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All Journal Medali Jurnal : Media Dental Intelektual ODONTO Dental Journal Jurnal Kreativitas PKM Interdental Jurnal Kedokteran Gigi (IJKG) WASIS : Jurnal Ilmiah Pendidikan Odonto dental journal Jurnal Pengabdian Masyarakat Dentmas Community Empowerment Journal Jurnal Muria Pengabdian Masyarakat Mauve Journal De Leardu
Sari, Rina Kartika
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Religion Arts Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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PENGARUH SUSU IBU HAMIL TERHADAP EKSPRESI KALLIKREIN-RELATED PEPTIDASE-4 (KLK-4) PADA SEL AMELOBLAS DALAM TUMBUH KEMBANG GIGI Samia, Salma; Christiono, Sandy; Sari, Rina Kartika
Odonto : Dental Journal Vol 7, No 2 (2020): December 2020
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.7.2.98-103

Abstract

Background: Tooth development during the embryonic period is a complex process that needs enough nutrition for the formation of healthy dental tissue. Kallikrein-related peptidase-4 (KLK-4) is a serine proteinase secreted by ameloblast during transition and maturation stages in the amelogenesis process which functions to degrade protein matrices so enamel could reach the final hardness. Pregnancy milk contains various nutrients that can increase KLK-4 expression of ameloblast cells in the tooth development. This study aims to determine the impact of pregnancy milk against the KLK-4 expression of ameloblast cell in the tooth development process.Method: 12 pregnant female mice (Mus Musculus L.) divided into control group (given sterile aquadest) and treatment group (given pregnancy milk + sterile aquadest) for 18 days then the tooth germ was taken. Samples were stained to see the KLK-4 expression. Data were analyzed using an Independent sample t-test.Result: Our study showed that the average amounts of KLK-4 expression in the treatment group are higher than the control group. Based on the Independent sample t-test statistic methods, there is a significant difference with the value of p=0,017.Conclusion: The pregnancy milk could influence the Kallikrein-related peptidase-4 (KLK-4) expression of ameloblast cell in the mice fetus’s tooth development.
Co-Authors Adam, Evans Amanda, Shania Dwika Hadi, Ahmad Asril Hapsari, Arzalia I Nyoman Gede Juwita Putra Ikhsandarujati, Renanda Rifki Indrawati, Marita Puji Insani, M. Afdholil Kholiqoh Insani, Muhammad Afdholil Kholiqoh Liftia Layyinatus Syifa Nafidzah, Bashroh Ollong, Niqmah Fatmasari Pratama, M. Fahrurozi Adi Rafiah, Salma Umi Rahman, Firdaus Noorhadi Rahmawati Sri Praptiningsih Rama Putranto Raziv Ganesha Rosa Pratiwi, Rosa Samia, Salma Sandy Christiono Setyaningsih, Winda Siti Masfuah Solahuddin, Rifqi Syifa', Liftia Layyinatus