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All Journal Buletin Farmatera Indonesian Journal of Cardiology Sumatera Medical Journal Heart Science Journal Cardiovascular and Cardiometabolic Journal (CCJ) Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) The Journal of Society Medicine (JSOCMED) Medistra Medical Journal (MMJ)
Sitepu, Andika
Departemen Jantung Dan Pembuluh Darah, Fakultas Kedokteran Universitas Sumatera Utara
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Wellens's Syndrome, Kenali karena setara dengan stemi: laporan kasus Kristivani Br Ginting; Andika Sitepu; FIHA; FASCC; FAPSC
Medistra Medical Journal (MMJ) Vol 1 No 2 (2024): Medistra Medical Journal (MMJ)
Publisher : Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/mmj.v1i2.2110

Abstract

Acute coronary syndrome (ACS) is one of the leading causes of acute chest pain, requiring emergency care and eventual hospitalization. Wellens’ syndrome is one such example, which in ACS patients is a catastrophic event often accompanied by extensive anterior myocardial infarction and high mortality rates. Wellens’ syndrome is a pattern of T-wave changes seen in the anterior (V2-V3) leads on critical stenosis of the left anterior descending (LAD) coronary artery. We reported a 65-year-old man admitted to our emergency facility because of intermittent chest pain that had been experienced for the past 2 days. An initial ECG performed in the emergency room while pain free showed sinus rhythm with biphasic T waves in V2–4 which is typical of Wellen's Syndrome. Chest x-ray shows cardiomegaly. Cardiac enzyme examination showed an increase in CKMB and Troponin T levels of 18.40 U/L and 560 ng/L respectively. The echocardiography (ECHO) demonstrated a hypokinesis of the anteroseptal with left ventricular ejection fraction (LVEF) of 47 %. Cardiac catheterization showed total occlusion in the mid-LAD and other coronary arteries had non-significant lesions. He then underwent balloon angioplasty and placement of a stent in the proximal and mid LAD with a good result. Wellen’s syndrome often represents a pre-infarction state of myocardial infarction. Early recognition of these ECG features is crucial to identify these high-risk clients, and the definitive evaluation and treatment is cardiac catheterization with intervention to relieve the LAD obstruction.
Tp-e/QTc ratio as a potential non-invasive marker of coronary lesion severity assessed by SYNTAX score in non-ST segment elevation myocardial infarction Ginting, Yehezkiel Bastanta; Sitepu, Andika; Ketaren, Andre Pasha; Hasan, Harris; Lubis, Anggia Chairuddin; Haykal, Teuku Bob; Ginting, Daniel
Heart Science Journal Vol. 7 No. 3 (2026): Predicting Restenosis in Coronary Artery Disease
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.03.8

Abstract

Background: Accurate assessment of coronary lesion burden in the initial stage is the basis for appropriate therapy in NSTEMI patients. As a parameter derived from the ECG that reflects ventricular repolarization variability, the Tp-e/QTc ratio is suggested as a noninvasive predictor for assessing anatomical complexity. Objective: Investigating the relationship of Tp-e/QTc with the severity of coronary lesions on angiography assessed using the SYNTAX score, in patients with NSTEMI. Methods: Utilized a retrospective cohort approach with a cross-sectional design. In total, 141 patients were selected by utilizing purposive sampling. The Tp-e and QTc intervals were manually measured from 12-lead ECGs using the tangent method, and the Tp-e/QTc ratio was calculated. SYNTAX scores were independently determined by two interventional cardiologists. Data were analyzed using bivariate and multivariate analyses. Result: Higher SYNTAX group (0.26 ± 0.047) had higher Tp-e/QTc than lower SYNTAX group (0.21 ± 0.052). Tp-e/QTc showed a positive correlation with SYNTAX score (r = 0.395; p < 0.001) and remained an independent predictor (β = 0.332; p = 0.001). The ROC curve displayed strong discrimination (AUC = 0.817), a cut-off of 0.24 yielded 82.7% sensitivity and 76.4% specificity. Conclusion: Tp-e/QTc is associated with angiographic complexity in NSTEMI and may support early risk stratification prior to angiography.
Co-Authors Abdullah Afif Siregar Abdullah Afif Siregar Abimanyu, Roni Ahmad Handayani Aldino Satria Adhitya Alfuadi, T. Rifki Mirza Ali Nafiah Nasution Andra, Cut Aryfa Andra, Cut Aryfa Chan, Muhammad Ikhsan Cut Aryfa Andra Daniel Ginting Dhilion, Har Rawishwar Singh dr Nicholas Prananda Sembiring Faisal Habib Faisal Habib FAPSC FASCC FIHA Ginting, Yehezkiel Bastanta Habib, Faisal Harris Hasan Harris Hasan Hasan, Harris Hasan, Refli Haykal, T. Bob Ilyas, Kamal Kharrazi Intan, Tengku Kemala Jaya Suganti Ketaren, Andre Pasha Kristivani Br Ginting Lubis, Ainil Wardah Lubis, Anggia Chairuddin Lubis, Hilfan Ade Putra Muhammad Azmi, Muhammad Mukhtar, Zulfikri Nasution, Ali Nafiah Putra, Muhammad Hafiz Mahruzza Ratna Mariana Tamba Raynaldo, Abdul Halim Sarastri, Yuke Setia Putra Tarigan Shafira Pramesi Putri Siahaan, Basten Jeremiah Siregar, Abdullah Afif Steven Winardi Syarifuddin, Fairuz Tamba, Ratna Mariana Tanjung, Ika Citra Dewi Teuku Bob Haykal Wirtanto, Ardy Putra Yuke Sarastri Zulfikri Mukhtar