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Studi Efektifitas Antiretroviral Regimen Obat Kombinasi Dosis Tetap (Tenofovir/Lamivudin/Efavirenz) Berdasarkan Peningkatan Kadar Cd4 T-Limfosit (Studi dilakukan di Intalasi Farmasi Rumah Sakit X Surabaya) Wardani, Putri Kusuma; Ulfa, Ninik Mas; Natalia, A.C Aditya
Journal of Pharmacy and Science Vol. 2 No. 1 (2017): Journal of Pharmacy and Science
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v2i1.62

Abstract

ABSTRAKHIV adalah virus yang secara bertahap menyerang sistem kekebalan tubuh manusia. HIV dapat menyebabkan AIDS (Acquired Immune Deficiency Syndrome) dan sel yang terinfeksi yang memiliki molekul Cluster of Differentiation 4 (CD4). Pengobatan dengan antiretroviral memiliki mekanisme tindakan untuk mencegah replikasi virus yang secara bertahap menurunkan jumlah virus dalam darah. Penelitian ini observasional yang dilakukan secara retrospektif selama 2 tahun (Januari 2014 - Desember 2015) pada pasien HIV / AIDS denganjumlah 51 pasien rawat jalan. Hasil studi observasional menunjukkan bahwa pengobatan dengan antiretroviral regimen obat kombinasi dosis tetap (Tenofovir 300 mg + Lamivudin 300 mg + Efavirenz 600 mg) mengalami peningkatan jumlah CD4 selama terapi dan analisis statistik deskriptif menunjukkan bahwa ada perbedaansebelum dan sesudah terapi, sehingga dapat disimpulkan bahwa antiretroviral regimen obat kombinasi dosis tetap efektif.Kata Kunci: HIV / AIDS, CD4 T-Limfosit, Tenofovir, Lamivudin, Efavirenz.ABSTRACTHIV is a virus that gradually attack the human immune system. HIV can lead to the AIDS (Acquired Immune Deficiency Syndrome) and infected cells that have molecul Cluster of Differentiation 4 (CD4). Treatment withantiretroviral have mechanism of action to prevent replication virus which is step by step decrease the amount of virus in blood. This observasional study conducted retrospectively during 2 years (Januari 2014 - December2015) againt patient HIV/AIDS with 51 outpatients. The result of the observational study showed that treatment with Antiretroviral Fixed Dose Combination (Tenofovir 300 mg + Lamivudin 300 mg + Efavirenz 600 mg) had increased CD4 level during therapy and descriptive statistic analysis showed that there was a differences in preand post theraphy, so if could be concluded that Antiretroviral Fixed Dose Combination administration was effective.Key Words: HIV/AIDS, CD4 T-Limfosit, Tenofovir, Lamivudin, Efavirenz.
ANALISIS MANAJEMEN LABA DITINJAU DARI KINERJA KEUANGAN, GOOD CORPORATE GOVERNANCE, DAN KEBIJAKAN DIVIDEN PADA PERUSAHAAN MAKANAN DAN MINUMAN Wardani, Putri Kusuma
Jurnal Perspektif Bisnis Vol. 6 No. 2 (2023): Jurnal Perspektif Bisnis
Publisher : Jurusan Administrasi Bisnis, FISIP, Universitas Lampung

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Abstract

Penelitian ini bertujuan untuk menguji pengaruh kinerja keuangan, good corporate governance, dan kebijakan dividen terhadap manajemen laba. Populasi dalam penelitian ini adalah perusahaan makanan dan minuman yang terdaftar di Bursa Efek Indonesia (BEI) selama periode tahun 2015-2020. Sampel penelitian ini diambil dengan menggunakan metode purposive sampling. Penelitian ini menggunakan teknik analisis data panel dengan menggunakan alat analisis eviews 11. Hasil penelitian ini menunjukkan bahwa variabel kinerja keuangan tidak berpengaruh terhadap manajemen laba, variabel good corporate governance tidak berpengaruh terhadap manajemen laba, dan variabel kabijakan dividen berpengaruh terhadap manajemen laba. Kata kunci : Kinerja Keuangan, Good Corporate Governance, Kebijakan Dividen, Manajemen Laba
HUBUNGAN NILAI KUAT PANTUL ALAT SCHMIDT HAMMER TERHADAP KUAT TEKAN BETON AGREGAT BOLA PLASTIK Alkhaly, Yulius Rief; Mukhlis, Mukhlis; Wardani, Putri Kusuma
TECHSI - Jurnal Teknik Informatika Vol 12, No 2 (2020)
Publisher : Teknik Informatika Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/techsi.v12i3.9195

