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Head Lice Eradication Efforts in a Group Home Environment: Yayasan Griya Asih Orphanage – A Case Study Natalia Puspadewi; Christian Ardianto; Gisella Anastasia
Jurnal Pengabdian kepada Masyarakat (Indonesian Journal of Community Engagement) Vol 9, No 2 (2023): June
Publisher : Direktorat Pengabdian kepada Masyarakat Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jpkm.82444

Children living in orphanages are generally vulnerable to close-contact transmission diseases, including head lice infestation. The clinical manifestation of head lice infestation was relatively mild, such as itchy scalp, and hence it is often overlooked as a community health issue. Education plays an essential role in preventing re-infection and eradicating head lice infestation. The treatment options include chemical treatment using pediculicides and physical management by shaving the head and manually removing the parasite. This community service activity aimed to eradicate head lice from Yayasan Griya Asih Orphanage. A series of three activities were conducted at Yayasan Griya Asih Orphanage in Central Jakarta. Each activity was done around one month apart to evaluate the effectiveness of treatment. Firstyear medical students were recruited to participate in these activities to familiarize them with real-world community health problems. Student volunteers helped applied pulse doses of Permethrin 1% shampoo and provided health education activity. Fiftyfive Yayasan Griya Asih Orphanage residents joined this activity from mid-October until December 2022. Residents were instructed not to share their personal items to prevent re-infection. Health education activities were done using one-to-many followed by a one-on-one format. In conclusion, head lice infestation screening is essential in crowded environments, and permethrin 1% pulsed dose followed by personalized health education activities and pest control effectively broke the disease transmission chain and eradicated the head lice infestation.

Perbandingan pemeriksaan kadar glukosa darah mandiri dengan uji laboratorium menggunakan metode baku emas Venna Venna; Jullyanny Waty Wijaya; Gregorio Gavriel Singgih; Christian Ardianto
Bahasa Indonesia Vol 22 No 2 (2023): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v22i2.4235

Pendahuluan: Ketersediaan point of care testing (POCT) glukosa darah saat ini dipakai secara luas untuk melakukan pemantauan glukosa darah mandiri (PGDM) bagi pasien diabetes. Saat ini berbagai pilihan alat POCT menggunakan metode glukosa dehidrogenase sudah tersedia. Penelitian ini berupaya membandingkan berbagai alat POCT dengan pemeriksaan laboratorium secara spektrofotometri menggunakan metode heksokinase yang merupakan baku emas dari pemeriksaan glukosa darah. Metode: Penelitian ini merupakan penelitian potong lintang dengan subjek penelitian berupa populasi dewasa muda laki laki dan perempuan dengan rentang usia 18-21 tahun dengan jumlah 97 sampel, dengan kriteria eksklusi sedang sakit berat, terdapat luka pada lokasi pengambilan darah, memiliki riwayat gangguan pembekuan darah, dan hasil pemeriksaan glukosa darah sewaktu >200 mg. Sampel yang diambil berupa darah kapiler yang langsung akan diujikan pada alat POCT dan sampel darah vena yang akan diuji menggunakan metode heksokinase. Analisis statistik dilakukan dengan menggunakan STATA versi 14.0. Data yang diperoleh akan dianalisis menggunakan Bland-Altman plot. Hasil: Didapatkan hasil glukosa darah POCT menggunakan alat Accu-chek® Performa dan Accu-chek® Instant memiliki rerata perbedaan dengan metode heksokinase yang bernilai negatif, sedangkan untuk GlucoDr.™Auto memiliki rerata perbedaan yang lebih mendekati angka nol dibandingkan dengan alat Accu-chek® Performa dan Accu-chek® Instant. Simpulan: Metode POCT dapat membantu dalam pemantauan glukosa darah pasien,namun tidak dapat menggantikan metode heksokinase.

EFFECT OF INTRAVENOUS ADMINISTRATION OF SECRETOME ON MALONDIALDEHYDE LEVELS IN ROTENONE-INDUCED PARKINSON'S DISEASE RATS Aliza, Sharla; Sidharta, Veronika Maria; Sasmita, Poppy Kristina; Ardianto, Christian; Barus, Jimmy
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.03

