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All Journal Jurnal Ilmiah Kedokteran Wijaya Kusuma Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Journal Orthopaedi and Traumatology Surabaya (JOINTS) SCRIPTA SCORE Scientific Medical Journal Jurnal Psikiatri Surabaya (Surabaya Psychiatry Journal) JHeS (Journal of Health Studies) Inisiasi Jurnal Penyakit Dalam Indonesia Journal of Diverse Medical Research: Medicosphere
Adnan, Muhammad Luthfi
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Threats of COVID-19 Reinfection: A Review of the Evidence from the Literature Adnan, Muhammad Luthfi; Fauziyati, Ana
Jurnal Penyakit Dalam Indonesia Vol. 9, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Case of COVID-19 reinfection are related to immune factors in patients who have recovered by the natural course of the infecting pathogen. However, the chance of COVID-19 reinfection are still not well established. This review aimed to discuss about reinfection-related studies, including causes and clinical manifestations, and reinfection management. Reinfection happens when a patient is infected by the SARS-CoV-2 virus, which has a different genome from previous infection. Although the comparison of clinical manifestation between reinfection and the previous infection is not clear, it is believed that vulnerable populations may have worse outcomes. Vaccination is the main option to reduce the severity of reinfection. Further studies are needed to understand the mechanisms and management of COVID-19 reinfection. Thus, the development of COVID-19 treatment and vaccine can be more effective.
Nutritional status, anemia status and application of the Mentzer index on complete blood examination results of students Pratama, Yanasta Yudo; Ratnaningsih, Tri; Arijadi, Desi; Adnan, Muhammad Luthfi; Widyasari, Vita; Tristifany, Annisa; Santoso, Griselda Elisse; Usman, Muhammad Alvin Ramadhan; Miftahurrahmi, Rofifah
JHeS (Journal of Health Studies) Vol. 7 No. 2 (2023): September
Publisher : Universitas 'Aisyiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31101/jhes.3199

Abstract

Thalassemia is a disease that attacks the hemoglobin gene, causing disturbances in erythropoiesis. Anemia is a condition in which the hemoglobin (Hb) concentration and the number of erythrocytes are below normal limits. The high number of anemia and thalassemia causes the need for early detection in order to prevent adverse effects in the future. Research objectives: to determine nutritional status, anemia status, and application of the Mentzer Index for SMK Muhammadiyah II Moyudan students. Methods: This study is a descriptive study with a cross-sectional design. The research subjects were first graders at SMK Muhammadiyah 2 Moyudan. Venous blood samples were examined at the Clinical Pathology Laboratory of FK-KMK UGM using the Sysmex XN-1000 tool on November 25, 2021. Data analysis used IBM SPSS Version 26 and Microsoft Office 365. Results: A total of 53 subjects participated in this study. A total of 47 (89%) respondents had normal hemoglobin values, and 6 (11%) respondents suffered from anemia. 31 (58.5%) respondents have normal nutrition, 15 (28%) respondents have less nutrition, 7 (13%) have excess nutrition, and 29 (54.7%) respondents have normal status. A total of 2 (3.8%) respondents showed Thalassemia. Conclusion: There are two students of SMK Muhammadiyah 2 Moyudan diagnosed with thalassemia and five students diagnosed with anemia. No statistically significant difference exists between Anemia Status in Adolescents at SMK Muhammadiyah 2 Moyudan and Nutritional Status. Further study is needed in wider and more diverse populations to analyze the influence of nutritional conditions on anemia in adolescents.
KARAKTERISTIK PASIEN PREEKLAMPSIA DI RUMAH SAKIT UMUM DAERAH SOEDIRAN MANGUN SOEMARSO WONOGIRI JAWA TENGAH Weningtyas, Vyanda Sri; Adnan, Muhammad Luthfi; Pramaningtyas, Miranti Dewi; Wahyana, Eka Budi
Inisiasi Volume 13, Edisi 1, Juni 2024
Publisher : Badan Perencanaan Pembangunan Daerah dan Penelitian dan Pengembangan Kabupaten Wonogiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59344/inisiasi.v13i1.233

