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AKTIVITAS ANTIDIABETES DARI TANAMAN FAMILI MYRTACEAE DENGAN INDUKSI ALOKSAN Alfani, Yustika; Hamdani, Siva; Renggana, Hesti
Jurnal Ilmiah As-Syifaa Vol 13, No 1 (2021): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v13i1.671

Diabetes mellitus is a metabolic disease characterized by hyperglycemia. This disease occurs due to abnormalities in insulin secretion, insulin work or both. Plants from the myrtaceae family that have been used traditionally as medicine and scientifically known to have various anti-inflammatory, anti-cancer, anti-diarrheal, antibacterial and antidiabetic activities. This review aims to provide information and efforts in the treatment of diabetes from several plants in the Myrtaceae family. The method used in this review is a literature review from various journals published online and I will discuss 8 plants from the myrtaceae family that are induced by alloxan. From the results it is known that of the 8 plants of the myrtaceae family that have been tested using alloxan induction has antidiabetic activity. Syzygium Polyanthum (Wight) is the most potential candidate in reducing blood glucose levels.

HYPNOTIC-SEDATIVE ACTIVITY TEST OF 70% ETHANOL EXTRACT OF LETTUCE (Lactuca sativa L.) IN MALE WHITE MICE SWISS WEBSTER STRAIN Sadino, Asman; Renggana, Hesti; Suwendar, Suwendar; Apriani, Riza; Nurhandayani, Yuni
Jurnal Ilmiah Farmako Bahari Vol 15, No 2 (2024): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v15i2.3090

Humans who use medicines for insomnia may experience a variety of adverse effects, including dependence. Traditional medicine frequently uses lettuce (Lactuca sativa L.) to treat various conditions, including sleep difficulties. Terpenoids, which are secondary metabolites found in lettuce plants, are to blame for this. This study aimed to see if an ethanolic extract of lettuce leaf had any sedative-hypnotic activity in Swiss Webster strain male white mice induced by phenobarbital at a dose of 90 mg/KgBB intraperitoneally. In this study, the post-test-only control strategy was employed. The animals were divided into six groups (n = 4): negative (aqua dest), positive (Na-CMC 0.5%), comparison (diazepam 1.3 mg/KgBB), and ethanolic extract of lettuce leaf at doses of 300 mg/KgBB, 400 mg/KgBB, and 500 mg/KgBB. The parameters observed in this study were a combination of parameters from previous studies, namely the number of falls, sleep onset, and sleep duration in mice. The data obtained were then processed statistically using the one-way ANOVA (analysis of variance) and post-hoc test follow-up analysis with the LSD (least significant difference) test. The results showed that the ethanolic extract of lettuce leaves at 300, 400, and 500 mg/KgBB had a sedative-hypnotic effect. Doses of 300 mg/KgBB only increased sleep duration. In contrast, 400 and 500 mg/KgBB increased the number of falls, rapid sleep onset, and increased sleep duration, significantly different from positive controls (p<0.05). The effective dose of ethanolic extract of lettuce leaf as a sedative-hypnotic was 400 mg/KgBB.

HYPNOTIC-SEDATIVE ACTIVITY TEST OF 70% ETHANOL EXTRACT OF LETTUCE (Lactuca sativa L.) IN MALE WHITE MICE SWISS WEBSTER STRAIN Sadino, Asman; Renggana, Hesti; Suwendar, Suwendar; Apriani, Riza; Nurhandayani, Yuni
Jurnal Ilmiah Farmako Bahari Vol 15 No 2 (2024): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v15i2.3090

