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All Journal HAYATI Journal of Biosciences Jurnal Agronomi Indonesia (Indonesian Journal of Agronomy) Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Agrivet JPSCR : Journal of Pharmaceutical Science and Clinical Research AL-HAYAT: Journal of Biology and Applied Biology Jurnal Riset Biologi dan Aplikasinya Berkala Ilmiah Biologi Buitenzorg: Journal of Tropical Science
Damayanti, Frisca
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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Antidiabetic Potential and Metabolite Profile of Leaf and Stem Extract of Castanopsis tungurrut (Blume) A.DC. Nabila, Bilqis Zahra; Surya, Muhammad Imam; Lailaty, Intani Quarta; Damayanti, Frisca; Nuringtyas, Tri Rini
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 1 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i1.74955

Abstract

Diabetes mellitus is a metabolic disorder caused by high blood sugar levels. One species in the Castanopsis genus is proven with a hypoglycemic effect. Therefore, the study aimed to discover the potential of Castanopsis tungurrut as an antidiabetic. Sample extraction, α-amylase inhibition, glucose diffusion analysis, GC-MS analysis, and molecular docking were applied in this study. Maceration of the leaf ethanol extract showed the highest yield value of 21.08%, while the stem extract was 14.04%. Leaf ethanol extract and stem ethyl acetate extract showed the highest inhibiting α-amylase activity with an inhibition value of 33.74%±1.54 and 34.45%±1.08 at 1 mg/mL concentration. The glucose entrapment assay showed that these two extracts could inhibit the diffusion of glucose in the dialysis bag. The final result was glucose concentration in dialysate for the two extracts of 0.114±0.001 mg/mL and 0.116±0.001 mg/mL which was lower than acarbose in 0.120±0.004 mg/mL. GC-MS analysis showed 6 metabolites in leaf ethanol extract and 22 metabolites in stems ethyl acetate extract from an alkane, salicylic, cinnamic, terpene, steroid, and fatty acid. Molecular docking resulting between the compounds with α-amylase enzymes complex showed γ-sitosterol and ß-bisabolene from C. tungurrut extract have the potential to be developed as an antidiabetic drug due to its good inhibitory activity with binding affinity values of -9.1 and -6.9 that considered better and quite close to acarbose as control of -7.7.
Co-Authors , Triadiati Albertus Husein Wawo Amalia, Alifa Danang Wahyu Purnomo Dhavalyra, Salwa DIAN LATIFAH, DIAN Endewip, Lidya N. Fitri Fatma Wardani Hamim Hamim Harto, Harto Helmanto, Hendra Husaini, Iin P.A Hutabarat, Prima Wahyu K. Hutabarat, Prima Wahyu Kusuma Indra Gunawan Indresputra, Faozan Iyan Robiansyah Kholidah, Nur Kusumaningtyas Pitaloka, Mutiara Lailaty, Intani Quarta MARTIANSYAH, Irfan Mayta Novaliza Isda Mochammad Imron Awalludin Muhammad Imam Surya Muhammad Rifqi Hariri Mujahidin Mujahidin Mulyani, Melza Nabila, Bilqis Zahra Nastiti, Anisa Diana Ning Tyas, Kartika Ninik Setyowati Peni Lestari Pratiwi, Widya Ayu Primananda, Enggal Putri Maulida, Azkia RACHMADIYANTO, ARIEF NOOR Rahmaningtiyas, Lutfi Rinandio, Dipta Sumeru Rismona, Nurwani Safarinanugraha, Dina Setyanti, Dwi SRI RAHAYU Suhatman, Agus Surta, Muhammad Imam Tri Rini Nuringtyas Yudaputra, Angga zulkarnaen, rizmoon Zulkarnaen, Rizmoon Nurul