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All Journal Medula Juke Majalah Kesehatan FKUB Jambura Journal of Health Sciences and Research JK Unila (Jurnal Kedokteran Universitas Lampung) Indian Journal of Forensic Medicine & Toxicology Jurnal Riset Multidisiplin Edukasi JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine Essentia: Journal of Medical Practice and Research
Hendra Tarigan Sibero
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

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Diagnosis dan Tatalaksana Psoriasis Muhammad Rafi Eka Putra; Dwi Indria Anggraini; Syahrul Hamidi Nasution; Hendra Tarigan Sibero
Medula Vol 13 No 2 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i2.656

Abstract

Psoriasis is a chronic skin inflammation characterized by clear erythematous plaques, rough scales, and layered silvery white plaques, especially on the elbows, knees, scalp, back, umbilicus, and lumbar region. 125 million people worldwide have psoriasis, with prevalence varying in different countries. Psoriasis has a prevalence of 1% to 3% in Europe and the United States. Psoriasis is a disease caused by an autoimmune condition. The diagnosis of psoriasis can be made based on the clinical picture. The physical examination should include examination of the primary lesion and other common areas affected by psoriasis including the scalp. A family history should be asked to support the diagnosis. The diagnosis can also be established by the presence of candle drip phenomenon, auspitz and kobner (isomorphic) which are symptoms of psoriasis. In addition, a histopathological examination can also be performed with a picture of hyperkeratosis, parakeratosis, acanthosis, Munro's abscess, papillomatosis and vasodilatation subepidermis. Psoriasis therapy is given topically in mild degrees and systemic therapy and phototherapy are given in moderate to severe psoriasis. Topical therapy that can be given is corticosteroids, vitamin D analogues, retinoids, TAR (LCD 3-10%), keratolytics (salicylic acid), and emollients. Systemic therapy used in moderate to severe cases includes acitretin, methotrexate, cyclosporin. Commonly used autotherapy in the treatment of psoriasis are narrowband ultraviolet B (NB-UVB), broadband ultraviolet B (BB-UVB), and topical 8-methoxypsoralen and UVA (PUVA).
LEINER’S DISEASE Marlintan Sukma Ambarwati; Hendra Tarigan Sibero
Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine Vol. 1 No. 1 (2014): Jurnal Agromedicine
Publisher : Fakultas Kedokteran Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Leiner’s disease is a disease affecting infants (4-20 weeks) which is a complication from seborrhoeic dermatitis, universal erythema and squama (erythroderma), usually found with anemia, diarrhea and vomit. It is followed by secondary bacterial infection. The etiology of this disease has not been known yet and also so rare. A Baby, 5 months old, had chief complain of red spots and rough shells all over the body during a week, accompanied by fever, vomit, and diarrhea. From physical findings, the general condition seemed to be in a serious illness, consciousness was compos mentis, regular pulse 96 x/minute, respiration rate 24 x/minute, temperature 37,3 OC. Nutrient status was normal (Z - Score WHO 2006 Curve). From dermatologic findings, the lesion was general, diffuse erythematous covered by rough scaly layer of squama, yellowish white, oily, wax drop phenomenon test (-). Laboratory assessment found leukocytes 16.700/ul, hemoglobin 11,1 gr/dl, hematocrit 34,4% and platelets 717.000/ul. The patient was diagnosed with Leiner’s disease and given systemic therapy dexamethasone, chlorpheniraminemaleat, paracetamol, lacto-bio, and zinc, and topical therapy gentamicyn ointment and emollients lanolin 10%. The etiology of Leiner, although has not been known yet, commonly caused by spreading seborrhoeic dermatitis. The diagnosis determined based on anamnesis, physical examination, and laboratory examination. With adequate management, clinical improvement obtained.[J Agromed Unila 2014; 1(1):28-34] Keywords: leiner’s disease, seborrhoeic dermatitis
HUBUNGAN ANTARA USIA IBU HAMIL DENGAN KEJADIAN INFEKSI SALURAN KEMIH PADA IBU HAMIL DI RSUD DR. H. ABDUL MOELOEK BANDAR LAMPUNG TAHUN 2024 Ida Laila; Sutarto; Muhammad Aditya; Hendra Tarigan Sibero
Jurnal Riset Multidisiplin Edukasi Vol. 3 No. 1 (2026): Jurnal Riset Multidisiplin Edukasi (Januari 2026)
Publisher : PT. Hasba Edukasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71282/jurmie.v3i1.1548

