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All Journal Medula Jurnal Aisyah : Jurnal Ilmu Kesehatan
Febrihartati, Isura
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Education Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Uncontrolled Type 2 Diabetes Mellitus Induces an Enterococcus faecalis Lung Abscess: A case report Aryana, Wayan Ferly; Wibowo, Adityo; Gozali, Achmad; Saputra, Tito Tri; SL, I Made Afryan; Febrihartati, Isura
Medula Vol 14 No 8 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i8.1184

Abstract

The incidence of lung abscess has increased due to the rise in antibiotic resistence, aging population, and immunocompromised patients.  Lung abscess is associated with high mortality rates, ranging from 1—20% globally, long treatment cycles, and significant management costs. Diabetes millitus affect innate and adaptive immunity, This dysregulation, microvascular complications, poor vascular flow, can further compromise an appropriate immune response and healing leading to worsening or secondary infections. Uncontrolled diabetes mellitus can lead patients to immunocompromised conditions, predisposing them to infectious disease. This study is a case report with data obtained through self-history, physical examination, and supporting examinations. A 49-year-old female patient presented with complaints of dyspnea, productive cough, and fever. The patient had a history of uncontrolled type 2 diabetes mellitus with fasting blood glucose 219 mg/dL. Chest examination showed a decreased of tactile fremitus on the left lung field, dullness on percussion of the left lung field, and decreased vesicular sound on auscultation of the left lung field. Laboratory and radiological examinations were also carried out. The CT show a well-demarcated lesion measuring 13.1x7.2x11.2 cm, air-fluid level (+), walled 0.5 cm thick  indicating suspicion of left lung abscess. The patient received treatments and showed clinical improvement so that therapy could be continued on an outpatient basis.
EVALUATION OF THE SENSITIVITY AND SPECIFITY OF THE TUBERCULOSIS SIGN AND SYMPTOM (TBSS) SCORE IN COMPARISON WITH CHEST RADIOGRAPHY AND RMT FOR DIAGNOSING TUBERCULOSIS AMONG BRICK KILN WORKERS Soemarwoto, Retno Ariza; Listiandoko, Raden Dicky; Valentiene Messah,, Anse Diana; Dilangga, Pad; Didiek Herdarto, Mohammad Junus; Hendarto, Gatot Sudiro; Febrihartati, Isura
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 10, No 1 (2025): March
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v10i1.3076

Abstract

This cross-sectional study aimed to evaluate the sensitivity and specificity of the Tuberculosis Sign and Symptom (TBSS) score in comparison to chest radiography and the Rapid Molecular Test (RMT) among brick kiln workers. The study employed a total sampling method, involving 92 participants. Data collection was conducted from February to March 2024 in a brick kiln located in Saribumi Village, Gading Rejo District, Pringsewu Regency, Lampung Province. The majority of participants were female (77.3%), while males accounted for 22.8%. The most common age range was 41–60 years, representing 48.9% of the total sample. Regarding job categories, most workers were employed in the molding section. Screening with the TBSS score and chest radiography showed a sensitivity of 0.25, a specificity of 0.93, a positive predictive value of 0.14, and a negative predictive value of 0.96. The sensitivity and specificity of the RMT compared to the TBSS score could not be assessed as all RMT results were negative for TB. This limitation may be attributed to suboptimal sputum sample quality. The study concludes that while the TBSS score demonstrates high specificity and a strong negative predictive value, the diagnostic utility of the RMT could not be evaluated due to uniformly negative results.
SERUM METALLOPRETEINASE 3 (MMP-3) LEVELS IN LUNG CANCER AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) PATIENTS Soemarwoto, Retno Ariza; Mustofa, Syazili; Suwarno, Sukarti San; Yunus, Faisal; Listiandoko, Raden Dicky Wirawan; Sinaga, Fransisca TY; Febrihartati, Isura
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 10, No 1 (2025): March
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v10i1.3077

Abstract

Chronic Obstructive Pulmonary Disease (COPD) and Lung Cancer are among the diseases with high mortality rates and a similar genetic disposition. COPD is known to be a significant risk factor for lung cancer. Matrix metalloproteinase-3 (MMP-3) is a protein that plays a role in the growth stage of cancer that has the potential to develop COPD into lung cancer. This descriptive observational study aimed to compare plasma MMP-3 levels among four groups: healthy individuals, lung cancer patients, COPD patients, and patients with both lung cancer and COPD. The findings revealed that plasma MMP-3 levels were lowest in the healthy group and higher in the other groups. The increase in plasma MMP-3 levels among pathological subjects suggests a potential association between serum MMP-3 levels and the development of lung cancer in COPD patients. However, further research is needed to clarify this relationship.
Co-Authors Adityo Wibowo, Adityo Aryana, Wayan Ferly Didiek Herdarto, Mohammad Junus Dilangga, Pad Faisal Yunus Gatot Sudiro Hendarto, Gatot Sudiro Gozali, Achmad Listiandoko, Raden Dicky Listiandoko, Raden Dicky Wirawan Saputra, Tito Tri Sinaga, Fransisca TY SL, I Made Afryan Soemarwoto, Retno Ariza Suwarno, Sukarti San Syazili Mustofa Valentiene Messah,, Anse Diana