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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Majalah Kesehatan FKUB Journal of Epidemiology and Public Health Sumatera Medical Journal Jurnal Prima Medika Sains SCRIPTA SCORE Scientific Medical Journal Indonesian Journal of Global Health research JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Paramita, Deryne Anggia
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Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health

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Journal : Indonesian Journal of Global Health research

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Clinical Features and Histopathologic Examination in Supporting The Diagnosis of Exfoliative Dermatitis Suspected Caused by Captopril in Child : A case report Astarina, Awalia; Alferraly, T Ibnu; Paramita, Deryne Anggia; Nababan, Kristo A
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.6870

Abstract

Exfoliative dermatitis (ED) is defined as diffuse erythema and scaling of the skin involving more than 90% of the total body skin surface area. It is a reaction pattern and cutaneous manifestation of a myriad of underlying ailments, including psoriasis and eczema, or a reaction to the consumption of certain drugs. Though some experts believe it does not pose a significant risk of death, erythroderma is a potentially life-threatening condition that requires proper diagnosis, identification of underlying etiology, and management. Several factors have been implicated as triggers for erythroderma and can be grouped into several general categories, including preexisting dermatoses, drugs, and malignancies. Drugs Involved in ED, one of the drugs that cause it is cardiac drugs such as captopril. Captopril, an angiotensin-converting enzyme (ACE) inhibitors containing a sulfhydryl group and has occasionally been implicated in complex immunological diseases, this chemical group has been considered the culprit of allergic reactions to captopril. Histopathologic examination is important to exclude differential diagnosis. Management of ED involves combining symptomatic relief with addressing the underlying etiology and potential systemic complications. In patient hospitalization is required in acute cases.
Case Report: Suspected Thiamphenicol-Induced Stevens-Johnshon Syndrome-Toxic Epidermal Necrolisis Overlap in A Child – Diagnosis and Management Apriano, Ika Diamanda; Paramita, Deryne Anggia; Nababan, Kristo Alberto
Indonesian Journal of Global Health Research Vol 7 No 4 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i4.6523

Abstract

Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare delayed-type hypersensitivity reactions characterized by detachment of the epidermis and mucous membranes, along with skin necrosis. While these conditions are rare in children, they are most commonly caused by antibiotics, antiepileptic drugs, and antipyretic drugs. This case report aims to highlight thiamphenicol as a rare and potentially overlooked cause of SJS/TEN in pediatric patients. A 14-year-old girl who developed painful red patches accompanied by fluid-filled blisters on almost her entire body which appeared five days after taking the antibiotic thiamphenicol. The patient also experienced red, watery eyes; blisters on the lips and oral cavity; involvement of the nipples; and was unable to swallow due to severe pain in the mouth and throat. The patient was diagnosed with SJS-TEN overlap, and showed a good response to systemic corticosteroids (methilprednisolone) and supportive therapy. Her overall prognosis was favorable, with a Severity-of-Illness Score for Toxic Epidermal Necrolysis (SCORTEN) score of 1. The management of SJS/TEN involves a multidisciplinary specialist approach, immediate withdrawal of the suspected drug, administration of corticosteroids, and comprehensive supportive care.
Co-Authors Alferraly, T Ibnu Andrew, Reynard Apriano, Ika Diamanda Ardiansyah, Edy Astarina, Awalia Butar Butar, Agatha Uli Angelica Dina Arwina Dalimunthe, Dina Arwina Hendri Wijaya, Hendri Lubis, Andriamuri Primaputra Lubis, Nenni Dwi Aprianti Nababan, Kristo A Nababan, Kristo Alberto Nasution, Afrida Aryani Nasution, Fitriyani Nasution, Muhammad Siddik Putri Amelia Ramadani, Sumi Restuti Hidayani Saragih Samosir, Fauzan Azmi Hasti Habibi Sinaga, Adinda Alleyda Sriwulan, Anyelin Suherman, Jessen Susanto, Claudia Widjaja, Sry Suryani Yoan Carolina Panggabean