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All Journal Journal of Research and Technology JURNAL EDUCATION AND DEVELOPMENT Journal of Pharmaceutical Care Anwar Medika Journal Pharmasci (Journal of Pharmacy and Science) International Journal of Islamic and Complementary Medicine Farmasis: Jurnal Sains Farmasi
Suryandari, Mercyska
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Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Physics Public Health

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Aktivitas Antibakteri Daun Pepaya (Carica Pepaya) Menggunakan Pelarut Etanol Terhadap Bakteri Escherichia Coli Sudarwati, Tri Puji Lestari; Suryandari, Mercyska
Journal of Pharmaceutical Care Anwar Medika (J-PhAM) Vol 1 No 2 (2019): Volume 1, Nomor 2, Juni 2019
Publisher : STIKES Rumah Sakit Anwar Medika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36932/jpcam.v1i2.11

Abstract

Isolasi zat aktif dari herba menimbulkan pandangan baru bahwa tiap herba memiliki zat aktif (satu atau lebih). Carica papaya L memiliki zat aktif yang berhasil diisolasi, zat – zat tersebut dapat menggantikan pemakaian herba untuk tujuan pengobatan. Escherichia coli merupakan bakteri yang banyak terdapat di usus besar (colon) manusia dan sebagai flora normal colon, sifat Escherichia coli dapat menyebabkan infeksi primer pada usus besar sehingga menyebabkan penyakit diare. Sampel yang digunakan adalah Daun Pepaya tua berwarna hijau tua yang diperoleh dari UPT Materia Medika Batu. Dicuci bersih kemudian dikeringkan, kemudian dihaluskan dengan cara diblender. Proses ekstraksi menggunakan metode maserasi. Pengujian dilakukan dengan menggunakan 5 konsentrasi dan kontrol negatif. Metode pengujian antibakteri yang digunakan adalah difusi kertas cakram. Diameter zona hambat pada tiap konsentrasi dianalisis menggunakan statistik menggunakan uji ANOVA. Berdasarkan hasil pengujian dengan melakukan replikasi sebanyak 6 kali pada konsentrasi 20 µ g/mL dengan rata – rata 7,25 mm, 40 µ g/mL dengan rata – rata 7,43 mm, 60µ g/mL dengan rata – rata 7,7 mm, 80 µ g/mL dengan rata – rata 7,8 dan 100 µ g/mL dengan rata – rata 7,9 mm dengan kategori sedang. Dapat dikatakan terdapat pengaruh aktivitas antibakteri pada Daun Pepaya (Carica papaya L) dengan bakteri Escherichia coli maka, semakin tinggi konsentrasi maka daya hambat yang dihasilkan semakin tinggi.
Profil Peresepan Penyakit Mata Glaukoma pada Pasien BPJS Rawat Jalan (Studi dilaksanakan di RS Mata Masyarakat JawaTimur Periode Januari - Desember 2015) Mustofa, Achmad; Ulfa, Ninik Mas; Suryandari, Mercyska
Journal of Pharmacy and Science Vol. 1 No. 1 (2016): Journal of Pharmacy and Science
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v1i1.57