Humans who use medicines for insomnia may experience a variety of adverse effects, including dependence. Traditional medicine frequently uses lettuce (Lactuca sativa L.) to treat various conditions, including sleep difficulties. Terpenoids, which are secondary metabolites found in lettuce plants, are to blame for this. This study aimed to see if an ethanolic extract of lettuce leaf had any sedative-hypnotic activity in Swiss Webster strain male white mice induced by phenobarbital at a dose of 90 mg/KgBB intraperitoneally. In this study, the post-test-only control strategy was employed. The animals were divided into six groups (n = 4): negative (aqua dest), positive (Na-CMC 0.5%), comparison (diazepam 1.3 mg/KgBB), and ethanolic extract of lettuce leaf at doses of 300 mg/KgBB, 400 mg/KgBB, and 500 mg/KgBB. The parameters observed in this study were a combination of parameters from previous studies, namely the number of falls, sleep onset, and sleep duration in mice. The data obtained were then processed statistically using the one-way ANOVA (analysis of variance) and post-hoc test follow-up analysis with the LSD (least significant difference) test. The results showed that the ethanolic extract of lettuce leaves at 300, 400, and 500 mg/KgBB had a sedative-hypnotic effect. Doses of 300 mg/KgBB only increased sleep duration. In contrast, 400 and 500 mg/KgBB increased the number of falls, rapid sleep onset, and increased sleep duration, significantly different from positive controls (p<0.05). The effective dose of ethanolic extract of lettuce leaf as a sedative-hypnotic was 400 mg/KgBB.

Uji Aktivitas Antibakteri Dari Ekstrak Etanol Bonggol Pisang Kepok (Musa paradisiaca L.) Terhadap Bakteri Staphylococus Aureus Dan Escherichia Coli Dengan Metode Difusi Agar Angrestian, Angga; Renggana, Hesti; nugraha, Yogi rahman
Jurnal Medika Farmaka Vol 2 No 1 (2024): Jurnal Medika Farmaka
Publisher : LP4M STIKes Karsa Husada Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33482/jmedfarm.v2i1.34

Medicinal plants that have more uses and value in traditional medicine against diseases. One of them is the kepok banana plant (Musa paradisiaca L.) as an herbal treatment the kepok banana plant is an annual shrub, this plant has a root system and rhizome Fruit only once (single fruit) then dies. Banana plants contain compounds such as flavonoids, saponins, tannins, and steroids. The method used in the research to be carried out is the experimental method. This study aims to determine the ethanol extract of kepok banana weevil (Musa paradisiaca L.) to test its antibacterial activity against Staphylococcus aureus and Escherichia coli using the agar diffusion method. In this study, the ethanol extract of kepok banana weevil (Musa paradisiaca L.) with concentrations of 2, 4, and 6 against Staphylococus aureus and Escherichia coli bacteria. In Staphylococus aureus bacteria with a concentration of 2 the average diameter of the inhibitor produced was 3.03 mm, the concentration of 4 of the diameter of the inhibitor produced was 6.4 mm, the concentration of 6 of the diameter of the inhibitor produced was 8.3 mm. In Escherichia coli bacteria with a concentration of 2 the average diameter of 6.7 mm was produced, the concentration of 4 was 7.7 mm in diameter, and the concentration of 6 was 8.2 mm in diameter. The three concentrations have antibacterial effect that is Resistant 14 mm. Ethanol extract of kepok banana weevil (Musa paradisiaca L.) can inhibit the growth of staphylococcus aureus and Escherichia coli bacteria. At concentrations of 2, 4, and 6 the ethanolic extract of the kepok banana weevil (Musa paradisiaca L.) with an average inhibitory diameter of 3.03 mm, 6.4 mm and 8.3 mm, these three concentrations had an antibacterial effect of 14 mm.

