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All Journal IZUMI Jurnal Abdi Masyarakat Indonesia Jurnal Visi Komunikasi Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Journal of The Indonesian Society of Integrated Chemistry
Dewi, Tribuana Tungga
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Humanities Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Engineering Languange, Linguistic, Communication & Media Medicine & Pharmacology Public Health Social Sciences

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In Silico Study of Bioactive Compounds of Putat Leaf Extract (Planchonia valida) as Anti-Cancer Against the VEGFR2 Receptor Bela, Anisa; Farid, Faizar; Nelson; Dewi, Tribuana Tungga; Prabawa, Satria; Khatib, Alfi; Yusnaidar, Yusnaidar; Latief, Madyawati; Tarigan, Indra Lasmana
Journal of The Indonesian Society of Integrated Chemistry Vol. 16 No. 1 (2024): Journal of The Indonesian Society of Integrated Chemistry
Publisher : Pendidikan Kimia FKIP Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jisic.v16i1.32049

Abstract

Cancer is the process of forming new tissue that is abnormal and malignant. Efforts to discover anti-cancer drug compounds continue to be made to minimize the toxic effects of chemotherapy, so it is necessary to look for other alternatives to treat cancer. This research aims to determine the anti-cancer activity of putat plant bioactive compounds through identification of receptor targets and interaction studies using the molecular docking method against the VEGFR2 (Vascular endothelial growth factor receptor-2) receptor. The results showed that in the test of eight putat plant bioactive compounds the best results were obtained for the compound 3-oxo-N-(1,3-thiazol-2-yl) butanamide with a binding free energy value of -9.86 kcal-mol-1 with an inhibition constant value of 1.47 Micromolar. The best docking result has an inhibition constant value that is higher than the native ligand and has a binding free energy that is almost close to the binding free energy of the native ligand with an inhibition constant value of 42.38 Micromolar and a binding free energy value of 10.06 kcal-mol-1. Therefore, the results of the docking of the bioactive compound 3-oxo-N-(1,3-thiazol-2-yl) butanamide with the VEGFR-2 receptor are considered capable of being an alternative as a candidate for anti-cancer drugs.
Keeping the Family Wisdom Alive through Family Storytelling Dewi, Tribuana Tungga; Hasanah, Siti Uswatun; Chania, Ines
Jurnal Visi Komunikasi Vol 23, No 02 (2024): November 2024
Publisher : Universitas Mercu Buana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22441/visikom.v23i02.30636

Abstract

ABSTRACTThere are not much research available regarding family storytelling, though this activity already proven to be effective on identity building, developing strong relationship within family member, and also as a foundation for building family values. That is why this research is conducted in order to identify the function of family storytelling and how the stories conducted. This research is conducted by qualitative method, with in-depth interview as the data collecting technique. All informants are female because research showed that the main storyteller in the family, usually are women. As a conclusion, it is identified that family storytelling practice is a very personal and unique process and each informant has a unique insight on understanding their family stories.The uniqueness might be occur because of the different dynamic and character of the family.     Keywords: Family Communication, Family Storytelling, Family Stories, Family Wisdom, Family Identity.
ANALISIS LC-MS/MS SENYAWA METABOLITE EKSTRAK DAUN PUTAT (Planchonia valida) DAN PREDIKSI POTENSINYA SEBAGAI KANDIDAT OBAT ANTIKANKER Dewi, Tribuana Tungga; Bela, Anisa; Prabawa, Satria; Latief, Madyawati; Tarigan, Indra Lasmana
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 2 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i2.1629

Abstract

Secondary metabolite compounds contained in plants are bioactive substances related to the chemical content in plants, so that some plants can be used as medicinal materials. Putat (Planchonia valida) is a medicinal plant that has bioactive compounds that have potential as anticancer. Compound analysis of LC-MS test results has been carried out which shows several metabolite compounds contained in putat. The method used is analyzing compounds obtained from LC-MS results, screening compounds using pchembl and chemspider websites. And using the pChEMBL webserver to find out the bioactivity of these compounds. The purpose of this study is to determine and predict the potential bioactivity of the compounds contained therein as new drug candidates. The results obtained from this study are metabolite compounds in putat have the potential as anticancer based on the screening results carried out using the pChEMBL webserver by looking at the highest pIC50 value, obtained the highest pIC50 value of 8.18 with target proteins namely Serine/threonin mTOR and Cholinesterase which are target proteins that have anticancer activity.
Ryōsai Kenbo: Domestikasi Perempuan dan Pembentukan Negara Bangsa dalam Era Meiji Jepang Agusta, Nisia Nur Dwi; Dewi, Tribuana Tungga
IZUMI Vol 14, No 1 (2025): June
Publisher : Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/izumi.14.1.77-89

