Article Per Year (5 Year)
p-Index From 2020 - 2025
1.203
P-Index
This Author published in this journals
All Journal Abdimas BERDIKARI : Jurnal Inovasi dan Penerapan Ipteks Dinamisia: Jurnal Pengabdian Kepada Masyarakat Biosaintifika: Journal of Biology & Biology Education Jurnal Pengabdian kepada Masyarakat Nusantara
Dimarti, Safira Chairani
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Arts Humanities Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Social Sciences Other

Published : 6 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 6 Documents
Search

 1 
PHYCOCYANIN FROM SPIRULINA PLATENSIS INDUCES CYTOTOXICITY AND APOPTOSIS IN T47D CELLS Dimarti, Safira Chairani; Susilaningsih, Neni; Yuniati, Renni
Biosaintifika: Journal of Biology & Biology Education Vol 12, No 1 (2020): April 2020 Article-in-Press
Publisher : Department of Biology, Faculty of Mathematics and Sciences, Semarang State University . Ro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (568.167 KB) | DOI: 10.15294/biosaintifika.v12i1.22992

Abstract

Breast cancer cases in Indonesia have risen in alarming rate. Herbal medicines have been developed to complement conventional cancer therapy and to lessen the negative effects of the therapies. Phycocyanin, blue-green photosynthetic pigment from Spirulina platensis, becomes a potential candidate of herbal medicine for cancer therapy due to its capability to eliminate various cancer cell line on in vitro level. This research aimed to analyse the effectivity of phycocyanin to induce cytotoxic and apoptotic activity of T47D cells (breast cancer cell line). MTT assay was perform to measure IC50 value. Double-staining assay and flow cytometry were applied to visualize the appearance of apoptotic cells and to measure the percentage of apoptotic and necrotic cells. Result showed that the IC50 value of phycocyanin towards T47D cells is 1650 ?g/mL. Phycocyanin was also proven to induce apoptosis at IC50 with the apoptosis percentage of 45.93%. This research presented different results from previous researches that used phycocyanin from saltwater Spirulina platensis. Based on the results of this study, phycocyanin has the potential to be developed as anticancer agent by inducing apoptosis.
CYTOTOXICITY AND ANTIPROLIFERATION OF PHYCOCYANIN FROM SPIRULINA PLATENSIS EXTRACT ON WIDR COLON CANCER CELL LINE Putri, Ajeng Kurniasari; Dimarti, Safira Chairani; Yuniati, Renni; Susilaningsih, Neni
Biosaintifika: Journal of Biology & Biology Education Vol 12, No 1 (2020): April 2020 Article-in-Press
Publisher : Department of Biology, Faculty of Mathematics and Sciences, Semarang State University . Ro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v12i1.22881

Abstract

Phycocyanin from Spirulina platensis extract has anticancer activity against various types of cancer cell cultures. However study about its effect on colon cancer cell lines, especially the WiDr, has not been reported before. This study aimed to reveal the anticancer activity of phycocyanin from Spirulina platensis extract on WiDr cells. The research was an in vitro experimental study, with the investigation on cytotoxicity also antiproliferation as the anticancer parameters. Both cytotoxicity and antiproliferation test was conducted through MTT assay to observe the visualization and inhibition of proliferation of different concentrations of phycocyanin in several incubation times on the WiDr colon cancer cell line. The obtained data were then processed statistically with the Two Way ANOVA test at a significance value of p <0.05 and followed with the Post Hoc test since there were significant differences. Based on the results, it could be postulated that phycocyanin extracted from freshwater Spirulina platensis was classified as non-toxic (IC50 of 855 µg/ml). Consequently, it is less potential to be used as the treatment for colon cancer. However, phycocyanin could inhibit the proliferation of the WiDr cell for approximately 47.4%, specifically at the concentration of 1710 µg/ml for 72 hours. It could be concluded that freshwater phycocyanin is less effective as an anticancer substance. The benefit of this study is to provide the new scientific evidence of the contrary results of freshwater phycocyanin activity from Spirulina platensis as an anticancer agent of colon cancer.
Training on Identification of Hazardous Food Preservatives and Utilization of Chitosan as A Natural Preservative Marianti, Aditya; Christijanti, Wulan; Dimarti, Safira Chairani; Wardani, Agata Iswiana Diah; Maulana, Silvia Faori; Tsaniyah, Nurotun Najmatus
Jurnal Abdimas Vol 27, No 2 (2023): December 2023
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/abdimas.v27i2.48307