Abstract

Preeclampsia is a condition of increased blood pressure accompanied by proteinuria during pregnancy. Preeclampsia is one of the causes of maternal and fetal death. Efforts to reduce the incidence of preeclampsia are one of the efforts to reduce maternal mortality, one of which is by knowing the characteristics of preeclampsia patients to plan to overcome the risk of preeclampsia in the future. This study aims to determine the characteristics of preeclampsia patients at Wonogiri Regional Hospital dr. Soediran Mangun Soemarso, Wonogiri, Central Java. This research was conducted in a retrospective cross-sectional manner on the medical records of preeclampsia patients in Wonogiri Regional Hospital dr. Soediran Mangun Soemarso, Wonogiri, Central Java during 2019-2022. Sampling was carried out using a purposive sampling method among pregnant women who gave birth in the hospital from November 2021 – Januari 2022. A total of 106 medical record data from pregnant women were obtained in this study. The average age of pregnant women in this study was 31.37 ± 6.72 years with the majority aged 20 – 35 years with a history of giving birth more than twice. The majority of preeclampsia patients at Wonogiri Regional Hospital were severe preeclampsia patients (53.8%). A total of 59 pregnant women gave birth using the vaginal delivery method and 47 pregnant women gave birth using the cesarean method.   Maternal age and pregnancy history are factors related to the risk of preeclampsia which can influence the mother's delivery method. Further research is needed on risk factors for preeclampsia in a wider population so as to improve the health of mothers and babies during pregnancy
Characteristics and Management of Neck and Trochanteric Femur Fractures at a Tertiary Hospital in Indonesia: A Retrospective, Single-Center Study Pulungan, Ndilalah; Thoriq, Yusa Muhammad; Hartono, Felix Giovanni; Adnan, Muhammad Luthfi; Sasetyo, Dadang Rona
(JOINTS) Journal Orthopaedi and Traumatology Surabaya Vol. 13 No. 2 (2024): October 2024
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/joints.v13i2.2024.61-68

Abstract

Background: Although hip fractures are common among the elderly population, there are still limited studies on neck-trochanteric fractures, one of the less common types of hip fractures. This study aims to describe the characteristics of patients and their management in patients with neck trochanteric fractures. Methods: This retrospective cross-sectional study analyzed medical records of patients aged >18 years with trochanteric fractures from a tertiary hospital in Central Java, Indonesia, between January and December 2021. Fracture types were identified and classified using the Garden, Pauwels, and AO/OTA classifications.  Demographic data, risk factors, fracture locations, and treatment types were also collected.  Statistical analysis was performed using SPSS 21.0 to describe patient characteristics. Results: The total sample was 77 patients, most were female (n = 55 (71.4%)) and aged > 60 years. More than a third of diagnosed fractures were neck of the femur fractures in 33 patients (42.9%). Among the most common classification types of fractures were Garden Type 3, Pauwels Type 3, and AO/OTA type A1.1. A total of 33 patients (42.9%) underwent open reduction of the fracture with internal fixation. Conclusions: Our findings show that the prevalence of neck-trochanteric fractures mostly occurs in patients > 60 years of age and in females. Although open reduction with internal fixation is generally performed, there are several cases of fractures that are not classifiable due to limited imaging examinations. Further research on a wider population is needed to confirm the findings of this study.
Religious-Spirituality Approach to Post-Stroke Depression Patients: An Evidence-Based Case Report Sausan; Adnan, Muhammad Luthfi; Rhadiana, Baiq Rohaslia
Jurnal Psikiatri Surabaya Vol. 14 No. 1 (2025): May
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jps.v14i1.56715

