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The Level of Effectiveness Use of Quinoline Drugs in COVID-19: A Literature Review M.Dedi Dermawan Dermawan; Afrita Amalia Laitupa; Muslim Andala Putra; Nenny Triastuti
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 4, No 2 (2020)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v4i2.4998

ABSTRACT Chloroquine is the first line of medicine in the treatment of malaria. Besides being antimalaria, the chloroquine also can be used as the anti-inflammation in the medicine of arthritis rheumatoid arthritis and lupus erythematosus discoid. Hydroxychloroquine sulfate is 4-aminoquinolin with hydroxylated chloroquine analog, having the same pharmacokinetic as chloroquine which is given orally in hydroxychloroquine sulfate form, processed by gastrointestinal absorption and very faster kidney elimination. The effectiveness of chloroquine and hydroxychloroquine towards COVID-19 in the in vitro experiment showed it could inhibit the duplication of the SARS-CoV-2 virus. The chloroquine function is to stop COVID-19 infection with (EC50) 1,13 μM and (CC50) larger than 100 μM. Meanwhile, the hydroxychloroquine function is to inhibit the attachment and entry of the virus into the host’s cell by enzymatic activation which is the lysosome acidification disorder and antigen presentation as the result of pH increase. Based on the clinical study, the 10 of 12 patients who have lopinavir/ritonavir therapy by virology, the chloroquine group showed RT-PCR negative on day 7, 10, and 14 in compare to lopinavir/ritonavir that showed RT-PCR negative on day 14. On the 9th day, 60% of the patients of chloroquine group showed the CT scan of Lungs image normal instead of the lopinavir/ritonavir at 25%. In the day 14 based on the CT test result, the pulmonary improvement increased twice rather than chloroquine group (Rate Ratio 2.21). It proved that the chloroquine role showed the result of the medicine has a significant effect by cleaning the virus or other clinical matters. The purpose of this literature review is to know the effectiveness quinoline class of drugs which is chloroquine and hydroxychloroquine in COVID-19 disease.Keywords: effectiveness, chloroquine, COVID-19Correspondence: dedydermawan555@gmail.com

Adobe Photoshop Express Application Enhances the Diagnosis of X-Ray Thorax of Covid-19 Patient Ahmad Mochtar Jamil; Muslim Andala Putra; Muhammad Anas
Indonesian Journal of Medical Sciences and Public Health Vol 1 No 2 (2020)
Publisher : Future Science

Covid-19 is a new infectious viral illness. The first one appeared in Wuhan, and within two months, it became a pandemic. Medical diagnosis is confirmed by fever, cough, shortness of breath, combined with neutrophil ratio lymphocyte analysis and chest x-ray or chest C.T. radiology imaging, with a ground-glass appearance. C.T. scans are not widely available in hospitals in Indonesia. Many hospitals only own x-ray for covid-19 as radiologic diagnostic imaging. With digital imaging capabilities, Due to the similarity of applications such as the radiological workstation, Adobe Photoshop Express will improve the capacity to diagnose Covid-19 from a chest x-ray. Adobe Photoshop Express has outstanding digital processing capabilities to enhance the presentation of images so that the efficiency of diagnosing plain x-ray thorax image cases with Covid-19 becomes easier and more manageable.

PERBEDAAN EFEK NIKOTIN PADA ROKOK DAN VAPE TERHADAP PENINGKATAN TEKANAN DARAH : LITERATURE REVIEW Fahreza Albar Mulyadi; Afrita Amalia Laitupa; Muslim Andala Putra; Irma Kartikasari
Jurnal Kesehatan Tambusai Vol. 4 No. 2 (2023): JUNI 2023
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v4i2.14713

