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All Journal JURNAL FARMASIMED (JFM) Jurnal Prima Medika Sains International Journal Of Science, Technology & Management (IJSTM) Jurnal Pengmas Kestra (JPK)
Cahya, Cucu Arum Dwi
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Analysis of Rhodamin B Levels in Lipbalms Sold Online Using Uv-Vis Spectrophotometry Cahya, Cucu Arum Dwi; Saragih, Agustinus; Br Sinaga, Hana Lorenta
Jurnal FARMASIMED (JFM) Vol 7 No 1 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i1.2352

Abstract

A frequent cosmetic preparation for moisturizing and shielding dry lips is lip balm. The textile industry uses a synthetic dye called rhodamine B. Because rhodamine B is a synthetic dye having carcinogenic qualities that can encourage the formation of cancer cells if used repeatedly, the Indonesian Food and Drug Administration (BPOM) forbids its usage as a cosmetic colorant. The purpose of the study is to ascertain, both qualitatively and quantitatively, if five distinct lip balm brands sold online contain the dangerous synthetic pigment Rhodamine B. The study was conducted quantitatively using UV Vis spectophotometry and qualitatively using the Thin Layer Chromatography (TLC) test and color response test with the reagents used, 10% NaOH. One of the five samples (sample B) tested positive for Rhodamine B according to the color response and TLC tests. With an Rf value of 0.91, which is near the typical Rhodamine B Rf value of 0.96, this was demonstrated by a color shift to red-orange upon the addition of 10% NaOH. Visual inspection of Sample B revealed a pink area as well. Rhodamine B was not detected in samples A, C, D, or E.Sample B had an average Rhodamine B content of 3,2281 mg/g.
Isolation and Structural Elucidation of Flavonoid Compounds from Ciplukan (Physalis angulata L.) Leaf Extract Cahya, Cucu Arum Dwi; Sinurat, Jhon Patar; Br Turnip, Nur Ulina M.; Br Karo, Reh Malem
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2667

Abstract

The exploration and utilization of herbal medicines continue to expand due to the presence of plant-derived secondary metabolites, which have been proven to prevent and treat various diseases with minimal side effects. One plant widely recognized for its medicinal properties is Physalis angulata L. (commonly known as ciplukan). Despite its frequent use in traditional medicine, particularly its leaves, limited studies have focused on the isolation of flavonoid compounds from this part of the plant. The isolation and structural elucidation of these flavonoids are essential to identify the bioactive compounds responsible for the plant's pharmacological effects. This study aimed to isolate and elucidate the chemical structure of flavonoid compounds from P. angulata leaf extract. The powdered leaves were subjected to maceration, solvent partitioning, phytochemical screening, thin-layer chromatography (TLC), and compound isolation using column chromatography. The isolated compounds were then characterized using UV-Visible (UV-Vis) spectroscopy, Fourier-transform infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR), and mass spectrometry (MS). The flavonoid compound isolated in this study was identified as quercetin (C??H??O?), a member of the flavonol subclass. It exhibited a molecular mass of 302 g/mol and showed maximum absorbance at wavelengths of 372.5 nm and 305.5 nm. Spectroscopic analyses revealed the presence of functional groups including C–O, C=C, C=O, CH, and OH, as well as 10 hydrogen and 15 carbon atoms in the NMR spectra. Based on these data, the isolated compound was confirmed to be 3,3',4',5,7-pentahydroxyflavone, commonly known as quercetin, with the molecular formula C??H??O?.
Anti-Inflammatory Effectiveness Test Of Ethanol Extract Of Ara Sungsang Leaf ((Asystasia gangetica) On Male White Mice (Mus musculus )Induced By 1% Carrageenan Cahya, Cucu Arum Dwi; Putri Alvanisia Saragih
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/brjms302

