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All Journal HAYATI Journal of Biosciences Pharmaciana: Jurnal Kefarmasian Biopropal Industri Indonesian Journal of Chemistry Sains Natural: Journal of Biology and Chemistry FITOFARMAKA: Jurnal Ilmiah Farmasi Jurnal Farmasi Indonesia Jurnal Ilmu Kefarmasian Indonesia Jurnal Farmamedika (Pharmamedica Journal) Jurnal Ilmiah Farmako Bahari Jurnal Farmasi Sains dan Praktis Riset Informasi Kesehatan Borneo Journal of Pharmacy Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Jurnal Farmapedia
Harry Noviardi
Sekolah Tinggi Teknologi Industri dan Farmasi Bogor
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Nursing Public Health

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Anti-inflammatory and Immunostimulant Therapy with Lactobacillus fermentum and Lactobacillus plantarum in COVID-19: A Literature Review Harry Noviardi; Dyah Iswantini; Sri Mulijani; Setyanto Tri Wahyudi; Tatik Khusniati
Borneo Journal of Pharmacy Vol. 5 No. 3 (2022): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v5i3.3367

Abstract

Inflammatory diseases are diseases characterized by inflammatory symptoms. Acute inflammatory disease can cause dysregulation of the inflammatory immune response, thereby inhibiting the development of protective immunity against infection. Among the acute inflammatory disease is COVID-19. The initial viral infection causes the antigen-presenting cells to detect the virus through a phagocytosis mechanism in the form of macrophage and dendritic cells. Lactobacillus fermentum and L. plantarum are gram-positive bacteria potentially serving as immunomodulators caused by inflammation and immune system response. Short-chain fatty acids (SCFA) produced by Lactobacillus can induce immune response through tolerogenic dendritic cells. This probiotic bacterium can induce the production of different cytokines or chemokines. Following the results of in vitro and in vivo tests, L. fermentum and L. plantarum can induce IL-10 release to activate regulatory T-cell and inhibit tumor necrosis factor-α (TNF-α) binding activity of nuclear factor kappa B (NF-κB). Literature review showed that dysregulation of inflammatory immune response disorders due to inflammatory disease could be treated using probiotic bacteria L. fermentum and L. plantarum. Therefore, it is necessary to conduct further studies on the potential of indigenous Indonesian strains of these two bacteria as anti-inflammatory and immunostimulants.
The In Vitro and In Silico Study of α-glucosidase Inhibition by Kombucha Derived from Syzygium polyanthum (Wight) Walp. Leaves Yuningtyas, Sitaresmi; Alfarabi, Muhammad; Lestari, Yunita; Noviardi, Harry
HAYATI Journal of Biosciences Vol. 31 No. 5 (2024): September 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.5.951-963

Abstract

Kombucha is a fermented tea drink using a symbiotic culture of bacteria and yeast. This drink has been widely used to maintain blood sugar levels. Meanwhile, leaf boiled water of Syzygium polyanthum (Wight) Walp. has been used as an alternative medicine for diabetes mellitus in Indonesia. If this herb is made into kombucha, it may have higher antihyperglycemic activity than kombucha from tea leaves. However, there are no scientific reports of antihyperglycemic activity from S. polyanthum leaf kombucha by inhibiting alpha-glucosidase. This study aims to determine the activity and kinetics inhibition of S. polyanthum leaves kombucha against α-glucosidase. Samples were prepared at varying concentrations (12.5, 25, 37.5, 50 g/L), while phytochemical components in the products were identified, and the inhibitory activity as well as kinetics were comprehensively analyzed. In silico evaluations were conducted to further explore the inhibitory activity. The results showed that the products contained secondary metabolites such as flavonoids, saponins, and tannins. The inhibitory activity against α-glucosidase ranged from 81.05 to 89.41%. The inhibition mechanism was identified as uncompetitive, with a Michaelis-Menten constant (KM) of 0.1357 mM and a vmax value of 27.7008 U/ml minute. Several metabolites showed promising inhibition potential due to their strong binding interactions with α-glucosidase, including hydrogen bonding (H-bond), hydrophobic interactions, van der Waals forces, and electrostatic forces. Additionally, two metabolites, farnesol and α-pinene, were found to interact with other human proteins. These observations showed the potential of S. polyanthum leaves kombucha as a health-promoting beverage that might aid blood sugar control in diabetic individuals.
SITOTOKSISITAS EKSTRAK ETANOL 70% KULIT JENGKOL (ARCHIDENDRON JIRINGA (JACK). I.C. NIELSEN) TERHADAP PENGHAMBATAN SEL KANKER PAYUDARA MCF-7 DAN KANKER SERVIKS HELA: Cytotoxicity Extract Ethanol 70% of Jengkol Skin (Archidendron jiringa (Jack). I.C. Nielsen) Against the Inhibition of Breast Cancer Cell MCF-7 and Cervical Cancer HeLa Harry Noviardi; Antonius Padua Ratu; Diah Ajeng Tri R
Jurnal Ilmiah Manuntung Vol 5 No 1 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v5i1.201