Background: Parkinson's disease (PD) is a progressive neurodegenerative disorder with an increasing prevalence. Oxidative stress is known to contribute to the development of PD through lipid peroxidation, which causes damage to the substantia nigra pars compacta. Lipid peroxidation produces malondialdehyde (MDA), which is known to be elevated in PD patients. Up till now, there is no cure for PD, and the available therapies are only symptomatic. The secretome from Mesenchymal Stem Cell (MSC) has antioxidant and neuroprotective components, making it a potential therapeutic agent that may slow the progression of PD. Objective: This study seeks to determine the effect of MSC secretome on oxidative stress in rotenone-induced PD rats. Methods: This research was an in-vivo experiment conducted with 30 male Sprague Dawley rats, divided into sham control, rotenone (+) secretome (-), and rotenone (+) secretome (+) groups. Rotenone (2.75 mg/kgBW) was administered for seven days to induce a PD model. Secretome administration (1 mg/ml) was carried out on days 3, 5, and 7. MDA levels were determined using the sandwich ELISA method. Results: This study found no significant difference in MDA levels among the three groups (p = 0.203). The sham control group had the lowest MDA 1.32(0.53) nmol/mL, followed by the rotenone (+) secretome (+) group 1.56(0.33) nmol/ml, and the highest MDA was observed in the rotenone (+) secretome (-) group 1.88(0.14) nmol/mL. Conclusion: Administration of MSC secretome did not significantly cause changes in plasma MDA levels of rotenone-induced Parkinson Disease rats.

EFFECTS OF MSC-DERIVED SECRETOME TOWARDS PLASMA-TOTAL CHOLESTEROL LEVELS ON ROTENONE-INDUCED PARKINSON’S DISEASE RAT MODELS Putria, Fani Mustika; Sasmita, Poppy Kristina; Sidharta, Veronika Maria; Ardianto, Christian; Barus, Jimmy
MNJ (Malang Neurology Journal) Vol. 11 No. 2 (2025): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.02.01

Background: Parkinson's disease (PD), a chronic progressive neurodegenerative disease, threatens much of the world's increasingly aging population and has no promise for disease-modifying drugs, only symptomatic treatment. One potential biomarker correlates PD to the disruption of cholesterol metabolizing processes that results in formation of cytotoxic bile acids (BA) which induces mitochondrial dysfunction that leads to the decrease of dopaminergic neurons in various PD models. Objective: This study aims to determine the effect of rotenone-induction as well as MSC-Secretome administration on plasma-total cholesterol levels in rat models.. Methods: This was an experimental research using 30 male Sprague Dawley rats divided into sham control, rotenone (+) secretome (-) and rotenone (+) secretome (+). Blood was withdrawn on day 0 and day 8 and analyzed under colorimetry and spectrophotometry for its plasma-total cholesterol concentration. Results: The Tukey Post-Hoc Test showed that there was no significant difference between the sham control and rotenone (+) secretome (-) (p = 0.073), plasma-total cholesterol level is lower in rotenone (+) secretome (-) than in the sham control. Furthermore, we were unable to prove for a significant difference between the rotenone (+) secretome (-) and rotenone (+) secretome (+) group (p= 0.234), even though in average the plasma-total cholesterol level is lower in the rotenone (+) secretome (+) group. Conclusion: Induction of rotenone followed by an intervention of MSC-Secretome has no effect on the change in plasma-total cholesterol levels on rat models.

PENINGKATAN PENGETAHUAN KANKER PAYUDARA DAN SADARI (PEMERIKSAAN PAYUDARA SENDIRI) PADA PEREMPUAN DI CILINCING, JAKARTA UTARA Bayu Perkasa Rosari; Christian Ardianto; Safira Aurea; Sitara Kirana
Mitramas: Jurnal Pengabdian dan Pemberdayaan Masyarakat Vol. 4 No. 02 (2026): Mitramas, Jurnal Pengabdian dan Pemberdayaan Masyarakat
Publisher : Universitas Katolik Indonesia Atma Jaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/mitramas.v4i02.7425

Organisasi Kesehatan Dunia (World Health Organization/WHO) melaporkan bahwa pada tahun 2022 terdapat sekitar 1,3 juta kasus baru kanker payudara dan 670.000 kematian akibat penyakit tersebut. Di Indonesia, data GLOBOCAN tahun 2022 mencatat 66.271 kasus dengan 22.598 kematian. Salah satu upaya untuk mendeteksi gejala kanker payudara secara dini adalah dengan melakukan teknik SADARI (Pemeriksaan Payudara Sendiri). Survei Kesehatan Indonesia tahun 2023 melaporkan bahwa 87–95% perempuan usia reproduksi belum pernah melakukan SADARI. Rendahnya praktik ini disebabkan kurangnya informasi, minimnya dukungan keluarga, serta terbatasnya edukasi kesehatan. Edukasi masyarakat dilakukan melalui kegiatan penyuluhan dengan topik “Pencegahan dan Deteksi Dini Kanker Payudara.” Kegiatan diawali dengan pelaksanaan pre-test, dilanjutkan dengan sesi penyampaian materi, dan diakhiri dengan pengisian post-test oleh peserta. Kegiatan ditutup dengan pembagian konsumsi, suvenir, serta leaflet edukasi mengenai langkah-langkah SADARI dan SADANIS (Pemeriksaan Payudara Klinis). Kegiatan pendidikan dan pelatihan kesehatan mengenai deteksi dini kanker payudara melalui metode SADARI terbukti efektif dalam meningkatkan pengetahuan peserta tentang kanker payudara dan SADARI. Rata-rata skor peserta meningkat dari 54,23 pada pre-test menjadi 88,46 pada post-test, menunjukkan peningkatan sebesar 70,49%.

