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POTENSI TERAPEUTIK Punica granatum SEBAGAI ANTIOKSIDAN ALAMI PADA STRES OKSIDATIF YANG DIINDUKSI PLASMA PREEKLAMPSI Januarsih, Januarsih
Jurnal Cakrawala Ilmiah Vol. 4 No. 10: Juni 2025
Publisher : Bajang Institute

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Abstract

Preeclampsia is a complication of pregnancy characterised by hypertension and endothelial dysfunction, with oxidative stress as one of its main mechanisms. An imbalance between reactive oxygen species (ROS) and the antioxidant system leads to endothelial cell damage that contributes to disease progression. The main biomarkers of oxidative stress include increased malondialdehyde (MDA) and decreased superoxide dismutase (SOD) activity. Assess the therapeutic potential of Punica granatum extract as a natural antioxidant against oxidative stress in HUVECs endothelial cells exposed to preeclamptic plasma. An in vitro experimental study was conducted using HUVECs cultures divided into five groups: negative control, preeclamptic control, and three treatment groups with 25, 50, and 100 µg/mL doses of Punica granatum extract. Parameters measured were MDA levels and SOD activity. Statistical analysis used one-way ANOVA with Tukey's post hoc test (p<0.05). Exposure to preeclamptic plasma increased MDA levels and decreased SOD activity significantly. Treatment with Punica granatum extract reduced MDA levels and increased SOD activity significantly, especially at a dose of 50 µg/mL which was close to normal control values. Punica granatum extract showed therapeutic potential as a natural antioxidant in reducing oxidative stress due to preeclampsia in HUVECs. This study supports the development of Punica granatum as a phytotherapy candidate in antioxidant-based management of preeclampsia
EDUKASI KESEHATAN REPRODUKSI PADA KELOMPOK WANITA TANI DI DESA LANDASAN ULIN UTARA Januarsih, Januarsih; Megawati, Megawati; Suhrawardi, Suhrawardi
JURNAL PENGABDIAN MANDIRI Vol. 4 No. 4: April 2025
Publisher : Bajang Institute

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Abstract

Women's reproductive health is an important factor that affects the overall quality of life, both in physical, mental, and social aspects. However, limited understanding of reproductive health, especially in rural areas, is still a major problem. One example is Landasan Ulin Utara Village, where the majority of the population work as farmers. The farm women group in this village faces various challenges in maintaining reproductive health, especially related to reproductive hygiene issues, such as abnormal vaginal discharge. Lack of understanding on how to maintain reproductive hygiene and lack of access to health services affect women's health in the village. The purpose of this community service activity is to provide education on reproductive health to a group of farm women in Landasan Ulin Utara Village. The approach used in this activity is a participatory community-based approach, with counselling methods, group discussions, and interactive question and answer sessions. Education focused on understanding reproductive hygiene, prevention of abnormal vaginal discharge, and the importance of accessing health services. In addition, this activity aims to reduce the existing social stigma related to the discussion of reproductive health issues. The results of this activity showed a significant increase in knowledge among participants. Before the education, the majority of participants did not know that abnormal vaginal discharge could be a sign of infection or a more serious health problem. After participating in the activity, more than 80% of participants were able to differentiate between normal and abnormal vaginal discharge and understood how to maintain reproductive hygiene. Through this activity, it is hoped that the women farmer groups in Landasan Ulin Utara Village will not only gain new knowledge, but also become agents of change who spread information about the importance of maintaining reproductive health in their communities.
KADAR SUPEROXYDE DISMUTASE PADA IBU POST PARTUM YANG MELAKUKAN SENAM OTARIA januarsih, januarsih; Rusmilawaty, Rusmilawaty; Noorhayati, Noorhayati
Jurnal Midwifery Update (MU) Vol. 6 No. 1 (2024): Jurnal Midwifery Update (MU)
Publisher : Poltekkes Kemenkes Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32807/jmu.v6i1.163

Abstract

AbstrakInvolusi uterus pada ibu postpartum dipengaruhi oleh banyak faktor, salah satunya dengan aktifitas fisik yaitu senam nifas atau senam pasca melahirkan (dengan kondisi ibu sehat) yang bertujuan untuk mengurangi infeksi yang terjadi pada involusi uterus yang diakibatkan sisa darah yang tidak dikeluarkan, mengurangi resiko perdarahan abnormal serta untuk menghindari pembekuan darah yang menyumbat vena. Pelaksanaan pada penelitian ini dilakukan dengan memberikan perlakuan senam post partum Otaria pada kelompok intervensi dan tidak senam post partum pada kelompok control selama 7 hari. Desain yang digunakan dalam penelitian ini dengan Post Test Only Control Group Design atau pasca tes dengan kelompok eksperimen dan kontrol. Pada histogram menunjukkan bahwa rata – rata kadar SOD meningkat pada kelompok perlakuan, yaitu ibu – ibu post partum yang melaksanakan senam Otaria. Pada kelompok kontrol  tampak rata – rata kadar SOD menurun, yaitu  ibu – ibu post partum yang tidak melakukan senam Otaria. ibu post partum yang tidak melakukan senam Otaria telah terjadi penuruan kadar SOD. Masa post partummerupakan suatu kondisi yang rentan terhadap segala macam  stres. Hal tersebut merupakan  akibat  dari terjadinya  perubahan  fisiologis maupunfungsi metabolik sejak awal masa kehamilan dan kelelahan pada saat persalinan, sehingga menyebabkan reaksi oksidatif meningkat untukmenghasilkan energi yang dibutuhkan oleh wanita pada masa post partum. Stress oksidatif pada ibu di masa post partum dapat dicegah dengan cara melakukan senam Otaria yang mampu meningkatkan kadar SOD pada plasma ibu post partumAbstractUterine involution in postpartum mothers is influenced by many factors, one of which is physical activity, namely postpartum exercise or postpartum exercise (if the mother is healthy) which aims to reduce infections that occur in uterine involution caused by remaining blood that is not expelled, reducing the risk of abnormal bleeding. and to avoid blood clots that block veins. The implementation of this research was carried out by providing Otaria post partum exercise treatment in the intervention group and no post partum exercise treatment in the control group for 7 days. The design used in this research was Post Test Only Control Group Design or post test with experimental and control groups. The histogram shows that the average SOD levels increased in the treatment group, namely post partum mothers who carried out the Otaria exercise. In the control group, the average SOD levels appeared to decrease, namely post partum mothers who did not do Otaria exercises. Post partum mothers who did not do Otaria exercises had a decrease in SOD levels. The post partum period is a condition that is vulnerable to all kinds of stress. This is the result of physiological changes and metabolic functions since the beginning of pregnancy and fatigue during childbirth, causing oxidative reactions to increase to produce the energy needed by women in the post partum period. Oxidative stress in mothers during the post-partum period can be prevented by doing Otaria exercises which can increase SOD levels in post-partum mothers' plasma