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All Journal Jurnal Ilmu Kedokteran dan Kesehatan World Nutrition Journal Respiratory Science Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Baskoro, Hario
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Sinyal Bradikinin Pada Covid-19: Tinjauan Pustaka Nurwidya, Fariz; Zulfiyah, Itsna Arifatuz; Hidayat, Moulid; Baskoro, Hario
Jurnal Ilmu Kedokteran dan Kesehatan Vol 11, No 7 (2024): Volume 11 Nomor 7
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v11i7.15551

Abstract

Patofisiologi COVID-19 melibatkan jalur persinyalan seluler dan molekuler kompleks terkait inflamasi. Salah satu jalur yang mungkin terlibat adalah jalur bradikinin yang mengalami disregulasi. Bradikinin adalah suatu nonapeptida linear derivat dari kininogen yang terdistribusi di berbagai jaringan dan di plasma. Bukti ilmiah memperlihatkan peningkatan produksi bradikinin pada inflamasi. Manifestasi klinis seperti batuk juga berhubungan dengan aktivitas bradikinin. Memahami patogenesi COVID-19 menjadi penting dalam upaya menemukan pendekatan baru pada terapi efektif yang melibatkan jalur bradikinin. Pada tinjauan pustaka ini, akan dibahas bagaimana peranan bradikinin dan metabolitnya pada patogenesis COVID-19.
Leucine-included liquid diet as medical nutrition therapy improved handgrip strength and mid-upper circumference in clinically malnourished pulmonary tuberculosis patient with high neutrophil lymphocyte ratio: A case report from Universitas Indonesia hospital Singal, Anna Maurina; Afifa, Nadhira Nuraini; Wardhani, Wahyu Ika; Baskoro, Hario
World Nutrition Journal Vol. 8 No. i2 (2025): Volume 08 Issue 2, February 2025
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V08.i2.0005

Abstract

Background and objectives: Muscle weakness delays clinical improvement in pulmonary tuberculosis patients. Higher neutrophil lymphocyte ratio, low handgrip strength, mid-upper arm circumference indicates bad clinical outcome. Weight loss must be managed from the start of treatment. Good muscle condition has benefits to the recovery rate. Leucine provides benefits in increasing the synthesis of muscle mass so as the clinical conditions. Unfortunately, leucine has not been the routine part of medical nutrition therapy in tuberculosis patients. Methods: This is a case report of a female patient with body weight 42 kg and height 150 cm, admitted to Universitas Indonesia Hospital, with lung tuberculosis. Leucine given, started from 1.95 g/day to the maximum amount of 7,34 g/day through the hospital tailored-made liquid food. There was an improvement of clinical signs and symptoms during 14 days of hospitalization. Mid-upper arm circumferences at day 1, 8, and 15 were 21.1, 21.4, and 12.9 21.9 cm in a row. The right and left handgrip strength at day 1, 8, and 15 were 9.7 kg and 8.1 kg, 10.9 kg and 8.9 kg, 15.1 kg and 13.4 kg, respectively. While the neutrophil lymphocyte ratio at day 0, 6, and 9 were increasing, at 6.89, 6.89, and 13.8, in a row. Conclusions: Leucine 1.95–7.34 g/day, in tailored-made liquid food, as part of tuberculosis management therapy, though the NLR 13.8, can improve the mid-upper arm circumference, handgrip strength, clinical signs and symptoms in 14 days of hospitalization.
Exploring Epigenetic Landscapes in COPD: Therapeutic Implications and Recent Insights Wirawan, Aditya; Kinasih, Tutug; Imaniar, Rania; Baskoro, Hario; Antariksa, Budhi; Matsumoto, Naohisa
Respiratory Science Vol. 5 No. 2 (2025): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v5i2.166

Abstract

Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of global mortality, primarily driven by an abnormal inflammatory response to harmful particles and gases. This review explores the epigenetic mechanisms underlying COPD pathogenesis and their therapeutic implications. A comprehensive literature review was conducted, analyzing recent findings on DNA methylation, histone modifications, and noncoding RNAs (ncRNAs) in COPD. Key studies highlighting the impact of these epigenetic changes on inflammation, cellular responses, and disease progression were evaluated. Our review highlights that epigenetic modifications, such as DNA methylation and histone modifications, significantly impact gene expression without altering the DNA sequence. Cigarette smoking has been shown to influence both DNA methylation and histone acetylation, leading to inflammatory responses and the the exacerbation of COPD. These modifications contribute to chronic inflammation and disease progression, with alterations in histone acetylation, methylation, and phosphorylation playing critical roles in COPD pathogenesis. The interplay between epigenetic changes and environmental factors, particularly tobacco smoke, reveals a complex mechanism driving COPD progression. Aberrant gene expression linked to these epigenetic modifications suggests potential disease severity and progression biomarkers. Targeting these alterations offers novel therapeutic strategies. Emerging treatments, such as quercetin and theophylline, promise to restore normal cellular functions and effectively manage COPD. Future research should focus on elucidating these mechanisms further and developing targeted therapies to mitigate the impact of epigenetic modifications on COPD.
Epidemiological and Clinical Features of COVID-19 Patients at National Emergency Hospital Wisma Atlet Kemayoran, Jakarta, Indonesia Susanto, Agus Dwi; Rozaliyani, Anna; Prasetyo, Budi; Agustin, Heidy; Baskoro, Hario; Arifin, Arief Riadi; Pratama, Satria; Zaini, Jamal; Hasto, Bambang Dwi; Ratmono, Tugas; Savitri, Ary Indriana; Samoedro, Erlang; Husain, Bahtiar; Nawas, Arifin; Burhan, Erlina
Kesmas Vol. 16, No. 5
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The emergency hospital is intended to prevent transmission of COVID-19 in the community by isolating patients without symptoms, with mild or moderate symptoms. This study evaluated the clinical characteristics and outcomes of COVID-19 patients who were admitted to this facility. This retrospective study re-viewed data of patients treated at the National Emergency Hospital Wisma Atlet Kemayoran in Jakarta, Indonesia, from March 23 to April 30, 2020. Patient characteristics (clinical symptoms, laboratory test results, Chest X-Ray, SARS-CoV-2 immunoserology, and RT-PCR results from nasopharyngeal/ oropharyngeal preparations) were compared between severity groups. There were 413 COVID-19 cases analyzed, of which 190 (46%) were asymptomatic, 93 (22.5%) were mild, and 130 (31.5%) were moderate cases. Most asymptomatic cases were male, with young age, and without comorbidity. Mild cases were dominated by female and young patients, while most moderate cases were male and older patients. The number of patients with comorbidities was higher in mild and mod-erate cases. The patient’s overall outcome was good and did not differ based on the severity of symptoms. Despite the many challenges, patients with moderate symptoms can be safely treated in the emergency hospital.
Co-Authors Aditya Wirawan, Aditya Afifa, Nadhira Nuraini Agus Dwi Susanto Agustin, Heidy Anna Rozaliyani Arifin Nawas Arifin, Arief Riadi Budhi Antariksa Budi Prasetyo Erlina Burhan Fariz, Nurwidya Hasto, Bambang Dwi Hidayat, Moulid Husain, Bahtiar Imaniar, Rania Kinasih, Tutug Matsumoto, Naohisa Samoedro, Erlang Satria Pratama Savitri, Ary Indriana Singal, Anna Maurina Tugas Ratmono, Tugas Wahyu Ika Wardhani Zaini, Jamal Zulfiyah, Itsna Arifatuz