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All Journal JURNAL FARMASIMED (JFM) Jurnal Prima Medika Sains International Journal Of Science, Technology & Management (IJSTM) Jurnal Pengmas Kestra (JPK)

Cahya, Cucu Arum Dwi

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Author-ID : 1239979

Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Engineering Health Professions Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology Nursing Public Health Transportation

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EFEKTIFITAS EKSTRAK ETANOL DAUN SAWI HIJAU (BRASSICA RAPA VAR. PARACHINENSIS) SEBAGAI PELEMBAB KULIT DENGAN SEDIAAN MASKER PEEL-OFF Cahya, Cucu Arum Dwi; Syarifuddin, Aminah; Syukur, Ahmad Syukur
Jurnal FARMASIMED (JFM) Vol 2 No 1 (2019): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Green mustard plants can be formulater into peel-off masks to moisturize the skin, because based on previous research green mustard leaves cointain flavonoids as antioxidants which can moisturize the skin. The purpose of this study was to find out green mustard leaves can be formulated into peel-off mask preparations and to find out the preparation and to find out the preparation off peel off mask with etanol extract of green mustard leaves can moisturize the skin. This study uses an experimental method. Green mustard leaves are extracted by maceration. In this study, a skin analyzer was usee as a mesure of skin moisture level after using peel off mask from a variety of dosage formulations which were divided into 5 preparations, blank (without mask, 3%,4%,5%), postive control (using peel off masks on the market). The Anova test results show a sig value of 0,000 or p<0,005 so it is concluded that the variabel has a difference. The conclusion of this study proves that the ethanol extract of green mustard leaves can be used as a peel-off mask for skin moisturizer, where the higher the concentration of mustard leaf extract, the higher the moisture vlue of the skin.

EFEKTIFITAS IMUNOSTIMULAN DARI EKSTRAK ETANOL DAUN SIRSAK (ANNONA MUCIRATA) PADA TIKUS JANTAN DENGAN METODE HYPERSENSITIVITAS TIPE LAMBAT Wulandari, Suci; Hasibuan, Ahmad Syukur; Cahya, Cucu Arum Dwi
Jurnal FARMASIMED (JFM) Vol 2 No 1 (2019): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Penelitian pada skripsi ini bertujuan untuk mengetahui efektifitas imunostimulan dari ekstrak etanol daun Sirsak (Annona mucirata), dengan empat varian dosis. Penelitian ini menggunakan hewan tikus putih jantan sebanyak 18 ekor dengan BB 200 gram yang dibagi menjadi 6 kelompok perlakuan. Tikus diinduksikan dengan bakteri Escherichia coli selama 7 hari berturut turut secara intra peritoneum, kemudian pada hari ke 7 beri tanda di kaki tikus yang sudah diukur (V0). Ekstrak etanol daun Sirsak (Annona mucirata), dengan varian dosis 50mg/kgBB, 100mg/kgBB, 200mg/kgBB, 400mg/kgBB, suspense CMC Na 0,5%, dan suspensi STIMUNO 25 mg/kgBB sebagai kontrol positif siberikan secara oral pada hari ke 8, setelah 24 jam setelah pemberian kemudian kaki tikus diukur kembali volumenya (Vt).catat hasil, selanjutnya seluruh data masing-masing kelompok diolah menggunakan uji ANOVA. Hasil penelitian menunjukan bahwa ekstrak etanol daun benalu kopi terbukti efektifbagai imunostimulan. Hal ini dibuktikan dengan adanya penurunan volume pembengkakan kaki tikus yang diuji dengan metode hipersensitifitas tipe lambat. Dikatakan efektif karena memiliki nilai mendekati control positif yaitu stimuno 25 mg dimulai dari dosis 200mgkg/bb sampai 400mgkg/BB. Dengan nilai rata-rata penurunan volume pembengkakan 1,4mm untuk dosis 400mgkg/BB dan 1,2mm untuk dosis 200mgkg/BB.

