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All Journal Disease Prevention and Public Health Journal Jurnal Kesehatan Andalas Media Ilmu Kesehatan JSFK (Jurnal Sains Farmasi & Klinis) JFIOnline Pharmaceutical Journal of Indonesia Majalah Farmasetika Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Journal of Innovation in Community Empowerment (JICE) Jurnal Farmasi Indonesia Acta Holistica Pharmaciana Journal of Pharmaceutical (JOP)
Padmasari, Siwi
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Laporan Kasus: Kajian Efek Samping Obat Antipsikotik pada Kejadian Gejala Ekstrapiramidal pada Pasien Skizofrenia Madury, Shalahuddin Al Madury; Padmasari, Siwi; Ishak, Ishak
JOURNAL OF PHARMACEUTICAL (JOP) Vol. 2 No. 2, Special Edition (2024): Journal of Pharmaceutical (JOP)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jop.v2i2, Special Edition.1474

Abstract

Background: Initial treatment of acute psychosis in schizophrenia patients is recommended to start second-generation antipsychotics rather than first-generation antipsychotics which have greater side effects on movement disorders, such as akathisia, and dystonia. Extrapyramidal symptoms (EPS) are one of the most common side effects of drugs experienced by patients due to dopamine receptor blocking agents in the form of uncontrolled movements that risk disrupting patient activities. Objective: The purpose of this case report is to determine the pattern of antipsychotic drug use, and the results of a clinical pharmacist study related to the side effects of drugs causing EPS in schizophrenia patients in the inpatient installation of Soerojo Hospital. Method: This study is in the form of a case report taken from an inpatient of Soerojo Hospital in Magelang City. Case data were collected through various methods during the pharmacist's visit, all patient-related data were recorded and a comprehensive assessment was carried out to see the suitability of therapy, DRP in patients by comparing it with existing literature. Result: Patient NH (18 years old) was diagnosed with Schizophrenia for the first time. The patient received Diazepam and haloperidol injection therapy while in the ER and was programmed with haloperidol 5 mg every 12 hours, and clozapine 100 mg 2x a day, on the third day the patient could not swallow the medicine because he showed symptoms of EPS such as stiffness, mouth could not close, walking like a robot, and hypersalivation. Pharmacists through pharmaceutical care found DRP related to potential ESO from the use of haloperidol injection which increased the incidence of EPS, especially in patients who first received antipsychotics. 2 days later, signs of EPS continued to NMS marked by severe hypersalivation, rigidity, and muscle stiffness disorders, and supported by high CK examination results of 2030 U / l. The patient received Trihexyphenidyl therapy 3x2 mg, and bromocriptine 2.5 mg / 8 hours. Slowly the symptoms of NMS experienced clinical improvement. Conclusion: Early discontinuation of antipsychotic agents that cause EPS can prevent the severity of EPS in patients. Bromocriptine can be an option for NMS patients.
Review: Utilization of Decision Support System in Identification of Drug-related Problems in Geriatric Patients Larasati, Niken; Sugiyono, Sugiyono; Padmasari, Siwi
Disease Prevention and Public Health Journal Vol. 19 No. 1 (2025): Disease Prevention and Public Health Journal
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/dpphj.v19i1.11908

