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Determinants of Insecticide-treated Net use among Pregnant Women with Malaria in West Papua, Indonesia Tita Husnita Madjid; KI Mantilidewi; H Susiarno; Ari Irawan Romulya
Andalas Obstetrics And Gynecology Journal Vol 6, No 1 (2022)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.6.1.16-20.2022

Introduction: Malaria in pregnancy is still a major cause of neonatal adverse outcome in West Papua, Indonesia. In accordance to the recommendation of the World Health Organization, local government have attempted to prevent malaria in pregnant women by distributing insecticide-treated nets (ITNs). Objective: This study aimed to assess the pattern of malaria infection and the use of ITNs among pregnant women in the city of Manokwari, West Papua, Indonesia.Methods: We recorded all pregnant women who were admitted to the Manokwari District Hospital during May 2017 to April 2018 with malaria. From a total of 335 cases, 125 women agreed to be interviewed on their ITN use at home.Results : Out of a total of 335 cases during the enrolment period, 175 (52%) were found to be infected with Plasmodium falciparum. Chief complaints were fever (28.8%), hyperemesis (25.6%); cephalgia (18.4%); anaemia (15.2%); preterm labor (8.8%) and diarrhoea (3.2%). Only 23.2% of the 125 samples used ITN at home. Most did not have access government-distributed free nets (43.8%); others did not use it due to the foul smell of the nets (17.7%); the heat experienced when sleeping under nets (29.1%); and fear of insecticide side-effect (9.4%). Conclusion: There is suboptimal use of ITN as a preventive measure against malaria in pregnancy in Manokwari, West Papua. Better distribution and other alternative to physical barriers should be considered by the governmentKeywords: Malaria, pregnancy, insecticide-treated net

Gambaran Karakteristik Klinis dan Histopatologi Kanker Ovarium Anak di RSUP Dr. Hasan Sadikin Bandung Haifa Tuffahati; Ali Budi Harsono; Muhammad Alamsyah Aziz; Kemala Isnainiasih Mantilidewi; Febia Erfiandi
Indonesian Journal of Obstetrics & Gynecology Science Volume 5 Nomor 1 Maret 2022
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v5n1.354

Tujuan: Untuk mengetahui gambaran karakteristik klinis dan histopatologi kanker ovarium anak di RSUP Dr. Hasan Sadikin Bandung.Metode: Penelitian ini menggunakan desain penelitian deskriptif. Data dikumpulkan dari rekam medis pasien kanker ovarium anak di RSUP Dr. Hasan Sadikin Bandung tahun 2017–2020.Hasil: Terdapat 22 pasien kanker ovarium anak yang sesuai dengan kriteria inklusi dan eksklusi. Ditemukan pasien kanker ovarium anak paling banyak usia 13–18 tahun sebanyak 13 orang (59,1%), stadium klinis I sebanyak 10 orang (45,4%), histopatologi jenis sel germinal sebanyak 17 orang (77%), dan gejala klinis benjolan pada perut sebanyak 16 orang (33%).Kesimpulan: Kanker ovarium anak di RSUP Dr. Hasan Sadikin Bandung Bandung periode 1 Januari 2017 – 31 Desember 2020 paling sering terjadi pada pasien dengan rentang usia 13–18 tahun, terdiagnosis pada stadium I, karakteristik histopatologi tipe sel germinal, dan memiliki gejala klinis berupa benjolan pada perut.Overview of Clinical Characteristics and Histopathology of Pediatric Ovarian Cancer at RSUP Dr. Hasan Sadikin Bandung AbstractObjective: To determine pediatric ovarian cancer’s clinical characteristics and histopathology at RSUP Dr. Hasan Sadikin Bandung.Methods: This study used a descriptive research design. Data were collected from medical records of pediatric ovarian cancer patients at RSUP Dr. Hasan Sadikin Bandung in 2017 – 2020.Result: 22 pediatric ovarian cancer patients met the inclusion and exclusion criteria. The majority of pediatric ovarian cancer patients were 13-18 years as many as 13 people (59.1%), clinical stage I as many as 10 people (45.4%), histopathological germ cell types as many as 17 people (77%), and clinical symptoms as lumps in the abdomen as many as 16 people (33%).Conclusion: Pediatric ovarian cancer at RSUP Dr. Hasan Sadikin Bandung period 1 January 2017 – 31 December 2020 most occurred in patients aged 13–18 years, diagnosed at stage I, histopathological characteristics of germ cell type, and had clinical symptoms in the form of abdominal lump.Key words: Ovary, Pediatric Ovarian Cancer, Clinical Characteristic, Histopathological Characteristic

