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All Journal JURNAL FARMASIMED (JFM) Science Midwifery Jurnal Pengmas Kestra (JPK) Jurnal Pengabdian Masyarakat Ilmu Kesehatan
Sihombing, Yanna Rotua
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Journal : JURNAL FARMASIMED (JFM)

 1 
UJI AKTIVITAS EKSTRAK ETANOL DAUN KARAMUNTING (Rhodomyrtus tomentosa.) TERHADAP PERTUMBUHAN BAKTERI Salmonella thypi Wulandari, Suci; Pranata, Chandra; Sihombing, Yanna Rotua; Nasution, Muhammad Hamim
Jurnal FARMASIMED (JFM) Vol 2 No 2 (2020): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v2i2.382

Abstract

Salmonella thypiis a bacterium that causes typhoid fever. Typhoid fever is an infectious disease that is still a health problem, especially in Indonesia. There are several studies on the types of plants that can control bacterial growth. Indonesian plants are often used as medicine, one of which is the karamunting (Rhodomyrtus tomentosa.). Traditionally a number of parasitic species have been used to prevent and treat various diseases such as cough, anticancer, diuretic, anti-inflammatory, antibacterial, wound or infection karamunting (Rhodomyrtus tomentosa.) Has active compounds such as flavonoids, alkaloids, tannins , saponins, and glycosides which have antibacterial abilities. The purpose of this study is to determine the inhibition of extract of karamunting (Rhodomyrtus tomentosa.) at concentrations of 5%, 10%, and 15%. Test samples using Salmonella thypi. This research is an experimental study with a design (posttest). The research methods included the collection of plant material, determination of plant material, making simplicia, phytochemical screening, making ethanol extract from simplicia by maceration, testing chemical compound groups, and antibacterial testing with paper disk diffusion methods. Karamunting is extracted by maceration process, using 70% ethanol solvent. The results of this study indicate that the benalu coffee leaf extract (Rhodomyrtus tomentosa.) has inhibitory capacity as an antibacterial in Salmonella thypi with a mean inhibition of 16.87 mm at a concentration of 5%, 17.24 mm at a concentration of 10%, and 18.21 mm at a concentration of 15%. The greatest inhibition is produced at a concentration of 15%, because the higher the concentration of the extract, the higher the diameter of the inhibition produced, because the more active substances contained in the extract.
The EVALUATION OF THE USE OF ANTI-INFLAMMATORY DRUGSIN PATIENTS RHEUMATOID ARTHRITIS OUTPATIENT AT GRANDMED HOSPITAL LUBUK PAKAM Sihombing, Yanna Rotua; Marbun, Romauli Anna Teresia; Zebua, Kristian Cahayani; Lestari, Dayana
Jurnal FARMASIMED (JFM) Vol 5 No 1 (2022): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v5i1.1315

Abstract

Rheumatoid arthritis is an autoimmune disease characterized by inflammation of the joints that can become chronic. Rational use of drugs aims to ensure that patients get safe and effective treatment in the right time frame and at an affordable price according to their needs In the outpatient facility of Lubuk Pakam Hospital, patients experience symptoms such as pain, inflammation, morning joint stiffness and difficulty moving at appropriate doses. This study aims to aim to obtain an objective picture or picture of the situation. Data collection was carried out retrospectively, namely by observing the medical records of rheumatoid arthritis patients at Grandmed Lubuk Pakam Hospital in 2021. A total of 13 (56.5%) female patients and 10 (56.5%) (43.5%) male patients, according to the number of rheumatoid arthritis patients at the outpatient facility of GrandMed Lubuk Pakam Hospital in 2021. This makes the inclusion criteria for all anti-inflammatory agents incomplete in rheumatoid arthritis and the exclusion criteria for all medical records in rheumatoid arthritis patients. Analysis of data based on age, gender, rationality of the drug, correct indications, correct patient, correct drug, correct dosage. The Outpatient Study of GrandMed Lubuk Pakam Hospital 2021 is: Correct Indications (100%), Correct Patients (100%), Correct Drugs (100%), Correct Dosage (91.3%). The treatment of patients with rheumatoid arthritis at GrandMed Lubuk Pakam Hospital can still be said to be fully good
TEST OF EFFECT KEDONDONG LEAF ETHANOL EXTRACT (SPONDIAS DULCIS) ON STAPHYLOCOCCUS AUREUS BACTERIA Situmorang, Novidawati Boru; Fatima, Nurdilla; Teresia Marbun, Romauli Anna; Sihombing, Yanna Rotua
Jurnal FARMASIMED (JFM) Vol 5 No 2 (2023): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v5i2.1541

