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All Journal Jurnal Kesehatan Reproduksi Universa Medicina Jurnal Penelitian dan Karya Ilmiah Lembaga Penelitian Universitas Trisakti JUARA: JURNAL WAHANA ABDIMAS SEJAHTERA The Journal of Society Medicine (JSOCMED) AMMA : Jurnal Pengabdian Masyarakat Neurona Sanus Medical Journal
Rachmiyani, Irmiya
Faculty of Medicine, Trisakti University
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Journal : Universa Medicina

 1 
Later age at menopause was associated with higher cognitive function in post-menopausal women Rachmiyani, Irmiya; Surjadi, Lily Marliany; Nirmalasari, Rully Ayu; Imran, Yudhisman
Universa Medicina Vol 37, No 3 (2018)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (736.075 KB) | DOI: 10.18051/UnivMed.2018.v37.203-208

Abstract

BACKGROUND Menopause is a condition in which the menstrual periods have stopped for the last 12 months due to cessation of ovarial functions causing estrogen hormones to decrease. Various studies find that many factors affect cognitive function at post-menopausal age among others the decrease in estrogens, age at menopause, duration of menopause, and education. However, the effects have been subject to controversy. The aim of this study was to determine the relationship of age, age at menopause, estradiol level, and education with cognitive function among healthy post-menopausal women. METHODS A cross-sectional study was conducted involving 31 post-menopausal women between 50 to 75 years old. Data on age, age at menopause, and education were collected using a questionnaire. The estradiol levels were measured using an electrochemiluminescent immunoassay (ECLIA). The Indonesian version of the Montreal Cognitive Assessment (MoCA INA) was used to assess the cognitive function. Multiple linear regression was used to analyze the data. A p<0.05 was considered statistically significant.RESULTS Age (b=-0.086; 95% C.I.=-0.263-0.090; p=324) and estradiol levels (b=0.106; 95% C.I.=-0.018 -0.230; p=0.092) were not significantly associated with cognitive function. However, education (b=1.537; 95% C.I.=0.176-2.898; p=0.028) and age at menopause (b=0.364;0.056-0.671; p=0.022) were significantly associated with cognitive function. Age at menopause was the most influential factor of cognitive function (Beta=0.402) compared to education (Beta=0.394).CONCLUSION Later age at menopause could increase cognitive function in post-menopausal women. Our findings are that modifiable factors that delay age at menopause should receive attention, in order to promote cognitive function. Keywords: Age at menopause, estrogens, cognitive function, post-menopausal women
Low 25-hydroxyvitamin D level increases carotid intima-media thickness in elderly women Imran, Yudhisman; Aswar, Andini; Rachmiyani, Irmiya; Adriani, Donna
Universa Medicina Vol 38, No 2 (2019)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2019.v38.114-120

Abstract

BackgroundCerebrovascular disease occurs due to atherosclerosis of the carotid artery triggered by endothelial dysfunction, which can be assessed by measuring the carotid intima-media thickness (CIMT). There are several risk factors contributing to endothelial dysfunction, such as 25-hydroxyvitamin D [25(OH)D] deficiency. A number of research studies have shown variable results on the relationship between 25(OH)D deficiency and endothelial dysfunction. The objective of the present study was to determine the relationship between 25(OH)D and CIMT in elderly women.METHODS A cross-sectional study was conducted involving 45 elderly women aged ≥60 years. The inclusion criteria were: able to communicate well and able to walk actively without any help. The exclusion criteria were: not having diabetes mellitus, stroke, heart disease, kidney disease, not consuming vitamin D or medicines containing corticosteroids, and not using hormone replacement therapy. Laboratory examination was conducted for fasting blood sugar, lipid profile, and 25(OH)D. CIMT was measured using carotid Doppler ultrasonography at the left carotid artery. Simple linear regression analysis was used to analyze the data.RESULTSMean 25(OH)D level was 11.753 ± 4.027 ng/mL, and mean CIMT 0.61 ± 0.10 mm. Simple regression analysis showed a significant relationship between 25(OH)D level and CIMT (β=-0.001; 95% C.I.=-0.020-0.003; p=0.009).CONCLUSION Our data suggest an inverse association between 25(OH)D level and CIMT in elderly women. This study supports the protective role of vitamin D against subclinical atherosclerosis in elderly women.
Co-Authors Adriani, Donna Amry, Carissa Maharani Aswar, Andini Diani Nazma Hilwa, Najwa Sufa Husnun Amalia Jordhi, Dimas Lira Panduwaty Nadhira Farah Puspitasaria Nasution, Dina Putri Nopala, Chandra Adi Patwa Amani, Patwa Pramana, Cipta Putri Nasution, Dina Putri, Mustika Anggiane Rahmansyah, Mulia Rully Ayu Nirmalasari, Rully Ayu Saroso, Ade Firman Surjadi, Lily Marliany Sutanto, Hans Utama Triasti Khusfiani Trilaksmi, Antin Umar, Aida Yudhisman Imran, Yudhisman