Abstract

Urinary Tract Infection (UTI) is one of the common complications during pregnancy and may cause serious adverse outcomes for both the mother and the fetus. Maternal age is recognized as a biological risk factor associated with the occurrence of UTI due to physiological and immunological changes during pregnancy. This study aimed to determine the association between maternal age and the incidence of urinary tract infection among pregnant women at RSUD Dr. H. Abdul Moeloek Bandar Lampung in 2024. This study employed an observational analytic design with a case-control approach. The study sample consisted of 52 pregnant women, comprising 26 pregnant women with UTI as the case group and 26 pregnant women without UTI as the control group. Data were obtained from medical records and questionnaires. Bivariate analysis was performed using the Fisher Exact test with a significance level of p < 0.05. The results showed a statistically significant association between maternal age and the incidence of UTI (p = 0.011; OR = 4.545; 95% CI: 1.370–15.077). In conclusion, there is a significant association between maternal age and the occurrence of urinary tract infection among pregnant women.
Identifikasi Kandungan Senyawa Aktif Antibakteri Ekstrak Etanol 70% Bunga Cengkeh (Syzigium Aromaticum) Dalam Menghambat Pertumbuhan Bakteri Cutibacterium Acnes Ratu Restu Casayora; Hendra Tarigan Sibero; Hesti Yuningrum; Tri Umiana Soleha
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 12 No 2 (2025): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol. 12.2 (2025)
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v12i2.1000

Abstract

Introduction: Acne (acne vulgaris) is caused by infection with the Cutibacterium acnes bacteria which is often treated with synthetic antibiotics, but long-term use can cause resistance. Clove flowers (Syzygium aromaticum) are known to contain active compounds such as eugenol, flavonoids, tannins and alkaloids which have the potential to act as natural antibacterials. This study aims to identify the active compound content and test the antibacterial activity of clove flower extract against C. acnes. Method: Experimental research was conducted using the post-test only control group design method. The bacterium used was Cutibacterium acnes. Clove flower powder was extracted with 70% ethanol using the maceration method, then tested for antibacterial activity using the well method. There were four concentration treatments: 25%, 50%, 75%, and 100%, alongside a positive control (clindamycin) and a negative control (aquadest). Results: Clove flower extract contains alkaloids, flavonoids, tannins, phenols, saponins, terpenoids and steroids. The Kruskal-Wallis statistical test results showing a significant difference (p < 0.001). Discussion: The antibacterial effectiveness of clove flowers is caused by the synergistic activity of active compounds, especially eugenol and tannin, which work by damaging cell membranes, inhibiting metabolic enzymes, and causing leakage of bacterial cell contents. Conclusion: Clove flower extract (Syzygium aromaticum) has strong antibacterial activity against Cutibacterium acnes.
Perbandingan Efektivitas Ekstrak Etanol Daun Binahong (Anredera cordifolia) dan Fusidic Acid terhadap Proses Penyembuhan pada Luka Insisi Kulit Tikus Putih Jantan Strain Sprague-Dawley Alvina Christy Maretta; Waluyo Rudiyanto; Anisa Nuraisa Jausal; Hendra Tarigan Sibero; Sugeng Dwi Hastono
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 12 No 2 (2025): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol. 12.2 (2025)
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v12i2.1008

Abstract

Pendahuluan: Penyembuhan luka insisi terdiri dari proses biologis kompleks yang melibatkan fase hemostasis, inflamasi, proliferasi, dan remodelling. Fusidic acid digunakan luas sebagai terapi topikal karena aktivitas antibakterinya, namun penggunaan jangka panjang berpotensi menimbulkan resistensi. Anredera cordifolia (binahong) mengandung flavonoid, saponin, dan tanin yang dilaporkan memiliki efek antiinflamasi, antioksidan, serta merangsang pembentukan kolagen, sehingga berpotensi sebagai alternatif terapi. Metode: Penelitian ini merupakan true experimental design dengan post-test only control group pada 25 ekor tikus putih jantan strain Sprague-Dawley yang dibagi menjadi empat kelompok: P0 (fusidic acid), serta P1, P2, dan P3 yang diberi ekstrak etanol daun binahong topikal konsentrasi 10%, 20%, dan 40%. Evaluasi penyembuhan luka dilakukan pada hari ke-3, 7, dan 14 melalui pengukuran penyusutan luka. Data dianalisis menggunakan One-Way ANOVA dan uji post hoc LSD. Hasil: Tidak terdapat perbedaan signifikan (p > 0,05) antara P1, P2, dan P3 dengan P0. Pembahasan: Efektivitas tertinggi pada konsentrasi 40% diduga terkait aktivitas antiinflamasi dan stimulasi proliferasi fibroblas dari kandungan metabolit sekundernya, sehingga mempercepat pembentukan jaringan granulasi. Hasil ini menunjukkan bahwa ekstrak binahong memiliki potensi sebagai alternatif terapi topikal yang sebanding dengan fusidic acid. Simpulan: Ekstrak etanol daun binahong memiliki efektivitas yang sebanding dan pada konsentrasi lebih tinggi berpotensi melebihi fusidic acid dalam mempercepat penyembuhan luka insisi kulit pada tikus putih. Binahong dapat dipertimbangkan sebagai terapi alternatif berbasis herbal dalam manajemen luka.
Kandungan Bahan Aktif Tumbuhan Serai (Cymbopogon citratus) dan Pemanfaatannya dalam Bidang Kesehatan Nadyanka Zafirah Daya Adiwiguna; Hendra Tarigan Sibero; Arif Yudho Prabowo; Khairun Nisa Berawi
Journal of Medical Practice and Research Vol 1 No 2 (2025): December: Essentia: Journal of Medical Practice and Research
Publisher : CV SCRIPTA INTELEKTUAL MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.65310/bfkpbq14