Apakah Kadar β-hCG Praevakuasi dan Gambaran Proliferasi Sel Trofoblas secara Mikroskopik dapat digunakan untuk Prediksi Transformasi Keganasan pada Mola Hidatidosa? Kemala Isnainiasih Mantilidewi; Zulvayanti Zulvayanti; Wiryawan Permadi
Indonesian Journal of Obstetrics & Gynecology Science Volume 1 Nomor 1 Maret 2018
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

AbstrakTujuan: Meneliti perbedaan karakteristik umur, paritas, besar uterus, kadar β-hCG, dan hiperproliferasi pada mola hidatidosa (MH) dengan regresi spontan dan pada MH dengan transformasi keganasan di RS Dr.Hasan Sadikin Bandung. Metode: Penelitian cross sectional deskriptif restrospektif mengambil data umur, paritas, besar uterus, kadar β-hCG pre-evakuasi, dan hiperproliferasi dari rekam medis pasien MH periode 2007-2016. Data diolah menggunakan program SPSS versi 20.0 for Windows. Nilai p<0,05 dianggap signifikan. Hasil: Dari 400 rekam medis yang dianalisis, 233 dengan data lengkap dapat dianalisis. Mayoritas pasien usia reproduktif 20-35(53,6%) tahun, paritas 1-2 (n=90, 38,6%), dan besar uterus rata-rata 19,12±4,633 (~minggu kehamilan). Kadar β-hCG <100000 mIU/mL sebanyak 78(33,5%), ≥100000 mIU/mL sebanyak 155(66,5%). Pasien dengan hiperproliferasi sebanyak 83(35,6%) sedangkan pasien tanpa hiperproliferasi sebanyak 150(64,4%). Terdapat 219(94,0%) dengan komplit MH, dan 14(6,0%) HM parsial (tidak dipublikasi). Pasien kemudian dikategorikan menjadi kelompok transformasi keganasan dan kelompok remisi spontan. Tidak terdapat perbedaan umur, paritas, dan besar uterus diantara dua kelompok (p>0,05). Perbedaan kadar βhCG (mIU/mL) dan tingkat proliferasi menunjukkan hasil signifikan (p<0.05). Kesimpulan: Kadar β-hCG preevakuasi dan status hiperproliferasi dapat digunakan sebagai prediktor transformasi keganasan pasien MH. Can Preevacuation Level β-hCG and Microscopic Trophoblast Proliferation Predict Malignant Transformation in Hydatidiform Mole?AbstractObjective: To describe differences among age, parity, size of uterus, level of β-hCG, and hyperproliferation state in HM with spontaneous remission and in that with malignancy transformation at dr.Hasan Sadikin General Hospital Bandung. Methods: This a cross sectional descriptive restrospective study of HM cases analyzing data on age, parity, size of uterus, pre-evacuation level of β-hCG, and hyperproliferation state taken from medical record of HM patients between 2007-2016. Data were statistically analyzed using SPSS version 20.0 for Windows. Result p<0.05 was considered significant. Results: Out of 400 cases, 233 cases were selected. Those with incomplete data were not included in the analysis. Majority of patients were in reproductive age 20-35(53.6%) years old, has parity 1-2(n=90, 38.6%), and the size of uterus has mean 19.12±4.633 (~week of pregnancy). The level of β-hCG <100000 mIU/mL was 78(33.5%), ≥100000 mIU/mL was 155(66.5%). Patients with hyperproliferation were 83(35.6%) while without hyperproliferation were 150(64.4%). There were 219(94.0%) with complete HM, and 14(6.0%) partial HM (unpublished data). There were no significant differences in age, parity, size of uterus between the two groups (p>0.05). Differences on level of βhCG (mIU/mL) and proliferation state showed significant result (p<0.05). Conclusion: Preevacuation level of β-hCG and histopatology (proliferation state) may predict malignancy transformation in HM.Keywords: Hydatidiform mole, risk factors, remission, malignancy transformation

