Garuda - Garba Rujukan Digital

Optimization And Characterization of Silver Nanoparticle Biosynthesis Using Parijoto Fruit (Medinilla speciosa) Water Extract With Box-Behnken Design Nurjana, Qinta Laily; Amin, Azizah; Annisa, Viviane; Munawiroh, Siti Zahliyatul
Journal of Food and Pharmaceutical Sciences Vol 13, No 2 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.21683

Silver nanoparticles in the medical field are used as additives in vaccines, anti-diabetic agents, wound and bone healing, biosensors and anticancer therapy in medical applications. One of the plants that can act as a reducing agent in the biosynthesis of silver nanoparticles is the parijoto fruit (Medinilla speciosa). This study aims to optimize and characterize the biosynthesis of silver nanoparticles from the water extract of parijoto fruit (M. speciosa) with a box-behnken design. The method used in this study starts from the manufacture of water extract of parijoto fruit (M. speciosa) then continued with the biosynthesis of silver nanoparticles. The formula for the biosynthesis of silver nanoparticles will be optimized with a box-behnken design and characterized by Particle Size Analyzer (PSA), Fourier Transform Infrared (FTIR), and Transmission Electron Microscopy (TEM). The results obtained in this study will be analyzed using descriptive techniques. The optimization results with the Behnken box design showed an optimal formula with an extract concentration of 1%, a sonication time of 6 minutes, and a sonicator pulser of 30. The particle size obtained was 85 ± 0.1 nm with a PI of 0.486 ± 0.006 and a zeta potential of -27.3 ± 1.5. The FTIR spectrum showed C=O, C-O and O-H groups indicating flavonoid compounds as bioreductant agents. The morphology of silver nanoparticles showed instability. (4) Conclusions:the optimization of silver nanoparticles from parijoto fruit water extract (M. speciosa) have been discovered used the Box-Behnken design and has good silver nanoparticle characteristics.

Quality By Design (QbD) Pada Pembuatan Tablet Alopurinol Menggunakan Kajian Literatur Annisa, Viviane
INHEALTH : INDONESIAN HEALTH JOURNAL Vol. 4 No. 2 (2025): INHEALTH JOURNAL
Publisher : CV. Eureka Murakabi Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56314/inhealth.v4i2.305

Quality by Design (QbD) dalam farmasi merupakan sistem manajemen mutu yang memprediksi, mengontrol, dan merespon secara sistematik terhadap risiko yang terjadi dalam tahap penelitian dan proses manufaktur. QbD telah memberikan pergeseran dari konvensional Quality by Testing (QbT) sebagai pendekatan untuk membangun kualitas produk dalam sistem yang dapat meminimalisisr terjadinya reject saat pengujian produk akhir. Pada artikel ini dilakukan implementasi QbD menggunakan kajian pustaka untuk mengembangkan tablet Allopurinol dengan cara mendefinisikan profil target, memilih faktor kritis, dan melakukan penilaian risiko. Tahapan awalnya dimulai dari mendefinisikan Quality Target Product Profile (QTPP), Critical Quality Attributes (CQA), Critical material Attributes (CMA) dan Critical Process Parameters (CPP), dan penilaian risiko. Dengan adanya studi pendekatan QbD dalam pembuatan tablet allopurinol, yield produk yang dihasilkan dapat maksimal dengan meminimalkan kegagalan selama produksi serta menghasilkan produk yang sesuai dengan spesifikasi sehingga mengurangi potensi reject selama pengujian.

Pelayanan Kesehatan bagi Lansia di Desa Bantulan Sleman melalui Kolaborasi Dokter Umum dan Dokter Spesialis Nugroho, Arie; Yahya, Taufik Nur; Mufattan, Ahmad; Annisa, Viviane
Nuansa Akademik: Jurnal Pembangunan Masyarakat Vol. 10 No. 2 (2025)
Publisher : Lembaga Dakwah dan Pembangunan Masyarakat Universitas Cokroaminoto Yogyakarta (LDPM UCY)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47200/jnajpm.v10i2.3082

Bantulan Village, located in Godean District, Sleman Regency, is an area with a relatively high elderly population. However, most of the elderly in this area have not received comprehensive health services, especially from specialist doctors capable of treating chronic complaints often experienced by the elderly, such as joint pain, mobility disorders, and heart or lung disease. Therefore, a Free Health Service activity was held. This series of activities was carried out by a social project team from the Department of Surgery, Faculty of Medicine, University of Indonesia (UII), several members of which are health workers, namely general practitioners, orthopedic specialists, and thoracic surgeons. The social project will take the form of free health checks by general practitioners, orthopedic specialists, and thoracic surgeons, distribution of free medicines by pharmacists, free health consultations, and provision of education and referrals for patients requiring further management. This activity shows the high enthusiasm of the residents in carrying out this activity.

