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All Journal Indonesian Journal of Cancer Chemoprevention Jurnal Kimia Riset Al-Kimia Chimica et Natura Acta Walisongo Journal of Chemistry Pharmacy Reports Sewagati Jurnal Tumbuhan Obat Indonesia al Kimiya : Jurnal Ilmu Kimia dan Terapan
Fadlan, Arif
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Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other

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Solvent-Free Synthesis of Dihydropyrimidinone by Using Molecular Iodine as Catalyst Fadlan, Arif; Pratama, Landaeta Yolga; Ilfahmi, Yan Alamanda
al Kimiya: Jurnal Ilmu Kimia dan Terapan Vol. 12 No. 1 (2025): June 2025
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ak.v12i1.42254

Abstract

Dihydropyrimidinone with diverse pharmacological activities can be obtained through the multicomponent of Biginelli reactions by heating aldehyde, ethyl acetoacetate and urea/thiourea in ethanol with the addition of hydrochloric acid. However, this reaction is toxic and shows several drawbacks. Further development for Biginelli reaction was conducted by using heterogeneous catalyst, green solvents, and sustainable heating such as microwave or ultrasound. But various obstacles are also found from these strategies. There are still chances to study the Biginelli reaction by using relatively simpler methods and the readily available and environmentally friendly chemicals. Iodine is a mild Lewis acid, easily available at an affordable price, non-toxic, and environmentally friendly. Iodine has been used in various reactions and organic transformations with high efficiency and selectivity. This report aims to study the solventless synthesis of ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate 4 by using molecular iodine. The reaction was studied by mixing benzaldehyde 1 as aromatic aldehyde, urea 2, and β-keto ester in the form of ethyl acetoacetate 3 with and without the addition of ethanol as solvent. The compound 4 (45% yield) was yielded from a solvent-free reaction whereas the use of ethanol gave the product 4 in 50%yield. The IR, NMR spectra, and HRMS analysis were used for the establishment of the structure of product 4. These finding give new perspective in the preparation of dihydropyrimidinone(s).
Pembuatan Biobriket dari Kotoran Sapi di kampung Sanan Blimbing Malang Kusumawati, Yuly; Gunawan, Triyanda; Zetra, Yulfi; Burhan, Perry; Rahmawati, Zeni; Fadlan, Arif; Nugraheni, Zjahra Vianita; Utomo, Wahyu Prasetyo; Fansuri, Hamzah; Widiastuti, Nurul; Putri, Oktavina Kartika
Sewagati Vol 9 No 4 (2025)
Publisher : Pusat Publikasi ITS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j26139960.v9i4.2397

Abstract

Kampung Sanan merupakan kampung yang mengelola perternakan sapi, sehingga menghasilkan banuak kotoran Sapi. Untuk memanfaatkan kotoran sapi di Kampung Sanan, kami mengajak warga Kampung Sanan mengembangkan pemanfaatan kotoran sapi menjadi biobriket. Biobriket yang dihasilkan dari kampung Sanan ini telah memenuhi standar SNI dan memiliki kualitas yang layak dengan pengujian sifat fisik dan termal. Selain itu, Program ini berpotensi menjadi aplikasi yang berkelanjutan dalam mendukung energi terbarukan berbasis biomassa, sekaligus memberikan dampak positif bagi pengelolaan limbah dan pemenuhan kebutuhan energi lokal.
Bioinformatics Analysis of Rho GTP-ase Activating Protein 35 (ARHGAP35) in Breast Cancer Migration Febrian, Dicky Rizky; Setyono, Joko; Fareza, Muhamad Salman; Choironi, Nur Amalia; Fadlan, Arif; Sarmoko, Sarmoko
Indonesian Journal of Cancer Chemoprevention Vol 12, No 3 (2021)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev12iss3pp161-169

Abstract

Breast cancer is a second deadly cancer after lung cancer worldwide. Progression of cancer is driven by mutated cancer drive gene such as ARHGAP35. This study aims to analyze the role of ARHGAP35 in the growth and development of breast cancer cells. ARHGAP35 expression level was analyzed using Oncomine (p-value<1E-4; gene rank top 10%). Overall survival (OS) and disease-free survival (DFS) were evaluated by using GEPIA (median cutoff; HR displayed with 95% CI). STRING was used for analyzing the protein-protein interaction network, while WEBGESTALT for KEGG pathway and gene ontology (GO) of ARHGAP35 and associated proteins and cBioPortal for gene mutation. ARHGAP35 was overexpressed in several types of breast cancer, namely invasive ductal breast carcinoma (IDC), invasive ductal and lobular breast carcinoma (IDLC), invasive lobular breast carcinoma (ILC), male breast carcinoma, and mixed ductal and lobular carcinoma (MDLC). High expression of ARHGAP35 had significantly lower OS (p=0.045) compared to low expression of ARHGAP35 and the difference in DFS was not significant (p=0.98). ARHGAP35 interacted with RHOA, RHOB, RHOC, RHOD, RASA1, RND1, RAC1, CDC42, FYN and SRC. KEGG pathway and GO analysis showed that these proteins are highly involved in actin-based processes through adherent junction, axon guidance, focal adhesion, regulation of actin cytoskeleton, and tight junction. Mutation rate analysis showed 34 missense, 29 truncating, 3 fusion, and 1 in frame on ARHGAP35. Taken together, ARHGAP35 may involve in the growth and development of breast cancer through regulation of actin cytoskeleton pathway.Keywords: ARHGAP35, breast cancer, KEGG pathway, mutation rate, actin cytoskeleton.
Co-Authors Agistya, Hamida Azza Agustin, Lela Fareza, Muhamad Salman Febrian, Dicky Rizky Gunawan, Triyanda Hamzah Fansuri Ilfahmi, Yan Alamanda Ingeswari, Aulya Vidiana Isman, Felysia Joko Setyono Josaphat, Frans Khozin, Muhamad Nur Khusnayaini, Intan Ali Kusumawati, Yuly Mardi Santoso Masitoh, Heni Niadisti, Bella Ratih Apsari Nugraheni, Zjahra Vianita Nur Amalia Choironi Nurhasan, Moch. Nurul - Widiastuti Nusantoro, Yesaya Reformyada Oktavina Kartika Putri Perry Burhan, Perry Pratama, Landaeta Yolga Pratama, Paundra Rahmawati, Zeni Roshuna, Jean Fitriani Sarmoko Sarmoko Seviani, Winda Wahyu Prasetyo Utomo Wirastuti, Vania Zetra, Yulfi