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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Interest : Jurnal Ilmu Kesehatan Indonesian Journal of Pharmaceutical Science and Technology JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Journal of Pharmacopolium Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat Majalah Farmasetika Journal of Experimental and Clinical Pharmacy (JECP) Pharmaqueous Edukasi Masyarakat Sehat Sejahtera (EMaSS) Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Ilmiah Nusantara
Aji, Nur
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Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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In Silico and In Vitro Antibiofilm Activity of Zingiber montanum Ethyl Acetate Fraction Against Propionibacterium acnes: Antibiofilm of Zingiber montanum Aji, Nur; Kumala, Shirly; Mumpuni, Esti; Rahmat, Deni
Journal of Tropical Life Science Vol. 15 No. 1 (2025)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/

Abstract

Propionibacterium acnes (P. acnes), a symbiotic bacterium involved in the development of acne, is recognized for its capacity to develop resistance due to its ability to generate biofilms. According to a previous investigation, the ethyl acetate fraction derived from Zingiber montanum exhibited anti-bacterial properties against P. acnes. Nevertheless, the causative role of biofilm formation in its resistance was not previously recognized. This study aims to ascertain the antibiofilm efficacy using in silico and in vivo methodologies. In this study, in silico examination utilized molecular docking to inhibit the quorum sensing mechanism by blocking the autoinducer 2 (AI-2) signal. The target protein was AI-2 binding periplasmic protein LuxP (PDB code: 4YRZ). Following that, an in vitro test was conducted using the crystal violet staining method, which was read using a microplate reader at a wavelength of 600 nm. The readings were expressed as percent inhibition and IC50. The in silico results showed that there were six compounds in the ethyl acetate fraction that have the potential to inhibit AI-2 signaling. Curcumin showed the highest inhibitory activity. Meanwhile, the in vitro results revealed that the ethyl acetate fraction of Z. montanum obtained the minimum biofilm inhibitory concentration (MBIC) of 2.5 % (w/v) and IC50 = 0.28 % (w/v). It can be concluded that the ethyl acetate fraction of Zingiber montanum could inhibit the biofilm formation of P. acnes.  
Co-Authors Afriyanti, Fatmasari Alifah Rahman, Qonita Aminah, Mimin Anwari, Muhammad Taufiq Asep Abdul Rahman Azizah, Zahra Nur Azzahrah, Nissa Ramdian Esti Mumpuni, Esti Irvan Herdiana Irvan Herdiana Martihandini, Nooryza Nuri Handayani RAHMAT, DENI Rani Rubiyanti, Rani Rismawati, Dewi Shirly Kumala Sri, Tovani Sutiswa, Shandra Isasi Syamsiyah, Cici Nurul Vania Armilda, Levina Hadi Yulia, Nunung