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A Bibliometric Study of 3D Printing In Pharmaceutical Technology For Tablet Dosage Form Annisa, Viviane
Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Vol. 6 No. 02 (2025): HERCLIPS VOL 06 NO 02
Publisher : Universitas Muhammadiyah Gresik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30587/herclips.v6i02.9608

Three-dimensional printing (3DP) is the process of producing 3D items layer by layer using computer-generated designs. 3DP has been utilized to manufacture numerous drug dosage forms. The goal of 3D printing products is to create personalized medicine so it can enhance medication compliance and obtain better treatment outcomes. There are a lot of publications about fabricated tablets using 3DP. However, the results of analyses based on previous research in this field are lower. We conducted a bibliometric study using RStudio and VOSviewer software to summarize tabletting using 3DP research from 2014-2024. This study was based on the Scopus Database, and 405 suitable publications were evaluated. The most productive authors are Basit, A.W, Goyanes, A., and Gaisford, S., from the Department of Pharmaceutics, UCL School of Pharmacy, University College London, United Kingdom. Its affiliations and its country are also ranked the highest in producing articles in this field. In the future, 3DP will be an attractive alternative for tablet printing. Pharmacists in hospitals and drugstores can produce personalized tablets to improve treatment outcomes.

Optimization And Characterization of Silver Nanoparticle Biosynthesis Using Parijoto Fruit (Medinilla speciosa) Water Extract With Box-Behnken Design Nurjana, Qinta Laily; Amin, Azizah; Annisa, Viviane; Munawiroh, Siti Zahliyatul
Journal of Food and Pharmaceutical Sciences Vol 13, No 2 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.21683

Silver nanoparticles in the medical field are used as additives in vaccines, anti-diabetic agents, wound and bone healing, biosensors and anticancer therapy in medical applications. One of the plants that can act as a reducing agent in the biosynthesis of silver nanoparticles is the parijoto fruit (Medinilla speciosa). This study aims to optimize and characterize the biosynthesis of silver nanoparticles from the water extract of parijoto fruit (M. speciosa) with a box-behnken design. The method used in this study starts from the manufacture of water extract of parijoto fruit (M. speciosa) then continued with the biosynthesis of silver nanoparticles. The formula for the biosynthesis of silver nanoparticles will be optimized with a box-behnken design and characterized by Particle Size Analyzer (PSA), Fourier Transform Infrared (FTIR), and Transmission Electron Microscopy (TEM). The results obtained in this study will be analyzed using descriptive techniques. The optimization results with the Behnken box design showed an optimal formula with an extract concentration of 1%, a sonication time of 6 minutes, and a sonicator pulser of 30. The particle size obtained was 85 ± 0.1 nm with a PI of 0.486 ± 0.006 and a zeta potential of -27.3 ± 1.5. The FTIR spectrum showed C=O, C-O and O-H groups indicating flavonoid compounds as bioreductant agents. The morphology of silver nanoparticles showed instability. (4) Conclusions:the optimization of silver nanoparticles from parijoto fruit water extract (M. speciosa) have been discovered used the Box-Behnken design and has good silver nanoparticle characteristics.

Quality By Design (QbD) Pada Pembuatan Tablet Alopurinol Menggunakan Kajian Literatur Annisa, Viviane
INHEALTH : INDONESIAN HEALTH JOURNAL Vol. 4 No. 2 (2025): INHEALTH JOURNAL
Publisher : CV. Eureka Murakabi Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56314/inhealth.v4i2.305