Abstract

ABSTRAKGlaukoma adalah penyakit kerusakan saraf optik mata, penyebabnya adalah tingginya tekanan bola mata, diatas 20mmHG. Rata-rata penderita glaukoma adalah glaukoma primer sudut terbuka (POAG) danglaukoma primer sudut tertutup (PACG). Di Rumah Sakit Mata Masyarakat (RSMM) JawaT imur, glaukoma menempati urutan ketiga dalam daftar 10 penyakit terbanyak. Sehingga dilakukan penelitian profil peresepan penyakit mataglaukoma pada pasien BPJS rawat jalan di RSMM Jatim periode Januari- Desember 2015.Penelitian ini bersifat observasional, pengambilan data bersifat retrospektif, penyajian data secara deskriptif. Observasi dengan mengumpulkan resep dokter mata, mencatat usia, golongan obat, nama generik, bentuk sediaan, prosentase obat glaukoma POAG dan glaukoma PACG. Hasil inklusi 2050 resepdan 1461 pasien glaukoma, terdapat 420 pasienglaukoma POAG, 190 pasien glaukoma PACG, dan 851 pasien glaukoma yang lain. Pasien terbanyak usia 61-80 tahun (52,50%), terendah usia ≥81 tahun sebanyak 49 pasien (3,35%). Bentuk sediaan terbanyak, yaitu tetes mata sebanyak 3766 (69,01%). Penggolongan obat terbanyak adalah penyekat β non selektif yaitu Timolol 1783 (32,67%), terendah golongan prostaglandin analog yaitu Travoprost 35 (0,64%). Pada glaukoma POAG, golongan terbanyak adalah golongan penyekat β non selektif yaitu Timolol 203 (29,29%), terendah adalah prostaglandin analog yaitu Latanoprost 83 (11,98%). Pada glaukoma PACG, terbanyak adalah penyekat β yaitu Timolol 81 (29,03%), terendah adalah golongan agonis kolinergik yaitu Pilokarpin 26 (9,32%). Pada penelitian ini disarankan agar dilakukan penelitian lebih lanjut tentang efektifitas peresepan penyakit mata glaukoma di RSMM Jatim.Kata kunci : peresepan glaukoma, glaukoma primer sudut terbuka, glaukoma primer sudut tertutup, klasifikasi obat.ABSTRACTGlaucoma is an eye disease that causes damages to the optic nerve, because high intraocular pressure, above 20mmHg.Glaucoma ranks third in the list of ten most diseases in RSMM. It is important to study the prescription profile of BPJS glaucoma patient in outpatient Eye Hospital in East Java Community period from January to December 2015. The inclusion in 2050 of a prescription, there are 1461 glaucoma patients. 420 with open-angle glaucoma(POAG), 120 patients with close-angle glaucoma (PACG), and 851 patients with others glaucoma. Based on the patient’s age, most patients aged 61-80 years (52.50%), lowest age of ≥81 years in 49 patients (3.35%). Based on the modest dosage forms, namely eye drops as much as 3766 (69.01%). Based on theclassification of drugs, most were non-selective β-blockers ie Timolol 1783 (32.67%), the least class of prostaglandin analogues were Travoprost 35 (0.64%). In POAG, the modest group was non-selective β-blockers ie Timolol 203 (29.29%), carbonic anhydrase inhibitors group, ie Acetazolamide 181 (26.12%), prostaglandin analogues group ie Latanoprost 83 (11.98%). In PACG the modest group was β-blockers, ie Timolol 81 (29.03%), carbonic anhydrase inhibitors group ie Acetazolamide 70 (25.09%), cholinergic agonist group ie Pilocarpine 26 (9.32%). In this study’s suggested that further research on the effectiveness of the prescription of eye disease glaucoma in Community Eye Hospital East Java.Keywords: Glaucoma prescription, primary open angle glaucoma, primary angle-closure glaucoma, drug classification
Validasi Metode Analisis Formaldehid Pada Tisu Basah Wahyuniati, Dwi; Yulianti, Cicik Herlina; Suryandari, Mercyska
Journal of Pharmacy and Science Vol. 3 No. 2 (2018): Journal of Pharmacy and Science
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v3i2.117