Abstract

Introduction: Stroke patients can develop a risk of depression due to decreased physiological and psychological functions. Management of post-stroke depression is one of the challenges in the care of stroke patients. A religious/spirituality management approach can be an alternative in the management of post-stroke depression. This evidence-based management is to evaluate management options with a religiosity/spirituality approach to reduce the risk of post-stroke depression. Case: A 54-year-old female patient came with her husband with complaints of changes in feelings and emotions, accompanied by difficulty sleeping and headaches. She felt dissatisfied with her religious worship properly. The patient was diagnosed with organic depression due to stroke. Discussion: Three quantitative studies have shown that a religiosity/spirituality approach in the management of post-stroke patients has the effect of reducing depression in patients through increased efficacy and self-acceptance. Based on three qualitative studies, it shows the effect of the religiosity/spirituality approach as a coping mechanism that can reduce depressive symptoms. The lack of quality of the study makes the religiosity/spirituality approach to reduce depression in the management of post-stroke patients need further study regarding its effectiveness and its effect on the wider population. Conclusion: The religiosity/spirituality approach can reduce depression and is suggested as one of the management options for post-stroke patients.
Maternal factors associated with low birth weight infants Choironi, Emi Azmi; Pratama, Yanasta Yudo; Asya, Kahaya Ainin; Adnan, Muhammad Luthfi; Kuntari, Titik; AbuHilail, Hamza Sameeh Abd El Qader
JHeS (Journal of Health Studies) Vol. 9 No. 2 (2025): September
Publisher : Universitas 'Aisyiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31101/jhes.3976

Abstract

Indonesia has the second-highest prevalence of low birth weight (LBW) babies in ASEAN countries. Various factors contribute to this high incidence. This study examined the association between gestational weight gain (GWG), pre-pregnancy body mass index (BMI), and antenatal care (ANC) visits frequency towards LBW in a region of Indonesia with a high prevalence of LBW. This is an analytical observational study using cross-sectional design with utilizing medical records data, conducted in June-August 2022. We analyzed 78 medical records of pregnant women who gave term-singleton birth. Main independent variables were gestational weight gain, pre-pregnancy BMI, and ANC frequency. Data analysis was performed using statistical package program, including descriptive statistics, bivariate and multivariate analyses to explore associations between those factors and LBW occurrence. The mean of infant birth weight was 3115.4± 465.2 grams. Low birth weight proportion was 11.5%. More than 90% of subjects follow frequency of ANC visits for K1 and K4, but only a third of participants meet K6 ANC visit recommendation. Approximately half of the subjects (48.7%) had inadequate GWG. Bivariate analysis revealed a strong association between insufficient GWG and LBW (OR = 10.4, 95% CI = 1.233–87.74, p=0.013). However, pre-pregnancy BMI and ANC frequency showed no association with LBW. Inadequate gestational weight gain is significantly linked to an elevated risk of LBW. Emphasizing the appropriate quantity of ANC visits and regular monitoring of maternal weight gain throughout pregnancy is crucial to mitigate the risk of LBW.
Association between Gender and Occupation with Hypercholesterolemia Risk among Hypertension Population: A Cross-sectional Study: A Case Report Adnan, Muhammad Luthfi; Pratama, Yanasta Yudo
Journal of Diverse Medical Research : Medicosphere Vol. 2 No. 9 (2025): J Divers Med Res 2025
Publisher : Faculty of Medicine - Universitas Pembangunan Nasional Veteran Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33005/jdiversemedres.v2i9.213