Abstract

Bacteria that cause infection and disease are commonly found in our environment, one of which is Staphylococcus aureus bacteria. Several infectious diseases are also caused by Staphylococcus aureus, including cellulitis, acne (acne), and infection with Staphylococcal Scalded Skin Syndrome (SSSS). To determine whether the ethanol extract of kedondong leaves (EEDK) has antibacterial activity against Staphylococcus aureus bacteria. This study used a laboratory experimental method with several stages such as sample collection, identification of plants for making simplicia, phytochemical screening, extract preparation and preparation of kedondong leaf extract test solutions with various concentrations of 15%, 25%, 35% and positive control (Chloramphenicol), negative control (DMSO), and antibacterial activity testing using the paper disc method. The results of phytochemical screening of kedondong leaf simplicia (Spondias dulcis) found that kedondong leaves contain secondary metabolites such as alkaloids, flavonoids, tannins and saponins that have the potential to inhibit bacterial growth. % of 9.4 mm, 25% concentration of 13.5 mm and the greatest inhibition was at a concentration of 35% of 19.5 mm. Kedondong leaf extract has antibacterial activity against the growth of Staphylococcus aureus bacteria, with moderate to strong categories. inhibit the activity of Staphylococcus aureus bacteria is a concentration of 35%. Based on the description above, it was found that the EED with a concentration of 35% had the greatest antibacterial effect compared to the concentration of 15% and 25%. and it can be concluded that the higher the concentration of the extract used, the higher the antibacterial effect.
EVALUATION OF THE USE OF THE DRUG IN PATIENTS ACUTE RESPIRATORY TRACT INFECTION (ARI) NON PNEUMONIA AT PUSKESMAS SIGUMPAR Sihombing, Yanna Rotua; Romauli Anna teresia Marbun; Friska Novita Pasaribu; Novidawati Br Situmorang
Jurnal FARMASIMED (JFM) Vol 6 No 1 (2023): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v6i1.1630

Abstract

Acute Respiratory Infection (ARI) is one of the main causes of patient visits to health centers (40%-60%) and hospitals (15%-30%). In Indonesia the level of use of antibiotics is still quite high. The unwise use of antibiotics and the incorrect application of standard precautions in health care facilities an lead to the occurrence of resistane. This study aims to determine the evaluation of drug use in non-pneumonia Aucute Respiratory Infection (ARI) patients at the Sigumpar Health Center. This Type of research is an observational study with a descriptive design and data taken retrospectively. The total sample of 101 medical records was taken by purposive sampling technique. The patients who often suffer from non-pneumonia acute respiratory infections at the Sigumpar Health Center occur in the age group of 6-11 years, namely children by 20,79%. Based on the results of this study, the most widely used drugs were analgesic-antipyretic (69.30%), antihistamine (65.34%), vitamins (62.37%), mucolytics (48.51%), expectorants (32.67%), antibiotics (27.72%) and corticosteroids (23.76%). The use antibiotics for non-pneumonia ARI patients at the Sigumpar Health Center was 27,72% so that it was categorized as not in accordance with the provisions of the Inonesian Ministry of Health in 2017 that the use of antibiotics in non-pneumonia ARI patients was ? 20%.
Comparison Of Naso Faring And Oro Pharynx Swab Samples On Positivity Rate For Covid – 19 With The Reverse Transcription Method Pcr (Rt–Pcr) In The Lab. Rsud Pcr. City Padang Sidempuan Sihombing, Yanna Rotua; Romauli Anna Teresia Marbun; Lenni Rismayanti; Ratih Anggraeni; Octavian Ashido Nababan; Kristian Cahayani Zebua
Jurnal FARMASIMED (JFM) Vol 6 No 2 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v6i2.2021

Abstract

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) could be a coronavirus that causes COVID-19 infection. SARS-CoV-2 is classified as an RNA infection that can cause gentle to severe respiratory diseases. Viral contaminations proceed to extend quickly, so it is critical to prevent the spread of the infection through nasopharyngeal and/or oropharyngeal swabs within the community. The point of this consider was to decide the exactness of nasopharyngeal or pharyngeal spread testing and the inspiration rate in RSUD patients. Padang Sidempuan City This think about was performed by collecting 20 nasopharyngeal swabs and 20 pharyngeal swabs from RSUD patients. City of Padang Sidempuan Infection testing was performed within the research facility by turn around transcriptase polymerase chain response (RT-PCR). Information were analyzed employing a chi-square test with p < 0.05. Judging from the nasopharynx and oropharynx positive rate comes about, the nasopharynx positive rate esteem is higher than the nasopharynx positive rate esteem, indeed in case it is the same persistent. The conclusion of this ponder is that the discovery of SARS-CoV-2 by nasopharyngeal swab will be more precise.
Test to Determine The Quercetin Content of Tenggiang (Polystichum setiferum) Using the High Performance Liquid Chromatography (HPLC) Method and Its Antifungal Activity Against Pityrosporum ovale Turnip, Nur Ulina M. Br.; Ratih Anggraeni; Sihombing, Yanna Rotua; Suci Wulandari
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2361