UJI AKTIVITAS EKSTRAK ETANOL DAUN LABU SIAM (SECHIUM EDULE (JACQ.) SWARTZ) TERHADAP AKTIVITAS ANTIBAKTERI STAPHYLOCOCCUS AUREUS Cahya, Cucu Arum Dwi; Priasa, Ayunda; M. Br. Turnip, Nur Ulina
Jurnal FARMASIMED (JFM) Vol 3 No 1 (2020): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v3i1.499

Labu siam merupakan tumbuhan jenis labu-labuan yang dapat dimakan buah dan pucuk mudanya. Tumbuhan labu siam mengandung senyawa metabolit sekunder antara flavonoid, alkaloid, saponin. Tujuan penelitian ini adalah untuk mengetahui pengaruh ekstrak daun labu siam (Sechium edele (Jacq.) Swartz) terhadap pertumbuhan bakteri Staphylococcus aureus. Penelitian ini dilakukan dengan menggunakan metode eksperimental murni. Metode yang digunakan dalam uji aktivitas antibakteri adalah metode difusi dengan kertas cakram. Konsentrasi yang digunakan pada ekstrak daun labu siam terdiri dari konsentrasi 20%, 40%,dan 60%. Hasil skrining fitokimia menunjukkan bahwa ekstak daun labu siam mengandung saponin, flavonoid, dan tanin. Pengaruh pemberian ekstrak daun labu siam terhadap Staphylococcus aureus ditandai dengan terbentuknya zona hambat pada konsentrasi 20%, 40%, dan 60% secara berurutan dengan rerata diameter sebesar 6,6 mm; 8,5 mm; 10,3 mm. Hasil uji One-Way ANOVA didapatkan nilai sig 0,000 (sig<0,05) dan berdasarkan hasil penelitian dapat disimpulkan bahwa terdapat pengaruh konsentrasi ekstrak daun labu siam terhadap pertumbuhan bakteri Staphylococcus aureus. Konsentrasi 60% yang paling efektif dalam menghambat pertumbuhan bakteri dengan potensi kuat dalam menghambat pertumbuhan bakteri Staphylococcus aureus dengan mengunakan metode difusi. Disarankan pada peneliti selanjutnya untuk melakukan uji aktivitas antibakteri pada bagian tumbuhan yang lain seperti bunga, batang dan akar.

FORMULATION OF RED SPINNING LEAVES (AMARANTHUS) TRICOLOR L. AS NATURAL DYES IN PREPARATIONS EYESHADOW COMPACT POWDER Cahya, Cucu Arum Dwi; Silalahi, Mega
Jurnal FARMASIMED (JFM) Vol 4 No 2 (2022): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v4i2.1015

Berbagai jenis kosmetik yang sering kali diminati bagi para wanita yaitu eye shadow. Pada sebagian produk eye shadow masih terdapat penyalahgunaan pewarna tekstil yang berbahaya jika digunakan bagi tubuh. Daun bayam merah (Amaranthus tricolor L.) mempunyai pigmen betasianin yang dapat dijadikan pewarna alami pada sediaan eye shadow compact powder. Penelitian ini bertujuan untuk membuat sediaan eye shadow compact powder dengan menggunakan ekstrak daun bayam merah sebagai pewarna alami serta memenuhi persyaratan mutu fisik dan tidak mengiritasi kulit.Daun bayam merah segar dilakukan ekstraksi dengan metode maserasi dengan menggunakan pelarut etanol 70% dan ditambahkan asam sitrat, kemudian pelarut diuapkan dengan bantuan alat rotary evaporator pada suhu 50°C, kemudian dipekatkan dengan waterbath (penangas air) pada suhu 78°C sampai didapatkan ekstrak kental. Kemudian diformulasikan ke dalam bentuk sediaan eye shadow compact powder dengan menggunakan kaolin, zink stearat, nipagin, isopropyl miristat, lanolin, oleum rosae, dan talkum. Dengan variasi konsentrasi ekstrak daun bayam merah F0 (Blanko), F1 (8%), F2 (12%) dan F3 (18%). Kemudian campuran serbuk dicetak dengan alat press. Selanjutnya dilakukan pemeriksaan persyaratan mutu fisik sediaan eye shadow compact powder yaitu uji dispersi warna (homogenitas), uji poles, uji kerapuhan, dan uji stabilitas terhadap bentuk,warna dan aroma pada penyimpanan suhu kamar selam 30 hari, serta uji iritasi terhadap sediaan F0 (Blanko), F1 (8%), F2 (12%) dan F3 (18%). Berdasarkan hasil yang diperoleh semua sediaan F0 (Blanko), F1 (8%), F2 (12%) dan F3 (18%) homogen terdispersi merata, tidak rapuh, stabil dalam penyimpanan suhu kamar selama 30 hari, dan tidak mengiritasi kulit. Namun pada pemeriksaan uji oles pada sediaan F3 (18%) memiliki daya oles yang kurang baik dikarenakan perlu 5 kali pengolesan agar warna terlihat jelas menempel pada kulit sedangkan pada sediaan F0 (Blanko), F1 (8%) dan F2 (12%) cukup dengan 3 kali pengolesan warna sudah terlihat dan menempel.