Abstract

Beton ringan adalah beton yang memiliki densitas lebih kecil dari beton pada umumnya. Padapenelitian ini, telah dihasilkan suatu beton ringan yang menggunakan bola plastik sebagaiagregat kasar. Pengujian terhadap beton agregat bola plastik (BP) dilakukan melalui uji kuatpantul dan uji kuat tekan. Penelitian dilakukan di Laboratorium Teknik Sipil UniversitasMalikussaleh. Benda uji dibuat sebanyak 12 buah berbentuk silender 15 cm x 30 cm, bolaplastik digunakan berdiameter 6 mm. Pada perencanaan campuran beton, agregat kasardigantikan dengan bola plastik sebesar 25%, 50%, dan 100% pada perbandingan volume. Fasyang digunakan 0.48, dengan bahan pengikat: semen Andalas type I. Dari hasil pengujiandiperoleh: untuk kuat pantul beton normal (BN) didapat 32,43 Mpa, untuk kuat pantul betonringan 25% (BP1) didapat 24,39 Mpa, untuk kuat pantul beton ringan 50% (BP2) didapat 22,61Mpa, dan untuk kuat pantul beton ringan 100% (BP3) didapat 20,56 Mpa. Sedangkan hasilpengujian kuat tekan untuk sampel BN didapat 24,72 Mpa, dan untuk sampel BP1, BP2, BP3,didapat hasil kuat tekan masing-masing 17,17 Mpa, 14,91 Mpa, 12,08 Mpa. Hasil nilai kuatpantul dan kuat tekan beton BP menunjukkan penurunanan yang signifikan dari pada nilai kuatpantul dan tekan beton normal. Sedangkan densitas kuat tekan beton BP juga menunjukkanpenurunan yang signifikan dari pada densitas kuat tekan beton normal. Hubungan nilai kuatpantul dan kuat tekan beton dapat dinyatakan dengan persamaan: untuk sampel BN, y =1.4402x – 3.1672, ( R2= 0.9595), untuk sampel BP1, y = 4.677x – 55.926, ( R2= 0.9874), untuksampel BP2, y = 0.2182x + 19.36, ( R2= 0.9839), dan untuk sampel BP3, y = 0.7412x + 11.509, (R2= 0.592). Selanjutnya beton dengan sampel BP1 dan BP2 tidak dapat dikategori sebagaibeton ringan, karena densitasnya masing-masing sebesar 2380 kg/m3 dan 2144 kg/m3.Sedangkan beton dengan BP3 dapat di kategorikan sebagai beton ringan, BP3 mempunyaidensitasnya 1724 kg/m3. Dengan demikian agregat bola plastik berpotensi sebagai agregatuntuk pembuatan beton ringan dengan mutu 12 Mpa. Kelas mutu tersebut tergolong kedalambeton ringan non struktural.
Pengaruh Motivasi Kerja, Fleksibilitas Jam Kerja, Dan Stres Kerja Terhadap Kinerja Karyawan Pada Warkop DKI Lagi Kota Malang Wardani, Putri Kusuma; Djaelani, Abdul Kodir; Novianto, Abdullah Syakur
E-JRM : Elektronik Jurnal Riset Manajemen E-JRM : Elektronik Jurnal Riset Manajemen Vol. 13 No. 01
Publisher : UNIVERSITAS ISLAM MALANG

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Abstract

Abstract This study aims to identify the effect of motivation, flexibility, and stress on employee performance at Warkop DKI Lagi Malang City. This study uses quantitative methods. The population of this research employees Warkop DKI Lagi Kota Malang by using a saturated sample, as many as 45 respondents. Methods of data collection using a questionnaire. The analytical method used in this study is multiple regression analysis with SPSS 26 for windows. The results of this study indicate a significant positive influence among the variables of motivation, flexibility, and stress on employee performance at Warkop DKI Lagi in Malang City. Keywords: Motivation, Flexibility, and Stress 
Project Activities Strengthening the Profile of Pancasila Students with Learning Based on Local Cultural Wisdom Utami, Budi; Probosari, Riezky Maya; Indriyanti, Nurma Yunita; Fakhrudin, Isma Aziz; Khasanah, Annisa Nur; Supurwoko, Supurwoko; Wardani, Putri Kusuma
Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan Vol 9, No 2: FEBRUARY 2024
Publisher : Graduate School of Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/jptpp.v9i2.25361