Abstract

Jengkol (Archidendron jiringa (Jack).I.C. Nielsen) skin for this belongs to the organic wastes that do not provide economic value. Compounds of natural ingredients on the Jengkol Skin among others, alkaloids, flavonoids, tannins, saponins, and triterpenoids. Some of the molecular structures of the compound are thought to potentially in inhibiting the growth of cancer cells. This research aimed to determine the cytotoxicity effect of 70% ethanol extract of Jengkol Skin as anticancer. Jengkol Skin was macerated in ethanol 70% then extract was concentrated with a rotary vacuum evaporator and water bath. Cytotoxicity test was carried out using cells MCF-7 (breast cancer) and HeLa cells (cervical cancer) based upon the method of MTT assay. The parameter was the value measured inhibition concentration (IC50). Extracts of the Jengkol Skin showed activity against cytotoxicity MCF-7 cells with IC50 values of 51.76 μg/mL and for the IC50 value of HeLa cells 39.618 μg/mL. IC50 values of the cell were less than 100 μg/mL, indicated categories of potential cytotoxicity. The Jengkol Skin extract could be used as anticancer agents.
AKTIVITAS ANTIOKSIDAN DAN KARAKTERISTIK DARI YOGHURT SARI KEDELAI DENGAN PENAMBAHAN SARI JAHE MERAH (Zingiber officinale var Rubrum) Amaliah, Putri; Yuningtyas, Sitaresmi; Noviardi, Harry
Jurnal Farmamedika (Pharmamedika Journal) Vol 10 No 1 (2025): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47219/ath.v10i1.446

Abstract

Antioksidan merupakan salah satu solusi untuk mencegah terjadinya oksidasi pada radikal bebas yang menyebabkan berbagi penyakit. Antioksidan dibedakan berdasarkan sumbernya, yaitu antioksidan alami dan buatan. Senyawa antioksidan alami umunya berasal dari senyawa fenolik dan polifenolik, yang merupakan golongan flavonoid. Kedelai mengandung flavonoid berupa isovlafon yang berperan sebagai antioksidan. Selain kedelai, jahe merah juga merupakan antioksidan alami, mengandung senyawa aktif fenolik seperti, gingreol, shagaol dan ginggerdiol. Penelitian ini bertujuan untuk menentukan aktivitas antioksidan dan menguji karakteristik dari yoghurt kacang kedelai yang ditambah sari jahe merah. Yoghurt sari kedelai yang diperoleh diuji karakteristik meliputi, pH, uji total asam, uji total bakteri asam laktat, uji organoleptik, uji aktivitas antioksidan dan uji toal fenol. Yoghurt sari kedelai dengan penambahan sari jahe merah yang difermentasi oleh Lactobacillus casei Shirotta strain, Lactobacillus acidophillus, dan kombinasinya mempunyai aktivitas peredaman radikal bebas DPPH beruturut-turut adalah 78,80%; 78,44%; dan 94,65%. Aktivitas tertinggi peredaman radikal bebas DPPH pada yoghurt sari kedelai yang difermentasi oleh Lactobacillus acidophillus dengan persentasi inhibisi 94,65%. Karakteristik yoghurt tersebut adalah pH 4,2 total asam laktat 0,51%, total bakteri asam laktat 2,9 x 1013 CFU/mL, dan total fenol 352,97 mg/L.
Virtual screening of bioactive compounds from the lamiaceae family as acetylcholinesterase inhibitors for alzheimer’s disease Noviardi, Harry; Utami, Mega; Masaenah, Eem
Pharmaciana Vol. 15 No. 2 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i2.30709