Abstract

The use of herbal plants such as Cymbopogon citratus (lemongrass) is increasingly important in the development of safe and sustainable natural therapies. This plant is widely used in Southeast Asia, including Indonesia, as a culinary ingredient and in traditional medicine. This study aims to identify the main bioactive compounds and the use of C. citratus in the health sector. The method used was a data-based literature review from Scopus from 2020 to 2025 with a PICOS approach to synthesize experimental, clinical, and systematic studies. The results show that lemongrass contains major compounds such as citral, geraniol, limonene, apigenin, and other flavonoids that have antibacterial, antifungal, anticancer, anti-inflammatory activities, as well as the ability to regulate glucose metabolism, cholesterol, and liver function. Several clinical trials have demonstrated the benefits of lemongrass aromatherapy in reducing anxiety and blood pressure. Overall, these findings reinforce the evidence that C. citratus has potential as a multifunctional therapeutic agent and a base material for phytopharmaceutical development.
PERBANDINGAN ZONA HAMBAT ANTARA ANTIBIOTIK TOPIKAL DAN PROBIOTIK Lactobacillus acidophilus TERHADAP PERTUMBUHAN BAKTERI Cutibacterium acnes PENYEBAB ACNE VULGARIS Evan Christian; Hendra Tarigan Sibero; Novita Carolia; Dwi Indria Anggraini
Majalah Kesehatan Vol. 0 No. 00 (2026): Article in Press
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/e2kd7z47

Abstract

Acne vulgaris merupakan satu dari banyak penyakit kulit yang paling sering menyerang remaja dan dewasa muda. Salah satu etiopatogenesis acne vulgaris adalah kolonisasi bakteri Cutibacterium acnes. Penelitian ini bertujuan membandingkan zona hambat yang terbentuk dari pemberian antibiotik topikal dengan probiotik Lactobacillus acidophilus. Penelitian ini merupakan penelitian eksperimental secara in vitro. Aktivitas antibakteri klindamisin fosfat 1,2%, eritromisin 2%, dan probiotik L. acidophilus terhadap C. acnes diuji menggunakan metode difusi Kirby–Bauer. Data diameter zona hambat dianalisis menggunakan uji one-way ANOVA dan uji post hoc. Hasil penelitian menunjukkan bahwa klindamisin fosfat 1,2%, eritromisin 2%, dan probiotik L. acidophilus menghasilkan rerata diameter zona hambat berturut-turut sebesar 32,0±3,4 mm, 22,6±2,3 mm, dan 14,2±1,2 mm. Hasil uji one-way ANOVA menunjukkan terdapat perbedaan bermakna antar kelompok perlakukan (p = 0,001). Uji post hoc menunjukkan bahwa tiap variabel satu dengan variabel lainnya memiliki perbedaan bermakna dalam menghambat pertumbuhan C. acnes, kecuali pada variabel eritromisin dengan kontrol positif. Kesimpulan dari penelitian ini adalah zona hambat yang terbentuk pada pemberian klindamisin fosfat 1,2% adalah yang terbesar, menunjukkan bahwa aktivitas antibakteri yang lebih kuat terhadap C. acnes dibandingkan dengan eritromisin 2% dan probiotik L. acidophilus.  
Co-Authors Ahmad Fauzi Ahmad Sirajudin Alvina Christy Maretta Anisa Nuraisa Jausal Arif Yudho Prabowo Dwi Indria Anggraini Eryati Darwin Evan Christian Fifa Argentina Hanna Mutiara Hesti Yuningrum Ida Laila Iffat Taqiyah Khairun Nisa Marcella Dena Fernanda Marlintan Sukma Ambarwati Muhammad Aditya Muhammad Rafi Eka Putra Muhammad Yusran Nadyanka Zafirah Daya Adiwiguna Novita Carolia Ratu Restu Casayora Rika Lukas Satya Wydya Yenny Sugeng Dwi Hastono Suharmanto Suharmanto Sutarto Syahrul Hamidi Nasution Tri Umiana Soleha Waluyo Rudiyanto Yan Wirasati