EFFECTIVENESS TEST ON PREPARATION GEL (Aleurites moluccana) AS ANTICEPTIC HAND SANITIZER AGAINST BACTERIA Staphylococcus aureus Cahya, Cucu Arum Dwi; Lubis, Devi Febby Yola
Jurnal FARMASIMED (JFM) Vol 5 No 2 (2023): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v5i2.1258

Salah satu cara yang efektif untuk menjaga kesehatan tubuh adalah dengan menjaga kebersihan, salah satunya adalah kebersihan tangan. Salah satu bakteri yang paling sering mengkontaminasi kulit tangan adalah Staphylococcus aureus. Penggunaan gel antiseptik (Hand sanitizer) yang mudah dan praktis semakin diminati masyarakat. Kebanyakan produk gel antiseptik tangan menggunakan alkohol sebagai antibakteri. Kemiri adalah salah satu tumbuhan dengan berbagai manfaat pada setiap bagian pohonnya. Kemiri dapat dimanfaatkan baik sebagai obat-obatan tradisional, bahan makanan, bahan pewarna, penerangan dan berbagai kegunaan lain. Namun belum ada studi yang meneliti apakah formulasi sediaan Gel Hand sanitizer minyak kemiri (Aleurites moluccana) efektif sebagai antibakteri. Penelitian ini untuk mengetahui efektivitas antibakteri minyak kemiri terhadap bakteri Staphylococcus aureus setelah diformulasikan dalam sediaan gel Hand sanitizer pada 3 formula dengan konsentrasi F1=5%, F2=10% dan F3=15%. Penelitian ini adalah penelitian eksperimental. Untuk mengetahui efektivitas anti bakteri minyak kemiri (Aluerites moluccana) terhadap bakteri Staphylococcus. aureus setelah diformulasikan kedalam sediaan gel Hand sanitizer. Penelitian ini menunjukkan bahwa pada formulasi F3 dengan kosentrasi 15% dapat menghambat aktivitas bakteri Staphylococcus aureus dengan zona hambat sebesar 19 mm dengan hasil sediaan gel yang homogen, pH sebesar 5 mendekati pH kulit, tidak mengiritasi kulit dan daya sebar menunjukkan hasil yang merata ke seluruh permukaan kulit yaitu 5 cm. Terdapat penghambatan bakteri Staphylococcus aureus setelah minyak kemiri (Aleurites moluccana) diformulasikan kedalam sediaan gel Hand sanitizer.

THE EFFECT OF ETHANOL EXTRACT OF SOURSOP LEAVES (ANNONA MURICATA L.) ON BODY TEMPERATURE IN MALE MICE (MUS MUSCULUS) INFECTED WITH BACTERIA SALMONELLA TYPHI Syarifuddin, Aminah; Cahya, Cucu Arum Dwi; Br Sihombing, Amelya Chyntia
Jurnal FARMASIMED (JFM) Vol 6 No 1 (2023): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v6i1.1929