Abstract

Alzheimer's disease is a progressive neurological disorder that can impact adults aged 65 and beyond. A primary factor contributing to Alzheimer’s is the diminished availability of the neurotransmitter acetylcholine in the brain. Plants from the Lamiaceae family have been believed to possess potential as acetylcholinesterase inhibitors (AChEI) that can alleviate the symptoms of Alzheimer’s disease. This study aims to find possible bioactive compounds from plants of the Lamiaceae family, specifically Salvia officinalis L., Salvia lavandulifolia Vahl., Rosmarinus officinalis L., Collinsonia canadensis L., and Melissa officinalis L., as acetylcholinesterase inhibitors using in silico approaches. Active compounds from the Lamiaceae family were evaluated based on physicochemical properties, toxicity, Gibbs free energy (∆G), inhibition constant (Ki), absorption, excretion, metabolism, distribution, and molecular dynamics. From a total of 1,370 compounds derived from Lamiaceae plants, the compound 3,5,5-Trimethyl-4-[3-[3,4,5-trihydroxy-6-(hydroxymethyl) oxan-2]-yl]oxybut-1-enyl] cyclohex-2-en-1-one (TOC) from Salvia officinalis L. exhibited potential as an AChEI, possessing a molecular weight of 370 Daltons, 4 hydrogen donors, 7 hydrogen acceptors, a Log P partition coefficient of 3.46, a molar refractivity of 100, a Gibbs free energy change (∆G) of -11.2 kcal/mol, an inhibition constant (Ki) of 0.981 μM, and a total energy calculated via Molecular Mechanics Generalized Born Surface Area of 31.381 kcal/mol. In silico, the TOC ligand inhibits acetylcholinesterase to treat Alzheimer's.
PEMBERDAYAAN KARANG TARUNA MELALUI PENGOLAHAN SAMPAH ORGANIK MENJADI ECO-ENZYME DAN SABUN CAIR RAMAH LINGKUNGAN DI DESA CARIU Nurma Angeliani Komalasari; Abdul Aziz Setiawan; Harry Noviardi; Sitaresmi Yuningtyas; Nanang Hermawan
Jurnal Farmapedia (Pharmapedia Journal) Vol 3 No 2 (2025): Jurnal Farmapedia
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47219/jfp.v3i2.49

Abstract

Pengelolaan sampah organik di tingkat desa masih menjadi permasalahan lingkungan yang memerlukan pendekatan edukatif dan pemberdayaan masyarakat. Kegiatan pengabdian ini bertujuan meningkatkan pengetahuan dan keterampilan Karang Taruna dalam mengolah sampah organik menjadi eco-enzyme serta sabun cair ramah lingkungan. Metode yang digunakan meliputi penyuluhan, pelatihan praktik, pendampingan produksi, dan evaluasi melalui kuesioner pre-test dan post-test. Tahapan kegiatan mencakup identifikasi kebutuhan, sosialisasi, pelatihan pembuatan eco-enzyme, formulasi sabun cair eco-enzyme, serta evaluasi tingkat pemahaman peserta. Hasil menunjukkan adanya peningkatan pengetahuan peserta dengan skor pemahaman yang meningkat setelah pelatihan. Selain itu, peserta mampu memproduksi eco-enzyme secara mandiri dan mengaplikasikannya sebagai bahan aktif sabun cair. Dokumentasi kegiatan juga menunjukkan partisipasi aktif dan antusiasme peserta selama seluruh tahapan pelaksanaan. Program ini membuktikan bahwa pemberdayaan berbasis pelatihan praktis dapat menjadi strategi efektif dalam mengurangi sampah organik sekaligus menciptakan produk ramah lingkungan yang bernilai guna. Kegiatan ini diharapkan dapat menjadi model pengelolaan sampah berbasis masyarakat yang berkelanjutan di tingkat desa.
Molecular Docking and Clustering of Apple (Malus sylvestris Mill) and Date (Phoenix dactylifera L.) Metabolites as Anti-Inflammatory Agents Amanda Oktaviani Setiawan; Dr. Harry Noviardi; Nina Imaniar
Sains Natural: Journal of Biology and Chemistry Vol. 16 No. 3 (2026): Sains Natural
Publisher : Universitas Nusa Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31938/jsn.v16i3.971

