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All Journal LEX ET SOCIETATIS JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Journals of Ners Community Jurnal Ilmiah Medicamento Jurnal Yoga Dan Kesehatan Jurnal Kesehatan Qamarul Huda Journal Pharmaceutical Science and Application (JPSA)
Made Krisna Adi Jaya
Program Studi Farmasi, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Udayana
Religion Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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THE EFFECTIVENESS TEST OF INFUSION CELERY ROOT (Apium graveolens L.) AS A DIURETIC IN WISTAR MALE WHITE RATS (Rattus Norvegicus): A LITERATURE STUDY Ida Ayu Dhea Rahnia; Made Krisna Adi Jaya
Journal Pharmaceutical Science and Application Vol. 4 No. 1 (2022): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2022.v04.i01.p03

Abstract

Background: Hypertension is defined by persistently elevated arterial blood pressure. The increase in systolic blood pressure is generally>140mmHg or diastolic blood pressure> 90mmHg. The prevalence of hypertension increases with lifestyle changes. Objective: To determine the diuretic effect of celery (Apium graveolens L.) on male wistar rats (Rattus norvegicus). Methods: This research uses a literature study method, the type of the research is descriptive qualitative with literature research (library research) systematic. Results: Based on research data, there were 5 groups of mice that received different treatments. Among the five treatment groups, 0.5 % CMC suspension (KP-) showed the least mean cumulative urine volume, and furosemide suspension (KP+) showed a large mean cumulative urine volume when compared to negative controls. Conclusion: Celery root infusion can increase urine volume, because it contains flavonoids that play a role in increasing urine volume (diuresis). Keywords: Diuretic; Celery (Apium graveolens L.); Furosemide; Hypertension; Wistar rats
ACTIVITY OF BAY LEAF EXTRACT (Eugenia polyantha) AS ANTIINFLAMMATORY IN WHITE RAT (Rattus norvegicus): NARRATIVE REVIEW Ida Ayu Nadia Kusumastuti; Made Krisna Adi Jaya
Journal Pharmaceutical Science and Application Vol. 4 No. 1 (2022): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2022.v04.i01.p04

Abstract

Background: Inflammation is the body's defense response against foreign body invasion, tissue injury, or both caused by microorganisms, mechanical trauma, chemical compounds, and physical factors. Anti-inflammatory agents can be used to treat inflammation. Bay leaves are one example of a plant that can be used. Ethanol extract and water extract of a bay leaf can be anti-inflammatory because they contain flavonoids. Objectives: The purpose of this study was to see how effective ethanol extract and aqueous extract of bay leaf were as antiinflammatory agents in mice. Methods: This study employs a systematic literature review approach, descriptive qualitative research, and library research. Results: The most efficacious dose was 150 mg/kg BW at a 70 percent concentration and at an 80 percent concentration for ethanol extract of bay leaves, and 50 mg/kg BW for the aqueous extract of bay leaves. Conclusion: Based on the results of this study, it can be concluded that bay leaf (Eugenia polyantha) ethanol extract and aqueous extract have anti-inflammatory activities. Keywords: Anti-inflammatory; Bay Leaf; Diclofenac sodium; Ethanol Extract; Aqueous
THE POTENTIAL OF FRANGIPANI FLOWER EXTRACT (Plumeria alba L.) AS AN ANTIBACTERIAL: A LITERATURE REVIEW Hana Yuniestica Sinaga; Made Krisna Adi Jaya
Journal Pharmaceutical Science and Application Vol. 4 No. 1 (2022): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2022.v04.i01.p05

Abstract

Background: Bacteria develop naturally in the human body to aid in protecting the individual. Antibiotic resistance is quickly increasing and is becoming a global health concern. In this situation, the risk of synthetic antibiotic resistance against bacterial infections makes it critical to find alternative medications that are safe, easy to obtain, and better than synthetic antibiotic alternatives. The frangipani plant is one of the medicinal plants used in traditional medicine as an antibacterial. The frangipani plant possesses antibacterial properties comparable to broadspectrum medicines against uro-gastro pathogens. Objective: The purpose of this study was to determine the activity of the frangipani flower as an antibacterial. Methods: studying literature from various databases, websites, national journals, and relevant international journals to identify frangipani flowers with antibacterial activity. Results: Results showed that frangipani flowers have antibacterial activity against gram-positive and gram-negative bacteria because frangipani flowers contain various antibacterial chemical components, such as terpenoids, saponins, phenols, flavonoids, tannins, and essential oils. Conclusion: Frangipani flowers have the potential to an antibacterial against gram-positive and gram-negative bacteria. Keywords: Frangipani flower; Antibacterial; Bacteria
ANTIBIOTICS USAGE OVERVIEW IN ORTHOPEDIC SURGERY PATIENTS AT A HOSPITAL IN BALI Putu Ary Pudak Wangi; Made Krisna Adi Jaya
Journal Pharmaceutical Science and Application Vol. 4 No. 2 (2022): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2022.v04.i02.p05