Abstract

This research aims to determine the implementation of project activities to strengthen the Pancasila Student Profile at State Junior High School 1 (SMP Negeri 1) Surakarta, Central Java, Indonesia, and the impact of its implementation on students. The profile of Pancasila students is: 1) Believer, devoted to God Almighty and has noble character, 2) Independent, 3) cooperation, 4) Global diversity, 5) Critical reasoning, 6) Creative based on local wisdom by making Batik, namely Batik Jumputan and Written Batik, in Solo (Surakarta), Central Java, Indonesia. The research population was in one of the junior high schools in Surakarta (SMP Negeri 1 Surakarta). The Pancasila Student Profile can be identified as starting to develop, currently developing according to expectations, and very developing. From the observations, it is known that the Project for Strengthening the Profile of Pancasila Students (P5) at SMP Negeri 1 Surakarta has developed according to expectations by 60% and has developed very well at 40%. However, there is still a weakness, namely that the assessment of the aspects of the Project for Strengthening the Profile of Pancasila Students (P5) as a group is not yet known individually so the aspects that stand out individually are not yet known.
PERAN FLAVONOID TERHADAP TNF ALPHA PADA ENDOMETRIOSIS Wardani, Putri Kusuma; Gunarti, Dwirini Retno; Wulandari, Yohannessa
JURNAL DARMA AGUNG Vol 31 No 3 (2023): JUNI
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Darma Agung (LPPM_UDA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46930/ojsuda.v31i3.3454

Abstract

Endometriosis adalah kondisi yang ditandai oleh pertumbuhan jaringan endometrium di luar rahim, yang dapat menyebabkan gejala nyeri panggul dan gangguan reproduksi. Penelitian sebelumnya telah menunjukkan bahwa tingkat sitokin pro-inflamasi, seperti TNF alpha, meningkat pada endometriosis. Flavonoid, senyawa yang ditemukan dalam berbagai tanaman, telah menunjukkan potensi antiinflamasi dan dapat mempengaruhi ekspresi TNF alpha. Oleh karena itu, penelitian ini bertujuan untuk memahami peran flavonoid dalam mengatur TNF alpha pada endometriosis. Tujuan penelitian ini adalah untuk menginvestigasi peran flavonoid terhadap ekspresi TNF alpha pada endometriosis. Penelitian ini menggunakan metode penelitian kualitatif untuk mendapatkan pemahaman mendalam tentang peran flavonoid dalam hubungannya dengan TNF alpha pada endometriosis. Data dikumpulkan melalui studi kepustakaan yang diperoleh melalui Google Schoolar dan PubMed. Hasil penelitian menunjukan bahwa peran flavonoid memiliki peran dalam mengatur produksi dan aktivitas TNF alpha dalam tubuh. Flavonoid dapat menghambat produksi TNF alpha di tingkat sel dengan mengganggu jalur sinyal yang terlibat dalam regulasi produksi sitokin ini. Sehingga dapat disimpulkan bahwa flavonoid memiliki peran penting dalam endometriosis melalui mekanisme anti-inflamasi dan antiangiogenesis sebagai penghambatan ekspresi dan aktivitas TNF alpha, pengendalian pertumbuhan jaringan endometrium, dan regulasi sistem imun.
Penerapan Permainan KarNuSik (Kartu Numerasi Asik) dalam Pembelajaran Matematika Wardani, Putri Kusuma
Journal of Innovation in Teaching and Instructional Media Vol 5 No 1 (2024): Journal of Innovation in Teaching and Instructional Media
Publisher : Yayasan Sembilan Pemuda Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52690/jitim.v5i1.939