Infeksi Luka Operasi pada Kanker Ginekologi Siti Salima; Kemala Isnainiasih Mantilidewi; Ali Budi Harsono
Indonesian Journal of Obstetrics & Gynecology Science Volume 5 Nomor 2 September 2022
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v5n2.425

Infeksi luka operasi (ILO) merupakan infeksi pada area operasi yang terjadi dalam waktu 30 hari setelah intervensi bedah. Menurut World Health Organization (WHO), ILO merupakan jenis infeksi nosokomial yang paling sering terjadi pada negara berpenghasilan rendah dan menengah dengan insidensi 11,8 episode per 100 prosedur bedah.1 Infeksi luka operasi dilaporkan terjadi pada 2.6-4.3% pasien yang menjalani operasi.2 Insidensi ILO setelah histerektomi bervariasi mulai dari 1.7-11% tergantung pendekatan operasi, indikasi operasi, dan penggunaan antibiotik profilaksis

Bacteriological Profile and Antibiotic Sensitivity Pattern of Surgical Site Infection Following Gynecologic Oncology Surgery at Hasan Sadikin General Hospital Kemala Isnainiasih Mantilidewi; Ali Budi Harsono; Jessica Kireina; Jaeni Pringgowibowo; Windy Natasya Al Baihaqi
Andalas Obstetrics And Gynecology Journal Vol. 6 No. 2 (2022)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.6.2.122-129.2022

Introduction: Surgical site infection (SSI) is the most common complication of gynecologic oncology surgeries. Understanding the characteristics, bacteriological profile, and antibiotic sensitivity pattern of SSI patients can help guide patientâ€™s management and reduce morbidity, mortality, and economic burden caused by SSI. The aim of this study is to describe the characteristics, bacteriological profile, and antibiotic sensitivity pattern of SSI patients following gynecologic oncology surgery at Hasan Sadikin General Hospital Bandung in 2021. Methods: This is a descriptive study that analyzed medical records of patients undergoing gynecologic oncology surgery at Hasan Sadikin Hospital Bandung from January to December 2021. Results: Out of 157 gynecologic oncology surgeries in 2021 that met the criteria, there were 11 incidences of SSI (7%). All SSI patients received postoperative antibiotics, with the most common type of antibiotic given being a combination of ceftriaxone and metronidazole. Ten out of the 11 specimens from SSI patients showed bacterial growth and a total of 17 bacterial isolates were found. Most specimens showed polymicrobial infection with the most common isolate being Escherichia coli Extended-Spectrum Beta-Lactamase (ESBL). Gram-positive bacteria in this study were most sensitive to Vancomycin, Tigecycline, and Gentamicin. Meanwhile, gram-negative bacteria were most sensitive to Ertapenem and Meropenem. Conclusion: Incidence of SSI following gynecologic oncology surgery at Hasan Sadikin General Hospital in 2021 is 7%. The most frequently found isolate was Escherichia coli ESBL. Gram-positive bacteria were most sensitive Vancomycin, Tigecycline, and Gentamicin; while gram-negative bacteria were most sensitive to Ertapenem and Meropenem.

