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All Journal International Journal of Advances in Applied Sciences Acta Pharmaceutica Indonesia Jurnal Fitofarmaka Indonesia Current Research on Biosciences and Biotechnology
Andi Rifki Rosandy
Bandung Institute Of Technology
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Environmental Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics

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NMR Study of Methyl β-orsellinate from Dirinaria sp. was Collected from Coastal Areas of Teluk Nipah, Pulau Pangkor, Perak Malaysia Andi Rifki Rosandy; Nurul Nadiah Binti Abdul Rahman; Rozida Khalid; Agus Chahyadi; Elfahmi Elfahmi
Acta Pharmaceutica Indonesia Vol. 46 No. 1 (2021)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The research was carried out to isolate and characterize the methyl β-orsellinate of lichen Dirinaria sp. collected from the coastal areas of Teluk Nipah, Pulau Pangkor, Perak Malaysia. The sample was extracted in methanol for three times at room temperature. Subsequently, the crude extracts and further analysed using thin-layer chromatography (TLC) and vacuum liquid chromatography (VLC). To derive the pure compounds, the isolation step was performed using radial chromatography (RC). The chemical structure of the isolated compound was determined by several spectroscopies i.e. infra-red (IR), nuclear magnetic resonances (NMR), and mass spectrometric (MS). The compound was identified as methyl β-orsellinate.  
Phenazine-1-carboxylic acid (PCA) from cold-adapted yeast Glaciozyma antarctica PI12 Andi Rifki Rosandy; Rozida Mohd. Khalid
Current Research on Bioscences and Biotechnology Vol. 2 No. 1 (2020)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2020.2.1/TLCY1641

Abstract

A phenazine alkaloid, phenazine-1-carboxylic acid (PCA) was isolated from the ethyl acetate extract of cold-adapted yeast Glaciozyma antarctica PI12 (Kriegeriales). The compounds were isolated by several chromatography techniques i.e. radial chromatography (RC) and thin-layer chromatography (TLC). The chemical structure was elucidated by ultraviolet (UV), infrared (IR), nuclear magnetic resonance (1D and 2D NMR) spectroscopy and mass spectrometry.
Antibacterial activity of lupeol from the bark of Dehaasia cuneate (Lauraceae) Andi Rifki Rosandy; Sumail Sidik Ode Ishak; Noor Aziiraa Sabri; Wan Yaacob Wan Ahmad; Laode Muhammad Ramadhan Al Muqarrabun
Current Research on Bioscences and Biotechnology Vol. 2 No. 2 (2021)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2021.2.2/BOFY6724

Abstract

Dehaasia cuneata, locally known in Malaysia as ‘gajus hutan or pekan’, belongs to family Lauraceae. From its bark, A triterpenoid, lupeol was isolated and characterized. The chemical structure of the isolated compound was determined using spectroscopic methods, such as UV–vis, FT-IR, 1D & 2D-NMR, and ESIMS spectrometer. The isolated compound was tested against Gram-negative and positive bacteria using agar disc diffusion technique. The results showed that lupeol had a moderate inhibition zone value of 10.0±0.00 mm against Gram-negative Serratia marcescens ATCC 14756 whereas low inhibition which is 7.0±0.00 mm against Escherichia coli ATCC 25922, Vibrio fluvialis ATCC 33809, Bacillus subtilis ATCC 6633, and Methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300.
Isolation of bioactive compounds with tyrosinase inhibitory activity from the methanol extract of meniran herb (Phyllanthus niruri Linn.) Syefira Salsabila; Rika Hartati; Laode M.R. Al Muqarrabun; Nurinanda Prisky Qomaladewi; Ariranur Haniffadli; Andi Rifki Rosandy; Agus Chahyadi; Elfahmi
Current Research on Bioscences and Biotechnology Vol. 3 No. 2 (2022)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2022.3.2/GOO6ZULV