Soursop leaves (Annona muricata L.) are a plant that has many health benefits that can be obtained from the fruit, leaves, and seeds. Soursop leaves contain saponins, flavonoids, tannins, and alkaloids which can act as an antiseptic-disinfectant or as an antibacterial. Flavonoid compounds can be used as wound medicine, antifungal, antimicrobial, anticancer, and antiviral. In society, it is used by boiling the leaves and then drinking the boiled water. This research aims to determine the effectiveness of soursop leaf ethanol extract as an antibacterial against Salmonella typhi so that fever can be reduced. The dosage includes 100; 150; 200; and 250 mg/kg BW. No treatment was given as a negative control and chloramphenicol tablets as a positive control. Based on data analysis, it shows that there is a significant difference in body temperature after being tested using the t-test with a value of 0.000 < 0.05. These results prove that body temperature which was initially normal during the acclimatization stage experienced an increase in body temperature when infected with Salmonella typhi. The results of the One-Way ANOVA test also showed an effect on reducing body temperature infected with Salmonella typhi. From several doses, the EDDS dose of 100 mg/kg BW was able to reduce body temperature by an average of 36.5°C.

Test of the Anti-Inflammatory Effectiveness of Ethanol Extract Gel Preparation of Sabrang Onion Bulb (Eleutherine bulbosa) on Incisional Wounds in Wistar Rats Harahap, Hasni Yaturramadhan; Syarifuddin, Shofian; Cahya, Cucu Arum Dwi; Br Sinaga, Irma Suryani Kristina
Jurnal FARMASIMED (JFM) Vol 7 No 1 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i1.2317

Background: The use of medicinal plants is increasingly widespread among the community, especially due to their properties in healing various diseases. One of the developing medicinal plants is bawang sabrang (Eleutherine bulbosa), which has been proven to accelerate the healing process of wounds. Objective: To evaluate the effectiveness of administering gel extract from bawang dayak tubers on the healing process of incised wounds in rats. The test subjects used were 25 male rats. Incisions measuring 2 cm were made on the backs of the rats using a surgical knife. Method: Laboratory experimental study with a Completely Randomized Design (CRD) consisting of five treatments: one positive control (bioplacenton gel), one negative control (gel base), and three graduated concentrations of gel extract, namely 5%, 10%, and 15%. Treatments were administered twice daily for 14 days. Results: Measurement of wound diameter showed that the gel extract of bawang sabrang at a concentration of 15% and the positive control provided a more effective healing effect compared to the gel extract at concentrations of 5%, 10%, and the negative control (gel base). Conclusion: Ethanol extract of bawang sabrang is effective as a gel for healing incised wounds in rats at a concentration of 15%. The physical properties of the gel show a characteristic aroma and a golden red color, homogenous without grains or lumps, a pH of 4.9, and a spreadability of 5 cm.Keywords: Bawang sabrang tuber, Anti-inflammatory, rats, Edema.

Analysis of Rhodamin B Levels in Lipbalms Sold Online Using Uv-Vis Spectrophotometry Cahya, Cucu Arum Dwi; Saragih, Agustinus; Br Sinaga, Hana Lorenta
Jurnal FARMASIMED (JFM) Vol 7 No 1 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i1.2352

A frequent cosmetic preparation for moisturizing and shielding dry lips is lip balm. The textile industry uses a synthetic dye called rhodamine B. Because rhodamine B is a synthetic dye having carcinogenic qualities that can encourage the formation of cancer cells if used repeatedly, the Indonesian Food and Drug Administration (BPOM) forbids its usage as a cosmetic colorant. The purpose of the study is to ascertain, both qualitatively and quantitatively, if five distinct lip balm brands sold online contain the dangerous synthetic pigment Rhodamine B. The study was conducted quantitatively using UV Vis spectophotometry and qualitatively using the Thin Layer Chromatography (TLC) test and color response test with the reagents used, 10% NaOH. One of the five samples (sample B) tested positive for Rhodamine B according to the color response and TLC tests. With an Rf value of 0.91, which is near the typical Rhodamine B Rf value of 0.96, this was demonstrated by a color shift to red-orange upon the addition of 10% NaOH. Visual inspection of Sample B revealed a pink area as well. Rhodamine B was not detected in samples A, C, D, or E.Sample B had an average Rhodamine B content of 3,2281 mg/g.