Abstract

Metabolic syndrome is one of the major global health problems. Hypertension and hypercholesterolemia are indicators in the diagnosis of metabolic syndrome. However, the analysis of the relationship between risk factors for hypercholesterolemia in the hypertensive population needs further study. This study aims to analyze the risk factors for hypercholesterolemia in hypertensive patients. This cross-sectional study was conducted at Depok 2 Community Healthcare Center with a focus on adult hypertensive patients. The results of blood pressure measurements, total cholesterol examinations, and participant characteristics were then analyzed using the Chi-Square test. 117 hypertensive patients were analyzed in this study with the majority being women (60.7%), elderly (70.1%), and household-based occupancy (70.1%). The majority of participants were diagnosed with grade I hypertension (53.8%) and hypercholesterolemia (59%). Women have higher risk of developing hypercholesterolemia than men (OR 3.38 (95% CI 1.555 – 7.361); p = 0.002), and non-household based occupancy were protective factor from hypercholesterolemia (OR 0.327 (95% CI 0.144 – 0.742); p = 0.008). Gender and occupation are risk factors for hypercholesterolemia in the hypertensive population. Education at the household level is needed for early detection of the risk of metabolic syndrome in the general population.
Relationship of History of Hypertension with Severity and Onset of Preeclampsia: A Cross-Sectional Study Adnan, Muhammad Luthfi; Weningtyas, Vyanda Sri; Pramaningtyas, Miranti Dewi; Wahyana, Eka Budi
Indonesian Journal of Obstetrics and Gynecology Volume 13. No. 3 July 2025
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v13i3.2168

Abstract

Objective: This study aimed to find correlation between a history of hypertension with severity and onset of preeclampsia.Methods: A retrospective cohort study with retrospective analysis of medical record data in patients with preeclampsia and severe preeclampsia from November 2021 – February 2022 was conducted at dr. Soediran Mangun Sumarso Regional General Public Hospital, Wonogiri, Central Java. Analysis was performed between the history of hypertension with severity and onset (<34 weeks and age ? 34 weeks gestational age). Data analysis was performed using SPSS software with univariate Chi-Square analysis.Results: A total of 44 medical record data were obtained in this study. A total of 20 patients (45.5%) had a history of hypertension and 24 (55.5%) patients had no history of hypertension. A total of 23 patients (52.3%) were diagnosed with severe preeclampsia and 21 patients (47.7%) were diagnosed with preeclampsia. Based on statistical analysis, it was found that there was no significant correlation between the history of hypertension and the severity of preeclampsia (p=0.741; OR (CI 95%): 0,818 (0,249 – 2,690)) and onset (p=0.88; OR (CI 95%): 1,133 (0,222 – 5,788)).Conclusion: There is no relationship between history of hypertension with the severity and onset of preeclampsia. Further studies with larger populations are needed to analyze the relationship between history of hypertension and preeclampsia.Keywords: blood pressure, cardiovascular disease, hypertension, onset, preeclampsia.
Peran Reseptor IL-21 (IL-21R) sebagai Target Terapi Pada Penyakit Arteri Perifer Adnan, Muhammad Luthfi
SCRIPTA SCORE Scientific Medical Journal Vol. 3 No. 1 (2021): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v3i1.4440