Edukasi Program PENA (Peduli Nyeri Anda) sebagai Upaya Promosi Kesehatan di Padukuhan Ngemplak Kembangarum Yulianto, Yulianto; Putri, Adilla Pratama; Ramahani, Akhmad Dzaikra; Mahendra, Ardelia Putri; Eskanda, Hana Atika Azah; Putri, Hesti Anjani; Az Zahra, Nanda Ghefira; Rahma, Raissa Laila; Mithari, Restika; Anggraini, Shelvi; Fauziah, Shopia Nur; Annisa, Viviane
Nuansa Akademik: Jurnal Pembangunan Masyarakat Vol. 11 No. 1 (2026): In Progress
Publisher : Lembaga Dakwah dan Pembangunan Masyarakat Universitas Cokroaminoto Yogyakarta (LDPM UCY)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47200/jnajpm.v11i1.3242

Pain is a common health problem that can reduce productivity and quality of life. The high rate of self-medication in pain management and the wide variety of over-the-counter medications often lead to the misuse of drugs. The PENA (Peduli Nyeri Anda) program is a health promotion activity that aims to increase the community's knowledge in Padukuhan Ngemplak Kembangarum about safe and rational pain management. This study used a quasi-experimental, one-group pretest-posttest design through health education activities. The results indicate that PENA education significantly increased community knowledge regarding pain management (p < 0.001), with income identified as the most correlated factor. This program is effective as a promotive effort, although further research with a larger sample size and more specific variables is required to strengthen the generalization of the findings.

Pengaruh Demografi Terhadap Tingkat Pengetahuan Penanganan Nyeri Dalam Penggunaan Obat Tanpa Resep Pada Masyarakat Desa Donokerto Annisa, Viviane; Handari, Aisya Aprilia; Hanifah, Ardiya Frida; Syahbani, Arikah; Indarwati, Chairunisa Shinta; Umiaroh, Dewi Nur; Rusdiana, Irma Arya Wandani; Qurrotuaini, Luthfiana; Lestari, Nonik Indrian; Belva, Ravi Antonio; Rahmadona, Tasha
Nuansa Akademik: Jurnal Pembangunan Masyarakat Vol. 11 No. 1 (2026): In Progress
Publisher : Lembaga Dakwah dan Pembangunan Masyarakat Universitas Cokroaminoto Yogyakarta (LDPM UCY)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47200/jnajpm.v11i1.3243

The main problem faced by the Donokerto Village community is the low level of public literacy regarding the safe use of over-the-counter medications, appropriate dosages, and awareness of consulting with health professionals. This community service program aims to increase public understanding of how to manage pain using over-the-counter medications through the SIPENA (Pharmacy Cares for Your Pain) program. The program was carried out through direct outreach activities that included a pre-test, distribution of educational leaflets, interactive lectures, question-and-answer discussions, and a post-test. The results showed an increase in the average knowledge score from 11.5 to 14.1 after the outreach. This proves that the outreach was effective for all groups. In conclusion, the SIPENA program successfully increased health literacy and public awareness about the rational use of pain medication.

Ultra-High Performance Liquid Chromatography Method Validation for Micro-dissolution Analysis of Ketoconazole in Alginate-Acacia Gum Composite Capsules Lumakso, Fajar Aji; Annisa, Viviane; Cermenda, Riska; Chabib, Lutfi
Journal of Food and Pharmaceutical Sciences Vol 13, No 4 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.24078

Ketoconazole, a BCS Class 2 antifungal drug, has good absorption but suffers from low solubility and poor bioavailability. To address this, a natural polymer-based matrix of alginate and acacia gum was formulated to enhance dissolution. This study aimed to validate a Ultra High Performance Liquid Chromatography method for analyzing ketoconazole content in micro-dissolution testing of capsule formulations. The method employed a C18 column with a mobile phase of acetonitrile:WFI (0.15% TEA, pH 3.5; 50:50) at 1 mL/min and detection at 265 nm. Validation demonstrated compliance with selectivity, linearity (r = 0.9996), sensitivity (LoD 6.51 µg/mL; LoQ 19.74 µg/mL), accuracy (99.6–101.3%), and precision (<2%, except one interday result at 2.08%). Micro-dissolution testing showed sustained ketoconazole release, exceeding 100% within 240 minutes. Data modeling (performed using DDSolver) indicated comparable fit for the Higuchi (R²_adj = 0.96) and Korsmeyer (R²_adj = 0.93) models, suggesting diffusion-controlled release of ketokonazole. The validated UHPLC method is suitable for micro-dissolution studies, and the alginate-acacia gum formulation effectively modulates drug release.

Ultra-High Performance Liquid Chromatography Method Validation for Micro-dissolution Analysis of Ketoconazole in Alginate-Acacia Gum Composite Capsules Lumakso, Fajar Aji; Annisa, Viviane; Cermenda, Riska; Chabib, Lutfi
Journal of Food and Pharmaceutical Sciences Vol 13, No 4 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.24078

Ketoconazole, a BCS Class 2 antifungal drug, has good absorption but suffers from low solubility and poor bioavailability. To address this, a natural polymer-based matrix of alginate and acacia gum was formulated to enhance dissolution. This study aimed to validate a Ultra High Performance Liquid Chromatography method for analyzing ketoconazole content in micro-dissolution testing of capsule formulations. The method employed a C18 column with a mobile phase of acetonitrile:WFI (0.15% TEA, pH 3.5; 50:50) at 1 mL/min and detection at 265 nm. Validation demonstrated compliance with selectivity, linearity (r = 0.9996), sensitivity (LoD 6.51 µg/mL; LoQ 19.74 µg/mL), accuracy (99.6–101.3%), and precision (<2%, except one interday result at 2.08%). Micro-dissolution testing showed sustained ketoconazole release, exceeding 100% within 240 minutes. Data modeling (performed using DDSolver) indicated comparable fit for the Higuchi (R²_adj = 0.96) and Korsmeyer (R²_adj = 0.93) models, suggesting diffusion-controlled release of ketokonazole. The validated UHPLC method is suitable for micro-dissolution studies, and the alginate-acacia gum formulation effectively modulates drug release.

Title

Found 17 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 17 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 17 Documents
Search