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Studi Karakterisasi dan Aktivitas Antibakteri Senyawa Kompleks dari Zink(II) Klorida, Kalium Tiosianat dan 2-Aminopiridina Mariyam, Dewi; Farida, Nani; Wijaya, Husni Wahyu; Dasna, I Wayan
Jurnal Riset Kimia Vol 13, No 1 (2022): March
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v13i1.465

Abstract

The development of complex compounds as antibacterial continues to be carried out to overcome cases of microbial resistance. One of them is the development of complex compounds with thiocyanate and aminopyridine ligands which show good potential as antibacterial. Complex compound of zinc(II) chloride with thiocyanate and 2-aminopyridine ligands was successfully synthesized. The synthesis was carried out by mixing the reactants with ratio of Zn2+: 2-aminopyridine: SCN 1:2:2 under heating and stirring continuously for 6 hours. The Obtained beam-shaped colorless crystals were characterized using melting point, electrical conductivity, thiocyanate ion qualitative, FTIR, SEM-EDX, XRD powder and antibacterial activity against Salmonella typhi and Staphylococcus aureus test. The crystals melt at 160-165 0C. The results of the electrical conductivity test, qualitative test of thiocyanate ion, FTIR and SEM-EDX analysis indicate the presence of Zn2+, thiocyanate and 2-aminopyridine with ratio 1: 2: 2. Based on XRD powder spectral data and theoritical analysis, the complex synthesized compounds had high crystallinity and predicted has tetrahedral structure. Antibacterial test showed that against S.aureus, the compound had higher antibacterial activity than free ligands, but lower than chloramphenicol. Therefore, the antibacterial activity of the complex compound was classified as moderate.
Efficacy of Black Cumin (Nigella sativa) Ameliorate Organophosphate Toxicity in Pregnant Rats Based on Progesterone Levels and Fetal Bone Development Hendrawan, Viski Fitri; Agustina, Galuh Chandra; Aditya, Siska; Oktanella, Yudit; Firmawati, Aulia; Mariyam, Dewi
Jurnal Medik Veteriner Vol. 7 No. 1 (2024): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol7.iss1.2024.134-142

Abstract

Black cumin (Nigella sativa), also referred to as black cumin, is a versatile herbal treatment that has recently grown in popularity, it contains antimicrobial, antibacterial, antifungal, anti-inflammatory, analgesic, antipyretic, antiparasitic, antihistamine, antihypertensive, antitumor, anticancer, antidiabetic, and anti-asthmatic properties are just a few of the positive and pharmacological effects of active ingredients in black cumin, such as thymoquinone and other compounds. This study aimed to evaluate black cumin activity ameliorates organophosphate toxicity in pregnant rats based on progesterone levels and fetal bone development. In this study, pregnant albino rats were divided into five treatment groups i.e. (K-) placebo; (K+) treated an organophosphate; treated an organophosphate and black cumin extract at a dose of (P1) 200 mg/kg BW, (P2) 400 mg/kg BW, and (P3) 600 mg/kg BW. The progesterone levels serum and fetal bone development were evaluated and calculated using ANOVA followed by Turkey. The results showed that P2 and P3 groups significantly increase in progesterone levels compared to K+ and P1 groups. Fetal bone was also reported increase in the growth of caudal vertebrae. In conclusion, 400 mg/kg BW of black cumin could ameliorated progesterone levels and fetal bone development in pregnant rats with organophosphate toxicity.
Synthesis, Structure, Antibacterial Activity, and Hirshfeld Surface Analysis of Complex [Co(4-ampy)4(NCS)2]·CO2 Savitri, Linggar Agil; Putra, Faaza'izzahaq Setta; Laksmana, Sutandyo Dwija; Mariyam, Dewi; Dasna, I Wayan
Indonesian Journal of Chemistry Vol 24, No 4 (2024)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.90585