Characteristics of Referral Patients with Gestational Trophoblastic Neoplasia in Dr. Hasan Sadikin General Hospital Bandung Kemala Isnainiasih Mantilidewi; Aditya Rifandi Zaenudin; Ali Budi Harsono; Anita Deborah Anwar; Jessica Kireina
Indonesian Journal of Cancer Vol 17, No 3 (2023): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i3.990

Background: : Gestational trophoblastic disease (GTD) is a heterogeneous group of lesions caused by abnormal trophoblast proliferation and the malignant form is called gestational trophoblastic neoplasia (GTN). Dr. Hasan Sadikin General Hospital, located in Bandung, West Java, is one of the main cancer referral hospitals in Indonesia. Consequently, the characteristics of GTN patients in this hospital can represent the general population in the province. This study aimed to elaborate on the characteristics of referral patients with GTN in Dr. Hasan Sadikin General Hospital.Methods: : Medical records of post-molar GTN patients in Dr. Hasan Sadikin General Hospital from between January 2019 to December 2020 were collected and analyzed. GTN was diagnosed according to the International Federation in Gynecology and Obstetrics (FIGO) criteria. Additionally, both the sociodemographic and clinical characteristics of patients were evaluated.Results: The results showed that among the 160 participants in this study, the overall mean age was 33±8.7 years, with a mean βhCG level of 241,461.81±630,557.90 mIU/mL. Moreover, approximately 16.3% had gestosis and 5% were diagnosed with hyperthyroidism. The majority of post-molar observations at the hospital were not carried out according to standards, with only 8.1% of patients receiving optimal surveillance. About 56.8% visited the hospital due to vaginal bleeding, while most histopathological results showed complete hydatidiform moles (44.4%), and choriocarcinomas (16.3%). Most of the patients were diagnosed as stage I (81.9%), had lowrisk FIGO scores (80.6%), and were treated with methotrexate (80.6%).Conclusions: GTN patients in Dr. Hasan Sadikin General Hospital showed clinical characteristics consistent with previous studies. The low percentage of patients receiving optimal post-molar surveillance could cause delayed referral. This suboptimal surveillance might be due to the high cost of βhCG testing, lack of facilities, and low patient compliance in West Java

Gambaran Faktor Risiko Kanker Endometrium di RSUP Dr. Hasan Sadikin pada Tahun 2020 – 2022 Erfiandi, Febia; Balqis, Shalma Alaika Aurel; Salima, Siti; Mantilidewi, Kemala Isnainiasih; Kurniadi, Andi; Wibowo, Viko Duvadilan
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 3 November 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v6i3.578

Tujuan: Mengetahui faktor risiko pasien kanker endometrium di RSUP Dr. Hasan Sadikin pada Tahun 2020 – 2022.Metode: Penelitian metode deskriptif dengan menggunakan data sekunder. Kriteria inklusi yaitu pasien dengan diagnosis utama kanker endometrium.Hasil: Mayoritas pasien kanker endometrium berusia 50 – 59 tahun (34,8%), multipara (40,9%), Indeks Masa Tubuh ≥25 kg/m2 (33,2%), usia menarche ≥12 tahun (68,8%), tidak memiliki riwayat infertilitas (49,0%), belum menopause (36,4%), tidak memiliki riwayat terapi hormon (74,1%), pasien tidak memiliki riwayat kanker/lynsch syndrome (71,7%), tidak memiliki riwayat keluarga dengan lynch syndrome (75,7%), tidak menggunakan kontrasepsi (42,5%), dan tidak memiliki riwayat hipertensi (72,9%).Kesimpulan: Pasien kanker endometrium di RSUP Dr. Hasan Sadikin Bandung periode tahun 2020 – 2022 ditemukan paling banyak pada rentang usia 50 – 59 tahun, status paritas yaitu multi para (≥2 kelahiran hidup), indeks massa tubuh ≥25 (obesitas), belum menopause, usia menarche ≥12 tahun, tidak memiliki riwayat terapi hormon, tidak terdapat riwayat infertilitas, pasien tanpa riwayat kanker, tidak memiliki riwayat keluarga dengan kanker, tidak menggunakan kontrasepsi, dan tidak memiliki riwayat hipertensi.Overview of Endometrial Cancer Risk Factors at RSUP Dr. Hasan Sadikin in 2020 - 2022AbstractObjective: Indentifying the risk factor of endometrial cancer patients at RSUP Dr. Hasan Sadikin in 2020 - 2022.Method: This research used descriptive method by collecting secondary data. The inclusion criteria was patients with primary diagnosis of endometrial cancerResults: In this research, the majority of endometrial cancer patients were aged 50 - 59 years (34,8%), multiparous (40,9%), with body mass index ≥25 kg/m² (33,2%), menarche age of ≥12 years (68,8%), no history of infertility (49,0%), not menopausal yet (36,4%), no history of hormone therapy (74,1%), no patient history of cancer/Lynch syndrome (71,7%), no family history of lynch syndrome (75,7%), no history of contraceptive use (42,55), and no history of hypertension (72,9%).Conclusion: In 2020 - 2022, endometrial cancer patient in Dr. Hasan Sadikin Central General Hospital Bandung were mostly foung in the aged range 50 - 59 years, multiparous, obesity, not menopausal yet, menarche age of ≥12 years, no history of hormone therapy, no patient and family history of cancer, no history of contraceptive use and hypertension.Key words: Endometrial cancer, risk factor, descriptive study

