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All Journal Jurnal Medik Veteriner journal of Basic Medical Veterinary
Hisyam, Mirza Atikah Madarina
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Veterinary

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The Efficacy of Madeira Vine Leaf Extract Combined with Turmeric Rhizome Extract Gel Topically on Second-Degree Burn Wound in Albino Rats Hisyam, Mirza Atikah Madarina; Yuniarti, Wiwik Misaco; Theresia, Sis Wisnuarti; Yudaniayanti, Ira Sari; Lukiswanto, Bambang Sektiari; Sudjarwo, Sri Agus; Widiyatno, Thomas Valentinus
Jurnal Medik Veteriner Vol. 6 No. 3 (2023): Special Issue: International Conference on Veterinary Medicine and Health Scien
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol6.iss3.2023.91-98

Abstract

Burns is now considered one of the most destructive forms of trauma affecting humans and animals. This study aimed to determine the effect of Madeira vine leaf extract combined with 2% Turmeric rhizome extract (MVLTR) gel administered topically on second-degree burn wound in albino rats based on the number of fibroblasts. A total of 25 male rats weighed 200–300 grams were divided into five groups i.e. (C-) was normal skin, (C+) was burn and treated using 1% silver sulfadiazine, (T1) was burn and treated using 1.25% MVLTR gel, (T2) was burn and treated using 2.5% MVLTR gel, and (T3) was burn and treated using 5% MVLTR gel. The burn wound was performed on the right gluteus of rats, and the therapy was applied twice a day topically, starting after the burn wounds were made. Skin samples were collected on day 15. The histopathological examination was performed by counting fibroblast cells and then analyzed using One-way ANOVA, continued with the Duncan test. Based on the results showed that the C- group was significantly different compared to C+, T1, T2, and T3 groups. C+ had a significant difference with the T1 and T3 groups, meanwhile not significantly different from the T2 group. T2 was not significantly different from the C+ and T3 groups. In conclusion, MVLTR gel at 5% concentration has the potential to be an effective treatment for second-degree burns, as indicated by the increased number of fibroblasts.
Strategic Infectious Diseases in Beef Cattle in Balongpanggang during 2023 Yuniarti, Wiwik Misaco; Lukiswanto, Bambang Sektiari; Setiawan, Boedi; Yudaniayanti, Ira Sari; Triakoso, Nusdianto; Hisyam, Mirza Atikah Madarina; Susanti, Lina; Niken Hastuti, Apriliwiyani; Sudjono, Budi Santoso
Jurnal Medik Veteriner Vol. 7 No. 2 (2024): October
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol7.iss2.2024.362-369

Abstract

Strategic infectious animal diseases have a great impact on the national economy as they may cause great economic loss, public anxiety, and high mortality. In Indonesia, among the diseases considered as strategic infectious animal diseases is foot and mouth disease (FMD). This study reported the incidence of strategic infectious animal diseases in Balongpanggang district during 2023. Throughout 2023, FMD only accounted for 4% of the total diseases of the year and was the only strategic infectious animal disease reported that year. Meanwhile, bovine ephemeral fever (BEF) incidence reached 57% (876/1546) of the total diseases in beef cattle in 2023. In addition to BEF, official veterinary services reported a total case of 1546 throughout 2023 that comprises; diarrhea (99), limping (24), helminthiasis (91), ectoparasite (11), hematochezia (3), wound (3), mastitis (4), allergy (1), dystocia (28), vaginal prolapse (11), dermatitis (45), enteritis (27), tympani (11), scabiosis (122), arthritis (67), ophthalmic problem (11), endometritis (1), uterine retention (13), indigestion (2), pneumonia (21), hypoglycemia (5), abscess (21), ovariohysterectomy (1), orchitis (1), intoxication (1), and papilloma (1). In conclusion, the only strategic infectious animal disease reported in 2023 in Balongpanggang was FMD with the incidence as high as 3% as compared to the non-strategic infectious animal diseases, BEF, which reached 54% of the total cases during 2023.
Antibacterial Activity of Bidara Leaf Extract (Ziziphus mauritiana) Against Staphylococcus aureus Isolated from Mastitis Case In Vitro Saraswati, Afif Tasya; Sugihartuti, Rahmi; Puspitasari, Yulianna; Witaningrum, Adiana Mutamsari; Rachmawati, Kadek; Maslachah, Lilik; Raharjo, Hartanto Mulyo; Hisyam, Mirza Atikah Madarina; Tacharina, Martia Rani
Journal of Basic Medical Veterinary Vol. 12 No. 2 (2023): Journal of Basic Medical Veterinary, December 2023
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbmv.v12i2.51106