Abstract

Meniran (Phyllanthus niruri L.) is a wild plant in the Euphorbiaceae family which grows in tropical climates. The plant is known to possess antioxidant activity and is rich in phenolic compounds. Since plants with high phenolic content and high antioxidant activity are known to exhibit high tyrosinase inhibitory activity, the purpose of this study is to determine the inhibitory activity of the tyrosinase enzyme by the methanol extract of meniran (P. niruri L.) and to isolate secondary metabolites from the extract and fractions which exhibit inhibitory activity against tyrosinase. The in vitro tyrosinase inhibitory activity assay was conducted using the 96-well microplate method with kojic acid as the positive control, while the separation and purification of compounds were carried out using chromatography techniques. The methanol extract and n-hexane fraction showed tyrosinase inhibitory activity with IC50 of 11.05±0.16 and 2.57±0.08 mg/ml, respectively. Three bioactive compounds were succesfully isolated from the n-hexane fraction. Based on the UV and NMR spectra, compounds 1, 2, and 3 were identified as phyllanthin, phyltetralin, and hypophyllanthin, respectively. Furthermore, phyllanthin (1) was shown to demonstrate inhibitory activity against tyrosinase with IC50 of 0.6322 mM. In conclusion, both meniran extract and phyllanthin (1) were found to exhibit inhibitory acitivity against the tyrosinase enzyme. In the future they can be candidates for the treatment against hyperpigmentation and also as an active ingredient in skincare formulations.
Identification and antioxidant activity test of β-tocopherol from Dompu corn oil as anti-aging Permadi, Adi; Budiastuti, Pramudita; Setyanto, Barry Nur; Wulandana, Rachmadian; Nuraisyah, Fatma; Novitasari, Putri Rachma; Syamsuddin, Arief; Ramadhan, Muhammad Kaisar Sutomo; Rosandy, Andi Rifki
International Journal of Advances in Applied Sciences Vol 14, No 1: March 2025
Publisher : Institute of Advanced Engineering and Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijaas.v14.i1.pp175-184

Abstract

Corn is a well-cultivated food crop that is grown extensively worldwide. The used portion of corn is its seeds, which are rich in oil. The objective of this study is to separate and characterize tocopherol from corn oil in Dompu, Sumbawa by employing spectroscopic techniques such as ultraviolet (UV) spectrophotometry, ultra-performance liquid chromatography (UPLC), nuclear magnetic resonance (NMR), and liquid chromatography-mass spectrometry (LC-MS). Subsequently, the in-vitro antioxidant activity of the tocopherol was assessed. 1 kilogram of dry maize kernels subjected to 70% ethanol extraction yielded 30 grams (35 ml) of corn oil. The purified isolate obtained from the fractionated extract, using radial chromatography, demonstrated the presence of tocopherol. The isolated sample exhibited the presence of beta-tocopherol. Beta-tocopherol's anti-aging properties were assessed by conducting an in-vitro antioxidant activity test utilizing the tyrosinase enzyme. The IC50 value obtained was 83.954±2.849 ppm. The IC50 value indicates that beta-tocopherol possesses significant antioxidant activity, making it suitable for usage as a primary ingredient in cosmetics and pharmaceutical products.
Determination of Routin Compound Content of Moringa Folium (Moringa oleifera) using Several Extraction Methods Hasnaeni, Hasnaeni; Rosandy, Andi Rifki; Apridamayanti, Pratiwi; Permadi, Adi; Rumaisha, Sanda
Jurnal Fitofarmaka Indonesia Vol 10, No 3 (2023): JURNAL FITOFARMAKA INDONESIA (ENGLISH EDITION)
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v10i3.1106

Abstract

Extraction has been carried out from Moringa folium using the Microwave-Assisted Extraction (MAE), Ultrasound-Assisted Extraction (UAE) and Reflux Extraction (RE) methods. Moringa Folium has many uses, including as a chemopreventive agent. In this research, identification was carried out to determine the compounds in Moringa folium. Extraction uses the MAE, UAE, and Reflux methods. The of chemical compound content was determined using HPLC and standardized of rutin. The identification results showed that the Moringa folium spectra were similar to the routine spectra.
Co-Authors Adi Permadi, Adi Agus Chahyadi Agus Chahyadi Ariranur Haniffadli Budiastuti, Pramudita Elfahmi Elfahmi, Elfahmi Fatma Nuraisyah, Fatma Hasnaeni hasnaeni, Hasnaeni Laode M.R. Al Muqarrabun Laode Muhammad Ramadhan Al Muqarrabun Noor Aziiraa Sabri Novitasari, Putri Rachma Nurinanda Prisky Qomaladewi Nurul Nadiah Binti Abdul Rahman Pratiwi Apridamayanti, Pratiwi Ramadhan, Muhammad Kaisar Sutomo Rika Hartati Rozida Khalid Rozida Mohd. Khalid Rumaisha, Sanda Setyanto, Barry Nur Sumail Sidik Ode Ishak Syamsuddin, Arief Syefira Salsabila Wan Yaacob Wan Ahmad Wulandana, Rachmadian