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<![CDATA[Anti Lithiasis Activity of Avocado (Persea americana Mill) Leaves Extract in White Male Rats ]]>
<![CDATA[IETJE WIENTARSIH]]>;
<![CDATA[RINI MADYASTUTI]]>;
<![CDATA[BAYU FEBRAM PRASETYO]]>;
<![CDATA[ANGGARA ALDOBRATA]]>
<![CDATA[ HAYATI Journal of Biosciences Vol. 19 No. 1 (2012): March 2012 ]]>
Publisher : <![CDATA[Bogor Agricultural University, Indonesia ]]>
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DOI: 10.4308/hjb.19.1.49
<![CDATA[In Indonesia, avocado leaves have been used as traditional medicines for diureticum to cure urolithiasis. This research was to determine anti lithiasis activity of avocado leaves (Persea americana Mill) extract on white male rats nefrolithiasis model induced by ethylene glycol. Ethanol extraction method was used to get extract of avogadro leaves. Twenty adult male white rats were divided into 4 different induction treatments i.e. aquadest, ethylene glycol 0.75% and ammonium chloride 2%, and extract of avocado leaves with different levels of 100 and 300 mg/kg bw respectively. Their body weight was measured daily to determine their growth ratio. And at the end of the trial, the kidney was analyzed its calcium level and inhibitory activity to formation of calcium oxalate crystals. The results showed that the amount of calcium level in the kidney of rats treated with extract of avogadro leaves was significantly decreased than that of rats treated with ethylene glycol 0.75% and ammonium chloride 2% (P < 0.05). The extract avocado leaves as a herbal remedy can be recommended as a phytotherapeutic agent especially for preventive action for urolithiasis diseases.]]>
<![CDATA[Aktivitas Diuretik dan Analisa Mineral Urin Perlakuan Ekstrak Tanaman Kumis Kucing (Orthosiphon Stamineus Benth) pada Tikus Jantan ]]>
<![CDATA[Rini Madyastuti]]>;
<![CDATA[Ietje wientarsih]]>;
<![CDATA[Setyo Widodo]]>;
<![CDATA[Erni H Purwaningsih]]>;
<![CDATA[Eva Harlina]]>
<![CDATA[ Acta VETERINARIA Indonesiana Vol. 8 No. 2 (2020): Juli 2020 ]]>
Publisher : <![CDATA[IPB University ]]>
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DOI: 10.29244/avi.8.2.16-23
<![CDATA[Tanaman Kumis Kucing merupakan salah satu tanaman yang memiliki banyak keuntungan dan sudah digunakan sejak dahulu dalam upaya menjaga kesehatan. Tujuan dari penelitian ini adalah mengevaluasi aktivitas diuretik dari penggunaan ekstrak Kumis Kucing dan mengukur kadar kalium dan natrium dalam urin. Sebanyak 24 ekor tikus dibagi menjadi empat grup; kontrol negatif (akuades), kontrol positif (furosemide), dosis ekstrak 1 (250mg/kg BB) dan dosis ekstrak 2 (500mg/kg BB). Ekstrak diberikan secara peroral selama 7 hari. Aktivitas diuretik pada kelompok ekstrak dan kontrol positif pada jam pertama (P>0.05) dan jam keenam (P<0.05). Volume urin kumulatif dosis 1 mendekati furosemide. Pengukuran mineral urin menunjukkan hasil kehilangan mineral natrium dan kalium pada kelompok ekstrak lebih kecil dibandingkan kelompok referensi. Hasil dari penelitian ini menunjukkan bahwa dosis efektif ekstrak Kumis Kucing adalah 250 mg/kg BB pada jam ke-2 dan menunjukkan kehilangan mineral dalam urin yang lebih kecil.]]>
<![CDATA[Aktivitas Ekstrak Etanol Daun Alpukat Terhadap Zat Nefrotoksik Ginjal Tikus (ACTIVITIES STUDY OF ETHANOL EXTRACTS OF AVOCADO LEAVES (PERSEA AMERICANA MILL) TO NEPHROTOXIC COMPOUND OF RAT’S KIDNEY) ]]>
<![CDATA[Ietje Wientarsih]]>;
<![CDATA[Eva Harlina]]>;
<![CDATA[Rini Madyastuti Purwono]]>;
<![CDATA[Ikrar Trisnaning Hardi Utami]]>
<![CDATA[ Jurnal Veteriner Vol 15 No 2 (2014) ]]>
Publisher : <![CDATA[Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association ]]>