PENINGKATAN PENGETAHUAN KANKER PAYUDARA DAN SADARI (PEMERIKSAAN PAYUDARA SENDIRI) PADA PEREMPUAN DI CILINCING, JAKARTA UTARA Bayu Perkasa Rosari; Christian Ardianto; Safira Aurea; Sitara Kirana
Mitramas: Jurnal Pengabdian dan Pemberdayaan Masyarakat Vol. 4 No. 02 (2026): Mitramas, Jurnal Pengabdian dan Pemberdayaan Masyarakat
Publisher : Universitas Katolik Indonesia Atma Jaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/mitramas.v4i02.7425

Organisasi Kesehatan Dunia (World Health Organization/WHO) melaporkan bahwa pada tahun 2022 terdapat sekitar 1,3 juta kasus baru kanker payudara dan 670.000 kematian akibat penyakit tersebut. Di Indonesia, data GLOBOCAN tahun 2022 mencatat 66.271 kasus dengan 22.598 kematian. Salah satu upaya untuk mendeteksi gejala kanker payudara secara dini adalah dengan melakukan teknik SADARI (Pemeriksaan Payudara Sendiri). Survei Kesehatan Indonesia tahun 2023 melaporkan bahwa 87–95% perempuan usia reproduksi belum pernah melakukan SADARI. Rendahnya praktik ini disebabkan kurangnya informasi, minimnya dukungan keluarga, serta terbatasnya edukasi kesehatan. Edukasi masyarakat dilakukan melalui kegiatan penyuluhan dengan topik “Pencegahan dan Deteksi Dini Kanker Payudara.” Kegiatan diawali dengan pelaksanaan pre-test, dilanjutkan dengan sesi penyampaian materi, dan diakhiri dengan pengisian post-test oleh peserta. Kegiatan ditutup dengan pembagian konsumsi, suvenir, serta leaflet edukasi mengenai langkah-langkah SADARI dan SADANIS (Pemeriksaan Payudara Klinis). Kegiatan pendidikan dan pelatihan kesehatan mengenai deteksi dini kanker payudara melalui metode SADARI terbukti efektif dalam meningkatkan pengetahuan peserta tentang kanker payudara dan SADARI. Rata-rata skor peserta meningkat dari 54,23 pada pre-test menjadi 88,46 pada post-test, menunjukkan peningkatan sebesar 70,49%.

Comparative analysis of stromal inflammatory cell infiltration and HPV infection status in cervical dysplasia and squamous cell carcinoma using the Klintrup-Mäkinen Scoring method Nicholas Adrian Fahendra; Daniel Edbert; Christian Ardianto; Lilis Lilis
Majalah Obstetri & Ginekologi Vol. 33 No. 3 (2025): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V33I32025.188-194

HIGHLIGHTS KM score is a reliable method to help determine the diagnosis of cervical dysplasia and squamous cell carcinoma. KM score cannot be used to differentiate infection status in cervical dysplasia and squamous cell carcinoma. ABSTRACT Objective: Cervical cancer is the second most common malignancy in women, with 604,127 new cases reported globally in 2020. Persistent high-risk human papillomavirus (HPV) infection is the primary cause. This study aimed to evaluate the relationship between stromal inflammatory cell infiltration using the Klintrup-Mäkinen (KM) score and HPV infection status in cervical dysplasia and squamous cell carcinoma (SCC). Materials and Methods: A cross-sectional study was conducted using secondary data from formalin-fixed paraffin-embedded (FFPE) cervical tissue samples diagnosed as dysplasia or SCC at Atma Jaya Catholic University of Indonesia from 2014 to 2022. HPV status was determined using PCR-based assays, while stromal inflammatory cell infiltration was assessed microscopically at 100× magnification and graded according to the KM scoring system by two blinded observers. Statistical analyses, including Chi-square and Spearman’s correlation tests, were performed using STATA/IC 15, with p < 0.05 considered significant. Results: A total of 38 samples were analyzed, comprising 20 (52.63%) cases of dysplasia and 18 (47.37%) cases of SCC. HPV positivity was identified in 70% of dysplasia and 94.44% of SCC cases. KM scores of 2/3, indicating moderate to severe inflammatory infiltration, were significantly more frequent in SCC (77.78%) compared to dysplasia (20%), showing a strong association with pathological diagnosis (p = 0.0019). However, no significant correlation was observed between KM score and HPV status in either lesion type. Conclusion: The KM scoring method provides a reliable and cost-effective approach for assessing stromal inflammatory cell infiltration in cervical lesions, aiding histopathological diagnosis, although it does not predict HPV infection status.

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