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All Journal Jurnal MIPA PHARMACON Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ Acta Biochimica Indonesiana The Studies of Social Sciences Vivabio : Jurnal Pengabdian Multidisiplin Jurnal Perempuan dan Anak Indonesia Borneo Journal of Pharmacy Jurnal Lentera: Penelitian dan Pengabdian Masyarakat
Datu, Olvie Syenni
Pharmacy Study Program, Faculty Of Mathematics And Natural Sciences, Sam Ratulangi University, Manado, North Sulawesi, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Immunology & microbiology Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Other

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Journal : PHARMACON

 1 
PENGARUH PEMBERIAN INFORMASI OBAT ANTIHIPERTENSI TERHADAP TINGKAT PENGETAHUAN DAN KEPATUHAN PASIEN PESERTA PROLANIS DI PUSKESMAS WORI Stevi Imanuela Yohanis; Gayatri Citraningtyas; Olvie Syenni Datu
PHARMACON Vol. 12 No. 3 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.48760

Abstract

Pemberian informasi obat merupakan bagian dari pelayanan kefarmasian. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian informasi obat antihipertensi terhadap tingkat pengetahuan dan kepatuhan pasien peserta prolanis di Puskesmas Wori. Penelitian ini merupakan penelitian kuantitatif dengan menggunakan metode penelitian eksperimen dengan desain penelitian yang diterapkan adalah one grup pre-test post-test dan untuk menentukan sampel menggunakan teknik purposive sampling. Responden berjumlah 60 pasien yang telah memenuhi kriteria. Data dianalisis dengan SPSS menggunakan uji beda berpasangan atau paired T-Test, nilai dari hasil kuesioner pengetahuan dan kepatuhan adalah 0,000 (<0,05). Nilai signifikasi yang diperoleh menunjukkan pengaruh dari perlakuan yang diberikan terhadap tingkat pengetahuan dan kepatuhan. Perlakuan yang diberikan kepada responden adalah pemberian informasi obat antihipertensi. Peningkatan hasil kuesioner tingkat pengetahuan dan kepatuhan pada pre-test dan post-test menunjukkan perubahan yang dipengaruhi oleh perlakuan yang diberikan. Disimpulkan terdapat pengaruh dari pemberian informasi obat antihipertensi terhadap tingkat pengetahuan dan kepatuhan pasien prolanis.
UJI AKTIVITAS FAGOSITOSIS MAKROFAG EKSTRAK TANAMAN GEDI Abelmoschus Manihot (L) SEBAGAI IMUNOMODULATOR Ciptanti Prakarsa; Widdhi Bodhi; Olvie Syenni Datu
PHARMACON Vol. 13 No. 1 (2024): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.13.2024.49698

Abstract

Gedi plant (Abelmoschus manihot L.) is one of the plants that contain flavonoids which have not been made into preparations for medicinal purposes. The purpose of this study was to determine the effectiveness of gedi plant extract as an immunomodulator. By looking at the activity and capacity of mouse macrophages (Rattus norvegicus) with Staphylococcus auereus bacteria in vitro. The results showed that gedi leaf extract had a significant effect on the activity and capacity of macrophages P(<0.05) which stated that gedi leaf extract had effectiveness as an immunostimulant. At a concentration of gedi plant extract of 1000 ppm, the activity and phagocytosis capacity showed the highest values, namely 87.66% and 4.23.   
EFFECTS OF ETHANOL EXTRACT OF LEILEM LEAVES (Clerodendrum minahassae) ON BLOOD GLUCOSE LEVELS OF MALE WHITE RATS Lengkong, Cheisy Anastasya Gratia; Bodhi, Widdhi; Datu, Olvie Syenni; Fatimawali
PHARMACON Vol. 13 No. 2 (2024): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.13.2024.49750

Abstract

Diabetes mellitus is a global chronic disease with more than 500 million patientes. Leilem leaf is an endemic plant of North Sulawesi from the genus Clerodendrum which is believed potentially antidiabetic. The purpose of this study was to determine the effect of ethanol extract of leilem leaf on blood glucose levels and body weight of male white rats. The extraction of leilem leaves using maceration method with 96% ethanol solvent. This study used the pretest posttest control group design method with 5 groups, namely group I positive control of metformin, group II negative control of 0.5% Na-CMC, group III, IV, and V were extract doses of 100, 200, and 400 mg/kgBW. All groups were induced with 120 mg/kg BW of alloxan. The results showed that leilem leaf extract had a significant effect (Asymp. Sig. (2-tailed) 0.001) on rats blood glucose levels with the best percentage in group V extract dose of 400 mg/kgBW and had no significant effect on body weight.
ANTIDIABETIC ACTIVITY TEST OF ETHANOL EXTRACT OF YELLOW PUMPKIN LEAVES (Cucurbita moschata) ON MALE WHITE RATS (Rattus norvegicus) Tamahiwu, Natasya Ester Rebeca; Bodhi, Widdhi; Datu, Olvie Syenni; Fatimawali , Fatimawali
PHARMACON Vol. 13 No. 2 (2024): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.13.2024.49751

Abstract

Pumpkin is a plant that contains many natural phenolic compounds, making it potential as an antioxidant, antidiabetic and antihyperglycemic. The aims of this study was to determine the antidiabetic activity of ethanol extract of pumpkin leaves on blood glucose levels and body weight on male white rats induced by alloxan at a dose of 120 mg/kgBW. The type of research used in this study was an experimental laboratory using the pre test and post test with control group design methods. Rats was divided into 5 groups, each group consisting of 3 rats. Group I as the positive control was given metformin, group II as the negative control was given 0,5% CMC Na, groups III, IV and V as the treatment group were given extract doses of 150 mg/kgBW, 300 mg/kgBW, and 600 mg/kgBW. The results showed that the ethanol extract of pumpkin leaves had a significant effect on decreasing blood glucose levels of rats P(< 0,05) and had no significant effect on the body weight of rats P(> 0,05) and the dose of the extract was the best in reducing glucose levels blood of rats is a dose of 600 mg/kgBW
Co-Authors Adithya Yudistira Annisa Hamka Ciptanti Prakarsa Elly Suoth ERLADYS MELINDAH RUMONDOR, ERLADYS MELINDAH Fatimawali , Fatimawali Fatimawali . Gayatri Citraningtyas Imam Jayanto Irma Antasionasti Jainer Pasca Siampa Jayanto, Imam Julianri Sari Lebang Julianri Sari Lebang Julianri Sari Lebang, Julianri Sari Khairuddin Lengkong, Cheisy Anastasya Gratia Lestari, Utami Sasmita Rundengan, Gerald Edward Sekeon, Crista Gretasia Siampa, Jainer Pasca Stevi Imanuela Yohanis Surya Sumantri Abdullah Tamahiwu, Natasya Ester Rebeca Trina Ekawati Tallei Utami Sasmita Lestari widdhi Bodhi Widdhi Bodhi Widya Astuty Lolo, Widya Astuty