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All Journal JPMS (Jurnal Pendidikan Matematika dan Sains) Jurnal Inovasi Pendidikan IPA Science and Technology Indonesia Jurnal Pendidikan Sains Indonesia (Indonesian Journal of Science Education) Jurnal Sains Materi Indonesia
Kamari, Azlan
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Education Engineering Environmental Science Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Physics

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Journal : Jurnal Sains Materi Indonesia

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Quercetin Encapsulation on Chitosan-Pectin Membranes as a Drug Delivery and Its Release Kinetics Hastuti, Budi; Hadi, Saptono; Nisriyah, Safarin; Martanisa, Mutiah; Kamari, Azlan
Jurnal Sains Materi Indonesia Vol. 27 No. 1 (2025): Jurnal Sains dan Materi Indonesia
Publisher : BRIN Publishing (Penerbit BRIN)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jsmi.2025.9988

Abstract

Chitosan-pectin membranes are biodegradable polyelectrolyte complexes, derived from biomaterials, with good stability for drug delivery applications. This study investigates the potential of these membranes to encapsulate quercetin, a flavonoid known for its therapeutic properties but limited for its low solubility, poor bioavailability, and rapid elimination. The membranes were synthesized using a 1:1 (w/w) chitosan-to-pectin ratio and loaded with quercetin via solvent evaporation. Characterization using FTIR confirmed the presence of OH, C=O, and NH groups; XRD indicated semi-crystalline structure; and SEM revealed a uniform, porous morphology. The maximum quercetin loading efficiency reached 82.43%, with the highest release (90.39%) observed at pH 1.2, following first-order kinetics. The resulting membrane was thin, brown, homogeneous, and tear-resistant, demonstrating its potential as a controlled drug delivery matrix for quercetin
Co-Authors Anti Kolonial Prodjosantoso Budi Hastuti Daud, Muhammad Fauzi Eli Rohaeti Endang Widjajanti Fauziyyah, Anas Zahra Habibi Hidayat, Habibi Haneef, Mehru Nisha Muhamad Is Fatimah Martanisa, Mutiah Nisriyah, Safarin Nurlaela, Nunung Oh, Won-Chun Priyadi*, Danang Restu Utami, Restu Romadhoni*, Siti Dzakiya Sagadevan, Suresh Saptono Hadi, Saptono Setyowati, Widiastuti Agustina Eko SRI ATUN Suci Widianingsih Yanti , Ika