Quality by Design (QbD) dalam farmasi merupakan sistem manajemen mutu yang memprediksi, mengontrol, dan merespon secara sistematik terhadap risiko yang terjadi dalam tahap penelitian dan proses manufaktur. QbD telah memberikan pergeseran dari konvensional Quality by Testing (QbT) sebagai pendekatan untuk membangun kualitas produk dalam sistem yang dapat meminimalisisr terjadinya reject saat pengujian produk akhir. Pada artikel ini dilakukan implementasi QbD menggunakan kajian pustaka untuk mengembangkan tablet Allopurinol dengan cara mendefinisikan profil target, memilih faktor kritis, dan melakukan penilaian risiko. Tahapan awalnya dimulai dari mendefinisikan Quality Target Product Profile (QTPP), Critical Quality Attributes (CQA), Critical material Attributes (CMA) dan Critical Process Parameters (CPP), dan penilaian risiko. Dengan adanya studi pendekatan QbD dalam pembuatan tablet allopurinol, yield produk yang dihasilkan dapat maksimal dengan meminimalkan kegagalan selama produksi serta menghasilkan produk yang sesuai dengan spesifikasi sehingga mengurangi potensi reject selama pengujian.

Ultra-High Performance Liquid Chromatography Method Validation for Micro-dissolution Analysis of Ketoconazole in Alginate-Acacia Gum Composite Capsules Lumakso, Fajar Aji; Annisa, Viviane; Cermenda, Riska; Chabib, Lutfi
Journal of Food and Pharmaceutical Sciences Vol 13, No 4 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.24078

Ketoconazole, a BCS Class 2 antifungal drug, has good absorption but suffers from low solubility and poor bioavailability. To address this, a natural polymer-based matrix of alginate and acacia gum was formulated to enhance dissolution. This study aimed to validate a Ultra High Performance Liquid Chromatography method for analyzing ketoconazole content in micro-dissolution testing of capsule formulations. The method employed a C18 column with a mobile phase of acetonitrile:WFI (0.15% TEA, pH 3.5; 50:50) at 1 mL/min and detection at 265 nm. Validation demonstrated compliance with selectivity, linearity (r = 0.9996), sensitivity (LoD 6.51 µg/mL; LoQ 19.74 µg/mL), accuracy (99.6–101.3%), and precision (<2%, except one interday result at 2.08%). Micro-dissolution testing showed sustained ketoconazole release, exceeding 100% within 240 minutes. Data modeling (performed using DDSolver) indicated comparable fit for the Higuchi (R²_adj = 0.96) and Korsmeyer (R²_adj = 0.93) models, suggesting diffusion-controlled release of ketokonazole. The validated UHPLC method is suitable for micro-dissolution studies, and the alginate-acacia gum formulation effectively modulates drug release.

Ultra-High Performance Liquid Chromatography Method Validation for Micro-dissolution Analysis of Ketoconazole in Alginate-Acacia Gum Composite Capsules Lumakso, Fajar Aji; Annisa, Viviane; Cermenda, Riska; Chabib, Lutfi
Journal of Food and Pharmaceutical Sciences Vol 13, No 4 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.24078

Ketoconazole, a BCS Class 2 antifungal drug, has good absorption but suffers from low solubility and poor bioavailability. To address this, a natural polymer-based matrix of alginate and acacia gum was formulated to enhance dissolution. This study aimed to validate a Ultra High Performance Liquid Chromatography method for analyzing ketoconazole content in micro-dissolution testing of capsule formulations. The method employed a C18 column with a mobile phase of acetonitrile:WFI (0.15% TEA, pH 3.5; 50:50) at 1 mL/min and detection at 265 nm. Validation demonstrated compliance with selectivity, linearity (r = 0.9996), sensitivity (LoD 6.51 µg/mL; LoQ 19.74 µg/mL), accuracy (99.6–101.3%), and precision (<2%, except one interday result at 2.08%). Micro-dissolution testing showed sustained ketoconazole release, exceeding 100% within 240 minutes. Data modeling (performed using DDSolver) indicated comparable fit for the Higuchi (R²_adj = 0.96) and Korsmeyer (R²_adj = 0.93) models, suggesting diffusion-controlled release of ketokonazole. The validated UHPLC method is suitable for micro-dissolution studies, and the alginate-acacia gum formulation effectively modulates drug release.