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<![CDATA[Based on WHO’s data, about 80% peoples in the word use plant’s extract as herbal medicine. Avocadoleaves has used as herbal medicine which is works as diuretikum, reduce stone in renal, and cure sprue.The purpose of this research is to study activities of ethanol extract of avocado leaves to ethylene glycolinduction on rat’s kidney by histopatologically. This experiment was continuing Adha’s research (2009)with research design as follows: twenty male rats were divided into 4 groups, negative control group (KN),positive control group (KP), treated group I by ethanol extract of avocado leaves 100 mg/kg BW (E100), andtreated group 2 by 300 mg/kg BW (E300). Sampling kidney were fixed in BNF 10% for histopathologicalslide and stained by Hematoxylin-Eosin. The kidney histopathological changes were edema of glomerulus,and protein deposit in the lumen, hyalin droplet and necrotic tubules. The results showed that ethanolextract of avocado leaves can’t significantly to reduce glomerulus edema with percentage cases 31.9% and33.5% for E100 and E300 and tend not to reduce the occurrence of protein deposits in the lumen of thetubule. Ethanol extract of avocado leaves tend to reduce the incidence of tubular necrosis and it wassignificantly different from the KP group (p <0.05). It is caused by flavonoid in etanol extract of avocadoleaves works as diuretikum and antioxidant.]]>
<![CDATA[Infusum Daun Alpukat Sebagai Inhibitor Kristalisasi Kalsium Oksalat pada Ginjal (THE AVOCADO LEAVES INFUSUM AS INHIBITOR ON RENAL CALCIUM OXALATE CRYSTALIZATION) ]]>
<![CDATA[Rini Madyastuti]]>;
<![CDATA[Setyo Widodo]]>;
<![CDATA[Ietje Wientarsih]]>;
<![CDATA[Eva Harlina]]>
<![CDATA[ Jurnal Veteriner Vol 16 No 4 (2015) ]]>
Publisher : <![CDATA[Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association ]]>
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<![CDATA[Urine crystal is a crystal nucleus which tend to form urine stone. The case of urine stone seems to beincreased every year. Crystallization could induce acute tubular necrosis which impact on renal dysfunction.The signs of this condition are high level of urea, creatinine and decrease glomerulus filtration rate. Theobjective of this research was to evaluate the effects of infusum Persea americana Mill as an inhibitorcrystallization which induced by ethylene glycol on white male rats. 20 male rats were divided into 4groups; K1 as negative group received only distilled water ad libitum, K2 as positive group receiveddistilled water containing ethylene glycol, K3 (dose 5%) and K4 (dose 10%) as treatment groups receivedwater containing ethylene glycol and avocado leaves infusion. Phytochemsitry screening of infusion avocadoleaves consisted of flavonoid, saponin, tanine and quinone. Result of analysis showed that the level ofureum and creatinine on K2 was higher than K3 and K4 group. The increased level could be inhibited byinfusion avocado leaves. The measurement of glomerular filtration rate in treatment groups wassignificantly different (p<0.05). Descriptive histopathology observation showed that renal lesio in grouptreatment (K3 and K4) were declined. Large crystal calcium oxalate on K2 group was observed by usingpolarized microscope, whereas small crystal calcium oxalate were seen in the infusion of avocado leavesgroups. These result showed the ability of infusion of avocado leaves as an inhibitor on the growth ofcrystallization calcium oxalate]]>
<![CDATA[Gambaran Serum Ureum, dan Kreatinin pada Tikus Putih yang diberi Fraksi Etil Asetat Daun Alpukat (THE PROFIL OF SERUM, UREUM AND CREATININE OF AETHYL ACETATE FRACTION AVOCADO LEAVES IN WHITE RATS) ]]>
<![CDATA[Ietje Wientarsih]]>;
<![CDATA[Rini Madyastuti]]>;
<![CDATA[Bayu Febran Prasetyo]]>;
<![CDATA[Dian Firnanda]]>
<![CDATA[ Jurnal Veteriner Vol 13 No 1 (2012) ]]>
Publisher : <![CDATA[Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association ]]>
