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All Journal Jurnal Natur Indonesia Biologi Edukasi : Jurnal Ilmiah Pendidikan Biologi Microbiology Indonesia Jurnal Bioleuser Jurnal AgroBiogen Elkawnie Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Penelitian Pendidikan IPA (JPPIPA) Biosaintifika: Journal of Biology & Biology Education Jurnal Entomologi Indonesia Depik Jurnal Ilmu-Ilmu Perairan, Pesisir dan Perikanan Biosaintifika: Journal of Biology & Biology Education JURNAL PENGABDIAN PEMBANGUNAN PERTANIAN DAN LINGKUNGAN (JP3L)
Lenni Fitri
Universitas Syiah Kuala
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Education Electrical & Electronics Engineering Engineering Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Physics Social Sciences

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Secondary Metabolites Profiling and Antimicrobial Activities of Ethanol Extract from Jamblang (Syzygium cumini L.) Stem Bark Fayza Meutia; Yulia Sari Ismail; Lenni Fitri
Jurnal Penelitian Pendidikan IPA Vol 11 No 5 (2025): May
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i5.10589

Abstract

This study was conducted to determine the secondary metabolite compounds and evaluate the antimicrobial activity of ethanol extract of jamblang stem bark (Syzygium cumini). The method used in this research is experimental method. The extraction was carried out using the maceration method with 96% ethanol as the solvent. Secondary metabolite compounds of the extract samples were analyzed using a Gas Chromatography-Mass Spectrometry (GC-MS). Antimicrobial activity of the extract against Cutibacterium acnes, Staphylococcus aureus, and Candida albicans using disc diffusion method tested on MHA (Mueller Hinton Agar) media with extract concentrations of 40%, 60%, 80%, and 100%.  Each experiment was repeated three times to ensure validity. The results revealed that the extract have dominant compounds such as 7-Tetradecenal (Z), Octadecanoic acid, and n-Hexadecanoic acid. The antimicrobial test showed that the highest inhibition zones were 7.45 mm for C. acnes, 8.04 mm for S. aureus, and 4.60 mm for C. albicans at 100% extract concentration. The inhibition zones increased with higher extract concentrations, indicating a dose-dependent relationship. Compared to the positive control results (20.70 mm; 22.29 mm; and 18.62 mm) the extract showed moderate antimicrobial activity. These findings suggest that jamblang stem bark extract has potential as a natural antimicrobial agent.
Co-Authors Amirunnas , Amirunnas Anja Meryandini Ariqah, Nada Aulia, Muhammad Rizqi Betty Mauliya Bustam Dhani, Desy Nurrahma DITA, SASMIATI FARACH Dyah Iswantini Essy Harnelly Eva Agustriana Fauziah Fauziah Fayza Meutia Firdus Firdus Firdus Firdus Fitria Ardani Ismail, Yulia Sari M. Nur Salim Putriani, Putriani Putriani, Putriani Rauzana, Anita Rizki, Alia RUHUL KHALILA Safriani, Suri Raihan Sri Rahayu Suhartono Suhartono Suhartono Syafitri, Aini Syavira Azzahra Warzatullisna, Warzatullisna Wira Dharma Yekki Yasmin Yekki Yasmin Yekki Yasmin Yekki Yasmin Yulia Sari Ismail Yulia Sari Ismail Yulia Sari Ismail YULIN LESTARI Zahrina, Yuni Zakaria, Rahmad