Merokok dengan kandungan nikotin merupakan penyebab kematian dini di seluruh dunia. Nikotin berperan sebagai obat sympathomimetic dan meningkatan aktivitas simpatik yang berkorelasi peningkatan tekanan darah dan risiko penyakit jantung. Tujuan review studi ini adalah untuk mengidentifikasi dan membuat kesimpulan berdasarkan temuan riset yang membahas tentang perbedaan efek nikotin pada rokok dan vape terhadap peningkatan tekanan darah. Metode menggunakan literature review dari hasil penelitian tahun 2012-2022 yang sudah terpublikasi di media elektronik seperti PubMed. 20 artikel yang memenuhi kriteria inklusi dan eksklusi. Rokok dan vape dapat meningkatkan tekanan darah sistolik dan diastolik. Terdapat perbedaan peningkatan tekanan darah yang signifikan atau tidak signifikan pada rokok dan vape antar studi, masih belum diketahui secara pasti bagaimana hal tersebut bisa terjadi walaupun keduanya mengandung nikotin. Simpulannya yaitu peningkatan tekanan darah akibat rokok ditemukan lebih tinggi dibanding vape pada 12 dari 20 literatur, dengan 8 literatur yang hanya membahas peningkatan tekanan darah khusus vape. Hasil analisis penulis berpendapat ada beberapa penyebab yang memungkinkan terjadinya peningkatan tekanan darah yang lebih tinggi pada rokok dibanding vape, antara lain, konstituen non-nikotin lain pada rokok, farmakokinetik rokok yang berbeda dengan vape sehingga retensi nikotin lebih rendah pada vape, metode intervensi hisapan yang berbeda, populasi, dan jenis vape atau rokok yang digunakan.

Differences in Chest X-Ray Imaging in Pulmonary Tuberculosis across Various Comorbidities Subkhan, Mohammad; Rezacharawa, Meltritania Arief; Putra, Muslim Andala; Laitupa, Afrita Amalia; Permana, Putu Bagus Dharma; Irfana, Laily
MAGNA MEDIKA Berkala Ilmiah Kedokteran dan Kesehatan Vol 11, No 2 (2024): August
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.11.2.2024.169-180

Background: Tuberculosis (TB) remains a significant public health concern in Indonesia, with a high prevalence of cases, particularly in patients with comorbidities such as HIV infection, chronic obstructive pulmonary disease (COPD), diabetes mellitus (DM), and chronic kidney disease (CKD). Evidence suggested radiological variations in chest X-ray findings among these complex condition, which may pose significant challenges in accurately diagnosing pulmonary TB in clinical practice.Objective: This study aimed to provide a comprehensive understanding of the variations in chest X-ray imaging in pulmonary TB patients with specific comorbidities, focusing on DM, CKD, and COPD.Methods: A cross-sectional study was conducted at Siti Khodijah Muhammadiyah Sepanjang Hospital by utilizing standardized medical records and chest X-ray results of 50 pulmonary patients with comorbidities.Results: The most prevalent comorbidity was DM, with radiological findings including fibroinfiltrates, consolidations, and cavities. CKD patients exhibited radiological features such as infiltrates, cavitations, and pleural effusion, while COPD patients presented with infiltrates and consolidations. Conclusion: The study provides valuable insights into the radiological manifestations of pulmonary TB and its comorbidities, offering a basis for improved management and treatment strategies for patients with pulmonary TB and comorbidities. Further research employing longitudinal designs and balanced representation of comorbid conditions is recommended to enhance the understanding of the interplay between TB and associated health conditions.

Smoking Behaviour is a Protective Factor Against the Degree of Knee Osteoarthritis Oky Caesario, Damara; Citra Wirashada, Briliant; Prahasanti, Kartika; Andala Putra, Muslim
Jurnal Ilmiah STIKES Yarsi Mataram Vol. 14 No. 1 (2024): Jurnal Ilmiah STIKES Yarsi Mataram
Publisher : Sekolah Tinggi Ilmu Kesehatan YARSI Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57267/jisym.v14i1.316

Osteoarthritis lutut adalah penyakit kronik progresif karena kelainan struktur sendi lutut yang menjadi keras sehingga dapat menyebabkan limitasi dalam bergerak. secara umum, osteoarthritis paling sering diakibatkan karena usia yang semakin tua. usaha untuk mencegah terjadinya osteoarthritis bertambah karena beberapa studi juga mengkomparasikan kejadian osteoarthritis dengan kebiasaan merokok. merokok adalah kebiasaan yang sering dilakukan oleh orang indonesia dengan total 1,1 milyar orang perokok dan indonesia peringkat tiga terbanyak dibawah cina dan india. Tujuan penelitian ini untuk mengetahui hubungan perilaku merokok dengan derajat osteoarthritis menurut Kellgren - lawrence di Rumah Sakit Muhammadiyah Siti Khodijah Sidoarjo. design penelitian cross sectional berjenis penelitian quantitative. Sampling akan menggunakan stratified sampling dengan 51 sample penelitian. teknis pengambilan sampel yaitu menggunakan kuisioner untuk mengetahui indikator perilaku merokok pada pasien dan foto radiologi lutut untuk mengetahui derajat dari osteoarthritis lutut. analisis Bivariat menggunakan uji spearman pada platform SPSS menunjukan hasil p value 0,000 (p<0,05). Hasil tersebut menunujukan adanya hubungan yang signifikan antara hubungan perilaku merokok terhadap derajat osteoarthritis menurut Kellgren - Lawrence. Kesimpulan dari penelitian ini adalah terdapat hubungan perilaku merokok terhadap derajat osteoarthritis menurut Kellgren - Lawrence di Rumah Sakit muhammadiyah Siti Khodijah Sidoarjo. Saran selanjutnya wajib untuk dicari tahu dengan penelitian percobaan agar melihat faktor kunci protektif pada osteoartritis lutut.