Abstract

This study aims to evaluate the effectiveness of implementing the KarNuSik game (Kartu Numerasi Asik) in enhancing mathematical understanding and learning motivation among fifth-grade students at SD Negeri 58 Palembang. The research method employed is an experimental design using pre-test and post-test. The respondents of this study are 30 students who face difficulties in mathematics learning. Data were collected through pre-tests, post-tests, questionnaires, and observation sheets. The results indicate that the average pre-test score of the students was 65, while the average post-test score increased to 82, with a t-test showing a p-value < 0.05, indicating a significant difference. Furthermore, questionnaire analysis revealed that approximately 85% of the students reported an increase in their learning motivation after participating in the game. These findings suggest that the KarNuSik game not only enhances students’ understanding of mathematical concepts but also motivates them to participate more actively in learning. The social interactions that occur during the game also contribute to the development of students’ communication and collaboration skills. Despite these positive outcomes, some students still encounter difficulties with certain concepts, highlighting the importance of providing additional support from teachers. This study is expected to contribute to the development of more innovative and effective teaching methods in the classroom.
The effect of video modeling and tell-show-do on anxiety during dental radiographic examinations among children Tania, Laura; Yanuaryska, Ryna Dwi; Wardani, Putri Kusuma
Majalah Kedokteran Gigi Indonesia Vol 11, No 1 (2025): April
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.97994

Abstract

Dental procedure anxiety refers to the fear experienced before and during dental treatment. To reduce anxiety levels in children undergoing radiographic examinations, non-pharmacological behavioral management techniques such as tell-show-do and modeling can be employed. This study aimed to compare the effectiveness of video modeling and the tell-show-do technique in reducing anxiety in children aged 5–7 years undergoing dental radiographic examinations at RSGM Prof. Soedomo, UGM. This quantitative study used a pretest–posttest control group design. The participants were children aged 5–7 years who underwent radiographic examinations at the Radiology Department of RSGM Prof. Soedomo, UGM, between September and December 2023. The sample was divided into three groups: Group A received the video modeling intervention, Group B received the tell-show-do intervention, and Group C served as the control group. Data were collected using the Modified Dental Anxiety Scale (MDAS) questionnaire and physiological anxiety measurements (blood pressure and pulse rate) using an Omron HEM-6161 digital tensiometer. MDAS scores were analyzed using the Kruskal-Wallis test, while blood pressure and pulse rate were analyzed using one-way ANOVA. A total of 146 participants were included. Significant differences were observed in MDAS scores, blood pressure, and pulse rate from pretest to posttest among all groups (p < 0.05). The tell-show-do group showed the greatest reduction in anxiety (3.74 ± 2.62), followed by the video modeling group (3.33 ± 2.30), and the control group (0.92 ± 2.33). Both the tell-show-do technique and video modeling are effective in reducing dental anxiety in children aged 5–7 years undergoing radiographic examinations at RSGM Prof. Soedomo, UGM.
Pengaruh Supervisi dan Kepemimpinan Kepala Sekolah terhadap Kinerja Guru SD di Ilir Timur II: The Influence of Principal Supervision and Leadership on Elementary School Teacher Performance in Ilir Timur II Wardani, Putri Kusuma; Arafat, Yasir; Eddy, Syaiful
Edu Cendikia: Jurnal Ilmiah Kependidikan Vol. 5 No. 02 (2025): Research Articles, August 2025
Publisher : ITScience (Information Technology and Science)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47709/educendikia.v5i02.6802

Abstract

This study aims to analyze the influence of supervision and principal leadership on the performance of elementary school teachers in Ilir Timur II District. The research employs a quantitative design, utilizing a survey method. The instrument, a questionnaire, has been tested for validity and reliability. The research population consists of all elementary school teachers in Ilir Timur II District, using a total sampling. Data are analyzed with multiple linear regression. The results indicate that supervision has a significant impact on teacher performance (? = 0.421; t = 4.32; p < 0.05). Principal leadership also significantly affects teacher performance (? = 0.367; t = 3.95; Sig. < 0.05). Together, supervision and principal leadership account for R² = 0.52, or 52%, of teacher performance. The remaining 48% is influenced by other factors. The novelty of this research lies in focusing on both supervision and principal leadership together in Ilir Timur II, a topic rarely studied integratively at the elementary level. This finding reinforces that a combination of systematic supervision strategies and effective leadership styles can be key to improving teacher performance in urban areas.