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All Journal Medula Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Aisyah : Jurnal Ilmu Kesehatan
Aryana, Wayan Ferly
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Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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LITERATURE REVIEW: PILIHAN TERAPI PASIEN ASMA DENGAN ATRIAL FIBRILASI Sanjaya, Rizki Putra; Nasruddin, Sigit Pratama Iustitia; Ekawati, Diyan; Rusmini, Hetti; Aryana, Wayan Ferly
Jurnal Ilmu Kedokteran dan Kesehatan Vol 10, No 8 (2023): Volume 10 Nomor 8
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v10i8.10200

Abstract

Abstrak: Review Literatur: Pilihan Terapi Pasien Asma dengan AtrialFibrilasi. Asma memiliki dampak sistemik terkait dengan perkembanganaterosklerosis dan modifikasi pada struktur dan fungsi pembuluh darah. Terapi asmadengan bronkodilator dan kortikosteroid oral atau sistemik telah diidentifikasi sebagaifaktor risiko kejadian CVD dan stroke, sedangkan pemberian bronkodilator inhalasiβ2-agonis dapat meningkatkan risiko terjadinya fibrilasi atrium. Terapi asmaberdasarkan GINA, merekomendasikan pemberian antibodi anti-IgE yang merupakanjenis terapi tipe controller asma, selain pemberian kortikosteroid oral, namunterkendala keterbatasan obat dan harga obat yang jauh lebih mahal dibandingkangolongan β2-agonis.
Uncontrolled Type 2 Diabetes Mellitus Induces an Enterococcus faecalis Lung Abscess: A case report Aryana, Wayan Ferly; Wibowo, Adityo; Gozali, Achmad; Saputra, Tito Tri; SL, I Made Afryan; Febrihartati, Isura
Medula Vol 14 No 8 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i8.1184

Abstract

The incidence of lung abscess has increased due to the rise in antibiotic resistence, aging population, and immunocompromised patients.  Lung abscess is associated with high mortality rates, ranging from 1—20% globally, long treatment cycles, and significant management costs. Diabetes millitus affect innate and adaptive immunity, This dysregulation, microvascular complications, poor vascular flow, can further compromise an appropriate immune response and healing leading to worsening or secondary infections. Uncontrolled diabetes mellitus can lead patients to immunocompromised conditions, predisposing them to infectious disease. This study is a case report with data obtained through self-history, physical examination, and supporting examinations. A 49-year-old female patient presented with complaints of dyspnea, productive cough, and fever. The patient had a history of uncontrolled type 2 diabetes mellitus with fasting blood glucose 219 mg/dL. Chest examination showed a decreased of tactile fremitus on the left lung field, dullness on percussion of the left lung field, and decreased vesicular sound on auscultation of the left lung field. Laboratory and radiological examinations were also carried out. The CT show a well-demarcated lesion measuring 13.1x7.2x11.2 cm, air-fluid level (+), walled 0.5 cm thick  indicating suspicion of left lung abscess. The patient received treatments and showed clinical improvement so that therapy could be continued on an outpatient basis.
EFFECTIVENESS OF TRIPLE THERAPY WITH SINGLE AND MULTIPLE INHALERS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE Soemarwoto, Retno Ariza; Putri, Maharani; Meirissa, Tria; Yunus, Faisal; Aryana, Wayan Ferly; Wibowo, Adityo; Oktobiannobel, Jordy
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 10, No 1 (2025): March
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v10i1.3050

Abstract

Introduction: Exacerbations of chronic obstructive pulmonary disease (COPD) contribute to 3 million annual deaths worldwide. Triple therapy (ICS + LABA + LAMA) helps reduce symptoms and exacerbation risk.Objective: To assess the effectiveness and clinical response of single versus multiple inhaler therapy in managing COPD.Methods: A pre-post study was conducted on two groups of COPD patients over 8 weeks. Group 1 (n=47) used a single inhaler, while Group 2 (n=45) used multiple inhalers. Outcomes were measured using the mMRC scale, blood eosinophil levels, and spirometry at weeks 2 and 8.Results: The single-inhaler group significantly reduced mMRC scores, with a median decrease from 4.00 to 2.00 (p0.05). Eosinophil levels also decreased significantly in both groups, with a larger reduction in the single-inhaler group (p0.05). Lung function improved in both groups, but no significant differences were found (p0.05) in terms of time or between-group comparisons.Conclusion: Single-inhaler therapy reduced dyspnea and eosinophil levels more effectively than multiple inhalers. The effectiveness of single inhalers may be attributed to higher adherence due to ease of use. 
Co-Authors Adityo Wibowo, Adityo Ekawati, Diyan Faisal Yunus Febrihartati, Isura Gozali, Achmad Jordy Oktobiannobel Meirissa, Tria Nasruddin, Sigit Pratama Iustitia Putri, Maharani Rizki Putra Sanjaya Rusmini, Hetti Saputra, Tito Tri SL, I Made Afryan Soemarwoto, Retno Ariza