Abstract

Inflammation is the body's defense response to infections, physical injuries, metabolic disorders, and autoimmune diseases. Foreign agents will attach to TLR (Toll Like Receptor) and initiate the activationNF-κB within nucleus. This signaling induce release of IL-1β, IL-6, TNF-α, and iNOS. The manalagi apple and sukari date fruit are known to have bioactive compounds like flavonoids and phenols that could help reduce inflammation. This study seeks to identify the potential compounds in Malus sylvestris Mill, and Phoenix dactylifera L. as anti-inflammatory agents that inhibit the cytokines IL-1β, IL-6, TNF-α, and iNOS. These compounds were tested with parameters such as binding affinity (∆G), inhibition constant (Ki), physicochemical properties, absorption, distribution, metabolism, excretion, and toxicity (ADMET), as well as molecular dynamics. Ellagic acid, one of the 76 compounds obtained, has the potential to be an effective anti-inflammatory agent. It inhibits IL-1β (-4.901 kkal/mol and 0.9918 uM), IL-6 (-6.424 kkal/mol and 0.9892 uM), iNOS (-8.597 kkal/mol and 0.9856 uM), and TNF-α (-9.347 kkal/mol and 0.9843 uM). Ellagic acid has a molecular weight of 302.194 g/mol, a LogP partition coefficient of 1.3128, 4 hydrogen donors, and 8 hydrogen acceptors. Ellagic acid also has good ADME properties with a toxicity class of 6, non-mutagenis, and non-hepatotoxic.
Co-Authors Abdul Aziz Setiawan Agustin, Lydia Ahmad Ben Amaliah, Putri Amanda Feby Safitri Amanda Oktaviani Setiawan Antonius Padua Ratu Antonius Padua Ratu Armi Wulanawati Baiq Annisa Apriyanti A.R Ben, Ahmad Bina Lohita Sari Citroreksoko, Padmono Devi Ratnasari Devi Ratnasari Diah Ajeng Tri R Diah Ajeng Tri R Dwi Suwarni Dyah Iswantini Eem Masaenah Fachrurrazie Fachrurrazie Fachrurrazie, Fachrurrazie Freddy Arifta Nassel Herson Cahaya Himawan Kurniati Indraswari Lestari, Yunita Lydia Agustin Masaenah, Eem Meita Sari Mandiri Moh. Syarif Muhamad Sholehuddin Malik Ibrohim Muhamad Sholehuddin Malik Ibrohim Muhamad Wildan Malik Muhammad Alfarabi Muhammad Fermadianto Muhammad Sholehuddin malik Ibrohim Nanang Hermawan Nina Imaniar Nur Apriani Kartini Nurma Angeliani Komalasari Padmono Citroreksoko Patoni Patoni Patoni, Patoni Rina Anggraeni Rizky Ramadhan Setyanto Tri Wahyudi Sitaresmi Yuningtyas Sri Mulijani Sumiati, Triyani Tatik Khusniati Tri R, Diah Ajeng Tri R, Diah Ajeng Triyani Sumiati Utami, Mega Vira Yuniar