Karakteristik Tumor Trofoblas Gestasional Risiko Tinggi di RSUP Dr. Hasan Sadikin Bandung Tahun 2019 – 2021 Hidayat, Yudi Mulyana; Megantari, Salsa Bila; Harsono, Ali Budi; Suardi, Dodi; Mantilidewi, Kemala Isnainiasih
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 3 November 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v6i3.493

Tujuan: Penelitian ini bertujuan mengidentifikasi karakteristik demografi dan klinis pasien TTG risiko tinggi di RSUP Dr. Hasan Sadikin Bandung pada tahun 2019 – 2021.Metode: Penelitian ini menggunakan analisis secara deskriptif yang didapatkan melalui rekam medis pasien TTG risiko tinggi di RSUP Dr. Hasan Sadikin Bandung pada tahun 2019 – 2021 dengan metode total sampling. Hasil: Terdapat 69 rekam medis pasien yang memenuhi kriteria inklusi dan eksklusi. Hasil tersebut menunjukkan banyaknya pasien yang memiliki pendidikan terakhir pada jenjang SMA (49%), tidak memiliki pekerjaan (84%) yang didominasi oleh ibu rumah tangga, beretnis Sunda (93%), berasal dari daerah wilayah IV Priangan (54%), berusia lebih dari 40 tahun (57%), multipara (61%), memiliki riwayat mola (71%), interval dengan kehamilan sebelumnya 7 hingga 12 bulan (54%), kadar β-hCG yang diukur sebelum terapi sebanyak 10.000 - <100.000 mIU/mL (42%), tidak terjadi metastasis (68%) diikuti hasil terjadinya metastasis pada paru-paru (26%), tidak memiliki hasil pemeriksaan tipe histopatologi (61%) diikuti hasil tipe histopatologi koriokarsinoma (33%), dan memiliki stadium I (59%).Kesimpulan: Kasus TTG risiko tinggi di RSUP Dr. Hasan Sadikin Bandung pada tahun 2019 – 2021 lebih umum terjadi pada pasien yang memiliki pendidikan terakhir pada jenjang SMA, tidak memiliki pekerjaan yang didominasi oleh ibu rumah tangga, beretnis Sunda, berasal dari daerah wilayah IV Priangan, berusia lebih dari 40 tahun, riwayat multipara, riwayat mola, interval dengan kehamilan sebelumnya 7 hingga 12 bulan, kadar β-hCG yang diukur sebelum terapi sebanyak 10.000 - < 100.000 mIU/mL, tidak terjadi metastasis, dan memiliki stadium I.Characteristics of High Risk Gestational Trophoblast Neoplasia at Dr. Hasan Sadikin General Hospital Bandung in 2019 – 2021AbstractObjective: This research aims to identify the demographic and clinical characteristics of patients with high-risk GTN at Dr. Hasan Sadikin Bandung in 2019–2021.Method: This research used descriptive analysis, which was obtained from the medical records of patients with high-risk GTN at Dr. Hasan Sadikin General Hospital Bandung in 2019–2021 using the total sampling method.Results: 69 patient medical records met the inclusion and exclusion criteria. These results show that the number of patients who have had their last education at the high school level (49%), do not have a job (84%), are dominated by housewives, are of Sundanese ethnicity (93%), and come from region IV Priangan (54%), aged over 40 years (57%), multiparous (61%), had a history of molar (71%), an interval with a previous pregnancy of 7 to 12 months (54%), β-hCG level measured before therapy of 10,000– 100,000 mIU/mL (42%), no metastases (68%) followed by lung metastases (26%), no histopathological type (61%) followed by choriocarcinoma histopathological type (33%), and staging I (59%).Conclusion: High-risk GTN cases at Dr. Hasan Sadikin Bandung in 2019 – 2021 are more common in patients who have the last education at the high school level, do not have a job dominated by housewives, are of Sundanese ethnicity, come from the IV Priangan region, are over 40 years old, have a history of multiparas, a history of moles, an interval with a previous pregnancy of 7 to 12 months, β-hCG level measured before therapy was 10,000– 100,000 mIU/mL, no metastases occurred, and had stage I.Key words: Characteristics, Demographic, Gestational Trophoblastic Neoplasia, High Risk

