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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Neurona Indonesian Journal of Biomedicine and Clinical Sciences Indonesian Journal of Pharmacology and Therapy Cermin Dunia Kedokteran
Mawaddah Ar-Rochmah
Department Of Neurology, Faculty Of Medicine, Public Health And Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Efektivitas Citicoline dalam Terapi Demensia Ar Rochmah, Mawaddah; Indrihapsari, Erupsiana Fitri; Nugroho, Dhite Bayu
Cermin Dunia Kedokteran Vol 51 No 1 (2024): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v51i1.990

Abstract

Background: In the development of pharmacological therapy for dementia, especially Alzheimer's disease, several types of therapy are widely used: acethylcholine esterase inhibitors/AChEI, N-methyl-D-aspartate (NMDA) receptors inhibitors, and cholinergic precursor. Aim: To review the evidence on the effectiveness of citicoline supplementation to the standard therapy of dementia to prevent the progression or improve the manifestations of dementia. Methods: A literature search was performed in three following databases: Pubmed, EBSCOhost, Scopus, and Cochrane within the last ten years. Results: Of the 239 articles, five studies were eligible for critical appraisal. Four studies showed a significant mean MMSE score increase in the citicoline + standard therapy group (intervention) compared to the standard therapy group (control) during the follow up period between 3 – 12 months. One study showed a significant mean MMSE score increase of in the intervention group compared to the control group. Conclusion: Oral citicoline supplementation of 1,000 mg/day to the standard therapy showed a positive effect on cognitive function in dementia patients. Critical appraisal of validity and application of the included studies should be considered upon daily clinical application.
The effect of Centella asiatica L. Urban. and Curcuma longa L. extracts combination in improving memory performance in stroke model rats and its acute toxicity Gofir, Abdul; Ar Rochmah, Mawaddah; Wibowo, Samekto; Hakimi, Mohammad; Mustofa
Indonesian Journal of Pharmacology and Therapy Vol 2 No 2 (2021)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.1765

Abstract

Post-stroke cognitive impairment involves memory, visuoconstructional, and spatial dysfunctions. Centella asiatica L. Urban. and Curcuma longa L. are both well-known herbs in South and South-East Asia countries that are believed to possess neuroprotective properties as memory enhancers. This study aimed to investigate the effects of C. asiatica L. Urban. and C. longa L. extracts combination in improving memory performance in stroke model rats and its acute toxicity. Twenty-five Wistar rats underwent transient bilateral common carotid artery occlusion. Y-maze pre-test was performed 24 h after the occlusion. The rats were then divided into five groups i.e. Group 1 received NaCMC dilution, Group 2 received donepezil 0. 7 mg/kg BW/day, and Groups 3, 4, and 5 received the extracts combination with dose of 59; 118; and 236 mg/kg BW/day, respectively. Y-maze post-test was performed 24 h after the last dose had been given. Spontaneous alternation behavior was used as the indicator of working memory measurement. The fixed-dose method according to OECD Guideline was used to estimate the LD50 in acute toxicity testing on Wistar rats. There was a significant difference in the delta spontaneous alternation percentage among groups tested (p<0. 05). Group 1 had significant difference with any other group (compared to Groups 2 to 5; p<0.05). No significant difference could be found between groups of the extracts combination and donepezil group suggesting that the effect is not more inferior nor dose-dependent in improving memory performance. The extracts combination at a single dose of 2000 mg/kg BW did not show related signs of toxicity or mortality in any of the rats during the 14-day observation period. In conclusion, the C. asiatica L. Urban. and C. longa L. extracts combination can improve performance of memory on stroke model animal. According to Globally Harmonized Classification System, the extracts combination can be classified as Category 5/unclassified.
PERAN CLINICAL PATHWAY DALAM PERAWATAN STROKE Paryono; Anindhita, Edina Ufairah; Ar Rochmah, Mawaddah
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 5: Edisi Suplemen Neurona Bekerjasama dengan JogjaCLAN 2025
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v41i5.863