Abstract

Background: Leaf Ara Sungsang, also known as Asystasia gangetica, is a plant that has been used for a long time to treat different health issues, including inflammation. This plant has compounds called flavonoids and tannins, which are thought to help reduce inflammation by stopping certain chemicals that cause it. Objective: This study looked at how well the ethanol extract from Asystasia gangetica leaves works as an anti-inflammatory treatment in male white mice that had been given 1% carrageenan to induce inflammation. Methods: The study used 25 mice, which were split into five groups. One group received sodium diclofenac at 6.5 mg per kg of body weight as a positive control. Another group got 0.5% Na-CMC as a negative control. The other three groups received different doses of the ethanol extract: 100 mg/kg, 200 mg/kg, and 250 mg/kg. All the mice were given 1% carrageenan to create inflammation. Result: The highest level of inflammation was seen at 6 hours. The strongest anti-inflammatory effect was found in the group that received sodium diclofenac. The groups that received the ethanol extract also showed some anti-inflammatory effects, with the highest dose (250 mg/kg) being the most effective. The Na-CMC group did not show any significant anti-inflammatory effect. The data was analyzed using One Way ANOVA, and there were significant differences in the percentage of inflammation reduction between the different treatment groups (p < 0.05). Conclusion:  Based on the percentage of inhibition, it can be concluded that the ethanol extract of ara sungsang leaves at a dose of 250 mg/kgBB has the best anti-inflammatory effect after sodium diclofenac.
Antioxidant Potential Of Ethanol Extract Of Kendondong Leaves (Spondias Dulcis), Characterization And Examination Of Quercetin By TLC Method Cahya, Cucu Arum Dwi; Harahap, Urip; Nasution, M. Pandapotan
International Journal of Science, Technology & Management Vol. 4 No. 4 (2023): July 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i4.854

Abstract

Indonesia has a variety of plants that can be used to cure various diseases. Natural therapies offer little negative effect, especially in degenerative diseases, due to decreased function of body cells damaged by oxidation. Antioxidants have a vital role in counteracting free radicals to prevent degenerative diseases. One of the most abundant sources of antioxidant compounds is flavonoids. Kedondong leaf (Spondias dulcis) is one of the plants which is also suspected to contain flavonoids. Spondias species contain triterpenoids, namely oleanolic acid and flavonoids such as quercetin, kaempferol, kaempferida and rhamnetin. Examination of simplicia characteristics, phytochemical screening, examination of quercetin with Thin Layer Chromatography, and determination of antioxidant activity and IC50 value of Kedondong leaves using the DPPH method were carried out in this study. The results of the characteristic examination showed that simplicia met the requirements with a water content of 8.63%, a water-soluble extract content of 19.42%, an ethanol-soluble extract content of 5.17%, a total ash content of 12.43%, an acid-insoluble ash content of 7 .81%. Phytochemical screening showed that the bright kedondong leaves contained flavonoids, alkaloids, glycosides, saponins, tannins, and steroids/triterpenes. Examination of quercetin thin layer chromatography with chloroform: methanol (70: 30) as eluent produced six stains with Rf values (0.5; 1; 1.2; 3; 4.3; 6.6), and compared with quercetin raw material on the sixth stain with an Rf value of 6.6 has the same stain as the ethanol extract of kendondong leaves. The results of antioxidant testing at a 400 – 800 nm wavelength using UV-Vis spectrophotometry obtained a maximum wavelength of 515 nm. IC50 value obtained an IC50 value of 68.6260 ppm, so it can be concluded that the ethanol extract of kendondong leaves has antioxidant activity in the strong category.
Co-Authors Br Sihombing, Amelya Chyntia Br Sinaga, Hana Lorenta Br Sinaga, Irma Suryani Kristina Br Turnip, Nur Ulina M. Br. Turnip, Nur Ulina M. Harahap, Hasni Yaturramadhan Hasibuan, Ahmad Syukur Lubis, Devi Febby Yola Nasution, M. Pandapotan Nur Ulina M. Br. Turnip Priasa, Ayunda Purba, Novandi Putri Alvanisia Saragih Reh Malem br Karo Saragih, Agustinus Silalahi, Mega Sinurat, Jhon Patar Suci Wulandari Sunariati, Sunariati Syarifuddin, Aminah Syarifuddin, Shofian Syukur, Ahmad Syukur Urip Harahap