Abstract

ABSTRAKTisu basah merupakan istilah umum untuk menggambarkan sepotong bahan, umumnya ditambahkan dengan komposisi cairan atau semi cair, dimaksudkan untuk membersihkan dan memberikan rasa lembut. Tisu basah memiliki struktur berserat terdiri dari campuran serat selulosa pulp dan regenerasi, seperti rayon dan atau liosel, dengan atau tanpa serat pengikat. Pada proses produksi, komponen-komponen yang sengaja ditambahkan pada pembuatan tisu basah salah satunya adalah formaldehid sebagai penguat keadaan basah. Akan tetapi penggunaan yang berlebihan dapat menyebabkan ruam pada kulit (dermatitis). Pada penelitian ini dilakukan validasi metode analisis formaldehid pada tisu basah dengan menggunakan metode absorpsi uap SNI ISO 14184-2:2015 dengan pereaksi nash menggunakan spektrofotometri UV-Vis. Sampel yang digunakan adalah tisu basah dari satu merek. Validasi metode dilakukan untuk memastikan metode SNI ISO 14184-2:2015 dapat diterapkan, diperoleh hasil valid, dengan nilai R = 0,9993, yang mendekati nilai 1, menghasilkan persamaan regresi linier y = 0,0294x - 0,0317. Pengujian akurasi diperoleh rata-rata persen recovery sebesar 84,54%, 102,05%, dan 106,13%. Nilai RSD sebesar 1,62%. Hasil nilai LOD sebesar 0,040, sedangkan hasil nilai LOQ sebesar 0,136. Hasil validasi terhadap metode SNI ISO 14184 – 2 : 2015 dapat disimpulkan bahwa metode SNI ISO 14184-2:2015 dapat digunakan untuk menguji formaldehid pada tisu basah. Kata kunci: Validasi, Tisu basah, Formaldehid, Pereaksi Nash, Spektrofotometri UV-Vis.ABSTRACT Wet wipes are the general terms to describe a piece of material, generally impregnated with a liquid or semi liquid composition, intended to both cleaning and providing a smooth feeling. Wet wipes has fibrous structures consist of a mixture of pulp and regenerated cellulose fibers, such as rayon and/or lyocell, with or without binding fibers. In product process, one of components expressly added was formaldehyde as strengthener as wet condition. But, excessive use of formaldehyde can cause skin rash (dermatitis). This study was aimed to Analysis Method Validation of Formaldehyde of Wet Wipes used vapour absorption SNI ISO 14184-2:2015 method with Nash Reagents by UV-Vis Spectrophotometry, and used vapour absorption method. The wet wipes sample used was from one brand. Method validation was conducted to definite SNI ISO 14184-2:2015 method can be applied, the result was valid, r value is 0,9993, the linear regression y = 0,0294x – 0,0317, accuracy percent recovery study showed 84,54%, 102,05%, and 106,13%., Related standar deviation showed 1,62%, limit of detection was 0,040, limit of quantitation was 0,136. The validation result of SNI ISO 14184-2:2015 method can be concluded that SNI ISO 14184-2:2015 method can be applied to examine formaldehid on wet wipes.Keywords: Wet wipes, Formaldehyde, Validation, Nash Reagent, UV-Vis Spectrophotometry.
Fraksinasi dan Identifikasi Ektrak Daun Mitragyna Speciosa Menggunakan Metode Kromatografi Fernanda, M.A. Hanny Ferry; Suryandari, Mercyska; Sudarwati, Tri Puji Lestari
FARMASIS: Jurnal Sains Farmasi Vol 2 No 2 (2021): Farmasis : Jurnal Sains Farmasi
Publisher : Universitas PGRI Adi Buana, Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36456/farmasis.v2i2.4072