Abstract

Stroke remains a leading cause of disability and mortality worldwide, demanding a comprehensive, structured, and evidence-based approach across the full continuum of care. Clinical pathways (CPs) are integrated, multidisciplinary protocols that operationalize guidelines into day-to-day practice—linking prehospital prenotification, emergency triage, acute treatment, early rehabilitation, and discharge planning. This narrative review synthesizes the rationale, design steps, core components, and clinical evidence for CP implementation in stroke care. Key pathway elements include time-critical targets (e.g., rapid brain imaging for reperfusion candidates), standardized assessments (e.g., National Institutes of Health Stroke Scale / NIHSS), complication prevention bundles (dysphagia screening, venous thromboembolism prophylaxis, glucose and temperature control), mobilization and nutrition plans, patient–caregiver education, and follow-up coordination, all embedded within audit/variance tracking for continuous quality improvement. Evidence indicates that CPs can reduce in-hospital complications, shorten length of stay, lower costs, increase documentation completeness, strengthen adherence to guidelines, and enhance patient satisfaction and team collaboration. Effects on hard clinical outcomes (mortality, long-term disability) are more variable and appear contingent on stroke-unit infrastructure, resource readiness, team training, and local adaptation. Overall, CPs remain a strategic tool within organized stroke systems, translating evidence into timely, coordinated care and supporting iterative improvements in quality and efficiency. Keywords: Clinical pathway, stroke, evidence-based medicine, multidisciplinary care, patient outcomes
VERTIGO SENTRAL: TINJAUAN TERKINI MENGENAI PATOFISIOLOGI DAN STRATEGI DIAGNOSIS Sutarni, Sri; Setyaningrum, Cempaka Thursina Srie; Ar Rochmah, Mawaddah; Bayuangga, Halwan Fuad
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 5: Edisi Suplemen Neurona Bekerjasama dengan JogjaCLAN 2025
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v41i5.865

Abstract

Recent advances have fundamentally reshaped the clinical and pathophysiological landscape of central vertigo, moving beyond a simplistic brainstem model to a sophisticated understanding of a distributed central vestibular network. This network, encompassing the brainstem, cerebellum, thalamus, and cortex, provides a robust framework for explaining how disruptions from stroke, demyelination, or functional disorders produce diverse symptoms. In parallel, diagnostic paradigms have evolved dramatically. The advent of quantitative ocular motor testing, epitomized by the HINTS protocol and enhanced by video-head impulse testing (vHIT), now allows for highly sensitive bedside identification of central causes in acute settings. Furthermore, advanced neuroimaging techniques, including optimized diffusion-weighted and vessel wall MRI, have revolutionized our ability to detect subtle posterior fossa infarcts and vascular pathology. These mechanistic and technological insights have also refined our perspective on specific syndromes, solidifying vestibular migraine and persistent postural-perceptual dizziness (PPPD) as central disorders of sensory integration. Ultimately, the integration of this modern network-based pathophysiology with targeted diagnostic tools is establishing a new standard of care, significantly improving diagnostic accuracy, enabling timely intervention, and guiding future therapeutic development for patients with central vertigo. Keywords: Vestibular network, HINTS examination, neuroimaging, acute vestibular syndrome, central vertigo
PENCEGAHAN PERBURUKAN PADA PENYAKIT PARKINSON: PENDEKATAN FARMAKOLOGIS DAN NON-FARMAKOLOGIS Subagya; Rohma, Novita Nur; Gofir, Abdul; Ar Rochmah, Mawaddah
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 5: Edisi Suplemen Neurona Bekerjasama dengan JogjaCLAN 2025
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v41i5.870

Abstract

Parkinson's disease (PD) is a complex neurodegenerative disorder with a progressive course. Most patients experience symptom deterioration over time, although the rate of progression varies between individuals. PD is the second most common neurodegenerative disease worldwide, with prevalence exceeding ~1% in people over 60 and ~5% in those over 85. Its incidence is rising globally with aging populations, and the number of PD cases is projected to double by 2040 compared to 2015. Despite significant advances in symptomatic treatments, no intervention has been proven to halt or reverse the underlying pathology of PD. This therapeutic gap underscores the importance of strategies aimed at preventing disease progression in order to preserve functional capacity and improve patients’ quality of life. This review provides an overview of the progressive nature of PD, current challenges in its management, and both pharmacological and non-pharmacological approaches aimed at preventing further deterioration. Keywords: Prevention, Parkinson’s disease, progressive, neurodegenerative
Co-Authors Abdul Gofir Amelia Nur Vidyanti Anindhita, Edina Ufairah Bayuangga, Halwan Fuad Desby Juananda Desin Pambudi Sejahtera Dhite Bayu Nugroho Dhite Bayu Nugroho Dwi Cahyani Ratna Sari Erupsiana Fitri Indrihapsari Haq, Arinal Indra Sari Kusuma Harahap Indrihapsari, Erupsiana Fitri Ismail Setyopranoto Juananda, Desby Mohammad Hakimi Mohammad Hakimi Muhammad Mansyur Romi Muhammad Mansyur Romi Mustofa Mustofa Mustofa Nadhilla, Nyimas Farisa Nugroho, Dhite Bayu Nur Arfian Nur Arfian Paryono Rohma, Novita Nur Samekto Wibowo Samekto Wibowo Sekar Satiti Setyaningrum, Cempaka Thursina Srie Setyawan, Tommy Rachmat Siti Farida Sri Sutarni Sri Sutarni Subagya Yogik Onky Silvana Wijaya