Abstract

During the Meiji era, Japan undertook rapid modernization to compete with Western powers. One of the cultural strategies employed by the government was the promotion of the ryōsai kenbo ideology—“good wife, wise mother”—to shape ideal women as domestic supporters of national progress. This study explores the development of ryōsai kenbo as a state policy in women's education, from the Charter Oath of 1868 and the Iwakura Mission to the Imperial Rescript on Education (1890) and the Girls' High School Order (1899). Using a qualitative historical approach, the research analyzes how ryōsai kenbo reflected Japan’s effort to establish a functional and harmonious society, as explained through Talcott Parsons’ structural-functional theory. Findings show that although the ideology confined women to domestic roles, it simultaneously legitimized women’s access to education and redefined their societal significance. Rather than viewing ryōsai kenbo solely as a tool of subjugation, this article argues it was a strategic effort to construct a cohesive national identity through clearly defined gender roles. Thus, the ideology served both as a means of female domestication and a pillar of Japan’s modernization agenda.
Pemanfaatan Limbah Kulit Nanas sebagai Sabun Antibakteri untuk Meningkatkan Ekonomi Masyarakat di Desa Jati Mulyo, Tanjung Jabung Timur Puspitasari, Ratih Dyah; Arnis, Suzi Guci; Ulvia, Tiara; Oktariyani, Salmiyah; Dewi, Tribuana Tungga; Shella, Ance Pramai
Jurnal Abdi Masyarakat Indonesia Vol 5 No 6 (2025): JAMSI - November 2025
Publisher : CV Firmos

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54082/jamsi.1362

Abstract

Limbah kulit nanas merupakan salah satu jenis limbah organik yang belum banyak diketahui pemanfaatannya secara optimal. Padahal kulit nanas dapat dimanfaatkan karena banyak mengandung senyawa aktif seperti bromelain, flavonoid, dan tanin yang memiliki potensi sebagai antibakteri alami. Pengabdian masyarakat ini bertujuan untuk mengelolah limbah kulit nanas menjadi sabun antibakteri sebagai bentuk inovatif dalam meningkatkan ekonomi masyarakat di Desa Jati Mulyo, Tanjung Jabung Timur. Metode yang digunakan meliputi eksperimental pembuatan sabun antibakteri dengan menggunakan kulit buah nanas, texapone, natrium klorida, essentials oil dan air mineral.  Hasil pengabdian masyarakat menunjukkan bahwa kulit nanas memiliki potensi untuk mendapatkan hak kekayaan intelektual pada proses pembuatan sabun cuci piring dari limbah kulit nanas yang dapat dimanfaatkan sebagai antibakteri. Program pengabdian masyarakat berhasil membuat sabun cuci piring antibakteri dari limbah kulit nanas, yang berpotensi untuk meningkatkan ekonomi masyarakat di Desa Jati Mulyo, khususnya UMKM (Usaha Mikro, Kecil dan Menengah), dengan memanfaatkan limbah yang sebelumnya tidak digunakan dan tidak bernilai di Masyarakat. Program ini sangat efektif untuk mengurangi pencemaran lingkungan melalui pemanfaatan limbah organik secara efektif. Rekomendasi untuk kegiatan lanjutan meliputi pelatihan lanjutan untuk produksi skala besar dan pendampingan pemasaran produk, yang dapat memaksimalkan potensi ekonomi dan dampak lingkungan positif yang telah dicapai.
Co-Authors Agusta, Nisia Nur Dwi Alfi Khatib, Alfi Arnis, Suzi Guci Bela, Anisa Chania, Ines Faizar Farid Indra Lasmana Tarigan Madyawati Latief Nelson Oktariyani, Salmiyah Prabawa, Satria Puspitasari, Ratih Dyah Shella, Ance Pramai Siti Uswatun Hasanah Ulvia, Tiara Yusnaidar, Yusnaidar