Hubungan Antara Volume Prostat dan IPSS Score pada Pasien BPH di Rumah Sakit Siti Khodijah Muhammadiyah Cabang Sepanjang Waskita, Shakina Reza; Putra, Muslim Andala; Mochtar, Nur Mujadiddah; Himawan, Budi
Jurnal Kesehatan Andalas Vol 13, No 1 (2024): March 2024
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v13i1.2317

Benign Prostatic Hyperplasia (BPH) is the growth of non-malignant cells or hyperplasia of prostate tissue, which causes Lower Urinary Tract Symptoms (LUTS) in men. One guide to direct and determine the symptoms of obstruction due to prostate enlargement is the International Prostate Symptom Score (IPSS). Objective: To determined the relationship between prostate volume and IPSS score in BPH patients at Siti Khodijah Muhammadiyah Cabang Sepanjang Hospital. Methods: This was an analytic observational study using a prospective cohort method. The sample selection used consecutive sampling techniques in accordance with predetermined inclusion and exclusion criteria for collecting data using primary and secondary data, abdominal ultrasound data, and the IPSS questionnaire. The number of samples used was 30 patients from November 2022 to April 2023. Results: The prostate volume in grade II was 46.7%, while for grade I and grade III were 33.3% and 20%, respectively. For the results of the IPSS, the moderate category was 76.7%, with mild and severe IPSS scores at 10% and 13.3%, respectively. The Spearman test results showed that the p-value was 0.006 <0.05, the value of r = 0.486, and the correlation coefficient was positive, meaning there was a unidirectional relationship between prostate volume and the IPSS score. Conclusion: There is a reasonably strong relationship between prostate volume and IPSS score in BPH patients at Siti Khodijah Muhammadiyah Cabang Sepanjang Hospital.Keywords: BPH, prostate volume, IPSS

Analisis Kualitas Jasa dalam Meningkatkan Pelayanan Pangkas Rambut Pandawa di Kecamatan Waringinkurung Kabupaten Serang Muji Andala Putra; Ahmad Lutfi Hamdani; Asrap Asrap
Jurnal Inovasi Manajemen, Kewirausahaan, Bisnis dan Digital Vol. 2 No. 1 (2025): Februari : Jurnal Inovasi Manajemen, Kewirausahaan, Bisnis dan Digital
Publisher : Asosiasi Riset Ilmu Manajemen dan Bisnis Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/jimakebidi.v2i1.449

The barbershop business is a promising business, because the need for haircutting services is increasing. The barbershop business in Serang Regency itself is increasingly popular, including in Waringinkurung District, but not all barbershops in Waringinkurung District are visited by many consumers. Competition between barbershops lies in the quality of excellent service for consumers, the implementation of a quality service influences the development of consumer satisfaction. The research method used is a descriptive method with a qualitative approach. Data was obtained through direct interviews with barbershop owners and consumers. Then the data is analyzed through the stages of data reduction or simplification, data display/presentation, and drawing conclusions. The quality of service provided at the Pandawa barbershop in Wariginkurung District, Serang Regency is quite good, this can be seen from the efforts made such as prioritizing appearance, neatly arranged facilities, tools that are always ready to use and choosing a strategic location. The reliability and responsiveness of the barbershop can be seen from consumer assessments of the indicators of reliability, responsiveness, empathy and guarantees of the barbershop which are quite good. The quality of service in increasing the satisfaction of barber service users according to an Islamic perspective in Waringinkurung District, Serang Regency is still low, this can be seen from the fact that there are still barbershops that provide hair styles.

