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All Journal Journal of Food and Pharmaceutical Science Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Journal of Islamic Pharmacy Acta Pharmaciae Indonesia : Acta Pharm Indo Majalah Farmasetika Jurnal Inovasi Farmasi Indonesia Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Jurnal Nuansa Akademik: Jurnal Pembangunan Masyarakat Indonesian Journal of Pharmaceutical Education Indonesian Health Journal Journal of Food and Pharmaceutical Sciences
Annisa, Viviane
Universitas Gadjah Mada
Religion Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary

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Optimization And Characterization of Silver Nanoparticle Biosynthesis Using Parijoto Fruit (Medinilla speciosa) Water Extract With Box-Behnken Design Nurjana, Qinta Laily; Amin, Azizah; Annisa, Viviane; Munawiroh, Siti Zahliyatul
Journal of Food and Pharmaceutical Sciences Vol 13, No 2 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.21683

Abstract

Silver nanoparticles in the medical field are used as additives in vaccines, anti-diabetic agents, wound and bone healing, biosensors and anticancer therapy in medical applications. One of the plants that can act as a reducing agent in the biosynthesis of silver nanoparticles is the parijoto fruit (Medinilla speciosa). This study aims to optimize and characterize the biosynthesis of silver nanoparticles from the water extract of parijoto fruit (M. speciosa) with a box-behnken design. The method used in this study starts from the manufacture of water extract of parijoto fruit (M. speciosa) then continued with the biosynthesis of silver nanoparticles. The formula for the biosynthesis of silver nanoparticles will be optimized with a box-behnken design and characterized by Particle Size Analyzer (PSA), Fourier Transform Infrared (FTIR), and Transmission Electron Microscopy (TEM). The results obtained in this study will be analyzed using descriptive techniques. The optimization results with the Behnken box design showed an optimal formula with an extract concentration of 1%, a sonication time of 6 minutes, and a sonicator pulser of 30. The particle size obtained was 85 ± 0.1 nm with a PI of 0.486 ± 0.006 and a zeta potential of -27.3 ± 1.5. The FTIR spectrum showed C=O, C-O and O-H groups indicating flavonoid compounds as bioreductant agents. The morphology of silver nanoparticles showed instability. (4) Conclusions:the optimization of silver nanoparticles from parijoto fruit water extract (M. speciosa) have been discovered used the Box-Behnken design and has good silver nanoparticle characteristics.
Quality By Design (QbD) Pada Pembuatan Tablet Alopurinol Menggunakan Kajian Literatur Annisa, Viviane
INHEALTH : INDONESIAN HEALTH JOURNAL Vol. 4 No. 2 (2025): INHEALTH JOURNAL
Publisher : CV. Eureka Murakabi Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56314/inhealth.v4i2.305

Abstract

Quality by Design (QbD) dalam farmasi merupakan sistem manajemen mutu yang memprediksi, mengontrol, dan merespon secara sistematik terhadap risiko yang terjadi dalam tahap penelitian dan proses manufaktur. QbD telah memberikan pergeseran dari konvensional Quality by Testing (QbT) sebagai pendekatan untuk membangun kualitas produk dalam sistem yang dapat meminimalisisr terjadinya reject saat pengujian produk akhir. Pada artikel ini dilakukan implementasi QbD menggunakan kajian pustaka untuk mengembangkan tablet Allopurinol dengan cara mendefinisikan profil target, memilih faktor kritis, dan melakukan penilaian risiko. Tahapan awalnya dimulai dari mendefinisikan Quality Target Product Profile (QTPP), Critical Quality Attributes (CQA), Critical material Attributes (CMA) dan Critical Process Parameters (CPP), dan penilaian risiko. Dengan adanya studi pendekatan QbD dalam pembuatan tablet allopurinol, yield produk yang dihasilkan dapat maksimal dengan meminimalkan kegagalan selama produksi serta menghasilkan produk yang sesuai dengan spesifikasi sehingga mengurangi potensi reject selama pengujian.
Pelayanan Kesehatan bagi Lansia di Desa Bantulan Sleman melalui Kolaborasi Dokter Umum dan Dokter Spesialis Nugroho, Arie; Yahya, Taufik Nur; Mufattan, Ahmad; Annisa, Viviane
Nuansa Akademik: Jurnal Pembangunan Masyarakat Vol. 10 No. 2 (2025): In Progress
Publisher : Lembaga Dakwah dan Pembangunan Masyarakat Universitas Cokroaminoto Yogyakarta (LDPM UCY)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47200/jnajpm.v10i2.3082

Abstract

Bantulan Village, located in Godean District, Sleman Regency, is an area with a relatively high elderly population. However, most of the elderly in this area have not received comprehensive health services, especially from specialist doctors capable of treating chronic complaints often experienced by the elderly, such as joint pain, mobility disorders, and heart or lung disease. Therefore, a Free Health Service activity was held. This series of activities was carried out by a social project team from the Department of Surgery, Faculty of Medicine, University of Indonesia (UII), several members of which are health workers, namely general practitioners, orthopedic specialists, and thoracic surgeons. The social project will take the form of free health checks by general practitioners, orthopedic specialists, and thoracic surgeons, distribution of free medicines by pharmacists, free health consultations, and provision of education and referrals for patients requiring further management. This activity shows the high enthusiasm of the residents in carrying out this activity.
Co-Authors Agung Endro Nugroho Akhmad Kharis Nugroho Ariansyah, Damas Baik Arie Nugroho, Arie Azizah Amin, Azizah Bella Novita Muktiari Febrina, Binta Setya Henityastama, Milinian Tree Multi Jafar La Kilo Mufattan, Ahmad Muhammad, Hasman Zhafiri Munawiroh, Siti Zahliyatul Nurjana, Qinta Laily Rebia, Rina Afiani Teuku Nanda Saifullah, Teuku Nanda Tuti Hidayah Wibowo, Rizky Yahya, Taufik Nur