Abstract

Food preservation with borax and formaldehyde is still widely practiced. The use of borax and formaldehyde as food preservatives has a negative impact on health. Knowledge and skills to identify borax and formaldehyde content using simple, cheap, and easy techniques need to be trained. A simple technique for testing borax uses the turmeric method, while formaldehyde uses young papaya sap. The public also needs to be given an alternative, safe way of preserving food with chitosan. Participatory methods were used in this activity. The activity stages begin with preparation and socialization, training, monitoring, and evaluation. The activity was attended by 23 people on the first day and 17 people on the second day, including cadres of the FKK, PKK, Karang Taruna, Elderly Forum, LPMK, and culinary UKM. There was a significant increase in the knowledge of training participants with an N gain of 0.58, including the moderate or quite effective category. Participants also responded positively. Participants have the skills to detect borax using the turmeric method and formaldehyde using papaya sap. Training participants are also skilled in using liquid chitosan as a natural food preservative. The conclusion of this activity is that the training participants increased their knowledge about dangerous food preservatives, had the skills to detect borax and formaldehyde in food ingredients with simple technology, and applied liquid chitosan as a natural preservative.
Pencegahan Stunting Melalui Family Empowerment bagi Ibu Hamil Mardiana, Mardiana; Oksidriyani, Safrina; Dimarti, Safira Chairani; Rokhmah, Farida Dwi; Rasyad, Ula Faza Nayli; Faizin, Miftahul; Rihadhatul, Shoofia; Bila, Syifa Salsa; Pratiwi, Salma Eka; Salma, Rania; Permata, Gracia Dara; Putri, Safna Afifa; Mumtazul, Alfi; Nur, Zakiah
Berdikari: Jurnal Inovasi dan Penerapan Ipteks Vol. 12 No. 2: August 2024
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/berdikari.v12i2.23852

Abstract

Various factors cause stunting in children, one of which is the mother’s malnutrition during pregnancy. Mothers who have Chronic Energy Deficiency (CED) and anemia have a high potential of giving birth to children prone to stunting. This community service aims to increase the knowledge of pregnant women and increase the role of the family in preventing CED and anemia in pregnant women in the Sekaran Puskesmas area by developing a class program for pregnant women, making pocketbooks, and supporting educational media. The applied methods were assistance and counseling for pregnant women and parents, education for pregnant women and companions, anthropometry training for cadres and TPK, preparation of e-booklet media for pregnant women, and cooking demos for healthy menus for pregnant women. The results of this activity showed an increase in knowledge based on the pre-test results of pregnant women <80 by 27.3% and scores >80 by 72.7%. After carrying out the posttest, 100% of participants obtained >80 scores. This shows an increase in the incidence of CED and anemia in pregnant women. In the pre-test results for pregnant women’s companions, 10% of the results were obtained with a score of <80 and a score of >80 of 90%. After carrying out the post-test, all participants had >80 scores. Accordingly, Family Empowerment activities for pregnant women with CED and anemia can increase the knowledge of pregnant women and their companions regarding the handling and prevention of CED and anemia. Keywords: Family empowerment, Pregnant Women with Chronic Energy Deficiency, Anemia, Stunting
Kespro For Teenagers: Sex Education berbasis Peer Group Activity pada Siswa SMA di Kota Semarang Khasanah, Amelia Fitra; Zainafree, Intan; Maharani, Chatila; Dimarti, Safira Chairani; Putra, Tyar Bhatara
Jurnal Pengabdian kepada Masyarakat Nusantara Vol. 6 No. 2 (2025): Jurnal Pengabdian kepada Masyarakat Nusantara Edisi April - Juni
Publisher : Lembaga Dongan Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Remaja menjadi salah satu kelompok masyarakat yang menjadi bonus demografi 2045 untuk Indonesia. Perbedaan antara remaja dan anak-anak antara lain adanya perkembangan secara fisik, sosial, mental, dan emosional. Keingintahuan yang tinggi, kesukaan pada petualangan dan aktivitas risiko tinggi yang ditambah dengan kebutuhan aktualisasi diri di lingkungannya menyebabkan remaja rentan kesulitan mengambil keputusan. Keputusan-keputusan yang diambil oleh remaja juga banyak dipengaruhi oleh teman sebayanya. Kondisi inilah yang seringkali membuat remaja rentan mengalami problematika yang berkaitan dengan keputusan-keputusan krusial tentang dirinya, termasuk atas otonomi sistem reproduksi dan pengetahuan seksual. Edukasi kesehatan reproduksi telah diberikan di tingkat sekolah. Meskipun pihak sekolah telah berupaya menyediakan informasi kesehatan reproduksi dalam beberapa program, isu yang berkaitan dengan psikologi remaja, kejahatan seksual, dan pornografi masih belum dibahas secara mendalam di program tersebut. Dengan demikian, upaya peningkatan pengetahuan dan kesadaran remaja terkait kesehatan reproduksi dan seksual masih perlu dilakukan, terutama dengan melibatkan pihak-pihak yang menguasai dan membawa informasi yang lebih mendalam mengenai kesehatan reproduksi remaja dan isu yang berkaitan. Salah satu metode yang digunakan adalah pembentukan peer group. Siswa SMA Negeri 1 Semarang dan SMA Negeri 3 Semarang diberdayakan untuk dapat menjadi tutor sebaya yang membantu meningkatkan pengetahuan dan kesadaran teman sebayanya dalam isu kesehatan reproduksi remaja. Tutor atau kader tersebut menjadi pemimpin dalam kelompok diskusi kesehatan reproduksi remaja. Kegiatan pengabdian yang telah dilakukan menunjukkan bahwa sharing dan verifikasi informasi kesehatan reproduksi remaja ke sebaya membuat remaja lebih paham dan terbuka. Ke depannya, kegiatan ini diharapkan dapat membantu siswa membentuk nalar dan kemampuan decision-making berkaitan dengan kesehatan reproduksi remaja.
- Product Diversification and Marketing Methods of Jamu Gendong in Kampung Jamu Semarang: DIVERSIFIKASI PRODUK OLAHAN JAMU GENDONG DAN METODE PEMASARANNYA DI KAMPUNG JAMU SEMARANG Marianti, Aditya; Susanti, R; Purwinarko, Aji; Dimarti, Safira Chairani; Sasi, Fitri Arum; Yuliantika, Atika; Hasani, Azharu Alfi; Rahmawati, Sinta Kurnia
Dinamisia : Jurnal Pengabdian Kepada Masyarakat Vol. 8 No. 1 (2024): Dinamisia: Jurnal Pengabdian Kepada Masyarakat
Publisher : Universitas Lancang Kuning