Abstract

Backgrounds: Antibiotic resistance can be prevented by controlling the use of antibiotics wisely. Based on WHO recommendations, controlling the use of antibiotics is done by grouping antibiotics with the AWaRe category. Objective: This work aims to present an overview of the use of antibiotics in orthopaedic surgery patients as an effort to monitor the use of antibiotics in a hospital in Bali. Methods: Based on the patient's medical record data, the antibiotics used for orthopaedic surgery were calculated and grouped with the AWaRe classification. Results: Results showed that the most prescribed antibiotic was ceftriaxone (84.74%). There were no antibiotics in the reserve category, but the highest percentage was 94.92% in the watch category, and the access category was 5.08%. Conclusion: There is still non-selective use of antibiotics in this hospital, so in the future, it is necessary to evaluate qualitatively and quantitatively to ensure rational use as well as efforts to prevent the occurrence of antibiotic resistance. Keywords: Antibiotics; Resistance; AwaRe; Hospital; Bali
DRUG MANAGEMENT EVALUATION THROUGH EXPIRED DRUG PROFILE ANALYSIS AT “X” HOSPITAL IN BALI Kadek Lia Andini; Made Krisna Adi Jaya
Journal Pharmaceutical Science and Application Vol. 5 No. 1 (2023): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2023.v05.i01.p04

Abstract

Background: One of the most important hospital management in the provision of health services as a whole is drug management. Remember the important position of drugs for hospitals; their management must be carried out effectively and efficiently because if they do not, they can have a negative impact on hospitals, both medically, socially and economically. Drug management is crucial in the drug management cycle to determine drug stocks that suit the needs of health services with guaranteed quality and can be obtained when needed. One of drug management is by controlling expired drugs. Medicines that have passed their expiry date can be dangerous because they reduce the stability of the drug and can cause toxic effects. Objective: This study aims to describe drug management in terms of expired drug profiles and determine the factors that influence the number of expired drugs in "X" Hospital. Methods: Research in the form of observational research with a descriptive approach. The samples used are all expired drugs in the warehouse and have not been destroyed. Factors affecting the number of expired drugs were observed by interview. Results: The results of the study show that the percentage of expired drugs in the period 2019 to 2022 is obtained from the loss value and inventory management value of 0.11%, respectively; 0.18%; 0.14%; and 0.93%. Expired drugs were also classified based on the ABC analysis, with the highest number in group C with 137 items; in the VEN analysis, the essential medicines group with the highest number of 122 items; and in the ABC-VEN combination analysis, the EC group occupied the highest rank. The existence of expired drugs is caused by several factors, including the influence of information systems, human resources and methods of recording drugs that are still manual. Conclusion: The management of expired drugs in the pharmaceutical installation of "X" Hospital is quite good because the percentage is still under control because it is less than 2%. Keywords: Drug management; Evaluation; Expired drugs
Digitalization of HYPOGLYRISK and Evaluation of Its Utility for Pharmacist-Led Hypoglycemia Risk Assessment in Type 2 Diabetes Mellitus Made Krisna Adi Jaya; Zullies Ikawati; Fita Rahmawati; Nanang Munif Yasin; I Gusti Ngurah Anom Cahyadi Putra
Jurnal Ilmiah Medicamento Vol 12 No 1 (2026): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v12i1.13619

Abstract

Background: We developed a tool for pharmacists to facilitate screening of medication-related hypoglycemia risk in patients with type 2 diabetes mellitus (T2DM), called HYPOGLYRISK. Although this instrument has been validated and proven reliable, the paper-based version was considered inefficient and prone to human error during routine screening.Objective: This study aimed to digitalize HYPOGLYRISK and evaluate its utility compared with the printed version.Methods: A mixed-method study design combining software development and a quasi-experimental trial was used. In the development stage, the application was created using Android Studio and validated through Black Box Testing and User Acceptance Testing (UAT). In the trial stage, 46 pharmacists participated and were divided into two groups using either the digital or paper-based HYPOGLYRISK to assess simulated ambulatory T2DM patients representing different hypoglycemia risk categories. The primary outcome was assessment time efficiency, while the secondary outcome was the potential for human error. Data were analyzed using the Mann-Whitney U test, chi-square test, and relative risk analysis.Results: The digital HYPOGLYRISK demonstrated significantly shorter assessment time compared with the conventional version (p<0.05) and reduced the probability of scoring errors by 3.3 times (p<0.05). The digital application also provided additional advantages, including efficiency, scalability, ease of use, rapid data access, and simplified data management.Conclusion: These findings suggest that digital HYPOGLYRISK can enhance pharmacist-led hypoglycemia risk assessment among ambulatory patients with T2DM.
Co-Authors Anak Agung Indah Astrijayanti Anisa Hanum Dewa Ayu Swastini Dewa Gede Wahyu Nuryatama Dewi Puspita Apsari Dewi Puspita Apsari Gabriel Quentin Hana Yuniestica Sinaga Hana Yuniestica Sinaga I Gusti Agung Ayu Kartika I Gusti Ayu Nyoman Dyah Sukmawati I Gusti Ayu Sintia Dewi I Gusti Lanang Made Rudiartha I Gusti Ngurah Agung Dewantara Putra I Gusti Ngurah Anom Cahyadi Putra I Made Bakta I Wayan Martadi Santika Ida Ayu Dhea Rahnia Ida Ayu Dhea Rahnia Ida Ayu Gendari Ida Ayu Nadia Kusumastuti Ida Ayu Nadia Kusumastuti Kadek Lia Andini Kadek Lia Andini Kadek Valentina Renita Dewi Ketut Widyani Astuti Luh Putu Febryana Larasanty Luh Putu Febryana Larasanty Nanang Munif Yasin Ni Ketut Tria Purnamisari Ni Luh Santiyani Dewi Ni Putu Aryati Suryaningsih Ni Putu Rutin Seciolini Agristy Ni Putu Wulanda Evayanti Putu Ary Pudak Wangi Putu Ary Pudak Wangi Rahmawati, Fita Safira Nur Syifa Setiawati Setiawati Setiawati Setiawati Sutema, Ida Ayu Manik Partha Wintariani, Ni Putu ZULLIES IKAWATI