciprofloxacin, which had a diameter of 25.92 mm. The best concentration formula for the combination of lemongrass stem (Cymbopogon citratus) and green betel leaf (Piper betle L.) ethanol extracts is at 15% concentration, resulting in an average diameter of 18.90 mm. Keywords: Antibacterial, Piper betle L., Cymbopogon citratus, Staphylococcus aureus

Testing The Activity Of Antimicrobial Cream Formulation Of Ethanol Extract Of Kedondong Leaves (Spondias Dulcis) Against Bacteria Propionibacterium Acnes And Staphylococcus Aureus Octora, Debi Dinha; Agnestine Jeliana Nababan; Pratiwi Christa Simarmata
Jurnal FARMASIMED (JFM) Vol 6 No 2 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v6i2.2118

One of the causes of infection in acne is bacteria, such as Propionibacterium acnes and Staphylococcus aureus. Kedondong leaves have been used to treat diseases caused by bacteria. The purpose of this research is to: formulate a cream preparation containing ethanol extract of kedondong leaves and assess whether the cream preparation has antibacterial activity against P. acnes and S. aureus bacteria. The research method employed in this study is experimental, involving the following steps: preparation of ethanol extract of kedondong leaves using the maceration method with 96% ethanol solvent, formulation of the cream with a base consisting of cetyl alcohol, liquid paraffin, albumen vaseline, and distilled water. It is made in three concentrations of extract: F I with 10%, F II with 15%, and F III with 20%. Subsequently, the evaluation of the preparation was conducted, including physical stability evaluation, homogeneity, and antibacterial activity test against P. acnes and S. aureus bacteria using agar diffusion method with disc paper. The research results indicate that the cream has good physical stability and homogeneity for 30 days of storage at room temperature. The antibacterial cream preparation containing ethanol extract of kedondong leaves showed antibacterial activity against P. acnes and S. aureus bacteria. The average inhibition zones against P. acnes for formulations I, II, and III were 12.25 mm, 16.15 mm, and 24.15 mm respectively, while for S. aureus, the average inhibition zones were 10.75 mm, 15.45 mm, and 17.55 mm respectively, and the Positive Control (Clindamycin Antibiotic) had an inhibition zone of 30.35 mm. Based on the obtained results, it can be concluded that the cream preparation containing ethanol extract of kedondong leaves has inhibitory activity against P. acnes and S. aureus bacteria.

Utilization of Cinnamon Leaves (Cinnamomum burmannii, Blume) and Effectiveness Test as Mouthwash against Oral Microbes Octora, Debi Dinha; Irwanto, Reno; Simarmata, Pratiwi Christa
Jurnal FARMASIMED (JFM) Vol 7 No 1 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i1.2287

Oral health is an important aspect to pay attention to because it is part of the digestive system. Disorders in oral health function can impact other bodily health. The use of mouthwash is necessary to improve the cleanliness and health of the mouth, especially when brushing alone is not optimal. The active compounds in mouthwash enhance cleanliness and effectively inhibit the growth of pathogenic oral microflora. Cinnamon leaves have not been widely utilized and are often left unused or discarded. Previous research has been conducted on the potential of the compounds in cinnamon leaves. This research was carried out by determining the best essential oil content of cinnamon leaves through several preliminary treatments and varying distillation times. Active compounds such as cinnamaldehyde, L-linalool, and cinnamyl acetate were found in the cinnamon leaves, making them a potential ingredient for mouthwash formulation. The aim of this study is to produce an effective mouthwash that reduces the growth of pathogenic oral microflora using underutilized local materials. The mouthwash preparation method was modified from several active ingredient mouthwash preparation methods by varying the concentration of cinnamon leaf essential oil at 5%, 10%, and 15%. The formulations were then evaluated for organoleptic properties, stability, homogeneity, and antibacterial activity against S. mutans using the disc diffusion method. The results showed that the preparations remained physically stable and homogeneous during 30 days of storage at room temperature. The cinnamon leaf mouthwash exhibited antibacterial activity against S. mutans, with average inhibition zones of 15.25 mm, 19.06 mm, and 24.34 mm for formulations I, II, and III, respectively. Based on these results, it can be concluded that the cinnamon leaf mouthwash has the potential to inhibit the growth of S. mutans bacteria."

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