Hubungan antara Volume Intracerebral Hemorrhage dan Derajat Midline Shift terhadap Tingkat Kesadaran Menurut Glasgow Coma Scale di Rumah Sakit (RS) Siti Khodijah Muhammadiyah Sepanjang Mahendra, Raditya Bayu; Putra, Muslim Andala; Hamdzi, Muhammad Azharul; Irfana, Laily; Mochtar, Nur Mujaddidah
Jurnal Ilmiah Universitas Batanghari Jambi Vol 25, No 1 (2025): Februari
Publisher : Universitas Batanghari Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33087/jiubj.v25i1.5713

The aim of this study was to determine the relationship between the volume of intracerebral hemorrhage (ICH) and the degree of midline shift with the level of consciousness according to the Glasgow Coma Scale at Siti Khodijah Muhammadiyah Panjang Hospital. ICH and midline shift data were collected from medical records, and ICH and midline shift measurements were carried out by 3 (three) radiology specialists, then the results of the medical records were linked using the Spearmen's correlation test. The results of the study found that there was a significant relationship between the volume of intracerebral hemorrhage (ICH) and the degree of midline shift on the Glasgow Coma Scale at the Siti Khodijah Muhammadiyah Panjang Hospital.

Hubungan Antara Volume Prostat dan IPSS Score pada Pasien BPH di Rumah Sakit Siti Khodijah Muhammadiyah Cabang Sepanjang Waskita, Shakina Reza; Putra, Muslim Andala; Mochtar, Nur Mujadiddah; Himawan, Budi
Jurnal Kesehatan Andalas Vol. 13 No. 1 (2024): March 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v13i1.2317

Benign Prostatic Hyperplasia (BPH) is the growth of non-malignant cells or hyperplasia of prostate tissue, which causes Lower Urinary Tract Symptoms (LUTS) in men. One guide to direct and determine the symptoms of obstruction due to prostate enlargement is the International Prostate Symptom Score (IPSS). Objective: To determined the relationship between prostate volume and IPSS score in BPH patients at Siti Khodijah Muhammadiyah Cabang Sepanjang Hospital. Methods: This was an analytic observational study using a prospective cohort method. The sample selection used consecutive sampling techniques in accordance with predetermined inclusion and exclusion criteria for collecting data using primary and secondary data, abdominal ultrasound data, and the IPSS questionnaire. The number of samples used was 30 patients from November 2022 to April 2023. Results: The prostate volume in grade II was 46.7%, while for grade I and grade III were 33.3% and 20%, respectively. For the results of the IPSS, the moderate category was 76.7%, with mild and severe IPSS scores at 10% and 13.3%, respectively. The Spearman test results showed that the p-value was 0.006 <0.05, the value of r = 0.486, and the correlation coefficient was positive, meaning there was a unidirectional relationship between prostate volume and the IPSS score. Conclusion: There is a reasonably strong relationship between prostate volume and IPSS score in BPH patients at Siti Khodijah Muhammadiyah Cabang Sepanjang Hospital.Keywords: Â BPH, prostate volume, IPSS

KOMPARASI TEKNIK ABC/2 DAN ASISTEN ANALISIS VOLUMETRIK KOMPUTER PADA SUBDURAL HEMATOMA DENGAN PEMERIKSAAN CT SCAN DI RUMAH SAKIT SITI KHODIJAH MUHAMMADIYAH SEPANJANG Rahmadhani, Vaiza Eka; Muslim Andala Putra; Laily Irfana
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 9 No 02 (2025): Qanun Medika Vol 09 No 02 July 2025
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v9i02.26123

Subdural Hematoma (SDH) is a common pathological condition characterized by venous bleeding in the subdural space between the dura mater and the arachnoid membrane. Computed tomography (CT) scan plays a crucial role in diagnosing SDH and assessing the severity of the hemorrhage by estimating the hematoma volume. Various measurement techniques, including the ABC/2 formula and volumetric analysis, are used to determine SDH volume. This study aimed to compare the SDH volume results obtained from the ABC/2 technique and the volumetric technique using Philips Access CT V2.0 computer software. A cross-sectional study was conducted involving 30 patients diagnosed with SDH based on CT scan findings at Siti Khodijah Muhammadiyah Hospital, Sepanjang, Sidoarjo. Volume measurements were performed by a radiologist using the hospital’s radiology computer. The ABC/2 technique involved manual measurement using linear dimensions, while the volumetric technique utilized Philips Access CT V2.0 computer software to obtain three-dimensional volume estimates. Data were analyzed using the Wilcoxon signed-rank test to determine statistical differences between the two techniques. The analysis showed no significant difference between the volumes measured by the ABC/2 and the volumetric techniques (p = 0.382; p > 0.05). In conclusion, the ABC/2 technique remains a practical and time-efficient method for estimating SDH volume, especially in clinical settings where rapid assessment is required.

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