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All Journal Jurnal Kedokteran Brawijaya Indonesian Journal of Urology Majalah Kesehatan FKUB Indonesian Andrology and Biomedical Journal Journal of Community Health and Preventive Medicine (JOCHAPM)
Hanggara, Dian Sukma
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Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health

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Journal : Jurnal Kedokteran Brawijaya

 1 
Leukemia Sel Plasma Primer Hanggara, Dian Sukma; Budiman, Budiman
Jurnal Kedokteran Brawijaya Vol 29, No. 3 (2017)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2017.029.03.17

Abstract

Leukemia sel plasma merupakan penyakit yang langka, hanya sekitar 2-4% dari plasma cell dyscrasia. Manifestasi klinis leukemia sel plasma primer lebih agresif dibandingkan dengan mieloma multipel. Artikel melaporkan kasus pasien laki-laki berumur 59 tahun datang ke Instalasi Gawat Darurat (IGD) dengan keluhan badan lemah dan nyeri pada kedua kaki sejak sebulan yang lalu dan memberat seminggu terakhir. Pasien juga mengeluhkan nyeri punggung, mual, penurunan nafsu makan, dan penurunan berat badan. Pemeriksaan fisik menunjukkan penurunan respon motorik pada ekstrimitas bawah. Pemeriksaan laboratorium menunjukkan anemia normokrom normositik, leukositosis dengan 60% sel plasma, trombositopenia, hipoglobulinemia, azotemia, hiperkalsemia, hiperfosfatemia, hiponatremia, hipogamaglobulinemia pada elektroforesis protein, dan 50% sel plasma pada aspirasi sumsum tulang. Bone survey menunjukkan proses metastasis pada tulang. Diagnosis leukemia sel plasma primer ditegakkan oleh adanya lebih dari 20% sel plasma atau jumlah absolut sel plasma lebih dari 2x109/l pada darah tepi, tidak ada riwayat mieloma multipel, dan gambaran klinis yang agresif. Kata Kunci: Leukemia sel plasma, mieloma multipel, sel plasma
Case Report: Multisystem Langerhans Cell Histiocytosis (LCH) and Myelodysplastic Syndrome (MDS) in a 13-Month-Old Female Hanggara, Dian Sukma; Desyi, Desyi
Jurnal Kedokteran Brawijaya Vol 31, No 3 (2021)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2021.031.03.10

Abstract

Langerhans Cell Histiocytosis or LCH and Myelodysplastic syndrome or MDS in children are rare diseases. It is estimated to be 1 to 4 cases per 1 million population and less than 5% of hematologic cases. MDS in LCH can occur due to genetic predisposition, impaired cytokine production, or secondary to chemotherapy.  The article reported a patient case of a 13-month-old female who came to hospital with paleness since two weeks before admission. The patient also experienced skin redness, abdominal distention, and weight loss. From the physical examination, anemia, maculopapular rash, and hepatosplenomegaly were obtained. From the laboratory test, anemia of hypochromic anisopoikilocytosis, monocytosis, thrombocytopenia, and hypoalbuminemia were obtained. On examination of bone marrow aspiration, MDS with Refractory Cytopenia of Childhood type or RCC was obtained. Positive results confirmed the diagnosis of Langerhans Cell Histiocytosis on CD68 and S100 in histopathological examinations.
Co-Authors Amalia, Christina Aprilia, Andrea Budiman Budiman Desyi Desyi Dhani, Fauzan Kurniawan Dicky Faizal Irnandi Evangelista, Bernike Azza Gonius, Andry Heni Pujiastuti Kusdijanto, Amanda Yuanita Kustono, Andri Nanik Setijowati Negara, Edvin Prawira Nikmatus Sholihah Paksi Satyagraha Purnomo, Athaya Febriantyo Retnani, Diah Prabawati Rifqi, Mochamad Shalahudin Siska, Fran Sri Andarini Yeti Indrawati