Abstract

Background: Peripheral Artery Disease (PAD) is caused due to the disruption of blood supply to the periphery caused by blockages in the arteries. PAD is a disease that is difficult to detect and the current therapy is still limited to pharmacological therapy to reduce the risk of PAP incidence and surgical therapy if complications of PAD arise. The interleukin-21 receptor (IL-21R) is a family of interleukins that has been widely studied for its role in many diseases. Objectives: The aim of this review is to discuss the effect of IL-21R on the pathogenesis of PAP. Methods: A literature search was performed with PubMed, Google Scholar, and ScienceDirect using the keywords “peripheral artery disease”, “interleukin-21 receptor”, “inflammation”, “angiogenesis”, and “therapy”. Discussion: PAD can arise due to the formation of atherosclerotic plaques that block arteries so that blood supply is impaired. In the case of PAD, activation of IL-21R has the ability to stimulate angiogenesis thereby modulating the perfusion of hypoxic tissues in cases of PAD. Further research is needed regarding IL-21R activity in the future to study the potential of IL-21R for the more effective treatment of PAD cases in the future. Conclusion: IL-21R can activate angiogenesis and avoid further tissue damage in PAP. Keywords: interleukin-21 receptors, peripheral artery disease, therapy   Latar Belakang: Penyakit Arteri Perifer (PAP) disebabkan karena gangguan suplai darah ke bagian perifer yang disebabkan karena sumbatan pada pembuluh darah arteri. PAP merupakan penyakit yang sulit terdeteksi dan terapi yang ada saat ini masih terbatas pada terapi farmakologis untuk menurunkan risiko kejadian PAP dan terapi pembedahan apabila timbul komplikasi PAP. Reseptor interleukin-21 (IL-21R) merupakan salah satu famili interleukin yang telah banyak dipelajari terkait perannya pada banyak penyakit. Tujuan: Tujuan dari tinjauan ini adalah untuk membahas pengaruh IL-21R terhadap perjalanan penyakit PAP. Metode: Pencarian literatur dilakukan dengan PubMed, Google Scholar, dan ScienceDirect menggunakan kata kunci “peripheral artery disease”, “reseptor interleukin-21”, “inflamasi”, ”angiogenesis”, dan “terapi”. Pembahasan: PAP dapat timbul karena pembentukan plak aterosklerosis yang menyumbat pembuluh darah arteri sehingga suplai darah terganggu. Pada kasus PAP, aktivasi IL-21R memiliki kemampuan untuk menstimulasi angiogenesis sehingga memodulasi perfusi jaringan yang mengalami hipoksia pada kasus PAP. Masih diperlukan penelitian lebih lanjut mengenai aktivitas IL-21R di masa depan untuk mempelajari potensi IL-21R untuk pengobatan kasus PAP yang lebih efektif di masa depan. Kesimpulan: IL-21R dapat mengaktivasi angiogenesis dan menghindari kerusakan jaringan lebih lanjut pada PAP. Kata Kunci: penyakit arteri perifer, reseptor interleukin-21, terapi
Anesthesia Management in Patient with Eclampsia and HELLP Syndrome: A Case Report Basith, Abd; Adnan, Muhammad Luthfi
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol. 15 No. 1 (2026): March 2026
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v15i1.4955

Abstract

Background: Eclampsia and HELLP Syndrome is one of the emergency that occurs in pregnant women and is one of the causes of death in pregnant women and fetus. It can be a challenge for an anesthesiologist for anesthetic management during and after pregnancy termination. Objective: This report presents anesthetic management using combination propofol, rocuronium, and fentanyl in cases of eclampsia with HELLP syndrome and monitoring during pregnancy termination surgery. Case Presentation: A 24-year-old female patient with a gestation age of 36 weeks came to the emergency room with seizure. During the latest antenatal care found high blood pressure (160/100 mmHg). Based physical and laboratory findings the patients diagnosed eclampsia and HELLP syndrome. The patient was given general anesthesia with induction of propofol 2 mg/kg with a rapid bolus, rocuronium 1 mg/kg IV, and fentanyl 2 mcg/kg with endotracheal intubation. During surgery, the patient was hemodynamically stable and the baby was born with an Apgar score of 9/10. The patient was admitted to the ICU for vital signs monitoring for 4 days before being discharged after the sixth day. Result: Patients with eclampsia and HELLP syndrome require careful anesthetic management because it not only impacts maternal condition, but also the outcome of the neonates. Conclusion: This condition required special treatment including by anesthesiologists. Treatment includes how to deal with seizures, the choice of anesthesia technique, prevention of seizures and intraoperative fluids management and ensuring safety for both the mother and the fetus. Lot of controversies with regard to fluid management and monitoring still remain unanswered.
Co-Authors AbuHilail, Hamza Sameeh Abd El Qader Arijadi, Desi Asya, Kahaya Ainin Dadang Rona Sasetyo Emi Azmi Choironi Fauziyati, Ana Hartono, Felix Giovanni Miftahurrahmi, Rofifah Miranti Dewi Pramaningtyas Pulungan, Ndilalah Rhadiana, Baiq Rohaslia Santoso, Griselda Elisse Sausan Thoriq, Yusa Muhammad Titik Kuntari Tri Ratnaningsih Tristifany, Annisa Usman, Muhammad Alvin Ramadhan Wahyana, Eka Budi Weningtyas, Vyanda Sri Widyasari, Vita Yanasta Yudo Pratama