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Januarsih, Januarsih
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POTENSI TERAPEUTIK Punica granatum SEBAGAI ANTIOKSIDAN ALAMI PADA STRES OKSIDATIF YANG DIINDUKSI PLASMA PREEKLAMPSI Januarsih, Januarsih
Jurnal Cakrawala Ilmiah Vol. 4 No. 10: Juni 2025
Publisher : Bajang Institute

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Abstract

Preeclampsia is a complication of pregnancy characterised by hypertension and endothelial dysfunction, with oxidative stress as one of its main mechanisms. An imbalance between reactive oxygen species (ROS) and the antioxidant system leads to endothelial cell damage that contributes to disease progression. The main biomarkers of oxidative stress include increased malondialdehyde (MDA) and decreased superoxide dismutase (SOD) activity. Assess the therapeutic potential of Punica granatum extract as a natural antioxidant against oxidative stress in HUVECs endothelial cells exposed to preeclamptic plasma. An in vitro experimental study was conducted using HUVECs cultures divided into five groups: negative control, preeclamptic control, and three treatment groups with 25, 50, and 100 µg/mL doses of Punica granatum extract. Parameters measured were MDA levels and SOD activity. Statistical analysis used one-way ANOVA with Tukey's post hoc test (p<0.05). Exposure to preeclamptic plasma increased MDA levels and decreased SOD activity significantly. Treatment with Punica granatum extract reduced MDA levels and increased SOD activity significantly, especially at a dose of 50 µg/mL which was close to normal control values. Punica granatum extract showed therapeutic potential as a natural antioxidant in reducing oxidative stress due to preeclampsia in HUVECs. This study supports the development of Punica granatum as a phytotherapy candidate in antioxidant-based management of preeclampsia
EDUKASI KESEHATAN REPRODUKSI PADA KELOMPOK WANITA TANI DI DESA LANDASAN ULIN UTARA Januarsih, Januarsih; Megawati, Megawati; Suhrawardi, Suhrawardi
JURNAL PENGABDIAN MANDIRI Vol. 4 No. 4: April 2025
Publisher : Bajang Institute

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Women's reproductive health is an important factor that affects the overall quality of life, both in physical, mental, and social aspects. However, limited understanding of reproductive health, especially in rural areas, is still a major problem. One example is Landasan Ulin Utara Village, where the majority of the population work as farmers. The farm women group in this village faces various challenges in maintaining reproductive health, especially related to reproductive hygiene issues, such as abnormal vaginal discharge. Lack of understanding on how to maintain reproductive hygiene and lack of access to health services affect women's health in the village. The purpose of this community service activity is to provide education on reproductive health to a group of farm women in Landasan Ulin Utara Village. The approach used in this activity is a participatory community-based approach, with counselling methods, group discussions, and interactive question and answer sessions. Education focused on understanding reproductive hygiene, prevention of abnormal vaginal discharge, and the importance of accessing health services. In addition, this activity aims to reduce the existing social stigma related to the discussion of reproductive health issues. The results of this activity showed a significant increase in knowledge among participants. Before the education, the majority of participants did not know that abnormal vaginal discharge could be a sign of infection or a more serious health problem. After participating in the activity, more than 80% of participants were able to differentiate between normal and abnormal vaginal discharge and understood how to maintain reproductive hygiene. Through this activity, it is hoped that the women farmer groups in Landasan Ulin Utara Village will not only gain new knowledge, but also become agents of change who spread information about the importance of maintaining reproductive health in their communities.
Co-Authors Agus Rachmadi Ahmad Rizani Ahmad Rizani, Ahmad Anita, Nur Fitria Jannatul Laili Isnaniah, Isnaniah Isrowiyatun Daiyah Maslani, Hj. Noorhayati maslani, noorhayati Megawati - Norlaila Sofia Nur Rohmah Prihatanti, Nur Rohmah Rafidah Rafidah Rita Kirana Rubiati Hipni, Rubiati Siti Fatimah Sofia, Norlaila suhrawardi, suhrawardi Tut Barkinah Vebruati, Vebruati