Characteristics of Endometrioma Recurrence Patients Maharani, Chintia Dewi; Bayuaji, Hartanto; Syam, Hanom Husni; Ritonga, Mulyanusa Amarullah; Mantilidewi, Kemala Isnainiasih; Rinaldi, Andi; Pratiwi, Yuni Susanti
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 3 November 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v6i3.576

Objective: To identify the characteristics of endometrioma recurrence cases. Method: This study was a descriptive retrospective, using secondary data taken from all medical records of Clinic Aster and Medical Records Installation in Dr. Hasan Sadikin General Hospital, Bandung, from 1st January 2018 – 31st December 2022. Data were presented in tables.Results: Of the 37 endometrioma recurrences, most of the patients are 20 to 35 in age. None of them has a parity history after the first surgical procedure. Both previous and recent cases are dominantly unilateral endometriomas. The history of postoperative medication is higher (54,1%). Obstetricians/Gynecologists appear to perform the most surgical procedure (67,6%). Mass is the main clinical manifestation of the recurrence. While menstrual and BMI profiles appear to be normal.Conclusions: The characteristic of the recurrence of endometrioma is related parity status after the first surgery, history of the previous medical treatment, and previous form of endometrioma are related to the current characteristic of endometrioma (age, lesion form, clinical manifestation, and recurrence interval).Karakteristik Pasien Endometrioma RekurenAbstrakTujuan: Mengetahui karakteristik dari pasien endometrioma rekuren.Metode: Penelitian ini merupakan penelitian deskripsi retrospektif dengan menggunakan data sekunder yang diambil dari seluruh rekam medis pasien kista endometriosis rekuren di Klinik Aster dan Instalasi Rekam Medis di Rumah Sakit Umum Pusat Dr. Hasan Sadikin Bandung dengan periode 1 Januari 2018 – 31 Desember 2022. Kemudian, data-data disajikan dalam bentuk tabel. . Hasil: Dari 37 kasus e ndometrioma rekuren, sebagian besar pasien berusia 20 hingga 35 tahun. Seluruh pasien tidak mempunyai riwayat paritas setelah prosedur pembedahan sebelumnya. Baik kasus-kasus kista endometriosis sebelumnya maupun yang kambuh, keduanya dominan dalam bentuk unilateral. Riwayat pengobatan pasca operasi lebih tinggi (54,1%). Dokter Spesialis Obstetri/Ginekologi tampak melakukan tindakan pembedahan terbanyak (67,6%). Massa adalah manifestasi klinis utama dari kekambuhan. Selain itu, profil menstruasi dan BMI tampak normal.Kesimpulan: Karakteristik pada endometrioma rekuren berkaitan dengan status paritas setelah operasi pertama, riwayat pengobatan medis sebelumnya, dan bentuk endometrioma sebelumnya berhubungan dengan karakteristik endometrioma saat ini (usia, bentuk lesi, manifestasi klinis, dan rentang rekurensi)Kata kunci: karakteristik, rekuren, endometrioma