Isolation and Structural Elucidation of Flavonoid Compounds from Ciplukan (Physalis angulata L.) Leaf Extract Cahya, Cucu Arum Dwi; Sinurat, Jhon Patar; Br Turnip, Nur Ulina M.; Br Karo, Reh Malem
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2667

The exploration and utilization of herbal medicines continue to expand due to the presence of plant-derived secondary metabolites, which have been proven to prevent and treat various diseases with minimal side effects. One plant widely recognized for its medicinal properties is Physalis angulata L. (commonly known as ciplukan). Despite its frequent use in traditional medicine, particularly its leaves, limited studies have focused on the isolation of flavonoid compounds from this part of the plant. The isolation and structural elucidation of these flavonoids are essential to identify the bioactive compounds responsible for the plant's pharmacological effects. This study aimed to isolate and elucidate the chemical structure of flavonoid compounds from P. angulata leaf extract. The powdered leaves were subjected to maceration, solvent partitioning, phytochemical screening, thin-layer chromatography (TLC), and compound isolation using column chromatography. The isolated compounds were then characterized using UV-Visible (UV-Vis) spectroscopy, Fourier-transform infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR), and mass spectrometry (MS). The flavonoid compound isolated in this study was identified as quercetin (C??H??O?), a member of the flavonol subclass. It exhibited a molecular mass of 302 g/mol and showed maximum absorbance at wavelengths of 372.5 nm and 305.5 nm. Spectroscopic analyses revealed the presence of functional groups including C–O, C=C, C=O, CH, and OH, as well as 10 hydrogen and 15 carbon atoms in the NMR spectra. Based on these data, the isolated compound was confirmed to be 3,3',4',5,7-pentahydroxyflavone, commonly known as quercetin, with the molecular formula C??H??O?.

Anti-Inflammatory Effectiveness Test Of Ethanol Extract Of Ara Sungsang Leaf ((Asystasia gangetica) On Male White Mice (Mus musculus )Induced By 1% Carrageenan Cahya, Cucu Arum Dwi; Putri Alvanisia Saragih
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/brjms302

Background: Leaf Ara Sungsang, also known as Asystasia gangetica, is a plant that has been used for a long time to treat different health issues, including inflammation. This plant has compounds called flavonoids and tannins, which are thought to help reduce inflammation by stopping certain chemicals that cause it. Objective: This study looked at how well the ethanol extract from Asystasia gangetica leaves works as an anti-inflammatory treatment in male white mice that had been given 1% carrageenan to induce inflammation. Methods: The study used 25 mice, which were split into five groups. One group received sodium diclofenac at 6.5 mg per kg of body weight as a positive control. Another group got 0.5% Na-CMC as a negative control. The other three groups received different doses of the ethanol extract: 100 mg/kg, 200 mg/kg, and 250 mg/kg. All the mice were given 1% carrageenan to create inflammation. Result: The highest level of inflammation was seen at 6 hours. The strongest anti-inflammatory effect was found in the group that received sodium diclofenac. The groups that received the ethanol extract also showed some anti-inflammatory effects, with the highest dose (250 mg/kg) being the most effective. The Na-CMC group did not show any significant anti-inflammatory effect. The data was analyzed using One Way ANOVA, and there were significant differences in the percentage of inflammation reduction between the different treatment groups (p < 0.05). Conclusion: Based on the percentage of inhibition, it can be concluded that the ethanol extract of ara sungsang leaves at a dose of 250 mg/kgBB has the best anti-inflammatory effect after sodium diclofenac.

Co-Authors Br Sihombing, Amelya Chyntia Br Sinaga, Hana Lorenta Br Sinaga, Irma Suryani Kristina Br Turnip, Nur Ulina M. Br. Turnip, Nur Ulina M. Harahap, Hasni Yaturramadhan Hasibuan, Ahmad Syukur Lubis, Devi Febby Yola Nasution, M. Pandapotan Nur Ulina M. Br. Turnip Priasa, Ayunda Purba, Novandi Putri Alvanisia Saragih Reh Malem br Karo Saragih, Agustinus Silalahi, Mega Sinurat, Jhon Patar Suci Wulandari Sunariati, Sunariati Syarifuddin, Aminah Syarifuddin, Shofian Syukur, Ahmad Syukur Urip Harahap

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