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<![CDATA[Nephrolithiasis is one of urologic disease due to crystallization urine in urinary system. Traditionally,avocado leaves has long been used for the treatment of nephrolithiasis because flavonoid in this plant canfacilitate the watering of crushing stone in the urinary tract. The aims of this study was to determine theeffect of aethyl acetate fraction of avocado leaves on ureum and creatinine level. Twenty white male rats(Sprague dawley, weight 200-300g) were divided into four groups. Normal control group (A) was givenaquadest ad libitum. Negative control group (B) and treatments group (C and D) were given ethyleneglycol 0.75% and ammonium chloride 2% to induce the formation of calcium oxalate crystal. Group C andD were given aethyl acetate fraction with different levels (100mg/kg bb and 300mg/kg bb for fourteen days).Blood samples were taken before and after treatment. The result showed that aethyl acetate fractioncould not decrease serum blood level of ureum and creatinine. Serum blood level ureum and creatinine ingroup D increased significantly compared to group A, B, C after fourteen days treatment. The used ofethylene glycol caused acute tubular necrosis. It therefore appears that ethyl acetate solvent was not ableto extract flavonoids to prevent renal dysfunction.]]>
<![CDATA[Terapi giardiasis penyebab diare non-spesifik pada kucing ]]>
<![CDATA[Rizal Arifin Akbari]]>;
<![CDATA[Ietje Wientarsih]]>;
<![CDATA[Bayu Febram Prasetyo]]>;
<![CDATA[Rini Madyastuti]]>
<![CDATA[ ARSHI Veterinary Letters Vol. 2 No. 1 (2018): ARSHI Veterinary Letters - Februari 2018 ]]>
Publisher : <![CDATA[School of Veterinary Medicine and Biomedical Sciences, Bogor Agricultural University ]]>
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DOI: 10.29244/avl.2.1.7-8
<![CDATA[Kucing jantan berumur 4 tahun bernama Rambo datang ke Klinik Star Vet Ciomas Bogor dengan keluhan menderita diare selama 6 bulan. Kucing memiliki kebiasaan diberikan minum air mentah, sering minum air toilet dan air got. Kucing di diagnosa menderita Giardiasis dengan menggunakan teknik fecal flotation yang ditunjukan dengan adanya kista Giardia sp. sebanyak >30 kista per lapang pandang. Kucing di terapi menggunakan antibiotika metronidazol dosis 20 mg/kg BB, imunomodulator (Echinacea extract) dosis 0.1 ml/kg BB dan Vitamin B12 dosis 0.025 mg/kg BB secara peroral selama 10 hari. Dilakukan pemantauan melalui pengamatan bentuk feses dan menghitung jumlah kista Giardia pada hari ke-0, 5, dan 10 pascaterapi. Pada hari ke-10 pascaterapi, feses sudah mulai berbentuk dan tidak ditemukan kista Giardia sp. sehingga kucing dinyatakan sembuh dari Giardiasis.]]>
<![CDATA[Gambaran kristal urin pada hewan model nefrolitiasis hasil induksi etilen glikol ]]>
<![CDATA[Rini Madyastuti Purwono]]>;
<![CDATA[Ietje Wientarsih]]>;
<![CDATA[Setyo Widodo]]>;
<![CDATA[Erni H Purwaningsih]]>;
<![CDATA[Eva Harlina]]>
<![CDATA[ ARSHI Veterinary Letters Vol. 3 No. 1 (2019): ARSHI Veterinary Letters - Februari 2019 ]]>
Publisher : <![CDATA[School of Veterinary Medicine and Biomedical Sciences, Bogor Agricultural University ]]>
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DOI: 10.29244/avl.3.1.19-20
<![CDATA[Tingginya tingkat keterulangan kasus urolitiasis baik pada hewan maupun manusia, menuntut penelitian dalam mencari solusi menurukan angka keterulangan. Penelitian urolitiasis membutuhkan hewan model urolitiasis yang sesuai dengan kondisi sebenarnya. Salah satu metode yang digunakan adalah menciptakan kondisi hiperoksaluria. Penggunaan induksi etilen glikol menjadi metode yang paling umum digunakan. Induksi ini menghasilkan kristal kalsium oksalat monohidrat. ]]>
<![CDATA[Evaluation of Drug Uses for Calicivirus and Panleukopenia Treatment in Bogor Animal Clinic on 2017 and 2018 ]]>
<![CDATA[Muhammad Agung Nulhakim]]>;
<![CDATA[Bayu Febram Prasetyo]]>;
<![CDATA[Rini Madyastuti Purwono]]>
<![CDATA[ Eduvest - Journal of Universal Studies Vol. 1 No. 9 (2021): Journal Eduvest - Journal of Universal Studies ]]>
Publisher : <![CDATA[Green Publisher Indonesia ]]>
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DOI: 10.59188/eduvest.v1i9.202