Analytical Method Validation of High Performance Liquid Chromatography for Ketoconazole Tablets Lumakso, Fajar Aji; Annisa, Viviane; Alviansyah, Muhammad Rizal; Chabib, Lutfi
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.69415

Ketoconazole is an azole antifungal with low solubility and classified as Biopharmaceutical Classification System (BCS) Class II. A tablet formulation based on an alginate-acacia gum matrix is developed to enhance the solubility of ketoconazole. This study aims to validate the analytical method using High-Performance Liquid Chromatography (HPLC) for the assay of ketoconazole in these tablet formulations. The analysis was performed using a C18 column (250×4.6 mm, 5 μm) with a mobile phase consisting of water for injection (WFI) containing 0.15% TEA (pH 3.3) and acetonitrile (50:50 v/v), flow rate 1.0 mL/min, and detection at 232 nm. Method validation included system suitability testing, linearity, accuracy, precision, specificity, LOD, and LOQ. Specificity testing indicated no interference at the retention time of ketoconazole. Good linearity was achieved over 10–250 ppm (r = 0.9996), with good accuracy (99.8–101.75%) and precision (intraday and interday; %RSD < 2%). LOD and LOQ were 2.357 ppm and 7.142 ppm, respectively. The developed HPLC method was shown to be valid, accurate, precise, selective, and reliable for the assay of ketoconazole in tablets formulated with an alginate-acacia gum matrix. This method can be used for routine quality control.

Optimization of Oral Disentegrating Film (ODF) Matrix from Alginate and Pectin/Gum Acacia/Carrageenan Polymer Using PEG/Glycerol as Plasticizer Viviane Annisa; Fajar Aji Lumakso; Ghiffari Ahnaf Danarwindu; Khasbi Andi Irawan
Journal of Food and Pharmaceutical Sciences Vol 14, No 3 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.27153

Oral dispersible film (ODF) is an innovative oral drug dosage form that is easy to consume, especially by pediatric, geriatric, and low-compliance patients. This preparation quickly disintegrates in the mouth without the need for water, providing a rapid onset of action, high bioavailability, and comfort of use. Hydrophilic polymers such as alginate are often used because they form strong films and dissolve readily in saliva. One important component in ODF formulations is a plasticizer, which increases flexibility and reduces film fragility. Two common plasticizers used are polyethylene glycol (PEG) and glycerol, each with different characteristics. This research method uses solvent casting. The polymers used are combinations of alginate:pectin, alginate:gum acacia, and alginate: carrageenan, with ratios of 3:0, 3:1, 3:2, 2:2, 2:1, and 0:3. Each polymer formulation was given additional PEG400 or glycerol at three concentration levels: 1%, 2.5%, and 5%. All formulas were tested for organoleptic, physical characteristics, disintegration time, strength, elongation, Scanning Electron Microscopy (SEM), and FTIR. The selection of glycerol and PEG400 plasticizers can affect disintegration time, tensile strength, elongation percentage, and SEM. Polymers also affect film characteristics, including the type of polymer and the concentration of the combined polymers.

Optimization of Oral Disentegrating Film (ODF) Matrix from Alginate and Pectin/Gum Acacia/Carrageenan Polymer Using PEG/Glycerol as Plasticizer Viviane Annisa; Fajar Aji Lumakso; Ghiffari Ahnaf Danarwindu; Khasbi Andi Irawan
Journal of Food and Pharmaceutical Sciences Vol 14, No 3 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.27153

