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All Journal Jurnal Kreativitas PKM journal of Basic Medical Veterinary
Yuliani, Gandul Atik
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Journal : journal of Basic Medical Veterinary

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The Effect of Probiotics on Hematology Profille of Domestic Chicken (Gallus domestiicus) Widiandini, Dara Adisti; Karim, Rizqi Mildia Nur; Susilowati, Aprilia; Putri, Camila Azzahra Hadi; Gianina, Gianina; Hasyyati, Hening; Siregar, Yohana Merylin; Mufliha, Salsabila Hasna; Yuliani, Gandul Atik
Journal of Basic Medical Veterinary Vol. 11 No. 1 (2022): Journal of Basic Medical Veterinary, June 2022
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbmv.v11i1.52222

Abstract

Domestic chickens are one of the most important commodities in fulfilling animal protein needs in Indonesia. Despite its advantages in environmental adaptability and ease of maintenance, local chickens also have the disadvantage of low productivity. The health of native chickens is a key factor affecting their productivity, and quality feed is important in supporting this health. To improve efficiency and productivity, improved feed is the main focus, but the use of antibiotics as growth promoters has been banned due to their residues in the body of the livestock. Alternatively, the use of probiotics in feed is a promising solution due to their benefits in improving gut microflora balance and overall health. Blood profile was used as a parameter to evaluate the health of livestock after feeding probiotics. This study aims to investigate the effect of probiotics on the hematological profile of kampung chickens including the number of erythrocytes, the number of leukocytes, hemoglobin levels, and hematocrit values. Experimental approach by applying four different treatments. The four treatments used were K0 (Use of basal feed), K1 (Use of basal feed supplemented with probiotics in liquid form at a concentration of 0.1 v/w.), K2: (Use of basal feed supplemented with probiotics in liquid form at a concentration of 0.3 v/w). K3 (Use of basal feed supplemented with probiotics in liquid form at a concentration of 0.5 v/w). At the next stage, observations were made on hematological profile parameters to evaluate the results of each treatment given. Based on the results of the research that has been done, it is found that the provision of probiotics affects the hematological profile of domestic chickens, the addition of probiotics can increase the number of erythrocytes, the number of leukocytes, hemoglobin levels, and hematocrit values. With an average erythrocyte count of 2.44 x 106/mm3, leukocyte count of 23.75 103/mm3, hemoglobin level of 11.25 g/dl, and hematocrit value of 11.25%.
Nephroprotective Activity of Ethanolic Extract of Papaya (Carica papaya) Seeds on Blood Urea Nitrogen and Creatinine Levels in Albino Rats Induced by Paracetamol Mubarok, Muhammad Syahrul; Yuliani, Gandul Atik; Sunarso, Agus; Hidayatik, Nanik; Kurnijasanti, Rochmah; Hisyam, Mirza Atikah Madarina
Journal of Basic Medical Veterinary Vol. 14 No. 2 (2025): Journal of Basic Medical Veterinary, December 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbmv.v14i2.78386

Abstract

Kidney damage caused by high-dose paracetamol leads to elevated Blood Urea Nitrogen (BUN) and creatinine levels as indicators of impaired renal function. This study aimed to evaluate the dose-dependent nephroprotective effects of ethanolic Carica papaya seed extract on BUN and creatinine levels in paracetamol-induced albino rats. A posttest-only control group design was applied using 25 male Wistar rats divided into five groups: negative control (1% CMC-Na), positive control (paracetamol 1000 mg/kgBW), and three treatment groups receiving Carica papaya seed extract at doses of 100, 200, and 400 mg/kgBW. The extract was administered orally for seven consecutive days before paracetamol induction on day 8 and continued until day 11. Blood samples were collected on day 11, and serum was stored at -20 °C before BUN and creatinine concentrations were analyzed spectrophotometrically. Data were statistically analyzed using one-way ANOVA followed by Duncan’s Multiple Range Test (DMRT) at a significance level of p < 0.05. The results showed a significant and dose-dependent reduction in both parameters in all treated groups compared to the positive control, with the 400 mg/kgBW dose showing the strongest effect and restoring values close to physiological levels. The nephroprotective activity was associated with the antioxidant and anti-inflammatory mechanisms of the bioactive compounds that counteract oxidative stress and preserve renal cellular integrity. In conclusion, the ethanolic extract of Carica papaya seeds demonstrates significant dose-dependent nephroprotection against paracetamol-induced kidney injury in rats.
Co-Authors Abid, Istiana Firqah Afdhila, Zakia Gianina, Gianina Hasyyati, Hening Hidayatik, Nanik Hisyam, Mirza Atikah Madarina Karim, Rizqi Mildia Nur Kristianto, Sonny Mubarok, Muhammad Syahrul Mufliha, Salsabila Hasna Putri, Camila Azzahra Hadi Rochmah Kurnijasanti Rury Eryna Putri Siregar, Yohana Merylin Sunarso, Agus Susilowati, Aprilia Uktutias, Sendy Ayu Mitra Widiandini, Dara Adisti Wimbuh Tri Widodo Zulqaida, Salma