Pulmonary tuberculosis (TB) remains a major public health problem due to its airborne transmission through droplets released when infected individuals cough, sneeze, or speak. Limited family knowledge regarding TB and its prevention often results in poor implementation of Clean and Healthy Living Behavior (Perilaku Hidup Bersih dan Sehat/PHBS), thereby increasing the risk of disease transmission among family members. This study aimed to describe the implementation of family nursing interventions through PHBS education in preventing the transmission of pulmonary tuberculosis at the Kambata Mapambuhang Community Health Center. This study employed a descriptive case study design involving two respondents selected based on predetermined inclusion and exclusion criteria. Data were collected through interviews, observation, physical examination, and documentation using a family nursing care assessment format. The nursing intervention consisted of health education on pulmonary TB, including its definition, modes of transmission, treatment adherence, cough etiquette, proper mask use, handwashing with soap, environmental hygiene, home ventilation, and the application of PHBS. Evaluation was conducted using the SOAP approach. The findings showed that both respondents initially had inadequate knowledge regarding pulmonary TB and its prevention. Following the educational intervention, both respondents and their families were able to explain the educational materials, understand transmission prevention measures, demonstrate improved awareness in implementing PHBS, wear masks during daily activities, practice proper cough etiquette, maintain environmental cleanliness, and express commitment to adhering to TB treatment. It can be concluded that family nursing interventions through PHBS education effectively improved the knowledge, awareness, and preventive behaviors of families in reducing the risk of pulmonary tuberculosis transmission.