Oral dispersible film (ODF) is an innovative oral drug dosage form that is easy to consume, especially by pediatric, geriatric, and low-compliance patients. This preparation quickly disintegrates in the mouth without the need for water, providing a rapid onset of action, high bioavailability, and comfort of use. Hydrophilic polymers such as alginate are often used because they form strong films and dissolve readily in saliva. One important component in ODF formulations is a plasticizer, which increases flexibility and reduces film fragility. Two common plasticizers used are polyethylene glycol (PEG) and glycerol, each with different characteristics. This research method uses solvent casting. The polymers used are combinations of alginate:pectin, alginate:gum acacia, and alginate: carrageenan, with ratios of 3:0, 3:1, 3:2, 2:2, 2:1, and 0:3. Each polymer formulation was given additional PEG400 or glycerol at three concentration levels: 1%, 2.5%, and 5%. All formulas were tested for organoleptic, physical characteristics, disintegration time, strength, elongation, Scanning Electron Microscopy (SEM), and FTIR. The selection of glycerol and PEG400 plasticizers can affect disintegration time, tensile strength, elongation percentage, and SEM. Polymers also affect film characteristics, including the type of polymer and the concentration of the combined polymers.

Inovasi Pengolahan Limbah Jelantah Menjadi Sabun Cuci untuk Kemandirian Ekonomi Kelompok Usaha Bersama Siti Zahliyatul Munawiroh; Viviane Annisa; Fajar Aji Lumakso; Awaluddin Nurmiyanto; Lutfi Chabib; Yulianto Yulianto; Hartanto Hartanto; Isnaini Pujimagfiroh; Abdul Mu’is Ardiyanto; Erlangga Prabowo; Muhammad Nurur Rifqi
Nuansa Akademik: Jurnal Pembangunan Masyarakat Vol. 11 No. 1 (2026)
Publisher : Lembaga Dakwah dan Pembangunan Masyarakat Universitas Cokroaminoto Yogyakarta (LDPM UCY)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47200/jnajpm.v11i1.3543

In Padukuhan Blekik, Sleman, the majority of residents (70%) still dispose of this waste into drains due to a lack of knowledge regarding environmental impacts and its economic potential. This community service activity aims to educate on the negative impacts of used cooking oil and train the women of the Kelompok Usaha Bersama (KUB) in processing this waste into solid and liquid laundry soap. The methods used included counseling based on a spiritual approach, education of management of Used Cooking Oil, and demonstrations of soap making. The results of the activity showed an increase in environmental awareness and technical skills among participants. Evaluation through pre-test and post-test showed a significant increase in the average score by 79%, from an initial score of 43 to 77. This activity successfully transformed the community's perception of waste into an economically valuable resource and provided skill capital for the economic independence of KUB Blekik.

Edukasi Program PENA (Peduli Nyeri Anda) sebagai Upaya Promosi Kesehatan di Padukuhan Ngemplak Kembangarum Yulianto Yulianto; Adilla Pratama Putri; Akhmad Dzaikra Ramahani; Ardelia Putri Mahendra; Hana Atika Azah Eskanda; Hesti Anjani Putri; Nanda Ghefira Az Zahra; Raissa Laila Rahma; Restika Mithari; Shelvi Anggraini; Shopia Nur Fauziah; Viviane Annisa
Nuansa Akademik: Jurnal Pembangunan Masyarakat Vol. 11 No. 1 (2026)
Publisher : Lembaga Dakwah dan Pembangunan Masyarakat Universitas Cokroaminoto Yogyakarta (LDPM UCY)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47200/jnajpm.v11i1.3242

Pain is a common health problem that can reduce productivity and quality of life. The high rate of self-medication in pain management and the wide variety of over-the-counter medications often lead to the misuse of drugs. The PENA (Peduli Nyeri Anda) program is a health promotion activity that aims to increase the community's knowledge in Padukuhan Ngemplak Kembangarum about safe and rational pain management. This study used a quasi-experimental, one-group pretest-posttest design through health education activities. The results indicate that PENA education significantly increased community knowledge regarding pain management (p < 0.001), with income identified as the most correlated factor. This program is effective as a promotive effort, although further research with a larger sample size and more specific variables is required to strengthen the generalization of the findings.

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