Abstract

Background: Mitragyna Speciosa or better known as Kratom is a typical plant from the Putusibau area, West Kalimantan. The most widely used part of this plant is the leaves. The kratom plant contains alkaloids, flavonoids, phenols, terpenoids-steroids, triterpenoids, saponins, and tannins. Alkaloid content is the most dominant and has benefits in this plant so it is necessary to do fractionation and identification of secondary metabolites. Objective: To fractionate and identify secondary metabolites from Mitragyna Speciosa leaf extract. Methods: The fractionation method was carried out using Column Chromatography while for identification using Thin Layer Chromatography. Results: 80 fractions were obtained from the column chromatography results, while the results of identification using thin layer chromatography showed that only the 2nd and 3rd fractions were obtained. The second fraction has two spots with Rf values of 0.51 and 0.73 and in the third fraction there are three spots with Rf values of 0.21; 0.52, and 0.74. Conclusion: Fractionation and identification by chromatographic method can be used as initial screening for secondary metabolite content in Mitragyna Speciosa leaf extract.
ANALISIS BEBAN KERJA PERSONIL SORTIR PADA PROSES PRODUKSI SEDIAAN KAPSUL LUNAK DI PT X Suryandari, Mercyska; Hatidja, Siti Annurijati; Avanti, Christina
Journal of Research and Technology Vol. 6 No. 1 (2020): JRT Volume 6 No 1 Jun 2020
Publisher : 2477 - 6165

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (376.398 KB) | DOI: 10.55732/jrt.v6i1.151

Abstract

Productivity is one of the important aspects that must be owned by a company to achieve the goals. Therefore, to improve productivity, it is necessary to analyze the workload of employees and improve the work procedures. Workload analysis carried out in this study aimed to determine the optimal workforce requirements of the sorting process in the soft capsule production unit at Pharmaceutical Company PT X. The observational method has been applied to this study. The data of this study were obtained by observing the process directly and conducting face-to-face interviews with the employees at the location of soft capsule production. Based on the workload analysis using a Full-Time Equivalent (FTE) method, it was found that a total value of 2.07 was obtained from the eleven activities in the sorting section. If the FTE was assessed for each person in the sorting section, then the FTE value for each personnel was 0.52. This value is in the underload category. Therefore, the number of personnel and the work procedures need to be adjusted.
IDENTIFICATION AND QUANTIFICATION OF MAJOR POLYPHENOLS IN DIFFERENT TYPES OF OLIVE OIL: A SYSTEMATIC REVIEW OF HEALTH BENEFITS Suryandari, Mercyska; Isdianto, Andik; Fitrianti, Novariza
International Journal of Islamic and Complementary Medicine Vol. 5 No. 1 (2024): International Journal of Islamic and Complementary Medicine
Publisher : International Islamic Medicine Forum

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55116/IJICM.V5I1.86

Abstract

Olive oil is a key component of the Mediterranean diet, renowned for its flavor and health benefits, especially for its polyphenol content. These polyphenols have strong antioxidant properties, protecting cells from oxidative stress and reducing the risk of chronic diseases such as cardiovascular disease, cancer, and neurodegenerative disorders. This study aims to systematically identify and quantify the main polyphenols in different types of olive oil, including Extra Virgin Olive Oil (EVOO), Virgin Olive Oil (VOO), Refined Olive Oil (ROO), Pure Olive Oil (POO), and Pomace Olive Oil. Using a qualitative approach and descriptive analysis, a comprehensive literature study was conducted to collect and evaluate research on polyphenol content in various olive oils. The results showed significant differences in polyphenol profiles. EVOO, which is produced through cold pressing without heat or chemicals, has the highest polyphenol content, offers superior health benefits and complex flavors. VOO, although more processed, still contained moderately high polyphenols, suitable for medium temperature cooking. ROO, which is extensively processed, has lower polyphenol levels, ideal for high temperature cooking but with fewer health benefits. POO, a blend of VOO and ROO, offers a balance of flavor and practicality. Pomace Olive Oil, with the lowest polyphenol content, is used mainly for industrial frying due to its high smoke point. In conclusion, this study emphasizes the importance of choosing the type of olive oil based on its use and health benefits. EVOO is optimal for raw or lightly cooked dishes, VOO for all- purpose cooking, and ROO and Pomace Olive Oil for high temperature applications. This research guides consumers and manufacturers in making the right choice to optimize the health benefits of olive oil.
PRESCRIPTION PROFILE OF ANTIHYPERTENSIVE DRUGS IN PREECLAMPSIA PATIENTS AT KIRANA HOSPITAL Lubada, Eziah Ika; Fandinata, Selly Septi; Alfiana, Silvina Sita; Suryandari, Mercyska; Isdianto, Andik
International Journal of Islamic and Complementary Medicine Vol. 5 No. 1 (2024): International Journal of Islamic and Complementary Medicine
Publisher : International Islamic Medicine Forum