Abstract

This research aimed to know the antibacterial activities of bidara leaf extract against Staphylococcus aureus isolated from mastitis cases. The isolate was identified before the antibacterial test. This study was done by five times repetitions on Mueller Hinton Agar. The concentrations used in this study were 30%, 40%, and 50% of bidara leaf extract then a blank disc was dipped into each concentration. Tetracycline disc was used as a positive control and aquadest was used as a negative control. The diameter of the clear zone was measured using calipers after incubation for 24 hours at 37℃. The results showed significant differences (p<0.05) between the positive control (K+), negative control K (-), and the concentration group. However, each concentration of bidara leaf extract showed insignificant differences in the diameter of the clear zone. It could be concluded that bidara leaf extract has antibacterial activities against Staphylococcus aureus isolated from mastitis cases.
Nephroprotective Activity of Ethanolic Extract of Papaya (Carica papaya) Seeds on Blood Urea Nitrogen and Creatinine Levels in Albino Rats Induced by Paracetamol Mubarok, Muhammad Syahrul; Yuliani, Gandul Atik; Sunarso, Agus; Hidayatik, Nanik; Kurnijasanti, Rochmah; Hisyam, Mirza Atikah Madarina
Journal of Basic Medical Veterinary Vol. 14 No. 2 (2025): Journal of Basic Medical Veterinary, December 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbmv.v14i2.78386

Abstract

Kidney damage caused by high-dose paracetamol leads to elevated Blood Urea Nitrogen (BUN) and creatinine levels as indicators of impaired renal function. This study aimed to evaluate the dose-dependent nephroprotective effects of ethanolic Carica papaya seed extract on BUN and creatinine levels in paracetamol-induced albino rats. A posttest-only control group design was applied using 25 male Wistar rats divided into five groups: negative control (1% CMC-Na), positive control (paracetamol 1000 mg/kgBW), and three treatment groups receiving Carica papaya seed extract at doses of 100, 200, and 400 mg/kgBW. The extract was administered orally for seven consecutive days before paracetamol induction on day 8 and continued until day 11. Blood samples were collected on day 11, and serum was stored at -20 °C before BUN and creatinine concentrations were analyzed spectrophotometrically. Data were statistically analyzed using one-way ANOVA followed by Duncan’s Multiple Range Test (DMRT) at a significance level of p < 0.05. The results showed a significant and dose-dependent reduction in both parameters in all treated groups compared to the positive control, with the 400 mg/kgBW dose showing the strongest effect and restoring values close to physiological levels. The nephroprotective activity was associated with the antioxidant and anti-inflammatory mechanisms of the bioactive compounds that counteract oxidative stress and preserve renal cellular integrity. In conclusion, the ethanolic extract of Carica papaya seeds demonstrates significant dose-dependent nephroprotection against paracetamol-induced kidney injury in rats.
Co-Authors Adiana Mutamsari Witaningrum Bambang Sektiari Lukiswanto Boedi Setiawan Hidayatik, Nanik Ira Sari Yudaniayanti Kadek Rachmawati Lilik Maslachah LINA SUSANTI Mubarok, Muhammad Syahrul Niken Hastuti, Apriliwiyani Nusdianto Triakoso Raharjo, Hartanto Mulyo Rahmi Sugihartuti, Rahmi Rochmah Kurnijasanti Saraswati, Afif Tasya Sudjono, Budi Santoso Sunarso, Agus Tacharina, Martia Rani Theresia, Sis Wisnuarti Widiyatno, Thomas Valentinus Wiwik Misaco Yuniarti Yuliani, Gandul Atik Yulianna Puspitasari