The Relationship between Knowledge Level and Self-Medication Behavior for Scabies at SMK Plus Al-Istiqomah Sadino, Asman; Suwandi, Deden Winda; Susanti, Risa; Nuari, Doni Anshar; Renggana, Hesti; Rohimah, Vina Siti; Apriliani, Nisa Siti
Indonesian Journal of Community Empowerment (IJCE) Vol 5 No 02 (2024): Indonesian Journal of Community Empowerment (May)
Publisher : Fakultas Kewirausahaan Universitas Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35899/ijce.v5i2.712

Scabies is a skin disease that is often ignored. Scabies is still common in Islamic boarding schools with a high prevalence rate. Self-medication is used to treat mild to moderate illnesses without consulting a doctor first. This community service aims to determine the relationship between the level of understanding of scabies' self-medication behavior at SMK Plus Al Istiqomah. The method used begins with the distribution of an initial questionnaire (pre-test), presentation of the material with the help of PowerPoint slides, a question and answer session between students (i) and the presenter, and distribution of the final questionnaire (post-test). The results of this community service activity showed an increase in knowledge of scabies from a percentage of 5% to 87.5%. This means that the education provided can be well received by students at SMK Plus Al-Istiqomah.

Introduction to the Pharmacist Profession and Education on Wise Choice of Snacks and the Dangers of Cigarettes and Drugs for Teenagers Renggana, Hesti; Susanti, Risa; Qowiyyah, Atun; Dewi, Asri; Winda, Deden; Anshar, Doni; Sadino, Asman
Indonesian Journal of Community Empowerment (IJCE) Vol 5 No 01 (2024): Indonesian Journal of Community Empowerment (February)
Publisher : Fakultas Kewirausahaan Universitas Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35899/ijce.v5i1.925

Pharmacists are competent health professionals in drug management. Many efforts have been made so that the role of pharmacists in carrying out pharmaceutical work is more felt in the community. Therefore, community service is carried out in the form of education on introducing the pharmacist profession, wisely choosing snacks, and about the dangers of cigarettes and drugs. It is expected that from this service, students who are part of the community can better understand the pharmacist profession and its role in adolescent health. Education was carried out on MIT and MTs Baitul Aziz Majalaya students. Before the education, a pretest was carried out and after the education, a posttest was carried out using a questionnaire related to the material. Data were processed and analyzed using descriptive statistics. The results of the education showed that the level of knowledge of MIT students increased, especially in the good category, from 8% to 76% for knowledge of the pharmacist profession, and from 80% to 95% for knowledge of wisely choosing snacks. In addition, the level of knowledge of MTs students regarding the dangers of cigarettes and drugs also increased, especially in the good category from 13% to 75% after education.

Analgesic and anti-inflammatory activities of the extract of Polypodium feei mett roots Suwandi, Deden Winda; Renggana, Hesti; Subarnas, Anas; Rostinawati, Tina; Muchtaridi, Muchtaridi; Sadino, Asman
Pharmaciana Vol. 15 No. 2 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i2.25133

The limited scientific evidence on the analgesic and anti-inflammatory effects of Polypodium feei roots, despite their traditional use in rheumatism treatment, highlights the need for pharmacological validation. The study investigates the analgesic and anti-inflammatory properties of Polypodium feei roots, a traditional medicine used to treat rheumatism, in mice and rats with carrageenan-induced paw edema, using acetylsalicylic acid and tramadol as analgesics and diclofenac sodium as an anti-inflammatory. The writhing test results demonstrate that the extract of P. feei roots (EPFR) at dosages of 50 and 100 mg/kgBW lowered the writhing responses of rat significantly (p <0.01). The dose of 100 mg/kgBW provided more protection than acetylsalicylic acid at a level of 65 mg/kgBW. In the hot plate method, the extract increased the latency period significantly (p <0.05) as compared with the control. In the anti-inflammatory examination, the EPFR decreased edema of rat paws induced by carrageenan. The significant effect of the EPFR was shown by the dose of 100 mg/kgBW (p <0.05), but its inhibition was lower than that of a standard agent, diclofenac sodium. This study concluded that the EPFR may have peripherally and centrally analgesic activity and anti-inflammatory activity. This evidence supports the folklore claim of the efficacy of EPFR as traditional medicine for rheumatism.

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