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55116/IJICM.V5I1.87

Abstract

Preeclampsia is a complication of pregnancy with symptoms of hypertension ≥ 140/90 mmHg and proteinuria ≥ 0.3 grams/24 hours or 30 mg/dl (+1 dipstick) arising after more than 20 weeks of gestation in previously normotensive pregnant women. Maternal deaths in Indonesia in 2021 related to hypertension in pregnancy reached 1077 cases (Source: Directorate General of Public Health, Ministry of Health, 2021). Pharmacological therapy intervention, antihypertensive treatment is also needed in addition to maintaining a healthy lifestyle. The purpose of the study was to determine the description of pharmacological therapy including the pharmacological class of drugs, drug names, drug doses, rules of use, and types of antihypertensive drug therapy (single / combination) in patients with preeclampsia. This type of descriptive observational research is retrospective with total sampling obtained from medical records and patient prescriptions. The results of this study were the incidence of preeclampsia aged 35 years and over by 21 patients (36%) and the most common diagnosis was mild preeclampsia by 38 samples (66%). The use of nifedipine which is included in the CCB (Calcium Channel Blocker) group was 42 respondents (72%). Meanwhile, the use of methyldopa which is included in the central sympatholytic group was 17 respondents (28%). In the single therapy type study, 59 prescriptions (100%) used nifedipine or methyldopa. Pregnant women are encouraged to routinely conduct antenatal care checks at the hospital every month.
KEAMANAN DAN EFEKTIVITAS MINYAK ZAITUN SEBAGAI TERAPI TOPIKAL DALAM MENGATASI PERADANGAN KULIT Suryandari, Mercyska; Isdianto, Andik
JURNAL EDUCATION AND DEVELOPMENT Vol 13 No 1 (2025): Vol 13 No 2 Mei 2025
Publisher : Institut Pendidikan Tapanuli Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37081/ed.v13i1.6890

Abstract

Penelitian ini mengkaji efek terapi minyak zaitun terhadap peradangan kulit melalui tinjauan literatur. Minyak zaitun, yang telah lama digunakan dalam pengobatan tradisional, mengandung komponen bioaktif seperti asam oleat, polifenol (hidroksitirosol dan oleuropein), serta vitamin E, yang memiliki sifat anti-inflamasi, antioksidan, dan antimikroba. Metode penelitian yang digunakan adalah literature review, yang mengumpulkan dan menganalisis berbagai sumber relevan, termasuk artikel jurnal, buku, laporan penelitian, dan sumber online terpercaya. Hasil penelitian menunjukkan bahwa asam oleat dalam minyak zaitun dapat mengurangi produksi molekul pro-inflamasi, polifenol mampu menetralkan radikal bebas dan mengurangi stres oksidatif, sementara vitamin E melindungi sel-sel kulit dari kerusakan oksidatif dan mempercepat regenerasi jaringan kulit. Beberapa penelitian klinis dan pra-klinis mendukung efek anti-inflamasi minyak zaitun, menunjukkan pengurangan gejala peradangan seperti kemerahan, gatal, dan pembengkakan pada pasien dengan dermatitis atopik. Penelitian ini memberikan dasar yang kuat untuk penelitian lebih lanjut dan aplikasi klinis minyak zaitun sebagai terapi topikal yang aman dan efektif dalam mengatasi peradangan kulit. Dengan demikian, minyak zaitun adalah alternatif bahan alami yang menjanjikan untuk perawatan peradangan kulit
MANFAAT MINYAK ZAITUN SEBAGAI AGEN TERAPI ALAMI UNTUK PENYEMBUHAN LUKA Isdianto, Andik; Suryandari, Mercyska; Fitrianti, Novariza
JURNAL EDUCATION AND DEVELOPMENT Vol 13 No 1 (2025): Vol 13 No 2 Mei 2025
Publisher : Institut Pendidikan Tapanuli Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37081/ed.v13i1.6408