Abstract

Background: Indonesia is a country with high temperature and humidity, which are supporting factors for the development of microbes. One of the microbes that causes infection is the fungus Pityrosporum ovale which can cause dandruff, especially on the scalp. Treatment is usually done using shampoo containing an antidandruff formula. Synthetic chemicals used in hair care have been widely known and used to treat various infections caused by fungi. Tenggiang, a shrub originating from the Toba Samosir area, is used empirically as a wound medicine. In previous studies, Tenggiang has been shown to have antimicrobial, antioxidant, and anti-inflammatory effects. This is related to the content of secondary metabolites found in tenggiang, such as flavonoids, terpenoids/steroids, saponins, and phenolics. Flavonoids, which are secondary metabolites of the polyphenol group. Objective: to measure the levels of quercetin in tenggiang using the HPLC method and to evaluate its antifungal activity against Pityrosporum ovale. Method: measurement of quercetin using the HPLC method and measurement of antifungal activity using the Kirby-bauer method. Results: The measurement results were then calculated as quercetin equivalents, the extract contained a total of 1.33% flavonoids. The retention time data of the standard quercetin was 5.405 minutes and the retention time of the ethanol extract of mackerel was 5.332. The ethanol extract of mackerel was  said to contain quercetin because it had a retention time that was relatively the same as the retention time of the standard quercetin. The extract also showed potential as an antimicrobial agent, where an increase in extract concentration was directly proportional to an increase in the diameter of the inhibition zone. In addition, when compared to the blank, the resulting difference was statistically significant (p <0.05). Conclusion: Tenggiang, extract has antifungal activity and antioxidant potential.
Activity Test of Daun Jati Belanda (Guazuma ulmifolia Lamk.) on Lymphocyte Proliferation and Immunoglobulin G Expressionas an Immunostimulatory Agent Sihombing, Yanna Rotua; Fitri Siska
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/7mw45p98

Abstract

Background: Infections that attack the immune system have become a major global health issue, including in Indonesia. In 2019, the emergence of Coronavirus created an urgent need for immediate therapy, followed by increased attention to other diseases such as tuberculosis (TB), PCP pneumonia (Pneumocystis jirovecii), candidiasis, and toxoplasmosis. If left untreated, infections can damage tissues and organs. Although immune-boosting drugs are available in healthcare settings, their side effects and potential drug interactions highlight the need for complementary therapies derived from natural ingredients. Indonesia’s biodiversity offers great potential for the development of natural immunostimulants. One such plant is Jati Belanda (Guazuma ulmifolia Lamk.), which is widely found in Deli Serdang, North Sumatra. Empirically, its leaves have been used to treat diarrhea, cough, abdominal pain, and as a tonic and astringent. Research has shown that Guazuma ulmifolia contains alkaloids, tannins, and flavonoids with antihyperlipidemic, antiviral, and anti-inflammatory properties, as well as potential immune-enhancing effects.Objective: This study aimed to analyze the immunostimulatory activity of Guazuma ulmifolia leaf extract on lymphocyte proliferation and IgG expression using male rats. Methods: The experimental method was applied, including a lymphocyte proliferation assay using the MTT method and serum IgG measurement using the ELISA technique. Results: The results showed that the extract significantly increased lymphocyte proliferation and IgG levels. The EC50 value of the extract (4.720 µg/mL) was comparable to that of Imboost (4.282 µg/mL), indicating similar effectiveness. Increased absorbance at various extract concentrations reflected enhanced cell proliferation. A dose of 400 mg/kg body weight effectively elevated IgG levels, strengthening the humoral immune response. The presence of flavonoids, tannins, and saponins is thought to play a role by activating B cells, promoting plasma cell differentiation, and modulating the NF-κB signaling pathway. Conclusion: Therefore, Guazuma ulmifolia leaf extract has potential as a natural immunostimulant that supports the body’s defense against pathogens.
Co-Authors Dalimunthe, Juliana Fatima, Nurdilla Fitri Siska Friska Novita Pasaribu Juliana, Iga Kristian Cahayani Zebua Lenni Rismayanti Lestari, Dayana Maharani, Anisa Marbun, Romauli Anna Nainggolan, Hotdoriska Nasution, Dina Wahyuni Nasution, Muhammad Hamim Novidawati Boru Situmorang Novidawati Br Situmorang Nur Ulina M. Br. Turnip Octavian Ashido Nababan Parinduri, Anggi Isnani Pranata, Chandra Ratih Anggraeni Ratih Anggraeni Romauli Anna Teresia Marbun S, Aminah. Sinaga, Falentina Siska, Fitri Siti Wahyuni Situmorang, Novidawati Br Suci Wulandari Suci Wulandari Syarifuddin, Aminah Zebua, Kristian Cahayani