Abstract

The [Co(4-ampy)4(NCS)]2·CO2 complex compound was successfully synthesized using the reflux method from the reaction between CoCl2·6H2O, 4-aminopyridine, and KSCN in methanol solvent for 6 h at 64 °C. The synthesized compound is a dark purple cube-shaped crystal with a melting point of 209 °C. FTIR test showed the presence of isothiocyanate anion at C=N stretching vibration wavenumber 1633 cm−1, C–N vibration on amine group belonging to 4-aminopyridine ligand at 1217 cm−1, and C=N vibration of pyridine aromatic group at 1334 cm−1. Single crystal X-ray diffraction data refinement results show the complex compound has octahedral geometry in a cubic lattice with space group Pn̄3n with lattice parameters a = b = c = 16.426(3) Å and α = β = γ = 90°. According to the crystal data, there was one molecule of CO2 in the crystal packing of the complex. Hirshfeld surface analysis showed the major interaction contributions from C⋯H/H⋯C, H⋯H, S⋯H/H⋯S, and O⋯H/H⋯O. The antibacterial activity test results showed that the activity of the synthesized complex was more active against Staphylococcus aureus but less effective against Escherichia coli.
PENGGUNAAN LEARNING MANAGEMENT SYSTEM (LMS) MOODLE DALAM PEMBELAJARAN KIMIA (SEBUAH STUDI LITERATUR) Rahmah, Siti; Mariyam, Dewi; Syafina, Khairi; Lestari, Dewi; Analita, Rizki Nur
JCAE (Journal of Chemistry And Education) Vol 7 No 3 (2024): JCAE APRIL 2024
Publisher : PROGRAM STUDI PENDIDIKAN KIMIA FKIP UNIVERSITAS LAMBUNG MANGKURAT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jcae.v7i3.2959

Abstract

Studi ini menyajikan tinjauan literatur mengenai efektivitas Moodle sebagai platform pembelajaran daring khususnya pembelajaran kimia di Indonesia, dengan tujuan mengevaluasi dampaknya terhadap minat, motivasi, dan hasil belajar peserta didik. Penelitian ini menggunakan metode analisis literatur dari berbagai sumber yang relevan untuk mengidentifikasi fitur-fitur utama Moodle, seperti User Management dan Course Management, serta bagaimana fitur-fitur ini mendukung aktivitas pembelajaran yang interaktif. Latar belakang penelitian ini didasarkan pada meningkatnya kebutuhan akan platform pembelajaran daring yang efektif di tengah pandemi, yang memaksa proses belajar mengajar dilakukan dari rumah. Manfaat dari penggunaan Moodle termasuk peningkatan kualitas belajar, fleksibilitas akses, dan efisiensi dalam pengelolaan kursus. Studi ini juga menemukan bahwa penerapan Moodle dalam pembelajaran kimia dapat meningkatkan pemahaman materi melalui fitur "Courses" yang disesuaikan dan E-modul interaktif. Namun, tantangan seperti kompleksitas penggunaan, masalah koneksi internet, dan kebutuhan akan penjelasan ulang dari pendidik perlu mendapat perhatian lebih lanjut untuk memaksimalkan efektivitas platform ini.
Comprehensive Literature Review : Analisis Persepsi Pasien dan Kualitas Layanan terhadap Inovasi Layanan Rumah Sakit melalui Telemedicine Mariyam, Dewi; Kustiani, Lilik; Estikowati
JEMeS - Jurnal Ekonomi Manajemen dan Sosial Vol. 8 No. 1 (2025): Jurnal Ekonomi Manajemen dan Sosial (JEMeS)
Publisher : Universitas Bojonegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56071/jemes.v8i1.1121

Abstract

Telemedicine has become an important innovation in healthcare services, especially in increasing patient accessibility to medical services. This study aims to analyze patient perceptions and service quality towards the implementation of telemedicine in hospitals. The method used is a comprehensive literature review, by analyzing various academic literature that discusses patient perceptions, dimensions of service quality, and challenges in implementing telemedicine. This study focuses on five dimensions of service quality, namely assurance, assurance, physical evidence, empathy, and responsiveness, and how these aspects affect patient experience and satisfaction. The results of the analysis show that patient perceptions of telemedicine are highly dependent on technological fitness, ease of access, and trust in medical personnel who provide consultations. In addition, patients prioritize aspects of data security and diagnostic accuracy, which are key factors in accepting telemedicine as an alternative healthcare service. Although telemedicine provides benefits such as ease of access and time efficiency, this study also found several challenges in its implementation. The gap in digital infrastructure, limited technological literacy among patients, and the need for stronger regulations are the main obstacles that need to be overcome. Therefore, the development of telemedicine in hospitals must focus on improving service quality, educating patients, and policies that support service desires.