HALP and SII: Innovative Biomarkers for Diagnosing Ovarian Cancer in Both Epithelial and Non-Epithelial Subtypes Ridwan, Steven; Mantilidewi, Kemala Isnainiasih; A.W., Gatot Nyarumenteng; Kurniadi, Andi; Suardi, Dodi; Salima, Siti; Rauf, Syahrul; Hidayat, Yudi Mulyana
Indonesian Journal of Obstetrics & Gynecology Science Volume 8 Nomor 2 July 2025
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v8i2.882

Objective: To evaluate the diagnostic utility of PHAL (Platelet, Hemoglobin, Albumin, and Lymphocyte), SII (Systemic Immune Inflammation Index), and SIRI (Systemic Inflammatory Response Index) for both epithelial and non-epithelial ovarian cancer.Methods: A cross-sectional study of 156 patients with ovarian masses was conducted using preoperative laboratory data to calculate PHAL, SII, and SIRI scores. Histopathology confirmed diagnoses. Population I included all ovarian cancer types and benign tumors, while Population II included only non-epithelial ovarian cancer and benign tumors. Statistical analysis using SPSS 25.0, involved ROC curve and validity testing to assess diagnostic performance.Result: SII showed the best performance in the overall population (AUC 0.738; sensitivity 71.25%; specificity 72.37%; accuracy 71.79%; LR+ 2.58; LR– 0.40). In the subgroup of non-epithelial ovarian cancer versus benign tumors, PHAL had the highest diagnostic accuracy (AUC 0.819; sensitivity 81.81%; specificity 73.68%; accuracy 75.51%; LR+ 3.11; LR– 0.25).Conclusion: PHAL and SII are effective, accessible, and low-cost biomarkers that can support ovarian cancer diagnosis through routine blood tests.PHAL dan SII: Biomarker Inovatif untuk Diagnosis Kanker Ovarium Subtipe Epitel dan Non-Epitel Abstrak Tujuan: Penelitian ini bertujuan untuk mengevaluasi nilai diagnostik dari PHAL (Platelet, Haemoglobin, Albumin, dan Limfosit), SII (Systemic Immune Inflammation Index), dan SIRI (Systemic Inflammatory Response Index) pada kanker ovarium epitelial dan non-epitelial. Metode: Penelitian dengan metode potong lintang ini melibatkan 156 pasien dengan massa ovarium. Data laboratorium pra-operatif digunakan untuk menghitung skor PHAL, SII, dan SIRI. Diagnosis ditegakkan melalui pemeriksaan histopatologi. Populasi I mencakup semua jenis kanker ovarium dan tumor jinak, sedangkan Populasi II hanya mencakup kanker ovarium non-epitelial dan tumor jinak. Analisis statistik dilakukan menggunakan SPSS 25.0, termasuk analisis kurva ROC dan uji validitas untuk menilai kinerja diagnostik. Hasil: Hasil penelitian menyimpulkan bahwa SII memiliki performa terbaik pada seluruh populasi (AUC 0,738; sensitivitas 71,25%; spesifisitas 72,37%; akurasi 71,79%; LR+ 2,58; LR– 0,40). Pada subkelompok kanker ovarium non-epitelial dibandingkan dengan tumor jinak, PHAL menunjukkan akurasi diagnostik tertinggi (AUC 0,819; sensitivitas 81,81%; spesifisitas 73,68%; akurasi 75,51%; LR+ 3,11; LR– 0,25). Kesimpulan: PHAL dan SII merupakan biomarker yang efektif, mudah diakses, dan berbiaya rendah yang dapat mendukung diagnosis kanker ovarium melalui pemeriksaan darah rutin. Kata kunci: Kanker ovarium, Skor PHAL (Platelet-Hemoglobin-Albumin-Limfosit), Systemic Immune-Inflammation Index, Systemic Inflammatory Response Index

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