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All Journal Medali Jurnal : Media Dental Intelektual Indonesian Journal of Pharmaceutical Science and Technology ODONTO Dental Journal Jurnal Kreativitas PKM Interdental Jurnal Kedokteran Gigi (IJKG) WASIS : Jurnal Ilmiah Pendidikan Odonto dental journal Jurnal Pengabdian Masyarakat Dentmas Community Empowerment Journal Jurnal Muria Pengabdian Masyarakat Mauve Journal De Leardu
Sari, Rina Kartika
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Religion Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Education Health Professions Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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PENGARUH SUSU IBU HAMIL TERHADAP EKSPRESI KALLIKREIN-RELATED PEPTIDASE-4 (KLK-4) PADA SEL AMELOBLAS DALAM TUMBUH KEMBANG GIGI Samia, Salma; Christiono, Sandy; Sari, Rina Kartika
Odonto : Dental Journal Vol 7, No 2 (2020): December 2020
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.7.2.98-103

Abstract

Background: Tooth development during the embryonic period is a complex process that needs enough nutrition for the formation of healthy dental tissue. Kallikrein-related peptidase-4 (KLK-4) is a serine proteinase secreted by ameloblast during transition and maturation stages in the amelogenesis process which functions to degrade protein matrices so enamel could reach the final hardness. Pregnancy milk contains various nutrients that can increase KLK-4 expression of ameloblast cells in the tooth development. This study aims to determine the impact of pregnancy milk against the KLK-4 expression of ameloblast cell in the tooth development process.Method: 12 pregnant female mice (Mus Musculus L.) divided into control group (given sterile aquadest) and treatment group (given pregnancy milk + sterile aquadest) for 18 days then the tooth germ was taken. Samples were stained to see the KLK-4 expression. Data were analyzed using an Independent sample t-test.Result: Our study showed that the average amounts of KLK-4 expression in the treatment group are higher than the control group. Based on the Independent sample t-test statistic methods, there is a significant difference with the value of p=0,017.Conclusion: The pregnancy milk could influence the Kallikrein-related peptidase-4 (KLK-4) expression of ameloblast cell in the mice fetus’s tooth development.
Mapping the Anticancer Mechanism of Asiatic Acid : A systematic review of preclinical evidence Sari, Rina Kartika; Dalimunthe, Rahmi Syaflida; Amir, Lisa Rinanda; Wimardhani, Yuniardini Septorini; Musfiroh, Ida; Sastradipura, Dewi Fatma Suniarti
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.62028

Abstract

Studies have demonstrated that Asiatic acid (AA) from Centella asiatica has anticancer properties in cancer cell lines, but translating these findings into clinical research remains challenging. This review aims to provide a robust scientific foundation for enhancing the translational potential of AA-based anticancer therapy. The PubMed, Scopus, and ScienceDirect databases were searched electronically using specific keywords and screened in accordance with the PRISMA 2020 guidelines.  Fourteen studies meet the criteria. All research was conducted in vitro; four studies were conducted both in vitro and in vivo, and three were conducted in silico.Asiatic acid (AA) demonstrates potent anticancer activity by modulating key signaling pathways, including PI3K/Akt and NF-κB, thereby inhibiting proliferation, promoting apoptosis, and reducing metastasis. Its cytotoxic effects are time- and dose-dependent (1–50 µM) and minimal in normal cells. While AA and its derivatives consistently outperform controls, limitations such as missing control dose data warrant further investigation. Future studies should focus on in vivo validation, clinical translation, and advanced strategies such as targeted delivery and AI-assisted drug development to fully realize AA’s therapeutic potential.
Co-Authors Adam, Evans Amanda, Shania Dwika Amir, Lisa Rinanda Dalimunthe, Rahmi Syaflida Hadi, Ahmad Asril Hapsari, Arzalia I Nyoman Gede Juwita Putra Ida Musfiroh -, Ida Musfiroh Ikhsandarujati, Renanda Rifki Indrawati, Marita Puji Insani, M. Afdholil Kholiqoh Insani, Muhammad Afdholil Kholiqoh Liftia Layyinatus Syifa Nafidzah, Bashroh Ollong, Niqmah Fatmasari Pratama, M. Fahrurozi Adi Rafiah, Salma Umi Rahman, Firdaus Noorhadi Rahmawati Sri Praptiningsih Rama Putranto Raziv Ganesha Rosa Pratiwi, Rosa Samia, Salma Sandy Christiono Sastradipura, Dewi Fatma Suniarti Setyaningsih, Winda Siti Masfuah Solahuddin, Rifqi Syifa', Liftia Layyinatus Yuniardini Septorini Wimardhani