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31849/dinamisia.v8i1.11605

Abstract

Kampung jamu di kelurahan Wonolopo kecamatan Mijen Semarang adalah sentra produsen jamu Gendong. Wilayah pemasarannya masih di Semarang karena produk tidak awet, sehingga berpotensi menurunkan daya saing dengan produk pabrikan. Tujuan kegiatan pengabdian kepada masyarakat (PPM) ini adalah melatih keterampilan mitra membuat jamu serbuk yang berkualitas, mengemasnya dan dapat memasarkan produknya secara online sehingga wilayah pemasarannya lebih luas Metode kegiatan PPM adalah pelatihan membuat jamu serbuk dan pengemasannya serta pelatihan pembuatan branding dan berjualan online. Pelatihan dilaksanakan pada 15 Juli dan 3 September 2022, kepada 15 orang anggota Paguyuban produsen jamu gendong “Sumber Husodo”. Hasil pelatihan adalah peserta dapat mempraktekkan membuat jamu serbuk dan mengemasnya. Peserta pelatihan juga dapat membuat branding produk jamunya. Peserta juga dapat mempraktekkan penggunaan aplikasi berjualan online, menggunakan facebook, instagram dan tiktok. Simpulan dari kegiatan PPM ini adalah mitra memiliki bekal untuk melakukan diversifikasi produk dan memperluas wilayah pemasarannya, sehingga diharapkan dapat bertahan dan bersaing dengan produk jamu pabrikan. Kata kunci: Kampung Jamu, Semarang, diversifikasi produk, pemasaran online
Co-Authors Aditya Marianti Aji Purwinarko, Aji Bila, Syifa Salsa Chatila Maharani Faizin, Miftahul Fitri Arum Sasi, Fitri Arum Hasani, Azharu Alfi Intan Zainafree, Intan Khasanah, Amelia Fitra Mardiana Mardiana Martien Herna Susanti Maulana, Silvia Faori Mumtazul, Alfi Neni Susilaningsih Nur, Zakiah Oksidriyani, Safrina Permata, Gracia Dara Pratiwi, Salma Eka Putra, Tyar Bhatara Putri, Ajeng Kurniasari Putri, Safna Afifa Rahmawati, Sinta Kurnia Rasyad, Ula Faza Nayli Renni Yuniati Rihadhatul, Shoofia Rokhmah, Farida Dwi Salma, Rania Tsaniyah, Nurotun Najmatus Wardani, Agata Iswiana Diah Wulan Christijanti Yuliantika, Atika