Abstract

Background: Globally, there were 703 million people aged 65 years or older in 2019. The largest population were in East and Southeast Asia (260 million) followed by Europe and North America (more than 200 million). This number is expected to grow to over 1.5 billion people by 2050. Treatment-related problems are events associated with drug use that may affect the patient's therapeutic goals. The prevalence of treatment-related problems is estimated to be 45.1% in populations meeting criteria for advanced age, polypharmacy, and multimorbidity. A decision support system (DSS) is developed based on individual conditions to provide recommendations for therapeutic and dosage selection, and to prevent drug interactions in complex cases. This study aims to evaluate the use of DSS in identifying treatment-related problems in geriatric patients across various countries. Method: This study uses a narrative review method to systematically discuss previous research findings. Results: This review examined journals on the use of decision support systems in identifying drug-related problems in geriatric patients. A search article published between 2016-2021 in the PubMed database yielded 10 relevant articles. DSS tools have shown to improve the continuity of care for geriatric patients. Previous DSS tools used include AGAlink, G-MEDSS, PRIMA-eDS, STRIPA, SENATOR, and TRIM. Conclusion: DSS represents a significant technological advancement that can be applied to prevent and reduce inaccuracies in prescribing, particularly for geriatric patients.
Gambaran Drug Related Problems (DRPs) Terapi Farmakologi Pasien ISPA Pediatrik di Rumah Sakit PKU Muhammadiyah Gamping Yogyakarta Husna, Nadia; Padmasari, Siwi
Andalas Journal of Health Vol. 10 No. 2 (2021): Online July 2021
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v10i2.1790

Abstract

Acute Respiratory Infection has become the major cause of death in children in developing countries. There were about 11.9 million episodes of severe acute lower respiratory infection that resulted in hospital admission in young children worldwide. The method of drug administered was the common Drug-Related Problems found in young children. Objectives: To evaluated Drug-Related Problems of Acute Respiratory Infection drug therapy in pediatric patients. Methods: Ninety-four pediatric patients were included in this study. Drug therapy data were obtained from medical records from January 2018 until July 2019, as this study was using a retrospective method. Drug-Related Problems of drug therapy were analyzed based on the Cipolle classification system. Results: Prevalence of female and male patients are in the same number (50%) with the highest prevalence on 2-11 years (72.34%) in young children. The number of Drug-Related Problems was found about 61.49% from 148 numbers of used drugs with improper drug selection as the major Drug Related Problems (51,65%)  followed by drugs without indication and underdose by 23.08% and 15.38%, respectively.Keywords:  acute respiratory infection, hospital, pediatrics, pharmacologic therapy
Hubungan Interaksi Obat Antidiabetik Dengan Luaran Klinik Pada Pasien DM Tipe 2 Rawat Inap di RS PKU Muhammadiyah Gamping Yogyakarta Sugiyono, Sugiyono; Padmasari, Siwi; Al Madury, Shalahuddin
MEDIA ILMU KESEHATAN Vol 14 No 1 (2025): Media Ilmu Kesehatan
Publisher : Universitas Jenderal Achmad Yani Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/mik.v14i1.1479

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a chronic disease that often requires combination therapy, increasing the risk of drug interactions due to polypharmacy, which can affect clinical outcomes. Objective: To examine the relationship between the potential for drug interactions and clinical outcomes in hospitalized T2DM patients at PKU Muhammadiyah Gamping Hospital, Yogyakarta, from January 2022 to August 2023. Methods: This study employed a non-experimental analytical method with a retrospective approach, involving 179 patients who met the inclusion criteria. Univariate analysis was used to describe patient characteristics, medication patterns, and Random Blood Glucose (RBG) levels, while bivariate analysis (Chi-Square test) assessed the relationship between the potential for drug interactions and clinical outcomes.Results: The majority of T2DM patients were aged 41-59 years (50.28%), female (54.75%), and had comorbidities (91.62%). The most common treatment regimen was monotherapy with metformin (46.37%). Most patients received ≥5 medications (88.27%), and 81.56% had potential drug interactions. The predominant interaction mechanism was pharmacodynamic (86.21%) with moderate severity (89.72%). Chi-Square analysis yielded a p-value of 0.082 (p>0.05).Conclusion: No significant relationship was found between the potential for antidiabetic drug interactions and clinical outcomes in patients
Co-Authors Al Madury, Shalahuddin Azizah, Fajriyati Nur Febriyani, Ghesa Hidayanti, Puri Husna, Nadia Ishak Ishak Laim, Lidya Adriana Clarita Lestari, Mardiana Puji Marchaban Niken Larasati Ningsih, Endang S Pangestika, Annisa Saepudin, . Setiawati, Margarita Krishna Shalahuddin Al Madury, Shalahuddin Al Sugiyono Sugiyono