<![CDATA[Drug therapy in cases of infections by viruses is only to prevent secondary infections. The use of drugs for each action must be evaluated through a drug use evaluation program (EPO) in order to guarantee a rational and effective drug. This study aims to examine the drugs in case for handling and the effectiveness of drug use in cases of infections caused by viruses, in this study the therapeutic use of drugs in cases of feline calicivirus and feline panleukopenia. This research is a descriptive study using data from 543 patients who came to get treatment of clinic in Bogor City during 2017 and 2018, 29 of which were infected with feline calicivirus and 32 infected with feline panleukopenia. Evaluation of drug use in these two viral diseases is done descriptively by comparing research data with literature. The results showed the use of drugs in the case of feline calicivirus there were 12 types of drug treatment, while in the case of feline panleukopenia there were 9 types of drug treatment. The use of drugs most often used is based on the records of veterinary clinical records, namely the preparation of metronidazole combined with cefadroxil to handle cases of feline calicivirus and metronidazole alone to handle cases of feline panleukopenia.]]>
<![CDATA[ANALISIS POTENSI DAUN TORBANGUN (Plectranthus amboinicus) SEBAGAI ANTIBAKTERI TERHADAP Klebsiella pneumoniae SECARA IN SILICO ]]>
<![CDATA[Nabila Nur Nafiati]]>;
<![CDATA[Rini Madyastuti Purwono]]>;
<![CDATA[Nurhidayat Nurhidayat]]>;
<![CDATA[Laksmi Ambarsari]]>
<![CDATA[ Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 8 No 1 (2023): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Buana Perjuangan Karawang ]]>
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DOI: 10.36805/jpx.v8i1.5190
<![CDATA[Antibiotic-resistant is a global issue. Klebsiella pneumoniae has high priority to find its antibiotic because it has extended-spectrum beta-lactamase (ESBL) enzyme that makes the bacteria easy to resist the antibiotic. The study of phytochemicals in medicinal plants is one of the efforts to find antibiotics. Indrulizia is one of the empirical medicinal plants containing flavonoids used to treat disease. The aim of this study was to analyze the potential of borage as an antibacterial agent against Klebsiella pneumoniae in silico. Docking is the method for this study using AutoDock Vina. This is an application for docking the enzyme ESBL from K. pneumoniae, referred to as SHV (sulfhydryl variable), and the metabolite second from plants. The parameters analyzed were binding free energies, inhibition constants and visualization in 3D and 2D. The free energy of binding and the inhibition constant of the native ligand are -6.7 kcal/mol and 12.118 μM. The binding free energy values of apigenin 7-glucuronide and rosmarinic acid show higher potencies than the native ligand of SHV-1 (1,4-thiazepine).]]>
<![CDATA[Aktivitas Antibakteri Senyawa Aktif Esktrak Jintan Hitam (Nigella sativa) Terhadap Bakteri MRSA secara In Silico ]]>
<![CDATA[Dea Khalissa Anidya]]>;
<![CDATA[Rini Madyastuti Purwono]]>;
<![CDATA[Dimas Andrianto]]>;
<![CDATA[Nina Tri Kusumawati]]>
<![CDATA[ Jurnal Veteriner dan Biomedis Vol. 1 No. 2 (2023): September ]]>
Publisher : <![CDATA[Sekolah Kedokteran Hewan dan Biomedis ]]>
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DOI: 10.29244/jvetbiomed.1.2.92-102.
<![CDATA[Semakin tinggi penggunaan antibiotik akan meningkatkan risiko terjadinya resistensi bakteri. S. aureus merupakan bakteri penyebab mastitis tertinggi yaitu mencapai 67% diantara bakteri patogen penyebab mastitis lainnya. Akibat tingginya penggunaan antibiotik, terbentuklah strain S. aureus yang resisten yaitu MRSA. Bahan alami seperti jintan hitam bisa menjadi alternatif pengobatan penyakit menular bakteri. Penelitian ini bertujuan untuk menguji sifat an-tibakteri ekstrak jintan hitam terhadap bakteri MRSA (ID:3VSL) secara in silico dan mengetahui zat aktif mana yang mempunyai potensi antibakteri terbaik. Berdasarkan hasil LC-MS dari 89 zat aktif yang teridentifikasi, 9 diantaranya mempunyai potensi antibakteri yang cukup baik dibandingkan sefotaksim setelah dilakukan prediksi bioavailabilitas dan toksisitas lipinski. Hasil analisis penelitian menunjukkan 3 zat aktif yang terdiri dari prolylleucine, (2-(1,3-ben-zodioxol-5-yl)-4,5,6,7-tetramethyl-1H-benzimidazole, dan Bis(4-ethylbenzylidene)) Sorbitol merupakan ligan produk alami dengan aktivitas antibakteri terbaik serta menjadi kandidat bahan aktif alternatif pengganti antibiotik.]]>
