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All Journal Jurnal Medik Veteriner Veterinary Biomedical and Clinical Journal
Agustina, Galuh Chandra
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Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Veterinary

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Solasodine and Gosipol Effectivity as a Male Contraception Inhibit LH Expression and Spermatogenesis in Rat Wulansari, Desi; Oktanella, Yudit; Hendrawan, Viski Fitri; Agustina, Galuh Chandra
Veterinary Biomedical and Clinical Journal Vol. 1 No. 2 (2019)
Publisher : Faculty of Veterinary Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (364.671 KB) | DOI: 10.21776/ub.VetBioClinJ.2019.001.02.7

Abstract

Rabies related to increasing canine population in Bali. Uncontrolled wild animal populations caused disease transmission from animal to human. Various attempt at population control are carried out such as the use of natural contraception. Some compounds are known to have potential as antifertility are solasodine and gosipol. Solasodine is known have an antifertility affect. Gosipol, fenolic compound in Ceiba pentandra, inhibits spermatogenesis, reduce sperm concentration, motility and viability. This research aims to compare effectiveness of terong cepoka and Ceiba pentandra as antifertility. This research was conducted at Mei-November 2018. Eight-teen rats were used in this study and divided into three groups: control, P1 extract Solanum torvum 1g/kg BW and P2 extract Ceiba pentandra 0,1g/kg BW PO. Rats were treated with extract for 10 days and euthanazed at day 11. Testis were collected for histopathology using HE staining to observe spermatogenesis and using immunohistochemistry to observe LH expression. The result are analyzed using one way ANOVA P<0.05. the result show that extract solanum torvum 1g/kg BW and ceiba pentandra 0,1g/kgBW cannot reduce spermatogenesis and LH expression. This study used crude extract which still consist any other compound like antioxidant. Future study we need use isolated and pure solasodine and gosipol.
The Effect of Black Cumin (Nigella sativa) on Histopathology of Liver and Kidney in Albino Rats with Organophosphate Exposure Hendrawan, Viski Fitri; Oktanella, Yudit; Firmawati, Aulia; Agustina, Galuh Chandra
Jurnal Medik Veteriner Vol. 6 No. 1 (2023): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol6.iss1.2023.35-42

Abstract

This study aimed to determine the effect of black cumin extract (Nigella sativa) on the histopathological of the liver and kidneys in albino rats exposed to organophosphates. This study used 20 male mice divided into five treatment groups, i.e. (K-) without organophosphate and black cumin, (K+) induced by organophosphate 40 mg/kg BW, treatment group induced by organophosphate 40 mg/kg BW and black cumin extract as therapy (P1 ) 200 mg/kg BW, (P2) 400 mg/kg BW, and (P3) 600 mg/kg BW. Organophosphate administration for eight weeks and black seed extract therapy was given for three weeks then the mice were euthanized, the liver and kidney organs were taken for histopathological observation using Haematoxylin-Eosin (HE). Data were analyzed using OneWay ANOVA test followed by Tukey test. The results showed that there were significant differences between the treatment groups for liver and kidney damage (p<0,05). Hepatic degeneration and necrosis in the P2 and P3 groups differed from K+ with an average of 2,24±0,9, in the kidneys with an average of 2,52±0,8. It can be concluded that black cumin extract has a significant effect on improving the liver and kidneys in groups P3 (600 mg/kgBW).
Foot and Mouth Disease Impact on Milk Productivity and Quality in KUD Kertajaya, Kediri, Indonesia Oktanella, Yudit; Cahyani, Ayunda Ageng; Hendrawan, Viski Fitri; Nugroho, Widi; Agustina, Galuh Chandra
Jurnal Medik Veteriner Vol. 6 No. 2 (2023): October
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol6.iss2.2023.244-249

Abstract

One of the impacts of foot and mouth disease (FMD) on the dairy farming sector is decreasing the quantity and quality of milk production. This study aimed to determine the impact of FMD by observing the productivity and quality of fresh milk during FMD outbreaks. Sampling was performed to obtain productivity data before and during the FMD outbreak using the cluster sampling method in five areas in KUD Kertajaya, Kediri, Indonesia. The lactoscan test was used to analyze the quality of fresh milk from 50 positive samples. Based on the statistical analysis using the paired parametric T-test, it was reported that there was a significant difference in milk productivity before and during the FMD outbreak (p < 0,05). The results of the Lactoscan test on 50 positive samples showed an average fat content of 4,43%, solid nonfat (SNF) content of 8,54%, specific gravity of 1,028, lactose content of 4,67%, total solids content of 12,97%, added water content of 1,44 and freezing point of -0,54°C. In conclusion, the milk of dairy cows during the FMD outbreak often displayed a quality value of milk that met SNI requirements, despite the fact that there was a major decline in productivity.
Efficacy of Black Cumin (Nigella sativa) Ameliorate Organophosphate Toxicity in Pregnant Rats Based on Progesterone Levels and Fetal Bone Development Hendrawan, Viski Fitri; Agustina, Galuh Chandra; Aditya, Siska; Oktanella, Yudit; Firmawati, Aulia; Mariyam, Dewi
Jurnal Medik Veteriner Vol. 7 No. 1 (2024): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol7.iss1.2024.134-142

Abstract

Black cumin (Nigella sativa), also referred to as black cumin, is a versatile herbal treatment that has recently grown in popularity, it contains antimicrobial, antibacterial, antifungal, anti-inflammatory, analgesic, antipyretic, antiparasitic, antihistamine, antihypertensive, antitumor, anticancer, antidiabetic, and anti-asthmatic properties are just a few of the positive and pharmacological effects of active ingredients in black cumin, such as thymoquinone and other compounds. This study aimed to evaluate black cumin activity ameliorates organophosphate toxicity in pregnant rats based on progesterone levels and fetal bone development. In this study, pregnant albino rats were divided into five treatment groups i.e. (K-) placebo; (K+) treated an organophosphate; treated an organophosphate and black cumin extract at a dose of (P1) 200 mg/kg BW, (P2) 400 mg/kg BW, and (P3) 600 mg/kg BW. The progesterone levels serum and fetal bone development were evaluated and calculated using ANOVA followed by Turkey. The results showed that P2 and P3 groups significantly increase in progesterone levels compared to K+ and P1 groups. Fetal bone was also reported increase in the growth of caudal vertebrae. In conclusion, 400 mg/kg BW of black cumin could ameliorated progesterone levels and fetal bone development in pregnant rats with organophosphate toxicity.
Co-Authors Aditya, Siska Cahyani, Ayunda Ageng Desi Wulansari Firmawati, Aulia Mariyam, Dewi Viski Fitri Hendrawan Widi Nugroho Yudit Oktanella, Yudit