Abstract

Penelitian ini mengkaji efek terapi minyak zaitun terhadap penyembuhan luka melalui tinjauan literatur. Minyak zaitun, yang telah lama digunakan dalam pengobatan tradisional, mengandung komponen bioaktif seperti asam oleat, vitamin E, dan polifenol yang memiliki sifat anti-inflamasi, antimikroba, dan antioksidan. Metode yang digunakan dalam penelitian ini adalah literature review, di mana artikel jurnal, buku, dan laporan penelitian yang relevan dianalisis untuk mengidentifikasi tema utama dan pola dalam literatur yang ada. Hasil tinjauan menunjukkan bahwa aplikasi topikal minyak zaitun dapat mengurangi peradangan, mencegah infeksi, meningkatkan produksi kolagen, dan menjaga hidrasi kulit, sehingga mempercepat proses penyembuhan luka. Studi klinis dan preklinis mendukung temuan ini, menunjukkan bahwa minyak zaitun dapat meningkatkan penutupan luka, mengurangi rasa sakit, dan meningkatkan kualitas hidup pasien. Selain itu, penelitian juga menemukan bahwa minyak zaitun memiliki efek ganda pada luka akut, termasuk pengaruh positif terhadap produksi sitokin dan migrasi fibroblas dermal melalui aktivasi jalur Nrf2. Meskipun hasil-hasil ini menjanjikan, masih diperlukan penelitian lebih lanjut untuk mengkonfirmasi temuan-temuan ini dan memperluas pemahaman tentang aplikasi klinis minyak zaitun dalam berbagai jenis luka dan kondisi kulit. Secara keseluruhan, minyak zaitun muncul sebagai terapi topikal yang efektif dan alami untuk penyembuhan luka, yang dapat dipertimbangkan sebagai alternatif atau pelengkap dalam perawatan luka dengan dukungan bukti ilmiah yang semakin kuat dari penelitian yang berkelanjutan.
ANALISIS BEBAN KERJA PERSONIL SORTIR PADA PROSES PRODUKSI SEDIAAN KAPSUL LUNAK DI PT X Suryandari, Mercyska; Hatidja, Siti Annurijati; Avanti, Christina
Journal of Research and Technology Vol. 6 No. 1 (2020): JRT Volume 6 No 1 Jun 2020
Publisher : 2477 - 6165

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55732/jrt.v6i1.151

Abstract

Productivity is one of the important aspects that must be owned by a company to achieve the goals. Therefore, to improve productivity, it is necessary to analyze the workload of employees and improve the work procedures. Workload analysis carried out in this study aimed to determine the optimal workforce requirements of the sorting process in the soft capsule production unit at Pharmaceutical Company PT X. The observational method has been applied to this study. The data of this study were obtained by observing the process directly and conducting face-to-face interviews with the employees at the location of soft capsule production. Based on the workload analysis using a Full-Time Equivalent (FTE) method, it was found that a total value of 2.07 was obtained from the eleven activities in the sorting section. If the FTE was assessed for each person in the sorting section, then the FTE value for each personnel was 0.52. This value is in the underload category. Therefore, the number of personnel and the work procedures need to be adjusted.
Co-Authors Alfiana, Silvina Sita Andik Isdianto Avanti, Christina Cicik Herlina Yulianti Fernanda, M.A. Hanny Ferry Fitrianti, Novariza Hatidja, Siti Annurijati Lubada, Eziah Ika Mustofa, Achmad Septi Fandinata, Selly Sudarwati, Tri Puji Lestari Ulfa, Ninik Mas Wahyuniati, Dwi